Epigenetic Programming and Fetal Metabolic Programming

Zhu, Ziqiang; Cao, Fang; Li, Xiaozhong

doi:10.3389/fendo.2019.00764

Cited by 158Birth, Development, and HealthEpigenetics and DNA MethylationGenetic Syndromes and Imprinting

Epigenetic Programming and Fetal Metabolic Programming

Open access

Zhu, Ziqiang, Cao, Fang, Li, Xiaozhong·2019·Frontiers in Endocrinology

DOI 10.3389/fendo.2019.00764PMC PMC6901800

Open this paper in CoChat — free account Open PDF

Abstract

Fetal metabolic programming caused by the adverse intrauterine environment can induce metabolic syndrome in adult offspring. Adverse intrauterine environment introduces fetal long-term relatively irreversible changes in organs and metabolism, and thus causes fetal metabolic programming leading metabolic syndrome in adult offspring. Fetal metabolic programming of obesity and insulin resistance plays a key role in this process. The mechanism of fetal metabolic programming is still not very clear. It is suggested that epigenetic programming, also induced by the adverse intrauterine environment, is a critical underlying mechanism of fetal metabolic programming. Fetal epigenetic programming affects gene expression changes and cellular function through epigenetic modifications without DNA nucleotide sequence changes. Epigenetic modifications can be relatively stably retained and transmitted through mitosis and generations, and thereby induce the development of metabolic syndrome in adult offspring. This manuscript provides an overview of the critical role of epigenetic programming in fetal metabolic programming.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fendo.2019.00764

Cites

198 of 198 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Such changes may also modify placental nutrient transport, promote compensatory nutrient delivery, and predispose offspring to metabolic disorders later in life.
“Such changes may also modify placental nutrient transport, promote compensatory nutrient delivery and predispose offspring to metabolic disorders later in life [18,173,174].”
From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [18]
The Fetal Metabolic Programming section says adverse intrauterine conditions may lead to obesity, insulin resistance, and metabolic syndrome in adult offspring. The cited paper discusses placental methylation in the Epigenetic Programming of Obesity section, but the passages found do not establish modified placental nutrient transport or compensatory nutrient delivery (searched: nutrient transport, placental transport, compensatory). (LLM, conf=0.86)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

2 retracted

RETRACTED: Impairment of Central Leptin-Mediated PI3K Signaling Manifested as Hepatic Steatosis Independent of Hyperphagia and Obesity
Warne, J. P., Alemi, F., Reed, A. S., Varonin, J. M., Chan, H., Piper, M. L., Mullin, M. E., Myers, M. G., Corvera, C. U., & Xu, A. W. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.001 · Cited by 44 · see citing works
Retracted
Retraction Notice to: Impairment of Central Leptin-Mediated PI3K Signaling Manifested as Hepatic Steatosis Independent of Hyperphagia and Obesity
Warne, J. P., Alemi, F., Reed, A. S., Varonin, J. M., Chan, H., Piper, M. L., Mullin, M. E., Myers, M. G., Corvera, C. U., & Xu, A. W. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.03.008 · Cited by 3 · see citing works
Retracted
Effect of In Utero and Early-Life Conditions on Adult Health and Disease
Gluckman, P. D., Hanson, M. A., Cooper, C., & Thornburg, K. L. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0708473 · Cited by 3,898 · see citing works
Persistent epigenetic differences associated with prenatal exposure to famine in humans
Heijmans, B. T., Tobi, E. W., Stein, A. D., Putter, H., Blauw, G. J., Susser, E. S., Slagboom, P. E., & Lumey, L. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806560105 · Cited by 3,082 · see citing works
Elective induction versus spontaneous labor after sonographic diagnosis of fetal macrosomia.
Combs, C. A., Singh, N. B., & Khoury, J. C. (1993) · PubMed · Cited by 2,462 · see citing works
In utero programming of chronic disease
BARKER, D. J. P. (1998) · Clinical Science · doi:10.1042/cs0950115 · Cited by 1,765 · see citing works
Obesity in Young Men after Famine Exposure in Utero and Early Infancy
Ravelli, G.-P., Stein, Z. A., & Susser, M. W. (1976) · New England Journal of Medicine · doi:10.1056/nejm197608122950701 · Cited by 1,647 · see citing works
Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress
Rodgers, A. B., Morgan, C. P., Leu, N. A., & Bale, T. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508347112 · Cited by 751 · see citing works
Fetuses of obese mothers develop insulin resistance in utero
Catalano, P. M., Presley, L., Minium, J., & Hauguel-de Mouzon, S. (2009) · Diabetes Care · doi:10.2337/dc08-2077 · Cited by 655 · see citing works
DNA methylation signatures link prenatal famine exposure to growth and metabolism
Tobi, E. W., Goeman, J. J., Monajemi, R., Gu, H., Putter, H., Zhang, Y., Slieker, R. C., Stok, A. P., Thijssen, P. E., Müller, F., et al. (2014) · Nature Communications · doi:10.1038/ncomms6592 · Cited by 630 · see citing works
The interplay of epigenetic marks during stem cell differentiation and development
Atlasi, Y., & Stunnenberg, H. G. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.57 · Cited by 569 · see citing works
Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health
Babenko, O., Kovalchuk, I., & Metz, G. A. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.013 · Cited by 513 · see citing works
Maternal nutrition at conception modulates DNA methylation of human metastable epialleles
Dominguez-Salas, P., Moore, S. E., Baker, M. S., Bergen, A. W., Cox, S. E., Dyer, R. A., Fulford, A. J., Guan, Y., Laritsky, E., Silver, M. J., et al. (2014) · Nature Communications · doi:10.1038/ncomms4746 · Cited by 506 · see citing works
Epigenetic and transgenerational reprogramming of brain development
Bale, T. L. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3818 · Cited by 505 · see citing works
Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome
Aagaard-Tillery, K. M., Grove, K. L., Bishop, J. M., Ke, X., Fu, Q., McKnight, R. A., & Lane, R. H. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-08-0025 · Cited by 433 · see citing works
Specification and epigenetic programming of the human germ line
Tang, W. W. C., Kobayashi, T., Irie, N., Dietmann, S., & Surani, M. (2016) · Nature reviews genetics · doi:10.1038/nrg.2016.88 · Cited by 400 · see citing works
Transgenerational inheritance: Models and mechanisms of non–DNA sequence–based inheritance
Miska, E. A., & Ferguson-Smith, A. C. (2016) · Science · doi:10.1126/science.aaf4945 · Cited by 367 · see citing works
Epigenetic germline inheritance of diet-induced obesity and insulin resistance
Huypens, P., Sass, S., Wu, M., Dyckhoff, D., Tschöp, M., Theis, F., Marschall, S., de Angelis, M. H., & Beckers, J. (2016) · Nature Genetics · doi:10.1038/ng.3527 · Cited by 366 · see citing works
Transgenerational Glucose Intolerance With Igf2/H19 Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia
Ding, G., Wang, F., Shu, J., Tian, S., Jiang, Y., Zhang, D., Wang, N., Luo, Q., Zhang, Y., Jin, F., et al. (2012) · Diabetes · doi:10.2337/db11-1314 · Cited by 292 · see citing works
Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state
Crevillén, P., Yang, H., Cui, X., Greeff, C., Trick, M., Qiu, Q., Cao, X., & Dean, C. (2014) · Nature · doi:10.1038/nature13722 · Cited by 280 · see citing works
Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium
Sharp, G. C., Salas, L. A., Monnereau, C., Allard, C., Yousefi, P., Everson, T. M., Bohlin, J., Xu, Z., Huang, R., Reese, S. E., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx290 · Cited by 277 · see citing works
Metabolic Syndrome Scientific Statement by the American Heart Association and the National Heart, Lung, and Blood Institute
Grundy, S. M. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000189155.75833.c7 · Cited by 248 · see citing works
Leptin Gene Epigenetic Adaptation to Impaired Glucose Metabolism During Pregnancy
Bouchard, L., Thibault, S., Guay, S., Santuré, M., Monpetit, A., St‐Pierre, J., Perron, P., & Brisson, D. (2010) · Diabetes Care · doi:10.2337/dc10-1024 · Cited by 237 · see citing works
Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance
Kim, A. Y., Park, Y. J., Pan, X., Shin, K. C., Kwak, S., Bassas, A. F., Sallam, R. M., Park, K. S., Alfadda, A. A., Xu, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms8585 · Cited by 235 · see citing works
Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective
Liang, G., & Zhang, Y. (2012) · Cell Research · doi:10.1038/cr.2012.175 · Cited by 223 · see citing works
Leptin resistance in obesity: An epigenetic landscape
Crujeiras, A. B., Carreira, M. C., Fernández, B. C., Andrade, S., Amil, M., & Casanueva, F. F. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.05.003 · Cited by 223 · see citing works
Effects of a High-Fat Diet Exposure in Utero on the Metabolic Syndrome-Like Phenomenon in Mouse Offspring through Epigenetic Changes in Adipocytokine Gene Expression
Masuyama, H., & Hiramatsu, Y. (2012) · Endocrinology · doi:10.1210/en.2011-2161 · Cited by 212 · see citing works
Chromatin “Prepattern” and Histone Modifiers in a Fate Choice for Liver and Pancreas
Xu, C., Cole, P. A., Meyers, D. J., Kormish, J. D., Dent, S., & Zaret, K. S. (2011) · Science · doi:10.1126/science.1202845 · Cited by 204 · see citing works
Diabetes mellitus—advances and challenges in human β-cell proliferation
Wang, P., Fiaschi‐Taesch, N., Vasavada, R. C., Scott, D. K., Garcı́a-Ocaña, A., & Stewart, A. F. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.9 · Cited by 204 · see citing works
The role of diet and exercise in the transgenerational epigenetic landscape of T2DM
Barrès, R., & Zierath, J. R. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.87 · Cited by 198 · see citing works
Dissecting neural differentiation regulatory networks through epigenetic footprinting
Ziller, M. J., Edri, R., Yaffe, Y., Donaghey, J., Pop, R., Mallard, W., Issner, R., Gifford, C. A., Goren, A., Xing, J. C., et al. (2014) · Nature · doi:10.1038/nature13990 · Cited by 197 · see citing works
Epigenetic transgenerational inheritance
Skinner, M. K. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.206 · Cited by 184 · see citing works
Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis
Strakovsky, R. S., Wang, H., Engeseth, N. J., Flaws, J. A., Helferich, W. G., Pan, Y., & Lezmi, S. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.02.021 · Cited by 180 · see citing works
Maternal Weight Gain in Pregnancy and Risk of Obesity among Offspring: A Systematic Review
Lau, E. Y., Liu, J., Archer, E., McDonald, S. M., & Liu, J. (2014) · Journal of Obesity · doi:10.1155/2014/524939 · Cited by 176 · see citing works
Embryonic defects induced by maternal obesity in mice derive from Stella insufficiency in oocytes
Han, L., Ren, C., Li, L., Li, X., Ge, J., Wang, H., Miao, Y., Guo, X., Moley, K. H., Shu, W., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0055-6 · Cited by 175 · see citing works
Self-citation
A maternal high‐fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates
Suter, M., Chen, A., Burdine, M., Choudhury, M., Harris, R. A., Lane, R. H., Friedman, J. E., Grove, K. L., Tackett, A. J., & Aagaard, K. M. (2012) · The FASEB Journal · doi:10.1096/fj.12-212878 · Cited by 171 · see citing works
Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring
Kang, S. S., Kurti, A., Fair, D. A., & Fryer, J. D. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0156-9 · Cited by 167 · see citing works
DNA methylation directs functional maturation of pancreatic β cells
Dhawan, S., Tschen, S.-I., Zeng, C., Guo, T., Hebrok, M., Matveyenko, A. V., & Bhushan, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79956 · Cited by 164 · see citing works
Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta
Filiberto, A. C., Maccani, M. A., Koestler, D. C., Wilhelm-Benartzi, C. S., Avissar-Whiting, M., Banister, C. E., Gagne, L. A., & Marsit, C. J. (2011) · Epigenetics · doi:10.4161/epi.6.5.15236 · Cited by 162 · see citing works
Longitudinal analysis of DNA methylation associated with birth weight and gestational age
Simpkin, A. J., Suderman, M. J., Gaunt, T. R., Lyttleton, O., McArdle, W. L., Ring, S. M., Tilling, K. M., Smith, G. D., & Relton, C. L. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv119 · Cited by 159 · see citing works
Epigenetic Changes in the Hypothalamic Proopiomelanocortin and Glucocorticoid Receptor Genes in the Ovine Fetus after Periconceptional Undernutrition
Stevens, A., Begum, G., Cook, A., Connor, K. L., Rumball, C. W. H., Oliver, M. H., Challis, J. R. G., Bloomfield, F. H., & White, A. E. (2010) · Endocrinology · doi:10.1210/en.2010-0094 · Cited by 155 · see citing works
Birthweight, Maternal Weight Trajectories and Global DNA Methylation of LINE-1 Repetitive Elements
Michels, K. B., Harris, H. R., & Barault, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025254 · Cited by 152 · see citing works
Maternal Obesity Induces Epigenetic Modifications to Facilitate Zfp423 Expression and Enhance Adipogenic Differentiation in Fetal Mice
Yang, Q.-Y., Liang, J.-F., Rogers, C. J., Zhao, J.-X., Zhu, M.-J., & Du, M. (2013) · Diabetes · doi:10.2337/db13-0433 · Cited by 152 · see citing works
Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice
Chamorro-García, R., Díaz-Castillo, C., Shoucri, B. M., Kaech, H., Leavitt, R., Shioda, T., & Blumberg, B. (2017) · Nature Communications · doi:10.1038/s41467-017-01944-z · Cited by 148 · see citing works
Association between maternal adherence to healthy lifestyle practices and risk of obesity in offspring: results from two prospective cohort studies of mother-child pairs in the United States
Dhana, K., Haines, J., Liu, G., Zhang, C., Wang, X., Field, A. E., Chavarro, J. E., & Sun, Q. (2018) · BMJ · doi:10.1136/bmj.k2486 · Cited by 146 · see citing works
Increased global placental DNA methylation levels are associated with gestational diabetes
Reichetzeder, C., Dwi Putra, S. E., Pfab, T., Slowinski, T., Neuber, C., Kleuser, B., & Hocher, B. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0247-9 · Cited by 144 · see citing works
Arsenic exposure in early pregnancy alters genome-wide DNA methylation in cord blood, particularly in boys
Bröberg, K., Ahmed, S., Engström, K. S., Hossain, M. B., Mlakar, S. J., Bottai, M., Grandér, M., Raqib, R., & Vahter, M. (2014) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174414000221 · Cited by 143 · see citing works
Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats
Strakovsky, R. S., Zhang, X., Zhou, D., & Pan, Y. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.203950 · Cited by 141 · see citing works
Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth
Tosh, D. N., Fu, Q., Callaway, C. W., McKnight, R. A., McMillen, I. C., Ross, M. G., Lane, R. H., & Desai, M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00052.2010 · Cited by 136 · see citing works
Maternal high-fat diet induces insulin resistance and deterioration of pancreatic β-cell function in adult offspring with sex differences in mice
Yokomizo, H., Inoguchi, T., Sonoda, N., Sakaki, Y., Maeda, Y., Inoue, T., Hirata, E., Takei, R., Ikeda, N., Fujii, M., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00688.2013 · Cited by 135 · see citing works
Maternal high-fat diet consumption modulates hepatic lipid metabolism and microRNA-122 (miR-122) and microRNA-370 (miR-370) expression in offspring
Benatti, R., Melo, A. M., Borges, F., Ignácio-Souza, L., Simino, L. A. P., Milanski, M., Velloso, L., Torsoni, M., & Torsoni, A. (2014) · British Journal of Nutrition · doi:10.1017/s0007114514000579 · Cited by 135 · see citing works
DNA methylation in blood from neonatal screening cards and the association with BMI and insulin sensitivity in early childhood
van Dijk, S. J., Peters, T. J., Buckley, M. J., Zhou, J., Jones, P. A., Gibson, R. A., Makrides, M., Mühlhäusler, B. S., & Molloy, P. L. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.228 · Cited by 135 · see citing works
Epigenetic programming of obesity and diabetes by in utero exposure to gestational diabetes mellitus
Ruchat, S.-M., Hivert, M., & Bouchard, L. (2013) · Nutrition Reviews · doi:10.1111/nure.12057 · Cited by 128 · see citing works
Dnmt3a is an epigenetic mediator of adipose insulin resistance
You, D., Nilsson, E., Tenen, D. E., Lyubetskaya, A., Lo, J. C., Jiang, R., Deng, J., Dawes, B. A., Vaag, A. A., Ling, C., et al. (2017) · eLife · doi:10.7554/elife.30766 · Cited by 124 · see citing works
The inheritance of acquired epigenetic variations.
Jablonka, E., & Lamb, M. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv020 · Cited by 123 · see citing works
Gene-specific DNA methylation in newborns in response to folic acid supplementation during the second and third trimesters of pregnancy: epigenetic analysis from a randomized controlled trial
Caffrey, A., Irwin, R. E., McNulty, H., Strain, J. J., Lees‐Murdock, D. J., McNulty, B. A., Ward, M., Walsh, C. P., & Pentieva, K. D. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqx069 · Cited by 121 · see citing works
Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning
Begum, G., Stevens, A., Smith, E. B., Connor, K. L., Challis, J. R. G., Bloomfield, F. H., & White, A. E. (2012) · The FASEB Journal · doi:10.1096/fj.11-198762 · Cited by 119 · see citing works
Epigenetic signatures of gestational diabetes mellitus on cord blood methylation
Haertle, L., Hajj, N. E., Dittrich, M. T., Müller, T., Nanda, I., Lehnen, H., & Haaf, T. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0329-3 · Cited by 118 · see citing works
Maternal diet–induced microRNAs and mTOR underlie β cell dysfunction in offspring
Alejandro, E. U., Gregg, B. E., Wallen, T. E., Kumusoglu, D., Meister, D. L., Chen, A., Merrins, M. J., Satin, L. S., Liu, M. R., Arvan, P. R., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74237 · Cited by 117 · see citing works
Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity
de Lartigue, G., Ronveaux, C. C., & Raybould, H. E. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.06.003 · Cited by 117 · see citing works
Differential effects of maternal obesity and weight loss in the periconceptional period on the epigenetic regulation of hepatic insulin‐signaling pathways in the offspring
Nicholas, L. M., Rattanatray, L., MacLaughlin, S. M., Ozanne, S. E., Kleemann, D. O., Walker, S. K., Morrison, J. L., Zhang, S., Mühlhäusler, B. S., Martin‐Gronert, M. S., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-227918 · Cited by 115 · see citing works
Maternal obesity and gestational diabetes are associated with placental leptin DNA methylation
Lesseur, C., Armstrong, D. A., Paquette, A. G., Li, Z., Padbury, J. F., & Marsit, C. J. (2014) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2014.06.037 · Cited by 115 · see citing works
Impact of Maternal Obesity on Perinatal and Childhood Outcomes
Santangeli, L., Sattar, N. A., & Huda, S. S. (2014) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2014.10.009 · Cited by 114 · see citing works
Maternal high-fat diets cause insulin resistance through inflammatory changes in fetal adipose tissue
Murabayashi, N., Sugiyama, T., Zhang, L., Kamimoto, Y., Umekawa, T., Ma, N., & Sagawa, N. (2013) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2013.02.003 · Cited by 114 · see citing works
Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms
Fernandez-Twinn, D. S., Alfaradhi, M. Z., Martin-Gronert, M. S., Duque-Guimaraes, D. E., Piekarz, A., Ferland-McCollough, D., Bushell, M., & Ozanne, S. E. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.01.007 · Cited by 114 · see citing works
Gestational Diabetes and Maternal Obesity Are Associated with Epigenome-Wide Methylation Changes in Children
Hjort, L., Martino, D., Grunnet, L. G., Naeem, H., Maksimovic, J., Olsson, A. H., Zhang, C., Ling, C., Olsen, S. F., Saffery, R., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.122572 · Cited by 114 · see citing works
The effects of paternal high-fat diet exposure on offspring metabolism with epigenetic changes in the mouse adiponectin and leptin gene promoters
Masuyama, H., Mitsui, T., Eguchi, T., Tamada, S., & Hiramatsu, Y. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00095.2016 · Cited by 110 · see citing works
Phthalate exposure in utero causes epigenetic changes and impairs insulin signalling
Parsanathan, R., & Balasubramanian, K. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0111 · Cited by 108 · see citing works
Maternal obesity influences expression and DNA methylation of the adiponectin and leptin systems in human third-trimester placenta
Nogues, P., Santos, E. D., Jammes, H., Berveiller, P., Arnould, L., Vialard, F., & Dieudonné, M. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0612-6 · Cited by 108 · see citing works
DNA methylation of leptin and adiponectin promoters in children is reduced by the combined presence of obesity and insulin resistance
García-Cardona, M. C., Huang, F., García-Vivas, J. M., López‐Camarillo, C., Navarro, B. E. D. R., Navarro-Olivos, E., Hong‐Chong, E., Bolaños‐Jiménez, F., & Marchat, L. A. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.30 · Cited by 104 · see citing works
The Effects of High-Fat Diet Exposure in Utero on the Obesogenic and Diabetogenic Traits through Epigenetic Changes in Adiponectin and Leptin Gene Expression for Multiple Generations in Female Mice
Masuyama, H., Mitsui, T., Nobumoto, E., & Hiramatsu, Y. (2015) · Endocrinology · doi:10.1210/en.2014-2020 · Cited by 104 · see citing works
High-fructose diet in pregnancy leads to fetal programming of hypertension, insulin resistance, and obesity in adult offspring
Saad, A. F., Dickerson, J., Kechichian, T. B., Yin, H., Gamble, P., Salazar, A. E., Patrikeev, I., Motamedi, M., Saade, G. R., & Costantine, M. M. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.03.038 · Cited by 103 · see citing works
Extracellular RNAs Are Associated With Insulin Resistance and Metabolic Phenotypes
Shah, R. V., Murthy, V. L., Pacold, M. E., Danielson, K., Tanrıverdi, K., Larson, M. G., Hanspers, K., Pico, A. R., Mick, E. O., Reis, J. P., et al. (2017) · Diabetes Care · doi:10.2337/dc16-1354 · Cited by 103 · see citing works
In utero exposure to a maternal high-fat diet alters the epigenetic histone code in a murine model
Suter, M., Ma, J., Vuguin, P. M., Hartil, K., Fiallo, A., Harris, R. A., Charron, M. J., & Aagaard, K. M. (2014) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2014.01.045 · Cited by 99 · see citing works
Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetes
Chandrakumar, S., Paramasivam, P., Balakumar, M., Lenin, R. R., Prabhu, D., Anjana, R. M., Mohan, V., & Balasubramanyam, M. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0293-3 · Cited by 95 · see citing works
The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity
Bricambert, J., Alves‐Guerra, M., Estèves, P., Prip‐Buus, C., Bertrand‐Michel, J., Guillou, H., Chang, C. J., Wal, M. N. V., Canonne‐Hergaux, F., Mathurin, P., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04361-y · Cited by 95 · see citing works
DNA methylation patterns in newborns exposed to tobacco in utero
Ivorra, C., Fraga, M. F., Bayón, G. F., Fernández, A. F., García-Vicent, C., Chaves, F. J., Redón, J., & Lurbe, E. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0384-5 · Cited by 93 · see citing works
Genome-wide DNA methylation pattern in visceral adipose tissue differentiates insulin-resistant from insulin-sensitive obese subjects
Crujeiras, A. B., Díaz‐Lagares, Á., Moreno‐Navarrete, J. M., Sandoval, J., Hervás, D., Gómez, A., Ricart, W., Casanueva, F. F., Esteller, M., & Fernández‐Real, J. M. (2016) · Translational research · doi:10.1016/j.trsl.2016.07.002 · Cited by 93 · see citing works
Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet
Aiken, C., Tarry‐Adkins, J. L., Penfold, N., Dearden, L., & Ozanne, S. E. (2015) · The FASEB Journal · doi:10.1096/fj.15-280800 · Cited by 92 · see citing works
Developmental Programming by Maternal Insulin Resistance: Hyperinsulinemia, Glucose Intolerance, and Dysregulated Lipid Metabolism in Male Offspring of Insulin-Resistant Mice
ISGANAITIS, E. M., Woo, M., Ma, H., Chen, M., Kong, W., Lytras, A., Sales, V., DeCoste-Lopez, J., Lee, K.-J., Leatherwood, C. L., et al. (2013) · Diabetes · doi:10.2337/db13-0558 · Cited by 89 · see citing works
Exposure to the Chinese Famine in Childhood Increases Type 2 Diabetes Risk in Adults
Wang, J., Li, Y., Han, X., Liu, B., Hu, H., Wang, F., Li, X., YANG, K. Y., Yuan, J., Yao, P., et al. (2016) · Journal of Nutrition · doi:10.3945/jn.116.234575 · Cited by 89 · see citing works
Self-citation
Placental and Cord Blood Methylation of Genes Involved in Energy Homeostasis: Association With Fetal Growth and Neonatal Body Composition
Díaz, M., García-Beltrán, C., Sebastiani, G., de Zegher, F., López‐Bermejo, A., & Ibáñez, L. (2016) · Diabetes · doi:10.2337/db16-0776 · Cited by 89 · see citing works
Alteration in Expression and Methylation of IGF2/H19 in Placenta and Umbilical Cord Blood Are Associated with Macrosomia Exposed to Intrauterine Hyperglycemia
Su, R., Wang, C., Feng, H., Lin, L., Liu, X., Wei, Y., & Yang, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148399 · Cited by 86 · see citing works
Metabolic Programming, Epigenetics, and Gestational Diabetes Mellitus
Pinney, S. E., & Simmons, R. A. (2011) · Current Diabetes Reports · doi:10.1007/s11892-011-0248-1 · Cited by 86 · see citing works
The epigenetic signature of systemic insulin resistance in obese women
Arner, P., Sahlqvist, A., Sinha, I., Xu, H. Y., Yao, X., Waterworth, D. M., Rajpal, D. K., Loomis, A. K., Freudenberg, J., Johnson, T., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-4074-5 · Cited by 85 · see citing works
Differential methylation of genes in individuals exposed to maternal diabetes in utero
Chen, P., Piaggi, P., Traurig, M. T., Bogardus, C., Knowler, W. C., Baier, L. J., & Hanson, R. L. (2017) · Diabetologia · doi:10.1007/s00125-016-4203-1 · Cited by 85 · see citing works
Maternal obesity has little effect on the immediate offspring but impacts on the next generation.
King, V., Dakin, R., Liu, L., Hadoke, P., Walker, B., Seckl, J., Norman, J., & Drake, A. (2013) · Endocrinology · doi:10.1210/en.2013-1013 · Cited by 82 · see citing works
Maternal obesity downregulates microRNA let-7g expression, a possible mechanism for enhanced adipogenesis during ovine fetal skeletal muscle development
Yan, X., Huang, Y., Jx, Z., Rogers, C. J., Zhu, M.-J., Ford, S. P., Nathanielsz, P. W., & Du, ‬. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.69 · Cited by 82 · see citing works
Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification
Xu, C., Li, L., Donahue, G., Ying, L., Zhang, Y., Gadue, P. J., & Zaret, K. S. (2014) · The EMBO Journal · doi:10.15252/embj.201488671 · Cited by 80 · see citing works
Maternal hyperinsulinemia predisposes rat fetuses for hyperinsulinemia, and adult-onset obesity and maternal mild food restriction reverses this phenotype
Srinivasan, M., Aalinkeel, R., Song, F., Mitrani, P., Pandya, J. D., Strutt, B. J., Hill, D. J., & Patel, M. S. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00248.2005 · Cited by 80 · see citing works
The Mechanism of Environmental Endocrine Disruptors (DEHP) Induces Epigenetic Transgenerational Inheritance of Cryptorchidism
Chen, J., Wu, S., Wen, S., Shen, L., Peng, J., Yan, C., Cao, X., Zhou, Y., Long, C., Lin, T., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126403 · Cited by 78 · see citing works
Hypothalamic endoplasmic reticulum stress and insulin resistance in offspring of mice dams fed high-fat diet during pregnancy and lactation
Melo, A. M., Benatti, R. O., Ignácio-Souza, L. M., Okino, C., Torsoni, A. S., Milanski, M., Velloso, L. A., & Torsoni, M. A. (2014) · Metabolism · doi:10.1016/j.metabol.2014.02.002 · Cited by 77 · see citing works
Expression of epigenetic machinery genes is sensitive to maternal obesity and weight loss in relation to fetal growth in mice
Panchenko, P. E., Voisin, S. A. C., Jouin, M., Jouneau, L., Prézelin, A., Lecoutre, S., Breton, C., Jammes, H., Junien, C., & Gabory, A. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0188-3 · Cited by 77 · see citing works
Prenatal Growth Patterns and Birthweight Are Associated With Differential DNA Methylation and Gene Expression of Cardiometabolic Risk Genes in Human Placentas: A Discovery-Based Approach
Chen, P., Chu, A., Liao, W., Rubbi, L., Janzen, C., Hsu, F., Thamotharan, S., Ganguly, A., Lam, L., Montoya, D. J., et al. (2017) · Reproductive Sciences · doi:10.1177/1933719117716779 · Cited by 75 · see citing works
Hyperinsulinemia in Cord Blood in Mothers With Type 2 Diabetes and Gestational Diabetes Mellitus in New Zealand
Westgate, J. A., Lindsay, R. S., Beattie, J., Pattison, N. S., Gamble, G. D., Mildenhall, L., Breier, B. H., & Johnstone, F. D. (2006) · Diabetes Care · doi:10.2337/dc05-1677 · Cited by 74 · see citing works
Multigenerational impact of maternal overnutrition/obesity in the sheep on the neonatal leptin surge in granddaughters
Shasa, D. R., Odhiambo, J. F., Long, N., Tuersunjiang, N., Nathanielsz, P. W., & Ford, S. P. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.190 · Cited by 74 · see citing works
The associations between triglyceride to high‐density lipoprotein cholesterol ratios and the risks of gestational diabetes mellitus and large‐for‐gestational‐age infant
Wang, D., Xu, S., Chen, H., Zhong, L., & Wang, Z. (2015) · Clinical Endocrinology · doi:10.1111/cen.12742 · Cited by 72 · see citing works
Alterations of adiponectin gene expression and DNA methylation in adipose tissues and blood cells are associated with gestational diabetes and neonatal outcome
Ott, R., Stupin, J. H., Melchior, K., Schellong, K., Ziska, T., Dudenhausen, J. W., Henrich, W., Rancourt, R. C., & Plagemann, A. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0567-z · Cited by 71 · see citing works
Maternal glucose tolerance in pregnancy affects fetal insulin sensitivity
Luo, Z.-C., Delvin, E., Fraser, W. D., Audibert, F., Deal, C. I., Julien, P., Girard, I., Shear, R., Levy, E., & Nuyt, A.-M. (2010) · Diabetes Care · doi:10.2337/dc10-0819 · Cited by 71 · see citing works
Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action
de Mello, V. D., Matte, A., Perfilyev, A., Männistö, V., Rönn, T., Nilsson, E., Käkelä, P., Ling, C., & Pihlajamäki, J. (2017) · Epigenetics · doi:10.1080/15592294.2017.1294305 · Cited by 70 · see citing works
Primate fetal hepatic responses to maternal obesity: epigenetic signalling pathways and lipid accumulation
Puppala, S., Li, C., Glenn, J. P., Saxena, R., Gawrieh, S., Quinn, A. R., Palarczyk, J., Dick, E. J., Nathanielsz, P. W., & Cox, L. A. (2018) · The Journal of Physiology · doi:10.1113/jp275422 · Cited by 69 · see citing works
Genome-wide DNA methylation profiling in infants born to gestational diabetes mellitus
Weng, X., Liu, F., Zhang, H., Kan, M., Wang, T., Dong, M., & Liu, Y. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.03.016 · Cited by 68 · see citing works
Dietary Alleviation of Maternal Obesity and Diabetes: Increased Resistance to Diet-Induced Obesity Transcriptional and Epigenetic Signatures
Attig, L., Vigé, A., Gabory, A., Karimi, M., Beauger, A. A., Gross, M., Athias, A., Gallou‐Kabani, C., Gambert, P., Ekström, T. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066816 · Cited by 67 · see citing works
Genome-wide DNA methylation variation in maternal and cord blood of gestational diabetes population
Kang, J., Lee, C., Li, H., Hsu, K.-H., & Lin, S. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.07.034 · Cited by 67 · see citing works
Gestational exposure to di(2-ethylhexyl) phthalate (DEHP) impairs pancreatic β-cell function in F1 rat offspring
Rajesh, P., & Balasubramanian, K. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.09.025 · Cited by 66 · see citing works
WNT2promoter methylation in human placenta is associated with low birthweight percentile in the neonate
Ferreira, J. C., Choufani, S., Grafodatskaya, D., Butcher, D. T., Zhao, C., Chitayat, D. A., Shuman, C. T., Kingdom, J. C., Keating, S., & Weksberg, R. (2011) · Epigenetics · doi:10.4161/epi.6.4.14554 · Cited by 65 · see citing works
Changes in Leptin Signaling by SOCS3 Modulate Fasting-Induced Hyperphagia and Weight Regain in Mice
Pedroso, J. A. B., Silveira, M. A., Lima, L. B., Furigo, I. C., Zampieri, T. T., Ramos-Lobo, A. M., Buonfiglio, D. D. C., Teixeira, P. D. S., Frazão, R., & Donato, J. (2016) · Endocrinology · doi:10.1210/en.2016-1038 · Cited by 65 · see citing works
Potential epigenetic dysregulation of genes associated with MODY and type 2 diabetes in humans exposed to a diabetic intrauterine environment: An analysis of genome-wide DNA methylation
del Rosario, M. C., Ossowski, V., Knowler, W. C., Bogardus, C., Baier, L. J., & Hanson, R. L. (2014) · Metabolism · doi:10.1016/j.metabol.2014.01.007 · Cited by 63 · see citing works
Testing the fuel-mediated hypothesis: maternal insulin resistance and glucose mediate the association between maternal and neonatal adiposity, the Healthy Start study
Shapiro, A. L. B., Schmiege, S. J., Brinton, J. T., Glueck, D. H., Crume, T., Friedman, J. E., & Dabelea, D. (2015) · Diabetologia · doi:10.1007/s00125-015-3505-z · Cited by 63 · see citing works
Placental Lipoprotein Lipase DNA Methylation Alterations Are Associated with Gestational Diabetes and Body Composition at 5 Years of Age
Gagné-Ouellet, V., Houde, A.-A., Guay, S.-P., Perron, P., Gaudet, D., Guérin, R., Jean-Patrice, B., Hivert, M.-F., Brisson, D., & Bouchard, L. (2017) · Epigenetics · doi:10.1080/15592294.2017.1322254 · Cited by 63 · see citing works
Intrauterine growth-restricted sheep fetuses exhibit smaller hindlimb muscle fibers and lower proportions of insulin-sensitive Type I fibers near term
Yates, D. T., Cadaret, C. N., Beede, K. A., Riley, H. E., Macko, A. R., Anderson, M. J., Camacho, L. E., & Limesand, S. W. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00528.2015 · Cited by 61 · see citing works
Maternal Vitamin D Deficiency during Pregnancy Results in Insulin Resistance in Rat Offspring, Which Is Associated with Inflammation and Iκbα Methylation
Zhang, H., Chu, X., Huang, Y., Li, G., Wang, Y., Li, Y., & Sun, C. (2014) · Diabetologia · doi:10.1007/s00125-014-3316-7 · Cited by 60 · see citing works
ACSL1 Is Associated With Fetal Programming of Insulin Sensitivity and Cellular Lipid Content
Joseph, R., Poschmann, J., Sukarieh, R., Too, P. G., Julien, S. G., Xu, F., Teh, A. L., Holbrook, J. D., Ng, K. L., Chong, Y. S., et al. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1020 · Cited by 60 · see citing works
Programming of Fetal Insulin Resistance in Pregnancies with Maternal Obesity by ER Stress and Inflammation
Westermeier, F., Sáez, P. J., Villalobos-Labra, R., Sobrevía, L., & Farías, M. (2014) · BioMed Research International · doi:10.1155/2014/917672 · Cited by 59 · see citing works
Maternal butyrate supplementation induces insulin resistance associated with enhanced intramuscular fat deposition in the offspring
Huang, Y., Gao, S., Chen, J., Albrecht, E., Zhao, R., & Yang, X. (2016) · Oncotarget · doi:10.18632/oncotarget.14375 · Cited by 59 · see citing works
Leptin, fetal growth and insulin resistance in non-diabetic pregnancies
Walsh, J., Byrne, J., Mahony, R. M., Foley, M. E., & McAuliffe, F. M. (2014) · Early Human Development · doi:10.1016/j.earlhumdev.2014.03.007 · Cited by 57 · see citing works
Fetal overnutrition and offspring insulin resistance and β‐cell function: the Exploring Perinatal Outcomes among Children ( EPOCH ) study
Sauder, K. A., Hockett, C. W., Ringham, B. M., Glueck, D. H., & Dabelea, D. (2017) · Diabetic Medicine · doi:10.1111/dme.13417 · Cited by 55 · see citing works
Epigenetic inheritance of cell fates during embryonic development
Cheedipudi, S. M., Genolet, O., & Dobreva, G. D. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00019 · Cited by 55 · see citing works
An Exercise‐Only Intervention in Obese Fathers Restores Glucose and Insulin Regulation in Conjunction with the Rescue of Pancreatic Islet Cell Morphology and MicroRNA Expression in Male Offspring
McPherson, N. O., Lane, M., Sandeman, L., Owens, J. A., & Fullston, T. (2017) · Nutrients · doi:10.3390/nu9020122 · Cited by 54 · see citing works
Sleep Fragmentation During Late Gestation Induces Metabolic Perturbations and Epigenetic Changes in Adiponectin Gene Expression in Male Adult Offspring Mice
Khalyfa, A., Mutskov, V. J., Carreras, A., Khalyfa, A. A., Hakim, F., & Gozal, D. (2014) · Diabetes · doi:10.2337/db14-0202 · Cited by 53 · see citing works
Maternal obesity and pregnancy outcome.
Begum, K. S., Sachchithanantham, K., & Somsubhra, S. D. (2011) · PubMed · Cited by 53 · see citing works
Maternal insulin sensitivity is associated with oral glucose-induced changes in fetal brain activity
Linder, K., Schleger, F., Ketterer, C., Fritsche, L., Kiefer‐Schmidt, I., Hennige, A. M., Häring, H., Preissl, H. T., & Fritsche, A. (2014) · Diabetologia · doi:10.1007/s00125-014-3217-9 · Cited by 51 · see citing works
Increased expression of microRNA-15a and microRNA-15b in skeletal muscle from adult offspring of women with diabetes in pregnancy
Houshmand‐Oeregaard, A. S., Schrölkamp, M., Kelstrup, L., Hansen, N. S., Hjort, L., Thuesen, A. C. B., Broholm, C., Mathiesen, E. R., Clausen, T. D., Vaag, A. A., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy085 · Cited by 51 · see citing works
DNA Methylation of the LY86 Gene is Associated With Obesity, Insulin Resistance, and Inflammation
Su, S., Zhu, H., Xu, X., Wang, X., Dong, Y., Kapuku, G. K., Treiber, F. A., Gutin, B., Harshfield, G., Snieder, H., et al. (2014) · Twin Research and Human Genetics · doi:10.1017/thg.2014.22 · Cited by 50 · see citing works
Fasting and OGTT-derived Measures of Insulin Resistance as Compared With the Euglycemic-Hyperinsulinemic Clamp in Nondiabetic Finnish Offspring of Type 2 Diabetic Individuals
Lorenzo, C., Haffner, S. M., Stančáková, A., Kuusisto, J., & Laakso, M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2299 · Cited by 50 · see citing works
Transgenerational effects of obesity and malnourishment on diabetes risk in F2 generation
Hanafi, M. Y., Saleh, M. M., Saad, M. I., Abdelkhalek, T. M., & Kamel, M. A. E.-N. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2633-6 · Cited by 50 · see citing works
Effect of maternal chronic intermittent hypoxia during gestation on offspring growth in the rat
Iqbal, W., & Ciriello, J. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.08.027 · Cited by 49 · see citing works
Contribution of the Long Noncoding RNA H19 to β-Cell Mass Expansion in Neonatal and Adult Rodents
Sanchez-Parra, C., Jacovetti, C., Dumortier, O., Lee, K., Peyot, M., Guay, C., Prentki, M., Laybutt, D. R., OBBERGHEN, E. V., & Regazzi, R. (2018) · Diabetes · doi:10.2337/db18-0201 · Cited by 49 · see citing works
Maternal androgen excess and obesity induce sexually dimorphic anxiety‐like behavior in the offspring
Manti, M., Fornes, R., Qi, X., Folmerz, E., Hirschberg, A. L., Barbosa, T. D. C., Maliqueo, M. A., Benrick, A., & Stener‐Victorin, E. (2018) · The FASEB Journal · doi:10.1096/fj.201701263rr · Cited by 48 · see citing works
Transgenerational epigenetic inheritance of diabetes risk as a consequence of early nutritional imbalances
Jiménez‐Chillarón, J. C., Ramon‐Krauel, M., Ribó, S., & Díaz, R. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115004231 · Cited by 47 · see citing works
Role of Non-Coding RNAs in the Transgenerational Epigenetic Transmission of the Effects of Reprotoxicants
Larriba, E., & Del Mazo, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040452 · Cited by 47 · see citing works
Pregestational maternal obesity impairs endocrine pancreas in male F1 and F2 progeny
Graus‐Nunes, F., Frantz, E. D. C., Lannes, W. R., Menezes, M. C. D. S., Mandarim‐de‐Lacerda, C. A., & Souza‐Mello, V. (2014) · Nutrition · doi:10.1016/j.nut.2014.08.002 · Cited by 45 · see citing works
Transgenerational Epigenetic Mechanisms in Adipose Tissue Development
Lecoutre, S., Petrus, P., Rydén, M., & Breton, C. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.07.004 · Cited by 45 · see citing works
High-glucose concentrations change DNA methylation levels in human IVM oocytes
Wang, Q., Tang, S., Song, X., Deng, T., Zhang, T., Yin, S., Luo, S., Shen, W., Zhang, C., & Ge, Z. (2018) · Human Reproduction · doi:10.1093/humrep/dey006 · Cited by 44 · see citing works
Epigenetic programming of adipose-derived stem cells in low birthweight individuals
Broholm, C., Olsson, A. H., Perfilyev, A., Hansen, N. S., Schrölkamp, M., Strasko, K. S., Scheele, C., Ribel-Madsen, R., Mortensen, B., Jørgensen, S. W., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-4099-9 · Cited by 43 · see citing works
Fetal and neonatal exposure to nicotine leads to augmented hepatic and circulating triglycerides in adult male offspring due to increased expression of fatty acid synthase
Ma, N., Nicholson, C. J., Wong, M., Holloway, A. C., & Hardy, D. B. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.12.010 · Cited by 42 · see citing works
Adiposopathy and epigenetics: an introduction to obesity as a transgenerational disease
Bays, H. E., & Scinta, W. (2015) · Current Medical Research and Opinion · doi:10.1185/03007995.2015.1087983 · Cited by 41 · see citing works
Acute and long-term nutrient-led modifications of gene expression: Potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue function
Holness, M. J., Caton, P., & Sugden, M. C. (2010) · Nutrition · doi:10.1016/j.nut.2009.09.012 · Cited by 40 · see citing works
LRP1B, BRD2 and CACNA1D : New Candidate Genes in Fetal Metabolic Programming of Newborns Exposed to Maternal Hyperglycemia
Houde, A.-A., Ruchat, S.-M., Allard, C., Baillargeon, J., St‐Pierre, J., Perron, P., Gaudet, D., Brisson, D., Hivert, M., & Bouchard, L. (2015) · Epigenomics · doi:10.2217/epi.15.72 · Cited by 40 · see citing works
Alterations in methylation and expression levels of imprinted genes H19 and Igf2 in the fetuses of diabetic mice.
Shao, W., Ling-yun, T., Gao, C., Xie, J.-Y., & Zhao, R. (2008) · PubMed Central · Cited by 39 · see citing works
Can Proopiomelanocortin Methylation Be Used as an Early Predictor of Metabolic Syndrome?
Yoo, J. Y., Lee, S., Lee, H. A., Park, H., Park, Y. J., Ha, E., & Kim, Y. J. (2013) · Diabetes Care · doi:10.2337/dc13-1012 · Cited by 39 · see citing works
Early-life exposure to high-fat diet may predispose rats to gender-specific hepatic fat accumulation by programming Pepck expression
Zhou, D., Wang, H., Cui, H., Chen, H., & Pan, Y. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.10.009 · Cited by 39 · see citing works
DNA methylation and gene expression of HIF3A: cross-tissue validation and associations with BMI and insulin resistance
Main, A. M., Gillberg, L., Jacobsen, A. L., Nilsson, E., Gjesing, A. P., Hansen, T. F., Pedersen, O. B., Ribel‐Madsen, R., & Vaag, A. A. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0258-6 · Cited by 39 · see citing works
IL-10 gene transfer upregulates arcuate POMC and ameliorates hyperphagia, obesity and diabetes by substituting for leptin
Nakata, M., Yamamoto, S., Okada, T., Gantulga, D., Okano, H., Ozawa, K., & Yada, T. (2016) · International Journal of Obesity · doi:10.1038/ijo.2015.201 · Cited by 39 · see citing works
Alterations in expression of imprinted genes from the H19/IGF2 loci in a multigenerational model of intrauterine growth restriction (IUGR)
Gonzalez‐Rodriguez, P. J., Cantu, J., O’Neil, D. S., Seferovic, M. D., Goodspeed, D. M., Suter, M., & Aagaard, K. M. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.01.194 · Cited by 38 · see citing works
Gene‐specific DNA methylation may mediate atypical antipsychotic‐induced insulin resistance
Burghardt, K. J., Goodrich, J. M., Dolinoy, D. C., & Ellingrod, V. L. (2016) · Bipolar Disorders · doi:10.1111/bdi.12422 · Cited by 36 · see citing works
Epigenetic control of β-cell function and failure
Bernstein, D., Golson, M. L., & Kaestner, K. H. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.11.009 · Cited by 36 · see citing works
Higher Fetal Insulin Resistance in Chinese Pregnant Women with Gestational Diabetes Mellitus and Correlation with Maternal Insulin Resistance
Wang, Q., Huang, R.-P., Yu, B., Cao, F., Wang, H., Zhang, M., Wang, X., Zhang, B., Zhou, H., & Zhu, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059845 · Cited by 35 · see citing works
Self-citation
The Combined Effect of Maternal Obesity and Fetal Macrosomia on Pregnancy Outcomes
Gaudet, L., Wen, S. W., & WALKER, M. C. (2014) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(15)30479-5 · Cited by 34 · see citing works
Maternal high-fat diet induces metabolic stress response disorders in offspring hypothalamus
Nguyen, L. T., Saad, S., Tan, Y., Pollock, C. A., & Chen, H. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0056 · Cited by 34 · see citing works
Preweaning Growth Hormone Treatment Ameliorates Adipose Tissue Insulin Resistance and Inflammation in Adult Male Offspring Following Maternal Undernutrition
Reynolds, C. M., Li, M., Gray, C. L., & Vickers, M. H. (2013) · Endocrinology · doi:10.1210/en.2013-1146 · Cited by 33 · see citing works
Transgenerational programming of nephron deficits and hypertension
Briffa, J. F., Wlodek, M. E., & Moritz, K. M. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.05.025 · Cited by 33 · see citing works
Early-postnatal changes in adiposity and lipids profile by transgenerational developmental programming in swine with obesity/leptin resistance
Gonzalez‐Bulnes, A., Astiz, S., Óvilo, C., López-Bote, C. J., Sánchez, R. S., Pérez-Solana, M. L., Torres-Rovira, L., Ayuso, M., & Gonzalez, J. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0217 · Cited by 33 · see citing works
Maternal folate status and obesity/insulin resistance in the offspring: a systematic review
Xie, R.-H., Liu, Y.-J., Retnakaran, R. R., MacFarlane, A. J., Hamilton, J., Smith, G. N., WALKER, M. C., & Wen, S. W. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.189 · Cited by 32 · see citing works
Insulin sensitivity linked skeletal muscle Nr4a1 DNA methylation is programmed by the maternal diet and modulated by voluntary exercise in mice
Kasch, J., Kanzleiter, I., Saussenthaler, S., Schürmann, A., Keijer, J., van Schothorst, E. M., Klaus, S., & Schumann, S. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.03.015 · Cited by 30 · see citing works
Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long‐term hepatic steatosis and insulin resistance
Ramon‐Krauel, M., Pentinat, T., Bloks, V. W., Cebrià, J., Ribó, S., Pérez-Wienese, R., Vilà, M., Palacios‐Marin, I., Fernández-Pérez, A., Vallejo, M., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201700717rr · Cited by 30 · see citing works
Influence of pre-pregnancy obesity on the development of macrosomia and large for gestational age in women with or without gestational diabetes mellitus in Chinese population
Wang, L.-F., Wang, H., Ao, D., Liu, Z., Wang, Y., & Yang, H.-X. (2015) · Journal of Perinatology · doi:10.1038/jp.2015.119 · Cited by 29 · see citing works
Histone methylation-associated transgenerational inheritance of reproductive defects in Caenorhabditis elegans exposed to crude oil under various exposure scenarios
Yang, J., Chatterjee, N., Kim, Y., Roh, J.-Y., Kwon, J., Park, M., & Choi, J. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.02.080 · Cited by 29 · see citing works
Exposure of pregnant mice to triclosan causes hyperphagic obesity of offspring via the hypermethylation of proopiomelanocortin promoter
Xu, H., Xiong, J., Zhang, Y., Cao, X., Sun, P. G., Wu, J., & Chen, L. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2338-1 · Cited by 29 · see citing works
Elevated S-Adenosylhomocysteine Alters Adipocyte Functionality With Corresponding Changes in Gene Expression and Associated Epigenetic Marks
Ngo, S., Li, X., O’Neill, R., Bhoothpur, C., Gluckman, P. D., & Sheppard, A. M. (2014) · Diabetes · doi:10.2337/db13-1640 · Cited by 28 · see citing works
Self-citation
Thyroid Hormone-Dependent Epigenetic Regulation of Melanocortin 4 Receptor Levels in Female Offspring of Obese Rats
Tabachnik, T., Kisliouk, T., Marco, A., Meiri, N., & Weller, A. (2017) · Endocrinology · doi:10.1210/en.2016-1854 · Cited by 28 · see citing works
Integrated stress response activation by sleep fragmentation during late gestation in mice leads to emergence of adverse metabolic phenotype in offspring
Trzépizur, W., Khalyfa, A., Qiao, Z., Popko, B., & Gozal, D. (2017) · Metabolism · doi:10.1016/j.metabol.2017.01.026 · Cited by 28 · see citing works
Insulin sensitivity, leptin, adiponectin, resistin, and testosterone in adult male and female rats after maternal-neonatal separation and environmental stress
Raff, H., Hoeynck, B., Jablonski, M., Leonovicz, C., Phillips, J. M., & Gehrand, A. L. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00271.2017 · Cited by 27 · see citing works
DNA methylation signatures at endoplasmic reticulum stress genes are associated with adiposity and insulin resistance
Ramos-López, O., Riezu‐Boj, J. I., Milagro, F. I., & Martínez, J. A. (2017) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2017.11.011 · Cited by 26 · see citing works
Birth weight is associated with placental fat mass- and obesity-associated gene expression and promoter methylation in a Chinese population
Liu, Z., Zhang, J., Cai, Q., Zhang, H.-X., Wang, Y., Yan, H., Wu, H., & Yang, X. (2014) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.987749 · Cited by 26 · see citing works
Potential epigenetic biomarkers of obesity-related insulin resistance in human whole-blood
Day, S. E., Coletta, R. L., Kim, J. Y., Garcia, L. A., Campbell, L. E., Benjamin, T. R., Roust, L. R., Filippis, E. A. D., Mandarino, L. J., & Coletta, D. K. (2017) · Epigenetics · doi:10.1080/15592294.2017.1281501 · Cited by 26 · see citing works
DNA Methylation Changes in theIGF1RGene in Birth Weight Discordant Adult Monozygotic Twins
Tsai, P.-C., van Dongen, J., Tan, Q., Willemsen, G. A. H. M., Christiansen, L., Boomsma, D. I., Spector, T. D., Valdes, A. M., & Bell, J. T. (2015) · Twin Research and Human Genetics · doi:10.1017/thg.2015.76 · Cited by 25 · see citing works
Review: Bio-compartmentalization of microRNAs in exosomes during gestational diabetes mellitus
Iljas, J. D., Guanzon, D., Elfeky, O. W. M., Rice, G. E., & Salomón, C. (2016) · Placenta · doi:10.1016/j.placenta.2016.12.002 · Cited by 25 · see citing works
The Effects of Maternal Obesity on Neonates, Infants, Children, Adolescents, and Adults
Hemond, J., Robbins, R., & Young, P. C. (2015) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000179 · Cited by 24 · see citing works
Decreased beige adipocyte number and mitochondrial respiration coincide with increased histone methyl transferase (G9a) and reduced FGF21 gene expression in Sprague–Dawley rats fed prenatal low protein and postnatal high-fat diets
Claycombe, K., Vomhof‐DeKrey, E. E., Garcia, R. A. G., Johnson, W. T., Uthus, E. O., & Roemmich, J. N. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.01.008 · Cited by 24 · see citing works
Regulation of postnatal pancreatic Pdx1 and downstream target genes after gestational exposure to protein restriction in rats
Abuzgaia, A. M., Hardy, D. B., & Arany, E. J. (2014) · Reproduction · doi:10.1530/rep-14-0245 · Cited by 24 · see citing works
Large-for-Gestational-Age May Be Associated With Lower Fetal Insulin Sensitivity and β-Cell Function Linked to Leptin
Dong, Y., Luo, Z., Nuyt, A. M., Audibert, F., Wei, S. Q., Abenhaim, H. A., Bujold, E., Julien, P., Huang, H., Levy, E. H., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00917 · Cited by 24 · see citing works
Insulin resistance, glucagon-like peptide-1 and factors influencing glucose homeostasis in neonates
Salis, E. R., Reith, D. M., Wheeler, B. J., Broadbent, R. S., & Medlicott, N. J. (2016) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2015-309174 · Cited by 23 · see citing works
Epigenetics and Fetal Metabolic Programming: A Call for Integrated Research on Larger Cohorts
Bouchard, L. (2013) · Diabetes · doi:10.2337/db12-1763 · Cited by 23 · see citing works
Protein calorie restriction has opposite effects on glucose metabolism and insulin gene expression in fetal and adult rat endocrine pancreas
Martín, M. Á., Fernández‐Millán, E., Pascual-Leone, A. M., Escrivá, F., & Álvarez, C. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00242.2003 · Cited by 23 · see citing works
Association Between Low Dairy Intake During Pregnancy and Risk of Small-for-Gestational-Age Infants
Olmedo‐Requena, R., Amezcua‐Prieto, C., Luna, J. D. D., Lewis-Mikhael, A.-M., Mozas‐Moreno, J., Bueno‐Cavanillas, A., & Jiménez‐Moleón, J. J. (2016) · Maternal and Child Health Journal · doi:10.1007/s10995-016-1931-2 · Cited by 22 · see citing works
Correlation Between Maternal and Fetal Insulin Resistance in Pregnant Women with Gestational Diabetes Mellitus
Wang, X., Yang, T., Miao, J., Liu, H., Wu, K., Guo, J., Chen, J., & Li, T. (2018) · Clinical Laboratory · doi:10.7754/clin.lab.2018.171214 · Cited by 22 · see citing works
IUGR with infantile overnutrition programs an insulin-resistant phenotype through DNA methylation of peroxisome proliferator–activated receptor-γ coactivator-1α in rats
Xie, X., Lin, T., Zhang, M., Liao, L., Yuan, G., Gao, H., Ning, Q., & Luo, X. (2015) · Pediatric Research · doi:10.1038/pr.2015.32 · Cited by 20 · see citing works
Estrogen deprivation in primate pregnancy leads to insulin resistance in offspring
Maniu, A., Aberdeen, G. W., Lynch, T. J., Nadler, J. L., Kim, S. O. K., Quon, M. J., Pepe, G. J., & Albrecht, E. D. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0530 · Cited by 20 · see citing works
A systems view of epigenetic networks regulating pancreas development and β-cell function
Xie, R., Carrano, A. C., & Sander, M. (2015) · Wiley Interdisciplinary Reviews: Systems Biology and Medicine · doi:10.1002/wsbm.1287 · Cited by 19 · see citing works
Complement Factor C3 Methylation and mRNA Expression Is Associated to BMI and Insulin Resistance in Obesity
Castellano‐Castillo, D., Moreno‐Indias, I., Fernández‐García, J. C., Clemente‐Postigo, M., Cabezas, M. C., Tinahones, F. J., Queipo‐Ortuño, M. I., & Cardona, F. (2018) · Genes · doi:10.3390/genes9080410 · Cited by 16 · see citing works
Epigenetic programming of Dnmt3a mediated by AP2α is required for granting preadipocyte the ability to differentiate
Guo, W., Chen, J., Yang, Y., Zhu, J., & Wu, J. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.378 · Cited by 15 · see citing works
Transgenerational Glucose Intolerance of Tumor Necrosis Factor with Epigenetic Alteration in Rat Perirenal Adipose Tissue Induced by Intrauterine Hyperglycemia
Su, R., Yan, J., & Yang, H. (2016) · Journal of Diabetes Research · doi:10.1155/2016/4952801 · Cited by 14 · see citing works
Differentiation of Mouse Embryonic Stem Cells toward Functional Pancreatic β-Cell Surrogates through Epigenetic Regulation of Pdx1 by Nitric Oxide
Salguero-Aranda, C., Tapia-Limonchi, R., Cahuana, G., Hitos, A. B., Díaz, I., Hmadcha, A., Fraga, M., Martín, F., Soria, B., Tejedo, J., et al. (2016) · Cell Transplantation · doi:10.3727/096368916x691178 · Cited by 14 · see citing works
Insulin resistance elicited in postpubertal primate offspring deprived of estrogen in utero
Pepe, G. J., Maniu, A., Aberdeen, G. W., Lynch, T. J., Kim, S. O., Nadler, J. L., & Albrecht, E. D. (2016) · Endocrine · doi:10.1007/s12020-016-1145-9 · Cited by 14 · see citing works
The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine-cell specification and postnatal β-cell maturation
Yang, Y., Magnuson, M. A., Stein, R. W., & Wright, C. V. E. (2016) · Development · doi:10.1242/dev.143123 · Cited by 13 · see citing works
In utero exposure to germinated brown rice and its oryzanol-rich extract attenuated high fat diet-induced insulin resistance in F1 generation of rats
Adamu, H. A., Imam, M. U., Ooi, D. J., Esa, N. M., Rosli, R., & Ismail, M. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1571-0 · Cited by 13 · see citing works
The Responses of Mouse Preimplantation Embryos to Leptin In Vitro in a Transgenerational Model for Obesity
Kšiňanová, M., Číkoš, Š., Babeľová, J., Šefčíková, Z., Špirková, A., Koppel, J., & Fabián, D. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00233 · Cited by 11 · see citing works
Effect of maternal body mass index and weight gain in women with gestational diabetes on the incidence of large-for-gestational-age infants
Santos, M. J., Fernandes, V., Marques, O., & Pereira, M. L. (2016) · Diabetes & Metabolism · doi:10.1016/j.diabet.2016.06.008 · Cited by 8 · see citing works
Intrauterine insulin resistance in fetuses of overweight mothers
Liu, B., Xu, Y., Liang, J., Voss, C., Huan-yu, X., Sheng, W., Sun, Y., & Wang, Z. (2012) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2012.01919.x · Cited by 8 · see citing works
Valproic Acid Exposure of Pregnant Rats During Organogenesis Disturbs Pancreas Development in Insulin Synthesis and Secretion of the Offspring
Komariah, K., Manalu, W., Kiranadi, B., Winarto, A., Handharyani, E., & Roeslan, M. O. (2018) · Toxicological Research · doi:10.5487/tr.2018.34.2.173 · Cited by 8 · see citing works
Effect of maternal hypothyroidism during pregnancy on insulin resistance, lipid accumulation, and mitochondrial dysfunction in skeletal muscle of fetal rats
Xia, T., Zhang, X., Wang, Y., & Deng, D. (2018) · Bioscience Reports · doi:10.1042/bsr20171731 · Cited by 8 · see citing works
Differential methylation of insulin-like growth factor 2 in offspring of physically active pregnant women
Marshall, M. R., Paneth, N., Gerlach, J., Mudd, L., Biery, L., Ferguson, D. P., & Pivarnik, J. (2018) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174417001106 · Cited by 7 · see citing works
Transgenerational analysis of H3K4me3 and H3K27me3 by ChIP-Seq links epigenetic inheritance to metabolism
An, K., Du, F., Hao, M., Li, G., Zhang, M., Liu, Z. Z., Zhao, Z., Zhang, Z., Yu, D., Wang, D., et al. (2017) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2017.11.004 · Cited by 5 · see citing works
Taming the young and restless—epigenetic gene regulation in pancreas and beta‐cell precursors
Russ, H. A., & Hebrok, M. (2014) · The EMBO Journal · doi:10.15252/embj.201489751 · Cited by 4 · see citing works
Maternal and fetal insulin levels at birth in women with PCOS
Pasquali, R. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.61 · Cited by 2 · see citing works
Author Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring
Sun, W., Dong, H., Becker, A. S., Dapito, D. H., Modica, S., Grandl, G., Opitz, L., Efthymiou, V., Straub, L. G., Sarker, G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0162-z · Cited by 2 · see citing works
Obésité maternelle et issue de grossesse
Asmar, J. T., & Sibiude, J. (2015) · Gynécologie Obstétrique & Fertilité · doi:10.1016/j.gyobfe.2015.03.001 · Cited by 1 · see citing works

Flagged first, then by citations

1 of the 199 references couldn’t be matched to a known paper.

Sorted by citations

Metabolic regulation of kisspeptin — the link between energy balance and reproduction
Navarro, V. M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0363-7 · Cited by 240 · see citing works
Short Chain Fatty Acid Metabolism in Relation to Gut Microbiota and Genetic Variability
Meyers, G. R., Samouda, H., & Bohn, T. (2022) · Nutrients · doi:10.3390/nu14245361 · Cited by 193 · see citing works
Obesity‐related glomerulopathy: Current approaches and future perspectives
Martínez‐Montoro, J. I., Morales, E., Cornejo-Pareja, I. M., Tinahones, F. J., & Fernández‐García, J. C. (2022) · Obesity Reviews · doi:10.1111/obr.13450 · Cited by 121 · see citing works
Delivery technologies for in utero gene therapy
Palanki, R., Peranteau, W. H., & Mitchell, M. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.11.002 · Cited by 64 · see citing works
The effects of assisted reproduction technologies on metabolic health and disease†
Heber, M. F., & Ptak, G. (2020) · Biology of Reproduction · doi:10.1093/biolre/ioaa224 · Cited by 61 · see citing works
Prenatal Hypoxia and Placental Oxidative Stress: Insights from Animal Models to Clinical Evidences
Silvestro, S., Calcaterra, V., Pelizzo, G., Bramanti, P., & Mazzon, E. (2020) · Antioxidants · doi:10.3390/antiox9050414 · Cited by 56 · see citing works
In utero exposure to cannabidiol disrupts select early-life behaviors in a sex-specific manner
Iezzi, D., Cáceres-Rodríguez, A., Chavis, P., & Manzoni, O. J. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02271-8 · Cited by 46 · see citing works
Epigenetic Mechanisms Contribute to Intraindividual Variations of Drug Metabolism Mediated by Cytochrome P450 Enzymes
Jin, J., & Zhong, X. (2023) · Drug Metabolism and Disposition · doi:10.1124/dmd.122.001007 · Cited by 47 · see citing works
The role of demethylases in cardiac development and disease
Davis, K., Azarcon, P., Hickenlooper, S. M., Bia, R. D., Horiuchi, E., Szulik, M. W., & Franklin, S. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.05.018 · Cited by 45 · see citing works
Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation
Xie, H., Yepuri, N., Meng, Q., Dhawan, R., Leech, C. A., Chepurny, O., Holz, G. G., & Cooney, R. (2020) · Reviews in Endocrine & Metabolic Disorders · doi:10.1007/s11154-020-09584-3 · Cited by 37 · see citing works
The Impact of Parental Preconception Nutrition, Body Weight, and Exercise Habits on Offspring Health Outcomes: A Narrative Review
Jahan-Mihan, A., Leftwich, J., Berg, K., Labyak, C. A., Nodarse, R. R., Allen, S., & Griggs, J. J. (2024) · Nutrients · doi:10.3390/nu16244276 · Cited by 40 · see citing works
Prenatal Exposure to Air Pollutants Associated with Allergic Diseases in Children: Which Pollutant, When Exposure, and What Disease? A Systematic Review and Meta-analysis
Ai, S., Liu, L., Xue, Y., Cheng, X., Li, M., & Deng, Q. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-08987-3 · Cited by 37 · see citing works
Epigenetic Modifications at the Center of the Barker Hypothesis and Their Transgenerational Implications
Ryznar, R. J., Phibbs, L., & Winkle, L. J. V. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182312728 · Cited by 36 · see citing works
Season-of-birth phenomenon in health and longevity: epidemiologic evidence and mechanistic considerations
Vaiserman, A. (2020) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174420001221 · Cited by 37 · see citing works
Dietary carbohydrates: Pathogenesis and potential therapeutic targets to obesity‐associated metabolic syndrome
Akter, S., Akhter, H., Chaudhury, H. S., Rahman, M. H., Gorski, A., Hasan, M. N., Shin, Y., Rahman, M. A., Nguyen, M. N., Choi, T. G., et al. (2022) · BioFactors · doi:10.1002/biof.1886 · Cited by 33 · see citing works
Epigenetic Genome Modifications during Pregnancy: The Impact of Essential Nutritional Supplements on DNA Methylation
Socha, M. W., Flis, W., & Wartęga, M. (2024) · Nutrients · doi:10.3390/nu16050678 · Cited by 32 · see citing works
Emerging Protein Biomarkers for the Diagnosis or Prediction of Gestational Diabetes—A Scoping Review
Bogdanet, D., Reddin, C., Murphy, D., Doheny, H. C., Halperin, J. A., Dunne, F., & O’Shea, P. M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10071533 · Cited by 32 · see citing works
Are epigenetic mechanisms and nutrition effective in male and female infertility?
Erdoğan, K., Şanlıer, N. T., & Şanlıer, N. (2023) · Journal of Nutritional Science · doi:10.1017/jns.2023.62 · Cited by 32 · see citing works
Maternal Diet, Nutritional Status, and Birth-Related Factors Influencing Offspring’s Bone Mineral Density: A Narrative Review of Observational, Cohort, and Randomized Controlled Trials
Masztalerz-Kozubek, D., Zielinska-Pukos, M. A., & Hamułka, J. (2021) · Nutrients · doi:10.3390/nu13072302 · Cited by 32 · see citing works
Early Roots of Childhood Obesity: Risk Factors, Mechanisms, and Prevention Strategies
Umano, G. R., Bellone, S., Buganza, R., Calcaterra, V., Corica, D., SANCTIS, L. D., Sessa, A. D., Faienza, M. F., Improda, N., Licenziati, M. R., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157388 · Cited by 37 · see citing works
Maternal hypothyroidism in mice influences glucose metabolism in adult offspring
Kemkem, Y., Nasteska, D., de Bray, A., Bargi‐Souza, P., Garcia, R. A. P., Guillou, A., Mollard, P., Hodson, D. J., & Schaeffer, M. (2020) · Diabetologia · doi:10.1007/s00125-020-05172-x · Cited by 26 · see citing works
Maternal obesity alters C19MC microRNAs expression profile in fetal umbilical cord blood
Jing, J., Wang, Y., Quan, Y., Wang, Z., Liu, Y., & Ding, Z. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-00475-7 · Cited by 26 · see citing works
Dichlorodiphenyltrichloroethane and the Adrenal Gland: From Toxicity to Endocrine Disruption
Timokhina, E. P., Yaglov, V. V., & Nazimova, S. V. (2021) · Toxics · doi:10.3390/toxics9100243 · Cited by 26 · see citing works
Prenatal dexamethasone exposure induced pancreatic β-cell dysfunction and glucose intolerance of male offspring rats: Role of the epigenetic repression of ACE2
Dai, Y., Kou, H., Gui, S., Guo, X.-L., Liu, H., Gong, Z., Sun, X., Wang, H., & Guo, Y. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.154095 · Cited by 25 · see citing works
Critical Windows: Exploring the Association Between Perinatal Trauma, Epigenetics, and Chronic Pain
Kodila, Z. N., Shultz, S. R., Yamakawa, G. R., & Mychasiuk, R. (2023) · The Neuroscientist · doi:10.1177/10738584231176233 · Cited by 23 · see citing works
Perspective on prenatal polychlorinated biphenyl exposure and the development of the progeny nervous system (Review)
Wang, Y., Hu, C., Fang, T., Jin, Y., & Wu, R. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4983 · Cited by 20 · see citing works
Environmental Alterations during Embryonic Development: Studying the Impact of Stressors on Pluripotent Stem Cell-Derived Cardiomyocytes
Lamberto, F., Peral-Sanchez, I., Muenthaisong, S., Zana, M., Willaime‐Morawek, S., & Dinnyés, A. (2021) · Genes · doi:10.3390/genes12101564 · Cited by 20 · see citing works
Perspective to Practice: Theoretical Frameworks Explaining Intergenerational Trauma, Violence, and Maltreatment and Implications for the Therapeutic Response
Bowe, C., Thomas, C. J., & Mackey, P. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22030321 · Cited by 22 · see citing works
Innate Immune Memory in Macrophages
Maheshwari, A. (2023) · Newborn · doi:10.5005/jp-journals-11002-0058 · Cited by 17 · see citing works
Offspring of Obese Dams Exhibit Sex-Differences in Pancreatic Heparan Sulfate Glycosaminoglycans and Islet Insulin Secretion
Casasnovas, J., Damron, C. L., JARRELL, J. C., Orr, K. S., Bone, R. N., Archer‐Hartmann, S. A., Azadi, P., & Kua, K. L. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.658439 · Cited by 18 · see citing works
Vitamin D receptor gene polymorphisms and haplotypes in the etiology of recurrent miscarriages
Wolski, H., Kurzawińska, G., Ożarowski, M., Mrozikiewicz, A. E., Drews, K., Karpiński, T. M. M., Bogacz, A., & Seremak‐Mrozikiewicz, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-84317-3 · Cited by 18 · see citing works
Unique adaptations in neonatal hepatic transcriptome, nutrient signaling, and one-carbon metabolism in response to feeding ethyl cellulose rumen-protected methionine during late-gestation in Holstein cows
Palombo, V., Alharthi, A. S., Batistel, F., Parys, C., Guyader, J., Trevisi, E., D’Andrea, M., & Loor, J. J. (2021) · BMC Genomics · doi:10.1186/s12864-021-07538-w · Cited by 16 · see citing works
A Mixture of Endocrine Disrupting Chemicals Associated with Lower Birth Weight in Children Induces Adipogenesis and DNA Methylation Changes in Human Mesenchymal Stem Cells
Lizunkova, P., Engdahl, E., Borbély, G., Gennings, C., Lindh, C. H., Bornehag, C., & Rüegg, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042320 · Cited by 16 · see citing works
Associations of birthweight and history of childhood obesity with beta cell mass in Japanese adults
Sasaki, H., Saisho, Y., Inaishi, J., Watanabe, Y., Tsuchiya, T., Makio, M., Sato, M., Kitago, M., Yamada, T., & Itoh, H. (2020) · Diabetologia · doi:10.1007/s00125-020-05127-2 · Cited by 16 · see citing works
Maternal Nutrition, Toxicants, and Epigenetic Programming of Obesity Across Generations
Alum, E., Aloh, H., Obasi, D., Okoroh, P., Aniokete, U., & Emeruwa, A. (2025) · Diabetes, Metabolic Syndrome and Obesity · doi:10.2147/dmso.s579409 · Cited by 14 · see citing works
Functional foods and dietary matrices for metabolic improvement: an integrative review of mechanisms, evidence, and future directions
Rahimah, S., Tallei, T. E., Savitri, M., Yamada, C., Kim, H. J., Choi, M., Park, M. N., Ophinni, Y., & Kim, B. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107240 · Cited by 14 · see citing works
Starvation-induced changes in somatic insulin/IGF-1R signaling drive metabolic programming across generations
Vogt, M. C., & Hobert, O. (2023) · Science Advances · doi:10.1126/sciadv.ade1817 · Cited by 14 · see citing works
Recent Insights and Recommendations for Preventing Excessive Gestational Weight Gain
Niebrzydowska-Tatus, M., Pełech, A., Rekowska, A. K., Satora, M., Masiarz, A., Kabała, Z., Kimber-Trojnar, Ż., & Trojnar, M. P. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13051461 · Cited by 16 · see citing works
Revisiting Regulators of Human β-cell Mass to Achieve β-cell–centric Approach Toward Type 2 Diabetes
Sasaki, H., Saisho, Y., Inaishi, J., & Itoh, H. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvab128 · Cited by 15 · see citing works
The Impact of the Quality of Nutrition and Lifestyle in the Reproductive Years of Women with PKU on the Long-Term Health of Their Children
Gama, M. I., Pinto, A., Daly, A., Rocha, J. C., & MacDonald, A. (2022) · Nutrients · doi:10.3390/nu14051021 · Cited by 14 · see citing works
Epigenetic programming of obesity in early life through modulation of the kynurenine pathway
Gharipour, M., Craig, J. M., & Stephenson, G. L. (2024) · International Journal of Obesity · doi:10.1038/s41366-024-01647-8 · Cited by 13 · see citing works
Pathomechanisms of Prenatally Programmed Adult Diseases
Sulyok, E., Farkas, B., & Bódis, J. (2023) · Antioxidants · doi:10.3390/antiox12071354 · Cited by 13 · see citing works
Sex‐Specific Effects of Myo‐Inositol Ingested During Lactation in the Improvement of Metabolic Health in Adult Rats
Castillo, P., Palou, M., Otero, D., Núñez, P., Palou, A., & Picó, C. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000965 · Cited by 12 · see citing works
“OMICS” in Human Milk: Focus on Biological Effects on Bone Homeostasis
Farella, I., D’Amato, G., Orellana‐Manzano, A., Segura, Y., Vitale, R., Clodoveo, M. L., Corbo, F., & Faienza, M. F. (2024) · Nutrients · doi:10.3390/nu16223921 · Cited by 11 · see citing works
The maternal reduced uteroplacental perfusion model of preeclampsia induces sexually dimorphic metabolic responses in rat offspring
Taheri, M. M. H., Mohammadifard, M., Erfanian, Z., & Hosseini, M. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00458-8 · Cited by 11 · see citing works
Neonatal adiposity is associated with microRNAs in adipocyte-derived extracellular vesicles in maternal and cord blood, a discovery analysis
Kunte, P. S., Barberio, M. D., Tiwari, P., Sukla, K. K., Harmon, B. T., Epstein, S. B., Bhat, D., Authelet, K. J., Goldberg, M., Rao, S., et al. (2023) · International Journal of Obesity · doi:10.1038/s41366-023-01432-z · Cited by 10 · see citing works
Maternal Transmission of Human OGG1 Protects Mice Against Genetically- and Diet-Induced Obesity Through Increased Tissue Mitochondrial Content
Burchat, N., Sharma, P., Ye, H., Komakula, S. S. B., Dobrzyń, A., Vartanian, V. L., Lloyd, R. S., & Sampath, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.718962 · Cited by 10 · see citing works
The Mother–Child Dyad Adipokine Pattern: A Review of Current Knowledge
Lis-Kuberka, J., Pupek, M., & Orczyk‐Pawiłowicz, M. (2023) · Nutrients · doi:10.3390/nu15184059 · Cited by 9 · see citing works
Alteration of Genomic Imprinting after Assisted Reproductive Technologies and Long-Term Health
Ochoa, E. (2021) · Life · doi:10.3390/life11080728 · Cited by 9 · see citing works
Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences
Schiera, G., Macajone, G., Volpes, S., Greco, L., Di Liegro, C. M., Serio, G., Caradonna, F., & Naselli, F. (2026) · Cells · doi:10.3390/cells15040366 · Cited by 8 · see citing works
Energy endocrine physiology, pathophysiology, and nutrition of the foal
Kinsella, H. M., Hostnik, L. D., & Toribio, R. E. (2022) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.22.08.0348 · Cited by 8 · see citing works
Prenatal Mercury Exposure and Infant Weight Trajectories in a UK Observational Birth Cohort
Dack, K., Wootton, R. E., Taylor, C. M., & Lewis, S. J. (2022) · Toxics · doi:10.3390/toxics11010010 · Cited by 8 · see citing works
Expanding Role of Epigenetics in Human Health and Disease
Chakrabarti, S. K., & Chattopadhyay, D. (2024) · Exploratory Research and Hypothesis in Medicine · doi:10.14218/erhm.2023.00086 · Cited by 8 · see citing works
Early Life Programming of Adipose Tissue Remodeling and Browning Capacity by Micronutrients and Bioactive Compounds as a Potential Anti-Obesity Strategy
Bonet, M. L., Ribot, J., Sánchez, J., Palou, A., & Picó, C. (2024) · Cells · doi:10.3390/cells13100870 · Cited by 9 · see citing works
Prenatal Maternal Occupation and Child Epigenetic Age Acceleration in an Agricultural Region
Daredia, S., Bozack, A. K., Riddell, C. A., Gunier, R. B., Harley, K. G., Bradman, A., Eskenazi, B., Holland, N., Deardorff, J., & Cárdenas, A. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.21824 · Cited by 8 · see citing works
The role of genetics in fetal programming of adult cardiometabolic disease
Sánchez-Soriano, C., Pearson, E. R., & Reynolds, R. M. (2021) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174421000350 · Cited by 8 · see citing works
A low-protein maternal diet during gestation affects the expression of key pancreatic β-cell genes and the methylation status of the regulatory region of the MafA gene in the offspring of Wistar rats
Sosa-Larios, T. C., Ortega-Márquez, A. L., Rodríguez‐Aguilera, J. R., Vázquez-Martínez, E. R., Domínguez‐López, A., & Morimoto, S. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1138564 · Cited by 8 · see citing works
Placental epigenetic marks related to gestational weight gain reveal potential genes associated with offspring obesity parameters
Gómez‐Vilarrubla, A., Mas‐Parés, B., Carreras‐Badosa, G., Xargay‐Torrent, S., Prats‐Puig, A., Bonmatí, A., de Zegher, F., Ibáñez, L., López‐Bermejo, A., & Bassols, J. (2023) · Obesity · doi:10.1002/oby.23780 · Cited by 8 · see citing works
Mechanisms of Fetal Overgrowth in Gestational Diabetes: The Potential Role of SOCS2
Hernández-Baraza, L., Brito‐Casillas, Y., Valverde‐Tercedor, C., Recio, C., Fernández‐Pérez, L., Guerra, B., & Wägner, A. M. (2025) · Nutrients · doi:10.3390/nu17091519 · Cited by 8 · see citing works
Maternal stress induced endoplasmic reticulum stress and impaired pancreatic islets’ insulin secretion via glucocorticoid receptor upregulation in adult male rat offspring
Salimi, M., Eskandari, F., Binayi, F., Eliassi, A., Ghanbarian, H., Hedayati, M., Babaei, J. F., Eftekhary, M., Keyhanmanesh, ‬., & Zardooz, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-16621-5 · Cited by 7 · see citing works
Maternal intake of alpha-lipoic acid prevents development of symptoms associated with a fructose-rich diet in the male offspring in Wistar rats
Rabaglino, M. B., Moreira‐Espinoza, M. J., Lagares, C., Garay, M. I., Quiroga, P., Pasqualini, M. E., Francini, F., & Beltramo, D. M. (2020) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174420001178 · Cited by 7 · see citing works
Intrauterine programming of cartilaginous 11β-HSD2 induced by corticosterone and caffeine mediated susceptibility to adult osteoarthritis
Shi, H., Li, B., Gao, H., He, H., Wu, Z., Magdaloud, J., Wang, H., & Chen, L. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113624 · Cited by 7 · see citing works
Fetal macrosomia, fetal insulin, and insulin-like growth factor- 1 among neonates in Lagos, Nigeria: A case-control study
Akinmola, O. O., Okusanya, B. O., Olorunfemi, G., Okpara, H. C., & Azinge, E. C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0266314 · Cited by 8 · see citing works
Preconception Diet Interventions in Obese Outbred Mice and the Impact on Female Offspring Metabolic Health and Oocyte Quality
Meulders, B., Marei, W. F. A., Xhonneux, I., Loier, L., Smits, A., & Leroy, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042236 · Cited by 7 · see citing works
High-fat diet during pregnancy promotes fetal skeletal muscle fatty acid oxidation and insulin resistance in an ovine model
Omar, A. K., Puma, L. C. L., Whitcomb, L. A., Risk, B. D., Witt, A. C., Bruemmer, J. E., Winger, Q. A., Bouma, G. J., & Chicco, A. J. (2023) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00059.2023 · Cited by 6 · see citing works
Multilevel prenatal socioeconomic predictors of Mexican American children’s cardiometabolic health in preschool and school age.
Curci, S. G., Luecken, L. J., Hernández, J. C., Winstone, L. K., & Pérez, M. (2023) · Health Psychology · doi:10.1037/hea0001311 · Cited by 6 · see citing works
Metabolic Programming and Nutrition
Brasiel, P. G. D. A., & Luquetti, S. C. P. D. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.92201 · Cited by 6 · see citing works
Maternal Intermittent Fasting Before Mating Alters Hepatic DNA Methylation in Offspring
Yin, W., Liang, Y. J., Sun, L., Yin, Y., & Zhang, W. (2021) · Epigenomics · doi:10.2217/epi-2020-0403 · Cited by 6 · see citing works
The Effect of Maternal Diet and Lifestyle on the Risk of Childhood Obesity
Łuszczki, E., Wyszyńska, J., Dymek, A., Drożdż, D., González-Ramos, L., Hartgring, I., García-Carbonell, N., Mazur, A., Erdine, S. E., Parnarauskienė, J., et al. (2024) · Metabolites · doi:10.3390/metabo14120655 · Cited by 7 · see citing works
White Adipocyte Stem Cell Expansion Through Infant Formula Feeding: New Insights into Epigenetic Programming Explaining the Early Protein Hypothesis of Obesity
Melnik, B. C., Weiskirchen, R., John, S. M., Stremmel, W., Leitzmann, C., Weiskirchen, S., & Schmitz, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104493 · Cited by 5 · see citing works
Skeletal Effects of Early-Life Exposure to Soy Isoflavones—A Review of Evidence From Rodent Models
Chin, K., & Pang, K.-L. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00563 · Cited by 5 · see citing works
Maternal Thyroid Function: Does It Have a Role in Fetal Programming and Later Offspring Growth?
de Morais, N. S., & Leung, A. M. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad552 · Cited by 5 · see citing works
Maternal Obesity and Neonatal Metabolic Health: Insights Into Insulin Resistance
Sonagra, A. D., Parchwani, D. N., Singh, R., Dholariya, S. J., Motiani, A., & Ramavataram, D. (2024) · Cureus · doi:10.7759/cureus.55923 · Cited by 4 · see citing works
How Early-Life Programming During Embryogenesis Imprints Cellular Memory
Alfian, N. F., Uechi, K., Morishita, Y., Sato, K., MARUHASHI, Y., Jharna, J. F., Bari, M. W., Ishiyama, S., Mochizuki, K., & Kishigami, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010163 · Cited by 4 · see citing works
Melatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular–Kidney–Metabolic Risk
Hsu, C., & Tain, Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052390 · Cited by 4 · see citing works
Fetal programming in sheep: Effects on pre- and postnatal organs and glands development in lambs
Sartori, E. D., Pereira, G. R., & Barcellos, J. O. J. (2022) · Research in Veterinary Science · doi:10.1016/j.rvsc.2022.07.014 · Cited by 4 · see citing works
Exploring Nutritional Status and Metabolic Imbalances in Children with FASD: A Cross-Sectional Study
Dyląg, K. A., Wieczorek-Stawińska, W., Burkot, K., Drzewiecki, Ł., Przybyszewska, K., Tokarz, A., & Dumnicka, P. (2024) · Nutrients · doi:10.3390/nu16193401 · Cited by 4 · see citing works
Early menopause in mothers and the risks of pre-diabetes and type 2 diabetes mellitus in female and male offspring: a population-based cohort study
Noroozzadeh, M., Mousavi, M. A., Naz, M. S. G., Farahmand, M., Azizi, F., & Tehrani, F. R. (2025) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-025-01405-z · Cited by 5 · see citing works
Effect of maternal apical periodontitis on the final step of insulin signalling and inflammatory pathway in the adult male offspring of rats
Tsosura, T. V. S., Mattera, M. S. D. L. C., Chiba, F. Y., Carnevali, A. C. N., Belardi, B. E., dos Santos, R. M., Cintra, L. T. Â., Lopes, F. L., Scaramele, N. F., & Matsushita, D. H. (2021) · International Endodontic Journal · doi:10.1111/iej.13610 · Cited by 4 · see citing works
Impact of Environmental Stressors on Gene Expression in the Embryo of the Italian Wall Lizard
Scudiero, R., Motta, C. M., & Simoniello, P. (2021) · Applied Sciences · doi:10.3390/app11114723 · Cited by 4 · see citing works
Long-term risk of offspring type 1 and type 2 diabetes following maternal gestational diabetes mellitus: a nationwide birth cohort study with 10-year follow-up
MOON, J. H., Jung, H. N., Kim, B., Kim, J., Jung, Y. M., Kim, H. J., Park, J. Y., Oh, T. J., Kwak, S. H., Han, K., et al. (2026) · BMC Medicine · doi:10.1186/s12916-026-04746-7 · Cited by 3 · see citing works
Altered metabolic profiles in male offspring conceived from intracytoplasmic sperm injection
Zhang, B., Ban, M., Chen, X., Hu, J., Cui, L., & Chen, Z. (2024) · BMC Medicine · doi:10.1186/s12916-024-03654-y · Cited by 3 · see citing works
Maternal Beslenmenin Yavrular Üzerine Etkileri: Fetal Programlama ve Epigenetik Mekanizmalar
Arslan, S., & Yıldıran, H. (2021) · Journal of Nutrition and Dietetics · doi:10.33076/2021.bdd.1437 · Cited by 3 · see citing works
Prophylactic Use of Natural Products against Developmentally Programmed Metabolic Syndrome
Ibrahim, K. G., Adeshina, K. A., Bello, M. B., Malami, I., Abubakar, B., Abubakar, M. B., & Imam, M. U. (2021) · Planta Medica · doi:10.1055/a-1482-2343 · Cited by 3 · see citing works
Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1
Peña‐Villalobos, I., Otárola, F. A., Casas, B. S., Sabat, P., & Palma, V. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.769444 · Cited by 3 · see citing works
Maternal folate and metabolic programming of the offspring: A systematic review of the literature
Pereira, A., & Keating, E. (2023) · Reproductive Toxicology · doi:10.1016/j.reprotox.2023.108439 · Cited by 3 · see citing works
Is Homocysteine a Biomarker of Environmental Health Risk and Epigenetic-DNA Methylation: Links to Cardiovascular Pathogenesis and B Vitamins
Djuric, D. M., Todorović, D., Bajić, Z., Mutavdžin, S., & Šobot, T. (2024) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-62806-1_15 · Cited by 3 · see citing works
Maternal Exposure to Ozone During Implantation Promotes a Feminized Transcriptomic Profile in the Male Adolescent Liver
Dye, J. A., Stewart, E. J., Schladweiler, M. C. J., Nguyen, H. H., Grindstaff, R. D., Padgett, W. T., Fisher, A., & Miller, C. N. (2025) · Endocrinology · doi:10.1210/endocr/bqaf018 · Cited by 3 · see citing works
Elevated cortisol concentration in preterm sheep fetuses impacts heart development
Amanollahi, R., Holman, S. L., Bertossa, M. R., Meakin, A. S., Clifton, V. L., Thornburg, K. L. R., McMillen, I. C., Wiese, M. D., Lock, M. C., & Morrison, J. L. (2025) · Experimental Physiology · doi:10.1113/ep092506 · Cited by 3 · see citing works
Therapeutic Potential of Dietary Polyphenols
Stockert, A., & Hall, S. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.99177 · Cited by 3 · see citing works
Intergenerational Trauma: Conceptual Frameworks, Mechanisms of Transmission, Impacts and Intervention Approaches
Karaburun, M. (2025) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.18863/pgy.1694859 · Cited by 2 · see citing works
Transgenerational Epigenetic Programming
Bautista, N. M. (2022) · Springer eBooks · doi:10.1007/978-3-031-13771-6_5 · Cited by 2 · see citing works
Nutrient restriction during pregnancy and litter size affect the feeding behaviour, feed preference and welfare of the aged ewe’s offspring
Pérez-Clariget, R., Corrales-Hlinka, M. F., Pérez, M. B. L., & Jorge‐Smeding, E. (2023) · Small Ruminant Research · doi:10.1016/j.smallrumres.2023.107025 · Cited by 2 · see citing works
Precocious evaluation of cardiovascular risk and its correlation with perinatal condition
Oliveira, W. R., RIGO, C. P., Ferreira, A. R. O., Ribeiro, M. V. G., Peres, M. N. C., & Palma‐Rigo, K. (2023) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765202320201702 · Cited by 1 · see citing works
Placental expression and methylation of angiogenic factors in assisted reproductive technology pregnancies from India
Sundrani, D. P., Kapare, A., Yadav, H., Randhir, K., Gupte, S., & Joshi, S. (2024) · Epigenomics · doi:10.1080/17501911.2024.2438593 · Cited by 2 · see citing works
The association between gestational selective serotonin reuptake inhibitor (SSRI) treatment and newborn thyroid screen: a large-scale cohort study
Raviv, O., Lebenthal, Y., Yackobovitch‐Gavan, M., Cohen‐Sela, E., Almashanu, S., Marom, R., Herzlich, J., Hiersch, L., & Brener, A. (2025) · BMC Pediatrics · doi:10.1186/s12887-025-05452-8 · Cited by 2 · see citing works
The Influence of Maternal Inflammatory Status on Fetal Telomere Length at Birth
Diaconu, M. M., Olaru, F., Abu-Awwad, A., Abu-Awwad, S.-A., Dragomir, T., Sacarin, G., Pilut, C. N., Sorop, B., Bicu, M., & Nitu, R. (2025) · Biomedicines · doi:10.3390/biomedicines13081974 · Cited by 2 · see citing works
Adverse weather duringin uterodevelopment is linked to higher rates of later-life herpesvirus reactivation in adult European badgers,Meles meles
Tsai, M.-S., Newman, C., Macdonald, D. W., & Buesching, C. D. (2022) · Royal Society Open Science · doi:10.1098/rsos.211749 · Cited by 1 · see citing works
Systematic Sampling of the Female Reproductive System for Molecular Characterization
Fisher, S. A., Grijalva, M., Guo, R. J., Johnston, S. A., Laurent, L. C., Nguyen, H., Renz, J., Rosario, J. G., Rudich, S. M., Gregory, B. D., et al. (2023) · Current Protocols · doi:10.1002/cpz1.848 · Cited by 2 · see citing works
Obesity and clinical psychosomatic women’s health
Lal, M., & Sarhadi, A. H. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817919-2.00032-2 · Cited by 2 · see citing works

Programación Fetal asociada a diabetes y obesidad: una revisión sistemática de las consecuencias epigenéticas en el niño
Pereira, N. V. D. M., & Nauman, J. V. P. (2023) · Interamerican Journal of Health Sciences · doi:10.59471/ijhsc2023148
Meccanismi epigenetici: come i 9 mesi in utero possono condizionare la salute metabolica della prole
Prudente, S. (2025) · il Diabete · doi:10.30682/ildia2504i
Fetal metabolic programming and epigenetic modifications: a systems biology approach
Sookoian, S. C., Gianotti, T. F., Burgueño, A. L., & Pirola, C. J. (2013) · Pediatric Research · doi:10.1038/pr.2013.2 · Cited by 138 · see citing works
Epigenomics, gestational programming and risk of metabolic syndrome
Desai, M., Jellyman, J. K., & Ross, M. G. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.13 · Cited by 277 · see citing works
Epigenetics and In Utero Acquired Predisposition to Metabolic Disease
Deodati, A., Inzaghi, E., & Cianfarani, S. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2019.01270 · Cited by 38 · see citing works

Authors: Zhu, Z., Cao, F., & Li, X.
Affiliations: Soochow University (CN)
Nanjing Medical University (CN)
Corresponding author: Li, Xiaozhong
ORCID: Zhu, Ziqiang
Li, Xiaozhong
Venue: Frontiers in Endocrinology
Publisher: Frontiers Media SA
Published: 2019-12-03
Volume: 10
Pages: 764-764
ISSN: 1664-2392 (ISSN-L)
DOI: 10.3389/fendo.2019.00764
PMC: PMC6901800
OpenAlex: W2981958174
Cited by: 158
References: 199
Citations by year: 2026: 27 · 2025: 24 · 2024: 24 · 2023: 23 · 2022: 21 · 2021: 22 · 2020: 17
FWCI: 3.16
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Endocrinology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Jiangsu Commission of Health
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords: epigenetic programming, metabolic syndrome, adult offspring, obesity, insulin resistance, epigenetic modifications, transgenerational epigenetic inheritance, fetal development

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Epigenetic Programming and Fetal Metabolic Programming

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks