The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Modulation of Macrophage Efferocytosis in Inflammation
Open accessAbstract
A critical function of macrophages within the inflammatory milieu is the removal of dying cells by a specialized phagocytic process called efferocytosis ("to carry to the grave"). Through specific receptor engagement and induction of downstream signaling, efferocytosing macrophages promote resolution of inflammation by (i) efficiently engulfing dying cells, thus avoiding cellular disruption and release of inflammatory contents, and (ii) producing anti-inflammatory mediators such as IL-10 and TGF-β that dampen pro-inflammatory responses. Evidence suggests that plasticity in macrophage programming, in response to changing environmental cues, modulates efferocytic capability. Essential to programming for enhanced efferocytosis is activation of the nuclear receptors PPARγ, PPARδ, LXR, and possibly RXRα. Additionally, a number of signals in the inflammatory milieu, including those from dying cells themselves, can influence efferocytic efficacy either by acting as immediate inhibitors/enhancers or by altering macrophage programming for longer-term effects. Importantly, sustained inflammatory programming of macrophages can lead to defective apoptotic cell clearance and is associated with development of autoimmunity and other chronic inflammatory disorders. This review summarizes the current knowledge of the multiple factors that modulate macrophage efferocytic ability and highlights emerging therapeutic targets with significant potential for limiting chronic inflammation.
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Cites
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Cited by
Apoptotic cell clearance: basic biology and therapeutic potential
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Transforming growth factor β—at the centre of systemic sclerosis
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Nonclassical Ly6C− Monocytes Drive the Development of Inflammatory Arthritis in Mice
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Metadata
- Authors
- Korns, D., Frasch, S. C., Fernandez-Boyanapalli, R., Henson, P. M., & Bratton, D. L.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2011
- Volume
- 2
- Pages
- 57-57
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W1986480779
- Cited by
- 349
- References
- 103
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- Korns, D., Frasch, S. C., Fernandez-Boyanapalli, R., Henson, P. M., & Bratton, D. L. (2011). Modulation of Macrophage Efferocytosis in Inflammation. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2011.00057
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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