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SOCS3, a Major Regulator of Infection and Inflammation
Open accessAbstract
In this review, we describe the role of suppressor of cytokine signaling-3 (SOCS3) in modulating the outcome of infections and autoimmune diseases as well as the underlying mechanisms. SOCS3 regulates cytokine or hormone signaling usually preventing, but in some cases aggravating, a variety of diseases. A main role of SOCS3 results from its binding to both the JAK kinase and the cytokine receptor, which results in the inhibition of STAT3 activation. Available data also indicate that SOCS3 can regulate signaling via other STATs than STAT3 and also controls cellular pathways unrelated to STAT activation. SOCS3 might either act directly by hampering JAK activation or by mediating the ubiquitination and subsequent proteasome degradation of the cytokine/growth factor/hormone receptor. Inflammation and infection stimulate SOCS3 expression in different myeloid and lymphoid cell populations as well as in diverse non-hematopoietic cells. The accumulated data suggest a relevant program coordinated by SOCS3 in different cell populations, devoted to the control of immune homeostasis in physiological and pathological conditions such as infection and autoimmunity.
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“HDAC5 promotes the upregulation of Chemokine ligand 2 (CCL2) by inhibiting SOCS3, thereby recruiting CCR2+ macrophages [147].”
From Targeting KRAS mutant cancers: from druggable therapy to drug resistance (2022) · cites this paper as [147]
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1 retracted
RETRACTED: Suppressors of Cytokine Signaling 2 and 3 Diametrically Control Macrophage Polarization
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Items 101–200 of 566
Cytokines reprogram airway sensory neurons in asthma
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“Because Socs3 is also an important regulator of a series of (cytokine) receptors (e.g., IL-6 receptor; Carow and Rottenberg, 2014), it will be very interesting to determine how additional inflammatory pathways are affected by the Ezh2 deletion–mediated induction of Socs3.”
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“SOCS3 is a member of eight molecules (SOCS1–7 and CIS that damp n the signal transducer and activator of transcription protein (STAT) activation by direct interactions with Ja us kinases (JAKs) and STAT (JAK-STAT)-activating receptors [26].”
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“Moreover, two of the genes commonly upregulated are the suppressor of cytokine signaling-3 (SOCS3) and the heat shock protein HSP90AB1, which contribute to the regulation of cytokines production and signaling and subsequently, immune response and inflammation (46, 47).”
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“However, Socs3 may also modulate signaling pathways other than Stat3, involving SMAD3, nuclear factor kappa B, and p38 mitogen-activated protein kinase, among others.(19) Therefore, these pathways in macrophages may also participate in the AD-prone phenotype of mSocs3-KO mice.”
BackgroundPeng, C., Wu, C., Lin, J.-Y., Peng, S.-C., Lee, C.-H., Huang, K., & Shen, C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219788 · Cited by 38
Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling
Tian, D., Teng, X., Jin, S., Chen, Y., Xue, H., Xiao, L., & Wu, Y. (2020) · Journal of Advanced Research · doi:10.1016/j.jare.2020.06.005 · Cited by 37
“On one side SOCS3 inhibits activity of Jak directly, on the other side SOCS3 degrades Jak by ubiquitination to suppress downstream signaling [13].”
BackgroundJAK-STAT signaling pathway in non-infectious uveitis
Su, Y., Tao, T., Liu, X., & Su, W. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115236 · Cited by 38
Dendritic cells and parasites: from recognition and activation to immune response instruction
Motrán, C. C., Ambrosio, L. F., Volpini, X., Celias, D. P., & Cervi, L. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0588-7 · Cited by 38
Valdés‐López, J. F., Hernández-Sarmiento, L. J., Tamayo-Molina, Y. S., Velilla, P. A., Rodenhuis‐Zybert, I. A., & Inchima, S. U. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1385473 · Cited by 44
Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells
Ushiki, T., Huntington, N. D., Glaser, S. P., Kiu, H., Georgiou, A., Zhang, J., Metcalf, D., Nicola, N. A., Roberts, A. W., & Alexander, W. S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162111 · Cited by 37
“Actions of SOCS3 in T cells have been implicated in modulating immune and inflammatory responses, although effects appear to vary and are likely due to the control by SOCS3 of STAT3 activity, which can promote both inflammatory and anti-inflammatory responses [2,18].”
BackgroundOncostatin M Suppresses Activation of IL-17/Th17 via SOCS3 Regulation in CD4+ T Cells
Son, H., Lee, S. H., Lee, S.-Y., Kim, E., Yang, E., Kim, J. K., Seo, H.-B., Park, S., & Cho, M. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1502314 · Cited by 36
“Previous reports have shown that STAT3 activation can contribute to the proliferation of Th17 cells (4, 16), that activation of STAT5 can induce Treg cell differentiation and inhibit Th17 cell differentiation (4, 17), and that SOCS3 can reduce STAT3 activation and the proliferation of Th17 cells (18, 19).”
BackgroundChen, M., Zhao, J., Ali, I. H. A., Marry, S., Augustine, J., Bhuckory, M. B., Lynch, A., Kissenpfennig, A., & Xu, H. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.12.021 · Cited by 34
Xie, J., Li, Y., Dai, J., He, Y., Sun, D., Dai, C., Xu, H., & Yin, Z. Q. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00341 · Cited by 35
Liu, Z.-Y., Easson, G. W. D., Zhao, J.-J., Makki, N., Ahituv, N., Hilton, M. J., Tang, S. Y., & Gray, R. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008096 · Cited by 31
“SOCS3 is known to directly regulate STAT1 (signal transducer and activator of transcription 1) and STAT3 activation [35].”
BackgroundEndothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice
Martino, N., Ramos, R. B., Lu, S., Leyden, K., Tomaszek, L., Sadhu, S., Fredman, G., Jaitovich, A., Vincent, P. A., & Adam, A. P. (2021) · JCI Insight · doi:10.1172/jci.insight.147280 · Cited by 33
Anti-IL5 mepolizumab minimally influences residual blood eosinophils in severe asthma
Hulst, G. V., Jorssen, J., Jacobs, N., Henket, M. A., Louis, R. E., Schleich, F., Bureau, F., & Desmet, C. J. (2021) · European Respiratory Journal · doi:10.1183/13993003.00935-2021 · Cited by 35
STAT3: too much may be worse than not enough!
Haddad, É. (2015) · Blood · doi:10.1182/blood-2014-11-610592 · Cited by 35
Bacteriophages targeting intestinal epithelial cells: a potential novel form of immunotherapy
Górski, A., Jończyk‐Matysiak, E., Łusiak-Szelachowska, M., Międzybrodzki, R., Weber‐Dąbrowska, B., & Borysowski, J. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2715-6 · Cited by 34
“Suppressor of cytokine signalling-3 (SOCS3) is a major regulator of inflammation [14].”
BackgroundDiallo, M., & Herrera, F. (2021) · FEBS Journal · doi:10.1111/febs.16116 · Cited by 36
Muskiet, F. A. J., Carrera‐Bastos, P., Pruimboom, L., Lucía, A., & Furman, D. (2022) · Nutrients · doi:10.3390/nu14071388 · Cited by 34
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“SOCS3 predominantly controls STAT3 activity; however, it has also been implicated in controlling other STATs and pathways unrelated to STAT activity (Carow and Rottenberg, 2014).”
Self-citationMarine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway
Mascuch, S. J., Boudreau, P. D., Carland, T. M., Pierce‐Ward, N. T., Olson, J., Hensler, M. E., Choi, H., Campanale, J. P., Hamdoun, A. M., Nizet, V., et al. (2017) · Journal of Natural Products · doi:10.1021/acs.jnatprod.7b00734 · Cited by 34
Biofilm‐induced profiles of immune response gene expression by oral epithelial cells
Ebersole, J. L., Peyyala, R., & Gonzalez, O. A. (2019) · Molecular Oral Microbiology · doi:10.1111/omi.12251 · Cited by 39
Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway
Ma, Z., Zhou, F., Jin, H., & Wu, X. (2024) · Cells · doi:10.3390/cells13121027 · Cited by 33
“In particular, the kinase inhibitory region of SOCS3 blocks the substrate-binding groove on JAK2, thereby inhibiting its kinase activity and promoting the ubiquitination and degradation of receptor proteins, which in turn suppresses STAT3 phosphorylation [53,54].”
BackgroundEl-Ghannam, M. S., Saad, M. A., Nassar, N. N., El-Yamany, M. F., & El-Bahy, A. A. Z. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.115906 · Cited by 33
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“inhibit STAT phosphorylation through binding of JAK kinase [43].”
BackgroundInflammatory Skin Diseases: Focus on the Role of Suppressors of Cytokine Signaling (SOCS) Proteins
Cianciulli, A., Calvello, R., Porro, C., Lofrumento, D. D., & Panaro, M. A. (2024) · Cells · doi:10.3390/cells13060505 · Cited by 34
“…with other cytokine receptors including the leptin receptor, the gp130 receptor, the IL-12 receptor, and the granulocyte-colony-stimulating factor (G-CSF) receptor (namely Tyr085, Tyr 757, Tyr800, and Tyr729), exhibiting an interference very similar to the one shown in the JAK/STAT pathway [24,39].”
BackgroundChen, J., Pan, J., Wang, J., Song, K., Zhu, D., Huang, C., & Duan, Y. (2016) · Scientific Reports · doi:10.1038/srep30957 · Cited by 30
MBD2-mediated Th17 differentiation in severe asthma is associated with impaired SOCS3 expression
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“Consequently, this inhibits STAT1-mediated IL-12 induction in macrophages & STAT4-mediated IFN-g synthesis in T cells.”
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Acute-on-Chronic Liver Failure From Chronic-Hepatitis-B, Who Is the Behind Scenes
Li, Q., Wang, J., Lu, M., Qiu, Y., & Lu, H. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.583423 · Cited by 28
“This result supports the hypothesis that SOCS3 is involved in immune homeostasis in pathological conditions by negatively regulating cytokine or hormone signaling (Carow and Rottenberg, 2014).”
ResultCD154-CD40 T-cell co-stimulation pathway is a key mechanism in kidney ischemia-reperfusion injury
de Ramón, L., Ripoll, È., Merino, A. M., Lúcia, M., Aran, J. M., Pérez‐Rentero, S., Lloberas, N., Cruzado, J. M., Grinyo, J. M., & Torrás, J. (2015) · Kidney International · doi:10.1038/ki.2015.146 · Cited by 28
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“Since SOCS3 can bind to interleukin (IL)-12 receptor, which can activate STAT3, SOCS3 can inhibit the IL-12-mediated activation of STAT3 (21).”
Risk Factors for Hepatocellular Carcinoma in Cirrhotic Patients with Chronic Hepatitis B
Zhang, Y., Peng, L., Cao, Y., Zeng, Z., Wu, Y., Shi, H., Cheng, S., Wang, J., Friedman, S. L., Sninsky, J. J., et al. (2016) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2016.0062 · Cited by 27
“SOCS3 protein is a negative feedback regulator of cytokine signaling pathways (Carow and Rottenberg, 2014).”
Vigors, S., O’Doherty, J. V., Ryan, M. T., & Sweeney, T. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00013.2019 · Cited by 27
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“Representative images displaying 3D reconstructions of retinal whole mounts in OIR mice at postnatal day (P) 17 are shown in Figure S1B.”
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“These include Nlrp12 (Table 1) [42], Nlrp6 (significantly increased at the site of infection on Days 1 and 4; S1 Table) [43], Irg1 (Table 1) [44], Olfm4 (Table 1) [45], Soscs3 (locally increased transcript levels on Days 1, 4, and 7; S1 Table) [46], zinc finger protein Zc3h12a (locally increased transcript levels on d…”
BackgroundTollip Inhibits ST2 Signaling in Airway Epithelial Cells Exposed to Type 2 Cytokines and Rhinovirus
Dakhama, A., Mubarak, R. A., Pavelka, N., Voelker, D. R., Seibold, M. A., Ledford, J. G., Kraft, M., Li, L., & Chu, H. W. (2019) · Journal of Innate Immunity · doi:10.1159/000497072 · Cited by 26
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“cascades associated with inflammatory and mitotic processes, respectively [34,35].”
BackgroundChimeric Peptidomimetics of SOCS 3 Able to Interact with JAK2 as Anti-inflammatory Compounds
Manna, S. L., Lopez‐Sanz, L., Mercurio, F. A., Fortuna, S., Leone, M., Gómez‐Guerrero, C., & Marasco, D. (2020) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.9b00664 · Cited by 26
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JAK3 Is Expressed in the Nucleus of Malignant T Cells in Cutaneous T Cell Lymphoma (CTCL)
Vadivel, C. K., Gluud, M., Torres‐Rusillo, S., Boding, L., Willerslev-Olsen, A., Buus, T. B., Nielsen, T. K., Persson, J. L., Bonefeld, C. M., Geisler, C., et al. (2021) · Cancers · doi:10.3390/cancers13020280 · Cited by 26
“Similarly, the NetNES also predicted a NES sequence corresponding to primary amino acid sequence from 16 to 22 (LDTSLRL) in SOCS3, a regulator of JAK-STAT signaling (reviewed in [42]).”
BackgroundAlves-Silva, T., Freitas, G., Húngaro, T., Arruda, A., Oyama, L., Avellar, M. C. W., & Araújo, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-90872-6 · Cited by 24
Han, H., Davidson, L. A., Fan, Y., Landrock, K. K., Jayaraman, A., Safe, S. H., & Chapkin, R. S. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00074.2021 · Cited by 26
Immunopathogenesis of Nipah Virus Infection and Associated Immune Responses
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“The suppressor of cytokine signaling (SOCS) family of proteins are well-known regulators of IL-6 signaling pathway, and, particularly, SOCS3 interacts with JAK2 and inhibits its catalytic activity leading to reduced STAT3 phosphorylation (1).”
BackgroundWhole blood transcriptional responses of very preterm infants during late-onset sepsis
Ng, S., Strunk, T., Lee, A. H., Gill, E. E., Falsafi, R., Woodman, T., Hibbert, J., Hancock, R. E. W., & Currie, A. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233841 · Cited by 27
“SOCS1 and SOCS3 code for the suppressor of cytokine signalling (SOCS) family of proteins that play a critical role in the maintenance of immune homeostasis [61].”
BackgroundInterleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis
Jafarzadeh, A., Nemati, M., Chauhan, P. S., Patidar, A., Sarkar, A., Sharifi, I., & Saha, B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01573 · Cited by 26
m6A mRNA modification potentiates Th17 functions to inflame autoimmunity
Wang, X., Chen, C., Sun, H.-W., Mao, K., Yao, J., Zhang, W., Zhan, M., Li, H., Zhang, Z., Zhu, S., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2323-4 · Cited by 28
“SOCS3 is a well-known negative regulator of STAT3 signaling (Carow and Rottenberg, 2014; Palmer and Restifo, 2009; Yoshimura et al., 2007).”
BackgroundWang, X., Si, X.-W., Sun, J., Yue, L., Wang, J., & Yu, Z. (2018) · DNA and Cell Biology · doi:10.1089/dna.2017.4008 · Cited by 25
“In addition, silencing SOCS3 promoted IL-1-induced inflammatory joint disease (Carow and Rottenberg, 2014).”
Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection
Fujiwara, S., Hoshizaki, M., Ichida, Y., Lex, D., Kuroda, E., Ishii, K. J., Magi, S., Okada, M., Takao, H., Gandou, M., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0289-1 · Cited by 25
Conole, E. L. S., Vaher, K., Blesa, M., Sullivan, G., Stevenson, A. J., Hall, J., Murphy, L., Thrippleton, M. J., Quigley, A. J., Bastin, M. E., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.03.011 · Cited by 25
Dendritic cells: understanding ontogeny, subsets, functions, and their clinical applications
Li, W., Yu, C., Zhang, X., Gu, Y., He, X., Xu, R., Xu, J. F., Yu, G., & Wu, Y. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00300-8 · Cited by 28
“The parasite further manipulates host immunity through TLR2-mediated induction of SOCS1/3, which inhibits JAK/STAT signaling and subsequent proinflammatory cytokine release [260].”
MicroRNA-30e-5p Regulates SOCS1 and SOCS3 During Bacterial Infection
Mishra, R., Krishnamoorthy, P., & Kumar, H. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.604016 · Cited by 24
Xiong, X., Yang, C., He, W., Yu, J., Yue, X., Zhang, X., Huang, R., Ma, H., Xu, S., Li, Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32846-4 · Cited by 28
Klaver, D., Gander, H., Dobler, G., Rahm, A., & Thurnher, M. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04548-z · Cited by 24
“In our study, the expression of SOCS3, a major regulator of inflammation [46], was upregulated during P2Y11 signaling and strongly enhanced by cAMP.”
BackgroundXiong, H., Zhang, Y., Chen, S., Ni, Z., He, J., Li, X., Li, B., Zhao, K., Yang, F., Zeng, Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19321 · Cited by 26
“Previous reports have shown that SOCS3 regulates numerous biological and pathological processes such as inflammation [16], immunity [17], diabetes [18], angiogenesis [19] and development [20].”
BackgroundHam, D.-W., Kim, S., Seo, S., Shin, J., Lee, S. H., & Shin, E. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00957-9 · Cited by 25
“IL-27, and effector molecules, such as SOCS3 and STAT3 [17, 18, 20, 22].”
BackgroundInfluentialSawoo, R., & Bishayi, B. (2024) · Immunobiology · doi:10.1016/j.imbio.2024.152840 · Cited by 27
Unravelling the druggability and immunological roles of the SOCS-family proteins
Lynch, D. M., Forrester, B., Webb, T., & Ciulli, A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1449397 · Cited by 25
Echevarría, F. D., & Rickman, A. E. (2016) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000439 · Cited by 23
“For example, SOCS3 is a downstream target of gp130 signaling that inhibits JAK/ STAT activity to establish a negative feedback loop [15,16].”
BackgroundRen, Q., Sun, S., Li, M., Gao, B., & Zhang, L. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.104961 · Cited by 23
Ding, S., Lu, G., Wang, B., Xiang, J., Hu, C., Lin, Z., Ding, Y., Xiao, W., & Gong, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.848957 · Cited by 23
“In general, SOCS3 and STAT3 are mutually regulated in cells (Carow and Rottenberg, 2014).”
BackgroundDegos, C., Gagnaire, A., Banchereau, R., Moriyón, I., & Gorvel, J. (2015) · Virulence · doi:10.4161/21505594.2014.979692 · Cited by 23
“CXCL2 and IL8 are chemokines that were previously described to promote neutrophil recruitment,(10) while SOCS3 negatively regulates pro-inflammatory cytokine secretion.(12,13) PTGS2 is involved in prostaglandins metabolism and TNFAIP6 has been shown to be an anti-inflammatory molecule.”
BackgroundGawish, R. A., Fahmy, H. A., Fattah, A. I. A. E., & Nada, A. S. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.108205 · Cited by 23
Sahin, G. S., Dhar, M., Dillon, C., Zhu, M., Shiina, H., Winters, B. D., Lambert, T. J., Impey, S., Appleyard, S. M., & Wayman, G. A. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103500 · Cited by 24
Effects of Controlled Cortical Impact on the Mouse Brain Vasculome
Guo, S., Lok, J. M., Zhao, S., Leung, W., Som, A. T., Hayakawa, K., Wang, Q., Xing, C., Wang, X., Ji, X., et al. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2015.4101 · Cited by 22
The Role of gp130 Cytokines in Tuberculosis
Ritter, K., Rousseau, J., & Hölscher, C. (2020) · Cells · doi:10.3390/cells9122695 · Cited by 24
“SOCS3 acts by inhibiting STAT3-mediated signaling by binding to gp130 [150].”
BackgroundBlanco-Lobo, P., Guisado-Hernández, P., Villaoslada, I., de Felipe, B., Carreras, C., Rodriguez, H., Carazo‐Gallego, B., Méndez-Echevarría, A. M., Lucena, J. M., Aljaro, P. O., et al. (2022) · Journal of Clinical Immunology · doi:10.1007/s10875-022-01273-x · Cited by 22
“Although the concrete mechanism remains to be elucidated, decreased SOCS3 expression has been described in the context of STAT1 hyperphosphorylation [17, 31, 42].”
BackgroundXie, J., Wang, M., Cheng, A., Zhao, X., Liu, M., Zhu, D., Chen, S., Jia, R., Yang, Q., Wu, Y., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00731 · Cited by 22
“Moreover, SOCS3 also plays a role in mediating the ubiquitination and subsequent proteasome degradation of cytokine/growth factor/hormone receptor (26).”
BackgroundEstrogen: the forgotten player in metaflammation
Zhu, B. T., Liao, Q.-Q., Tian, H., Yu, D., Xie, T., Sun, X., Zhou, X.-M., Han, Y., Zhao, Y., El‐Kassas, M., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1478819 · Cited by 22
“The suppressor of cytokine signaling (SOCS) has anti-in fl ammatory and metabolic regulation effects in many diseases, including AS (Carow and Rottenberg, 2014; Pedroso et al., 2019).”
Duncan, S. A., Sahu, R., Dixit, S., Singh, S. R., & Dennis, V. A. (2020) · Mediators of Inflammation · doi:10.1155/2020/7461742 · Cited by 22
“We targeted IL-6 and TNF because they reportedly can stimulate SOCS1 and SOCS3 expression in macrophages [52]; and also to evaluate if they exhibit any anti-inflammatory properties.”
BackgroundDNA methylation analysis of SOCS1, SOCS3, and LINE-1 in microdissected gingival tissue
Andia, D. C., Planello, A. C., Portinho, D., da Silva, R. A., Salmon, C. R., Sallum, E. A., Nociti, F. H., & de Souza, A. P. (2015) · Clinical Oral Investigations · doi:10.1007/s00784-015-1460-1 · Cited by 21
Carion, T. W., McWhirter, C. R., Grewal, D. K., & Berger, E. A. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17315 · Cited by 21
“In fact, generation of two synthetic VIP analogs (VIP51 and VIP51 [6-30]) by Campos-Salinas et al.”
BackgroundSOCS3 genetic variants and promoter hypermethylation in patients with chronic hepatitis B
Hoan, N. X., Tong, H. V., Giang, D. P., Cuong, B. K., Toàn, N. L., Wedemeyer, H. H., Bock, C. –., Kremsner, P. G., Song, L. H., & Velavan, T. P. (2017) · Oncotarget · doi:10.18632/oncotarget.15083 · Cited by 23
“Total bilirubin (μmol/l) 17 [8-788] 29 [3-752] 14 [5-235] 22 [7-419] NR”
BackgroundLiu, K., Wu, Z., Chu, J., Yang, L., & Wang, N. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108913 · Cited by 21
Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset
Witas, R., Peck, A. B., Ambrus, J. L., & Nguyen, C. Q. (2019) · Journal of Immunology Research · doi:10.1155/2019/4813795 · Cited by 21
“This interaction blocks the catalytic site of JAKs, thereby preventing phosphorylation of STATs and inhibiting cytokine signaling [89, 90].”
BackgroundFujii, M., Kawashima, N., Tazawa, K., Hashimoto, K., Nara, K., Noda, S., Kuramoto, M., Orikasa, S., Nagai, S., & Okiji, T. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.032 · Cited by 21
SOCS3 Attenuates GM-CSF/IFN-γ-Mediated Inflammation During Spontaneous Spinal Cord Regeneration
Zhang, X., He, B., Li, H., Wang, Y., Zhou, Y., Wang, W., Song, T., Gu, X., Gu, X., Luo, Y., et al. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00493-8 · Cited by 20
Ji, X., Shi, Y.-J., Zhang, Y., Chang, M., & Zhao, G. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.586905 · Cited by 21
“IL-6, as a pro-inflammatory cytokine, has been proposed to contribute to the progression of rheumatoid arthritis and Crohn’s disease, while SOCS3 is a major negative regulator of the IL6-related cytokine-STAT3 pathway and enhanced expression of SOCS3 inhibits these inflammatory responses (11, 24, 25).”
BackgroundSlot, E., Boers, R., Boers, J., van IJcken, W. F. J., Tibboel, D., Gribnau, J. H., Rottier, R. J., & de Klein, A. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01134-1 · Cited by 20
“SOCS3, an inhibitor of the JAK/STAT signalling pathway [35, 36] was among the potentially upregulated genes as well, in line with the previously demonstrated reduction of STAT3 protein in lung tissue of ACD/MPV patients [37].”
ResultPredicted COVID-19 molecular effects on endometrium reveal key dysregulated genes and functions
Henarejos-Castillo, I., Devesa-Peiró, A., de Miguel–Gómez, L., Sebastián-León, P., Romeu, M., Alemán, A., Molina-Gil, C., Pellicer, A., Cervelló, I., & Díaz-Gimeno, P. (2022) · Molecular Human Reproduction · doi:10.1093/molehr/gaac035 · Cited by 19
Hu, J. S., Lin, F., Yin, Y., Shang, Y., Xiao, Z., & Xu, W. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106278 · Cited by 21
Mast cells: new therapeutic target in helminth immune modulation
Vukman, K. V., Lalor, R., Aldridge, A. M., & O’Neill, S. M. (2015) · Parasite Immunology · doi:10.1111/pim.12295 · Cited by 20
Hansen, I. S., Schoonejans, J. M., Sritharan, L., van Burgsteden, J. A., Ambarus, C. A., Baeten, D., & den Dunnen, J. (2019) · Inflammation Research · doi:10.1007/s00011-019-01261-9 · Cited by 21
Hong, J. Y., Davaa, G., Yoo, H., Hong, K., & Hyun, J. K. (2020) · Cells · doi:10.3390/cells9051310 · Cited by 21
“For example, Socs3 plays an inhibitory role in pro-inflammatory cytokine-induced immune responses [48,49] In CNS, Socs3 is expressed in not only immune cells but other cell types, including neurons, astrocytes, oligodendrocytes, and microglia, and its expression is regulated by inflammatory cytokines [48].”
BackgroundHogendorf, A., Zieliński, M., Constantinou, M., Śmigiel, R. S., Wierzba, J., Wyka, K., Wędrychowicz, A., Jakubiuk‐Tomaszuk, A., Budzyńska, E., Piotrowicz, M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.742834 · Cited by 20
Interleukin-10 in the Vasculature: Pathophysiological Implications
de Freitas, R. A., Lima, V. V., Bomfim, G. F., & Giachini, F. R. C. (2021) · Current Vascular Pharmacology · doi:10.2174/1570161120666211227143459 · Cited by 19
Cook, C. P., Taylor, M. A., Liu, Y., Schmidt, R. L. J., Sedgewick, A. J., Kim, E., Hailer, A., North, J. P., Harirchian, P., Wang, H., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100715 · Cited by 22
Metadata
- Authors
- Carow, B., & Rottenberg, M. E.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Carow, Berit
- ORCID
- Carow, Berit
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2014
- Volume
- 5
- Pages
- 58-58
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC3928676
- OpenAlex
- W2140013858
- Cited by
- 555
- References
- 179
- Citations by year
- 2026: 31 · 2025: 55 · 2024: 65 · 2023: 71 · 2022: 64 · 2021: 58 · 2020: 43 · 2019: 52 · 2018: 31 · 2017: 25 · 2016: 27 · 2015: 24 · 2014: 9
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- SOCS3, suppressor of cytokine signaling, infection, inflammation, autoimmune disease, STAT3 activation, JAK kinases, cytokine signaling, receptor ubiquitination, proteasomal degradation, immune homeostasis, myeloid cells, lymphoid cells
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