Cited by 566Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic DiseasesProtein Tyrosine Phosphatases

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SOCS3, a Major Regulator of Infection and Inflammation

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Carow, Berit, Rottenberg, Martin E.·2014·Frontiers in Immunology

DOI 10.3389/fimmu.2014.00058PMC PMC3928676

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Abstract

In this review, we describe the role of suppressor of cytokine signaling-3 (SOCS3) in modulating the outcome of infections and autoimmune diseases as well as the underlying mechanisms. SOCS3 regulates cytokine or hormone signaling usually preventing, but in some cases aggravating, a variety of diseases. A main role of SOCS3 results from its binding to both the JAK kinase and the cytokine receptor, which results in the inhibition of STAT3 activation. Available data also indicate that SOCS3 can regulate signaling via other STATs than STAT3 and also controls cellular pathways unrelated to STAT activation. SOCS3 might either act directly by hampering JAK activation or by mediating the ubiquitination and subsequent proteasome degradation of the cytokine/growth factor/hormone receptor. Inflammation and infection stimulate SOCS3 expression in different myeloid and lymphoid cell populations as well as in diverse non-hematopoietic cells. The accumulated data suggest a relevant program coordinated by SOCS3 in different cell populations, devoted to the control of immune homeostasis in physiological and pathological conditions such as infection and autoimmunity.

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RETRACTED: Suppressors of Cytokine Signaling 2 and 3 Diametrically Control Macrophage Polarization
Spence, S., Fitzsimons, A., Boyd, C. R., Kessler, J., Fitzgerald, D. C., Elliott, J., Gabhann, J. N., Smith, S., Sica, A., Hams, E., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.013 · Cited by 96
Retracted
Yaşlı Kadınlarda Üreme Sağlığı
Kokanalı, D., & Engin Üstün, Y. (n.d.) · DergiPark (Istanbul University) · Cited by 170,090
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · cited 1×
“Binding to the cytokine activates the kinase function of JAK, a tyrosine kinase that binds to the receptor, which auto-phosphorylates itself, cross-phosphorylates a JAK molecule bound to the accompanying heterodimer chain of the cytokine receptor and also different tyrosine sites on the cytokine receptor (1).”
Background
Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
Untitled work
Colman (2022) · doi:10.1073/pnas · Cited by 4,370
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · cited 4×
“SOCS3 has been also suggested to inhibit IL-12-induced STAT4 activation by direct binding to IL-12Rβ2 (37), the IL-12R subunit that is not shared with the IL-23R.”
BackgroundInfluential
Journal of Biological Chemistry
Kurkinensp, M., CondongT, M. R., Blumberg, B., Barlow, D. P., Quiñones, S., Sausg, J., & Pihlajaniemisyy, T. (2021) · Journal of Biological Chemistry · doi:10.1074/jbc · Cited by 3,427
STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201
Drug delivery with carbon nanotubes for in vivo cancer treatment
Liu, Z., Chen, K., Davis, C. R., Sherlock, S. P., Cao, Q., Chen, X. S., & Dai, H. (2008) · PubMed · doi:10.48550/arxiv.0808.2070 · Cited by 2,287
The STATs of cancer — new molecular targets come of age
Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278
A family of cytokine-inducible inhibitors of signalling
Starr, R., Willson, T. A., Viney, E. M., Murray, L. J. L., Rayner, J. R., Jenkins, B. J., Gonda, T. J., Alexander, W. S., Metcalf, D., Nicola, N. A., et al. (1997) · Nature · doi:10.1038/43206 · Cited by 2,066
SOCS proteins, cytokine signalling and immune regulation
Yoshimura, A., Naka, T., & Kubo, M. (2007) · Nature Reviews Immunology · doi:10.1038/nri2093 · Cited by 1,580
The JAK-STAT Pathway at Twenty
Stark, G. R., & Darnell, J. E., Jr. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.013 · Cited by 1,577
Regulation of JAK–STAT signalling in the immune system
Shuai, K., & Liu, B. (2003) · Nature reviews. Immunology · doi:10.1038/nri1226 · Cited by 1,410
A new protein containing an SH2 domain that inhibits JAK kinases
Endo, T. A., Masuhara, M., Yokouchi, M., Suzuki, R., Sakamoto, H., Mitsui, K., Matsumoto, A., Tanimura, S., Ohtsubo, M., Misawa, H., et al. (1997) · Nature · doi:10.1038/43213 · Cited by 1,408
STATs: Signal Transducers and Activators of Transcription
Ihle, J. N. (1996) · Cell · doi:10.1016/s0092-8674(00)81277-5 · Cited by 1,381
Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
Milner, J. D., Brenchley, J. M., Laurence, A., Freeman, A. F., Hill, B. J., Elias, K. M., Kanno, Y., Spalding, C., Elloumi, H. Z., Paulson, M. L., et al. (2008) · Nature · doi:10.1038/nature06764 · Cited by 1,157
Structure and function of a new STAT-induced STAT inhibitor
Naka, T., Narazaki, M., Hirata, M., Matsumoto, T., Minamoto, S., Aono, A., Nishimoto, N., Kajita, T., Taga, T., Yoshizaki, K., et al. (1997) · Nature · doi:10.1038/43219 · Cited by 1,040
Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
Bjørbæk, C., Elmquist, J. K., Frantz, J. D., Shoelson, S. E., & Flier, J. S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80062-3 · Cited by 1,014
Function of Mitochondrial Stat3 in Cellular Respiration
Wegrzyn, J., Potla, R., Chwae, Y.-J., Sepuri, N. B. V., Zhang, Q., Koeck, T., Derecka, M., Szczepanek, K., Szelag, M., Gornicka, A., et al. (2009) · Science · doi:10.1126/science.1164551 · Cited by 1,014
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
Rui, L., Yuan, M., Frantz, D., Shoelson, S., & White, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200444200 · Cited by 904
SOCS3 negatively regulates IL-6 signaling in vivo
Croker, B. A., Krebs, D. L., Zhang, J.-G., Wormald, S., Willson, T. A., Stanley, E. G., Robb, L., Greenhalgh, C. J., Förster, I., Clausen, B. E., et al. (2003) · Nature Immunology · doi:10.1038/ni931 · Cited by 840
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
Yasukawa, H., Ohishi, M., Mori, H., Murakami, M., Chinen, T., Aki, D., Hanada, T., Takeda, K., Akira, S., Hoshijima, M., et al. (2003) · Nature Immunology · doi:10.1038/ni938 · Cited by 771
Inhibition of Stat1-mediated gene activation by PIAS1
Liu, B., Liao, J., Rao, X., Kushner, S. A., Chung, C. D., Chang, D. D., & Shuai, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10626 · Cited by 765
A novel cytokine‐inducible gene CIS encodes an SH2‐containing protein that binds to tyrosine‐phosphorylated interleukin 3 and erythropoietin receptors.
Yoshimura, A., Ohkubo, T., Kiguchi, T., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Hara, T., & Miyajima, A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07281.x · Cited by 751
Twenty proteins containing a C-terminal SOCS box form five structural classes
Hilton, D. J., Richardson, R. T., Alexander, W. S., Viney, E. M., Willson, T. A., Sprigg, N. S., Starr, R., Nicholson, S. E., Metcalf, D., & Nicola, N. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.114 · Cited by 728
The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
Yasukawa, H., Misawa, H., Sakamoto, H., Masuhara, M., Sasaki, A., Wakioka, T., Ohtsuka, S., Imaizumi, T., Matsuda, T., Ihle, J. N., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1309 · Cited by 719
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
Chen, Z. J., Laurence, A. D. J., Kanno, Y., Pacher-Zavisin, M. C., Zhu, B., Tato, C. M., Yoshimura, A., Hennighausen, L. G., & O’Shea, J. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600666103 · Cited by 664
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
Mori, H., Hanada, R., Hanada, T., Aki, D., Mashima, R., Nishinakamura, H., Torisu, T., Chien, K. R., Yasukawa, H., & Yoshimura, A. (2004) · Nature Medicine · doi:10.1038/nm1071 · Cited by 651
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.
Yoshida, K., Taga, T., Saito, M., Suematsu, S., Kumanogoh, A., Tanaka, T., Fujiwara, H., Hirata, M., Yamagami, T., Nakahata, T., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.407 · Cited by 634
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
Zhang, J., Farley, A., Nicholson, S. E., Willson, T. A., Zugaro, L. M., Simpson, R. J., Moritz, R. L., Cary, D., Richardson, R. T., Hausmann, G., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2071 · Cited by 626
Suppressor of Cytokine Signaling-3 (SOCS-3), a Potential Mediator of Interleukin-6-dependent Insulin Resistance in Hepatocytes
Senn, J. J., Klover, P. J., Nowak, I. A., Zimmers, T. A., Koniaris, L. G., Furlanetto, R. W., & Mooney, R. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210689200 · Cited by 620
Suppressors of cytokine signaling and immunity
Kubo, M., Hanada, T., & Yoshimura, A. (2003) · Nature Immunology · doi:10.1038/ni1012 · Cited by 617
Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction
Ogura, H., Murakami, M., Okuyama, Y., Tsuruoka, M., Kitabayashi, C., Kanamoto, M., Nishihara, M., Iwakura, Y., & Hirano, T. (2008) · Immunity · doi:10.1016/j.immuni.2008.07.018 · Cited by 564
SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985
Bjørbæk, C., Lavery, H. J., Bates, S. H., Olson, R. K., Davis, S. M., Flier, J. S., & Myers, M. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007577200 · Cited by 537
Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3
Kawaguchi, T., Yoshida, T., Harada, M., Hisamoto, T., Nagao, Y., Ide, T., Taniguchi, E., Kumemura, H., Hanada, S., Maeyama, M., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63408-6 · Cited by 534
Gigantism in mice lacking suppressor of cytokine signalling-2
Metcalf, D., Greenhalgh, C. J., Viney, E. M., Willson, T. A., Starr, R., Nicola, N. A., Hilton, D. J., & Alexander, W. S. (2000) · Nature · doi:10.1038/35016611 · Cited by 490
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
Howard, J. K., Cave, B. J., Oksanen, L. J., Tzameli, I., Bjørbæk, C., & Flier, J. S. (2004) · Nature Medicine · doi:10.1038/nm1072 · Cited by 490
Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses
Wang, Y., He, F., Feng, F., Liu, X., Dong, G., Qin, H., Hu, X., Zheng, M., Liang, L., Feng, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0269 · Cited by 483
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
Tebbutt, N. C., Giraud, A. S., Inglese, M., Jenkins, B., Waring, P., Clay, F. J., Malki, S., Alderman, B. M., Grail, D., Hollande, F., et al. (2002) · Nature Medicine · doi:10.1038/nm763 · Cited by 474
Cis3/Socs3/Ssi3 Plays a Negative Regulatory Role in Stat3 Activation and Intestinal Inflammation
Suzuki, A., Hanada, T., Mitsuyama, K., Yoshida, T., Kamizono, S., Hoshino, T., Kubo, M., Yamashita, A., Okabe, M., Takeda, K., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.4.471 · Cited by 473
SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling
Emanuelli, B., Peraldi, P., Filloux, C., Sawka‐Verhelle, D., Hilton, D. J., & OBBERGHEN, E. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.15985 · Cited by 468
Regulation of gene-activation pathways by PIAS proteins in the immune system
Shuai, K., & Liu, B. (2005) · Nature reviews. Immunology · doi:10.1038/nri1667 · Cited by 467
SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation
Qin, H., Holdbrooks, A. T., Liu, Y., Reynolds, S. L., Yanagisawa, L. L., & Benveniste, E. N. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201168 · Cited by 458
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
Nicholson, S. E., De Souza, D., Fabri, L. J., Corbin, J., Willson, T. A., Zhang, J.-G., Silva, A., Asimakis, M., Farley, A., Nash, A. D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100135197 · Cited by 456
SOCS3 regulates the plasticity of gp130 signaling
Lang, R., Pauleau, A.-L., Parganas, E., Takahashi, Y., Mages, J., Ihle, J. N., Rutschman, R., & Murray, P. J. (2003) · Nature Immunology · doi:10.1038/ni932 · Cited by 439
Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis
Taleb, S., Romain, M., Ramkhelawon, B., Uyttenhove, C., Pasterkamp, G., Herbin, O., Esposito, B., Pérez, N., Yasukawa, H., Snick, J. V., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090545 · Cited by 426
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
Starr, R., Metcalf, D., Elefanty, A. G., Brysha, M., Willson, T. A., Nicola, N. A., Hilton, D. J., & Alexander, W. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14395 · Cited by 421
An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells
Cui, W., Liu, Y., Weinstein, J. S., Craft, J., & Kaech, S. M. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.017 · Cited by 410
Cytokine‐inducible SH2 protein‐3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N‐terminal kinase inhibitory region as well as SH2 domain
Sasaki, A., Yasukawa, H., Suzuki, A., Kamizono, S., Syoda, T., Kinjyo, I., Sasaki, M., Johnston, J. A., & Yoshimura, A. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00263.x · Cited by 398
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
Shouda, T., Yoshida, T., Hanada, T., Wakioka, T., Oishi, M., Miyoshi, K., Komiya, S., Kosai, K.-I., Hanakawa, Y., Hashimoto, K., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13568 · Cited by 394
SOCS3 Exerts Its Inhibitory Function on Interleukin-6 Signal Transduction through the SHP2 Recruitment Site of gp130
Schmitz, J., Weissenbach, M., Haan, S., Heinrich, P. C., & Schaper, F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.12848 · Cited by 388
SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis
Marine, J.-C., McKay, C., Wang, D., Topham, D. J., Parganas, E., Nakajima, H., Pendeville, H., Yasukawa, H., Sasaki, A., Yoshimura, A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80049-5 · Cited by 372
Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation
Escary, J.-L., Perreau, J., Dumènil, D., Ezine, S., & Brûlet, P. (1993) · Nature · doi:10.1038/363361a0 · Cited by 363
SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses
Seki, Y.-I., Inoue, H., Nagata, N., Hayashi, K., Fukuyama, S., Matsumoto, K., Komine, O., Hamano, S., Himeno, K., Inagaki‐Ohara, K., et al. (2003) · Nature Medicine · doi:10.1038/nm896 · Cited by 361
STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice
Ernst, M., Najdovska, M., Grail, D., Lundgren–May, T., Büchert, M., Tye, H., Matthews, V. B., Armes, J. E., Bhathal, P. S., Hughes, N. R., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34944 · Cited by 349
STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor
Wang, Y., van Boxel-Dezaire, A. H. H., Cheon, H., Yang, J., & Stark, G. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315862110 · Cited by 327
IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology
Pellegrini, M., Calzascia, T., Toe, J. G., Preston, S., Lin, A. E., Elford, A. R., Shahinian, A., Lang, P. A., Lang, K. S., Morre, M., et al. (2011) · Cell · doi:10.1016/j.cell.2011.01.011 · Cited by 317
Protein tyrosine phosphatases in the JAK/STAT pathway
Xu, D. (2008) · Frontiers in bioscience · doi:10.2741/3051 · Cited by 314
Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling
Jenkins, B. J., Grail, D., Nheu, T., Najdovska, M., Wang, B., Waring, P., Inglese, M., McLoughlin, R. M., Jones, S. A., Topley, N., et al. (2005) · Nature Medicine · doi:10.1038/nm1282 · Cited by 308
SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition
Kershaw, N. J., Murphy, J. M., Liau, N. P. D., Varghese, L. N., Laktyushin, A., Whitlock, E. L., Lucet, I. S., Nicola, N. A., & Babon, J. J. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2519 · Cited by 301
Canonical and non-canonical JAK–STAT signaling
Li, W. X. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.08.008 · Cited by 300
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
Roberts, A. W., Robb, L., Rakar, S., Hartley, L., Cluse, L., Nicola, N. A., Metcalf, D., Hilton, D. J., & Alexander, W. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161271798 · Cited by 300
SOCS3 Is a Critical Physiological Negative Regulator of G-CSF Signaling and Emergency Granulopoiesis
Croker, B. A., Metcalf, D., Robb, L., Wei, W., Mifsud, S., DiRago, L., Cluse, L. A., Sutherland, K. D., Hartley, L., Williams, E., et al. (2004) · Immunity · doi:10.1016/s1074-7613(04)00022-6 · Cited by 285
Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.
Ohtani, T., Ishihara, K., Atsumi, T., Nishida, K., Kaneko, Y., Miyata, T., Itoh, S., Narimatsu, M., Maeda, H., Fukada, T., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)80162-4 · Cited by 284
Influenza A Virus Inhibits Type I IFN Signaling via NF-κB-Dependent Induction of SOCS-3 Expression
Pauli, E.-K., Schmolke, M., Wolff, T., Viemann, D., Roth, J., Bode, J. G., & Ludwig, S. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000196 · Cited by 280
Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity
Babon, J. J., Kershaw, N. J., Murphy, J. M., Varghese, L. N., Laktyushin, A., Young, S. N., Lucet, I. S., Norton, R. S., & Nicola, N. A. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.015 · Cited by 279
Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis
Jo, D., Liu, D., Yao, S., Collins, R. D., & Hawiger, J. (2005) · Nature Medicine · doi:10.1038/nm1269 · Cited by 272
Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation
Qin, H., Yeh, W.-I., Sarno, P. D., Holdbrooks, A. T., Liu, Y., Muldowney, M., Reynolds, S. L., Yanagisawa, L. L., Fox, T. H., Park, K., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117218109 · Cited by 271
IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state
Nishihara, M., Ogura, H., Ueda, N., Tsuruoka, M., Kitabayashi, C., Tsuji, F., Aono, H., Ishihara, K., Huseby, E., Betz, U. A. K., et al. (2007) · International Immunology · doi:10.1093/intimm/dxm045 · Cited by 268
TGF-β Promotes Th17 Cell Development through Inhibition of SOCS3
Qin, H., Wang, L., Feng, T., Elson, C. O., Niyongere, S., Lee, S. J., Reynolds, S. L., Weaver, C. T., Roarty, K. P., Serra, R. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801986 · Cited by 253
Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-β1 production
Ogata, H., Chinen, T., Yoshida, T., Kinjyo, I., Takaesu, G., Shiraishi, H., Iida, M., Kobayashi, T., & Yoshimura, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209281 · Cited by 246
Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations
Han, W., & Lo, H. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.01.011 · Cited by 245
Identification and Functional Expression of a Glutamate- and Avermectin-Gated Chloride Channel from Caligus rogercresseyi, a Southern Hemisphere Sea Louse Affecting Farmed Fish
Cornejo, I., Andrini, O., Niemeyer, M. I., Marabolí, V., González-Nilo, F. D., Teulon, J., Sepúlveda, F. V., & Cid, L. P. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004402 · Cited by 245
Signal Transducer and Activator of Transcription 3 Is Required for the Oncogenic Effects of Non–Small-Cell Lung Cancer–Associated Mutations of the Epidermal Growth Factor Receptor
Alvarez, J. V., Greulich, H. E., Sellers, W. R., Meyerson, M. M., & Frank, D. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3757 · Cited by 243
Interleukin-6 Induces Early Gamma Interferon Production in the Infected Lung but Is Not Required for Generation of Specific Immunity to Mycobacterium tuberculosisInfection
Saunders, B., Frank, A., Orme, I., & Cooper, A. (2000) · Infection and Immunity · doi:10.1128/iai.68.6.3322-3326.2000 · Cited by 240
Suppressors of Cytokine Signaling Proteins Are Differentially Expressed in Th1 and Th2 Cells: Implications for Th Cell Lineage Commitment and Maintenance
Egwuagu, C. E., Yu, C., Zhang, M., Mahdi, R. M., Kim, S. J., & Gery, I. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3181 · Cited by 239
A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3
Yamamoto, M., Standley, D. M., Takashima, S., Saiga, H., Okuyama, M., Kayama, H., Kubo, E., Ito, H., Takaura, M., Matsuda, T., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091703 · Cited by 236
SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130
Lehmann, U., Schmitz, J., Weissenbach, M., Sobota, R. M., Hörtner, M., Friederichs, K., Behrmann, I., Tsiaris, W., Sasaki, A., Schneider-Mergener, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210552200 · Cited by 236
Roles of JAKs in Activation of STATs and Stimulation of c- fos Gene Expression by Epidermal Growth Factor
Leaman, D. W., Pisharody, S., Flickinger, T. W., Commane, M., Schlessinger, J., Kerr, I. M., Levy, D. E., & Stark, G. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.1.369 · Cited by 226
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor–β1
Kinjyo, I., Inoue, H., Hamano, S., Fukuyama, S., Yoshimura, T., Koga, K., Takaki, H., Himeno, K., Takaesu, G., Kobayashi, T., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052333 · Cited by 225
Suppressor of Cytokine Signaling 3 Is a Physiological Regulator of Adipocyte Insulin Signaling
Shi, H., Tzameli, I., Bjørbæk, C., & Flier, J. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403886200 · Cited by 223
SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis
Orabona, C., Pallotta, M. T., Volpi, C., Fallarino, F., Vacca, C., Bianchi, R., Belladonna, M. L., Fioretti, M. C., Grohmann, U., & Puccetti, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810278105 · Cited by 214
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis
Wong, P. K. K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25660 · Cited by 214
STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers
Wang, X., Crowe, P. J., Goldstein, D., & Yang, J. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1568 · Cited by 204
Transforming Growth Factor–β Signaling in T Cells Promotes Stabilization of Atherosclerotic Plaques Through an Interleukin-17–Dependent Pathway
Gisterå, A., Robertson, A.-K. L., Andersson, J., Ketelhuth, D. F. J., Овчинникова, О. А., Nilsson, S. K., Lundberg, A. M., Li, M. O., Flavell, R. A., & Hansson, G. K. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006133 · Cited by 194
Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-γ on STAT3 and Smads
Tanaka, K., Ichiyama, K., Hashimoto, M., Yoshida, H., Takimoto, T., Takaesu, G., Torisu, T., Hanada, T., Yasukawa, H., Fukuyama, S., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.3746 · Cited by 188
Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity
Wunderlich, C. M., Hövelmeyer, N., & Wunderlich, F. T. (2013) · JAK-STAT · doi:10.4161/jkst.23878 · Cited by 176
Cytokine Response Is Determined by Duration of Receptor and Signal Transducers and Activators of Transcription 3 (STAT3) Activation
Braun, D. A., Fribourg, M., & Sealfon, S. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.386573 · Cited by 168 · cited 2×
“as the putative cause of SOCS3’s effect: the suppressive effect of IL-6 signaling on TNF and IL-12 secretion in absence of SOCS3 was explained to be due to a sustained STAT3 activation (101, 102).”
Background
Leukemia Inhibitory Factor Inhibits T Helper 17 Cell Differentiation and Confers Treatment Effects of Neural Progenitor Cell Therapy in Autoimmune Disease
Cao, W., Yang, Y., Wang, Z., Liu, A., Fang, L., Wu, F., Hong, J., Shi, Y., Leung, S., Dong, C., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.06.011 · Cited by 168
Unique Expression of Suppressor of Cytokine Signaling 3 Is Essential for Classical Macrophage Activation in Rodents In Vitro and In Vivo
Liu, Y., Stewart, K. N., Bishop, E., Marek, C. J., Kluth, D., Rees, A. J., & Wilson, H. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.6270 · Cited by 168
Cutting Edge: Innate Immune Response Triggered by Influenza A Virus Is Negatively Regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-Dependent Pathway
Pothlichet, J., Chignard, M., & Si‐Tahar, M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2034 · Cited by 165
Suppressor of cytokine signaling 3 (SOCS3) expression and hepatitis C virus–related chronic hepatitis
Persico, M., Capasso, M., Persico, E., Svelto, M., Russo, R., Spano, D., Crocè, L. S., Mura, V. L., Moschella, F., Masutti, F., et al. (2007) · Hepatology · doi:10.1002/hep.21782 · Cited by 164
The Structure of SOCS3 Reveals the Basis of the Extended SH2 Domain Function and Identifies an Unstructured Insertion That Regulates Stability
Babon, J. J., McManus, E. J., Yao, S., DeSouza, D. P., Mielke, L. A., Sprigg, N. S., Willson, T. A., Hilton, D. J., Nicola, N. A., Baca, M., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.024 · Cited by 163
Cloning and Functional Analysis of New Members of STAT Induced STAT Inhibitor (SSI) Family: SSI-2 and SSI-3
Minamoto, S., Ikegame, K., Ueno, K., Narazaki, M., Naka, T., Yamamoto, H., Matsumoto, T., Saito, H., Hosoe, S., & Kishimoto, T. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7080 · Cited by 163
Suppressor of Cytokine Signaling-3 Inhibits Interleukin-1 Signaling by Targeting the TRAF-6/TAK1 Complex
Frobøse, H., Rønn, S. G., Heding, P. E., Mendoza, H., Cohen, P., Mandrup-Poulsen, T. R., & Billestrup, N. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0301 · Cited by 161
STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction
Nguyen-Jackson, H., Panopoulos, A. D., Zhang, H., Li, H. S., & Watowich, S. S. (2010) · Blood · doi:10.1182/blood-2009-08-240317 · Cited by 151
The SOCS Box Encodes a Hierarchy of Affinities for Cullin5: Implications for Ubiquitin Ligase Formation and Cytokine Signalling Suppression
Babon, J. J., Sabo, J. K., Zhang, J., Nicola, N. A., & Norton, R. S. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.01.024 · Cited by 146
Dendritic Cells Transduced with SOCS-3 Exhibit a Tolerogenic/DC2 Phenotype That Directs Type 2 Th Cell Differentiation In Vitro and In Vivo
Li, Y., Chu, N., Rostami, A. M., & Zhang, G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1679 · Cited by 144
IL‐27 increases the proliferation and effector functions of human naïve CD8+ T lymphocytes and promotes their development into Tc1 cells
Schneider, R., Yaneva, T., Beauseigle, D., El‐Khoury, L., & Arbour, N. (2010) · European Journal of Immunology · doi:10.1002/eji.201040804 · Cited by 143
Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor
Eyckerman, S., Broekaert, D., Verhee, A., Vandekerckhove, J. S., & Tavernier, J. H. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02205-5 · Cited by 143
IL-27 Suppresses CD28-Medicated IL-2 Production through Suppressor of Cytokine Signaling 3
Owaki, T., Asakawa, M., Kamiya, S., Takeda, K., Fukai, F., Mizuguchi, J., & Yoshimoto, T. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.5.2773 · Cited by 137
Suppressor of Cytokine Signaling-3 Suppresses the Ability of Activated Signal Transducer and Activator of Transcription-3 to Stimulate Neurite Growth in Rat Primary Sensory Neurons
Miao, T., Wu, D., Zhang, Y., Bo, X., Subang, M. C., Wang, P., & Richardson, P. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2160-06.2006 · Cited by 131
SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor β2 subunit
Yamamoto, K., Yamaguchi, M., Miyasaka, N., & Miura, O. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.140 · Cited by 131
The biology and mechanism of action of suppressor of cytokine signaling 3
Babon, J. J., & Nicola, N. A. (2012) · Growth Factors · doi:10.3109/08977194.2012.687375 · Cited by 129
Suppressor of Cytokine Signaling-3 Is Recruited to the Activated Granulocyte-Colony Stimulating Factor Receptor and Modulates its Signal Transduction
Hörtner, M., Nielsch, U., Mayr, L. M., Johnston, J. A., Heinrich, P. C., & Haan, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.3.1219 · Cited by 128
Suppressors of Cytokine Signaling Modulate JAK/STAT-Mediated Cell Responses During Atherosclerosis
Ortiz-Muñoz, G., Martı́n-Ventura, J. L., Hernández-Vargas, P., Mallavia, B., López-Parra, V., López‐Franco, Ó., Muñoz‐García, B., Fernández‐Vizarra, P., Ortega, L. M., Egido, J., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.173781 · Cited by 124
The Comparative Roles of Suppressor of Cytokine Signaling-1 and -3 in the Inhibition and Desensitization of Cytokine Signaling
Wormald, S., Zhang, J.-G., Krebs, D. L., Mielke, L. A., Silver, J., Alexander, W. S., Speed, T. P., Nicola, N. A., & Hilton, D. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509595200 · Cited by 123 · cited 2×
“Interestingly, after the initial phosphorylation of STAT3 in response to IL-6 followed by a subsequent inhibition by SOCS3, a second wave of activation leads to the re-phosphorylation of STAT3 (101).”
Background
SOCS3 Is a Physiological Negative Regulator for Granulopoiesis and Granulocyte Colony-stimulating Factor Receptor Signaling
Kimura, A., Kinjyo, I., Matsumura, Y., Mori, H., Mashima, R., Harada, M., Chien, K. R., Yasukawa, H., & Yoshimura, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300496200 · Cited by 119
Selective Expansion of Foxp3-Positive Regulatory T Cells and Immunosuppression by Suppressors of Cytokine Signaling 3-Deficient Dendritic Cells
Matsumura, Y., Kobayashi, T., Ichiyama, K., Yoshida, R., Hashimoto, M., Takimoto, T., Tanaka, K., Chinen, T., Shichita, T., Wyss‐Coray, T., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2170 · Cited by 109
The Control of Allergic Conjunctivitis by Suppressor of Cytokine Signaling (SOCS)3 and SOCS5 in a Murine Model
Ozaki, A., Seki, Y.-I., Fukushima, A., & Kubo, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5489 · Cited by 109
Suppressor of Cytokine Signaling 3 Inhibits Antiviral IFN-β Signaling To Enhance HIV-1 Replication in Macrophages
Akhtar, L. N., Qin, H., Muldowney, M., Yanagisawa, L. L., Kutsch, O., Clements, J. E., & Benveniste, E. N. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903563 · Cited by 99
CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover
Orr, S. J., Morgan, N. M., Elliott, J., Burrows, J. F., Scott, C. J., McVicar, D. W., & Johnston, J. A. (2006) · Blood · doi:10.1182/blood-2006-05-023556 · Cited by 96
Pituitary Corticotroph SOCS-3: Novel Intracellular Regulation of Leukemia-Inhibitory Factor-Mediated Proopiomelanocortin Gene Expression and Adrenocorticotropin Secretion
Auernhammer, C. J., Chesnokova, V., Bousquet, C., & Melmed, S. K. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.7.0140 · Cited by 95
NOTCH1 Up-regulation and Signaling Involved in Mycobacterium bovis BCG-induced SOCS3 Expression in Macrophages
Yeddula, N., & Balaji, K. N. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709960200 · Cited by 93
The PPE18 Protein of Mycobacterium tuberculosis Inhibits NF-κB/rel–Mediated Proinflammatory Cytokine Production by Upregulating and Phosphorylating Suppressor of Cytokine Signaling 3 Protein
Nair, S., Pandey, A. D., & Mukhopadhyay, S. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000773 · Cited by 92
Suppressor of cytokine signaling 3 controls lysosomal routing of G‐CSF receptor
Irandoust, M. I., Aarts, L. H. J., Roovers, O., Gits, J., Erkeland, S. J., & Touw, I. P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601640 · Cited by 91
A new high affinity binding site for suppressor of cytokine signaling‐3 on the erythropoietin receptor
Hörtner, M., Nielsch, U., Mayr, L. M., Heinrich, P. C., & Haan, S. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02916.x · Cited by 88
Cutting Edge: Silencing Suppressor of Cytokine Signaling 3 Expression in Dendritic Cells Turns CD28-Ig from Immune Adjuvant to Suppressant
Orabona, C., Belladonna, M. L., Vacca, C., Bianchi, R., Fallarino, F., Volpi, C., Gizzi, S., Fioretti, M. C., Grohmann, U., & Puccetti, P. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.6582 · Cited by 88
Elevated SOCS3 and altered IL-6 signaling is associated with age-related human muscle stem cell dysfunction
McKay, B. R., Ogborn, D. I., Baker, J. M., Toth, K., Tarnopolsky, M. A., & Parise, G. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00305.2012 · Cited by 87
Elevated expression and polymorphisms of SOCS3 influence patient response to antiviral therapy in chronic hepatitis C
Persico, M., Capasso, M., Russo, R., Persico, E., Crocè, L. S., Tiribelli, C., & Iolascon, A. (2007) · Gut · doi:10.1136/gut.2007.129478 · Cited by 85
A Critical Role for SOCS3 in Innate Resistance to Toxoplasma gondii
Whitmarsh, R. J., Gray, C. M., Gregg, B., Christian, D. A., May, M. J., Murray, P. J., & Hunter, C. A. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.07.009 · Cited by 80
Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination
Emery, B., Cate, H. S., Marriott, M., Merson, T., Binder, M. D., Snell, C., Soo, P. Y., Murray, S., Croker, B., Zhang, J.-G., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602574103 · Cited by 78
Hypoxia-inducible Factor 1α Regulates a SOCS3-STAT3-Adiponectin Signal Transduction Pathway in Adipocytes
Jiang, C., Kim, J. H., Li, F., Qu, A., Gavrilova, O., Shah, Y. M., & Gonzalez, F. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.426338 · Cited by 78
Transforming growth factor-beta signaling in t cells promotes stabilization of atherosclerotic plaques through an interleukin-17 dependent pathway
Gisterå, A., Robertson, A.-K., Andersson, J., Ketelhuth, D. F. J., Овчинникова, О. А., Nilsson, S. K., Lundberg, A. M., Li, M. O., Flavell, R. A., & Hansson, G. K. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.05.233 · Cited by 78
The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo
Boyle, K., Egan, P. J., Rakar, S., Willson, T. A., Wicks, I. P., Metcalf, D., Hilton, D. J., Nicola, N. A., Alexander, W. S., Roberts, A. W., et al. (2007) · Blood · doi:10.1182/blood-2007-03-079178 · Cited by 74
Silencing of microRNA-122 enhances interferon-α signaling in the liver through regulating SOCS3 promoter methylation
Yoshikawa, T., Takata, A., Otsuka, M., Kishikawa, T., Kojima, K., Yoshida, H., & Koike, K. (2012) · Scientific Reports · doi:10.1038/srep00637 · Cited by 72
Cardiac-Specific Deletion of SOCS-3 Prevents Development of Left Ventricular Remodeling After Acute Myocardial Infarction
Oba, T., Yasukawa, H., Hoshijima, M., Sasaki, K., Futamata, N., Fukui, D., Mawatari, K., Nagata, T., Kyogoku, S., Ohshima, H., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.10.887 · Cited by 71
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replication
Yokota, S., Yokosawa, N., Okabayashi, T., Suzutani, T., & Fujii, N. (2005) · Virology · doi:10.1016/j.virol.2005.04.028 · Cited by 67
Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis
Sodenkamp, J., Waetzig, G. H., Scheller, J., Seegert, D., Grötzinger, J., Rose‐John, S., Ehlers, S., & Hölscher, C. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.01.015 · Cited by 66
Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27
Brender, C., Tannahill, G. M., Jenkins, B. J., Fletcher, J. G., Columbus, R., Saris, C. J. M., Ernst, M., Nicola, N. A., Hilton, D. J., Alexander, W. S., et al. (2007) · Blood · doi:10.1182/blood-2006-08-041541 · Cited by 65
SOCS3 Targets Siglec 7 for Proteasomal Degradation and Blocks Siglec 7-mediated Responses
Orr, S. J., Morgan, N. M., Buick, R. J., Boyd, C. R., Elliott, J., Burrows, J. F., Jefferies, C. A., Crocker, P. R., & Johnston, J. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c600216200 · Cited by 64
Silencing Suppressor of Cytokine Signaling-1 (SOCS1) in Macrophages Improves Mycobacterium tuberculosis Control in an Interferon-γ (IFN-γ)-dependent Manner
Carow, B., Ye, X. Q., Gavier‐Widén, D., Bhuju, S., Oehlmann, W., Singh, M., Sköld, M., Ignatowicz, L., Yoshimura, A., Wigzell, H., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.238287 · Cited by 63
Self-citation
Hepatitis B Virus X Protein Impairs Hepatic Insulin Signaling Through Degradation of IRS1 and Induction of SOCS3
Kim, K., Kim, K. H., & Cheong, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008649 · Cited by 62
Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase–dependent induction of Socs-3
Caruso, R., Stolfi, C., Sarra, M., Rizzo, A., Fantini, M. C., Pallone, F., MacDonald, T. T., & Monteleone, G. (2009) · Blood · doi:10.1182/blood-2008-08-172767 · Cited by 62
Structural Basis for Phosphotyrosine Recognition by Suppressor of Cytokine Signaling-3
Bergamin, E., Wu, J., & Hubbard, S. R. (2006) · Structure · doi:10.1016/j.str.2006.06.011 · Cited by 60
Expression of M. tuberculosis-induced suppressor of cytokine signaling (SOCS) 1, SOCS3, FoxP3 and secretion of IL-6 associates with differing clinical severity of tuberculosis
Masood, K. I., Rottenberg, M. E., Salahuddin, N., Irfan, M., Rao, N. A., Carow, B., Islam, M., Hussain, R., & Hasan, Z. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-13 · Cited by 58
Self-citation
Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function
Lee, J. E., Yang, Y., Liang, F., Gough, D. J., Levy, D. E., & Sehgal, P. B. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00379.2011 · Cited by 58
Hepatic SOCS3 expression is strongly associated with non-response to therapy and race in HCV and HCV/HIV infection
Kim, K., Lin, W., Tai, A. W., Shao, R., Weinberg, E. M., Borges, C. B. D. S., Bhan, A. K., Zheng, H., Kamegaya, Y., & Chung, R. T. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2008.12.021 · Cited by 57
IL‐6 promotes acute and chronic inflammatory disease in the absence of SOCS3
Croker, B. A., Kiu, H., Pellegrini, M., Toe, J. G., Preston, S., Metcalf, D., O’Donnell, J. A., Cengia, L. H., McArthur, K., Nicola, N. A., et al. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2011.29 · Cited by 53
Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance
Palanivel, R., Fullerton, M. D., Galić, S., Honeyman, J. E., Hewitt, K., Jørgensen, S. B., & Steinberg, G. R. (2012) · Diabetologia · doi:10.1007/s00125-012-2665-3 · Cited by 53
Epstein-Barr Virus Interferes with the Amplification of IFNα Secretion by Activating Suppressor of Cytokine Signaling 3 in Primary Human Monocytes
Michaud, F., Coulombe, F., Gaudreault, É., Paquet‐Bouchard, C., Rola‐Pleszczynski, M., & Gosselin, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011908 · Cited by 52
Overexpression of SOCS3 in T Lymphocytes Leads to Impaired Interleukin-17 Production and Severe Aortic Aneurysm Formation in Mice—Brief Report
Romain, M., Taleb, S., Dalloz, M., Ponnuswamy, P., Esposito, B., Pérez, N., Wang, Y., Yoshimura, A., Tedgui, A., & Mallat, Z. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300516 · Cited by 52
Analysis of Interferon Signaling by Infectious Hepatitis C Virus Clones with Substitutions of Core Amino Acids 70 and 91
Funaoka, Y., Sakamoto, N., Suda, G., Itsui, Y., Nakagawa, M., Kakinuma, S., Watanabe, T., Mishima, K., Ueyama, M., Onozuka, I., et al. (2011) · Journal of Virology · doi:10.1128/jvi.02583-10 · Cited by 51
Elevated Expression and Genetic Association Links the SOCS3 Gene to Atopic Dermatitis
Ekelund, E., Sääf, A. M., Tengvall-Linder, M., Melén, E., Link, J., Barker, J. N., Reynolds, N. J., Meggitt, S. J., Kere, J., Wahlgren, C., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/504272 · Cited by 51
SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-β1/Smad3 signaling
Liu, X., Zhang, Y., Yu, Y., Yang, X. Y., & Cao, X. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.08.018 · Cited by 50
Antigen Presentation by Dendritic Cells in Tumors Is Disrupted by Altered Metabolism that Involves Pyruvate Kinase M2 and Its Interaction with SOCS3
Zhang, Z., Liu, Q., Che, Y., Yuan, X., Dai, L., Zeng, B., Jiao, G., Zhang, Y., Wu, X., Yu, Y., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2970 · Cited by 50
Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 Is Involved in gp130 Resistance in Cardiovascular System in Rat Treated With Cardiotrophin-1 In Vivo
Hamanaka, I., Saito, Y., Yasukawa, H., Kishimoto, I., Kuwahara, K., Miyamoto, Y., Harada, M., Ogawa, E., Kajiyama, N., Takahashi, N., et al. (2001) · Circulation Research · doi:10.1161/hh0701.088512 · Cited by 49
Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease
Robb, L. G., Boyle, K., Rakar, S., Hartley, L., Lochland, J., Roberts, A. W., Alexander, W. S., & Metcalf, D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508023102 · Cited by 48
TGF-β-induced SOCS3 expression augments TNF-α-induced osteoclast formation
Lovibond, A. C., Haque, S. J., Chambers, T. J., & Fox, S. W. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.068 · Cited by 48
Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3)
Magrangeas, F., Boisteau, O., DENIS, S., Jacques, Y., & Minvielle, S. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530223 · Cited by 48
RSV replication is attenuated by counteracting expression of the suppressor of cytokine signaling (SOCS) molecules
Hashimoto, K., Ishibashi, K., Ishioka, K., Zhao, D., Sato, M., Ohara, S., Abe, Y., Kawasaki, Y., Sato, Y., Yokota, S., et al. (2009) · Virology · doi:10.1016/j.virol.2009.06.026 · Cited by 46
Myeloid depletion of SOCS3 enhances LPS‐induced acute lung injury through CCAAT/enhancer binding protein δ pathway
Yan, C., Ward, P. A., Wang, X., & Gao, H. (2013) · The FASEB Journal · doi:10.1096/fj.12-225797 · Cited by 46
Suppressors of Cytokine Signaling 2 and 3 Diametrically Control Macrophage Polarization
Spence, S., Fitzsimons, A., Boyd, C. R., Kessler, J., Fitzgerald, D. C., Elliott, J., Gabhann, J. N., Smith, S., Sica, A., Hams, E., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.06.016 · Cited by 45
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
Shouda, T., Yoshida, T., Hanada, T., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113568 · Cited by 44
IL-6 Mediates the Susceptibility of Glycoprotein 130 Hypermorphs to Toxoplasma gondii
Silver, J. S., Stumhofer, J. S., Passos, S., Ernst, M., & Hunter, C. A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004144 · Cited by 42
Critical and Independent Role for SOCS3 in Either Myeloid or T Cells in Resistance to Mycobacterium tuberculosis
Carow, B., Reuschl, A., Gavier‐Widén, D., Jenkins, B. J., Ernst, M., Yoshimura, A., Chambers, B. J., & Rottenberg, M. E. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003442 · Cited by 42
Self-citation
SOCS3 regulates graft-versus-host disease
Hill, G. R., Kuns, R. D., Raffelt, N. C., Don, A. L. J., Olver, S. D., Markey, K. A., Wilson, Y. A., Tocker, J. E., Alexander, W. S., Clouston, A. D., et al. (2010) · Blood · doi:10.1182/blood-2009-12-259598 · Cited by 40
Suppressed Th17 Levels Correlate with Elevated PIAS3, SHP2, and SOCS3 Expression in CD4 T Cells during Acute Simian Immunodeficiency Virus Infection
Bixler, S. L., Utay, N. S., Douek, D. C., & Mattapallil, J. J. (2013) · Journal of Virology · doi:10.1128/jvi.00600-13 · Cited by 37
Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation
Croker, B. A., Mielke, L. A., Wormald, S., Metcalf, D., Kiu, H., Alexander, W. S., Hilton, D. J., & Roberts, A. W. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.02.008 · Cited by 34
Extended Anti-inflammatory Action of a Degradation-resistant Mutant of Cell-penetrating Suppressor of Cytokine Signaling 3
Fletcher, T. C., DiGiandomenico, A., & Hawiger, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.095216 · Cited by 33
T Cell Treatment with Small Interfering RNA for Suppressor of Cytokine Signaling 3 Modulates Allergic Airway Responses in a Murine Model of Asthma
Moriwaki, A., Inoue, H., Nakano, T., Matsunaga, Y., Matsuno, Y., Matsumoto, T., Fukuyama, S., Kan‐o, K., Matsumoto, K., Tsuda, M., et al. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0051oc · Cited by 33
Splenic suppressor of cytokine signaling 3 transgene expression affects T cell responses and prevents development of collagen‐induced arthritis
Veenbergen, S., Bennink, M. B., de Hooge, A. S. K., Arntz, O. J., Smeets, R. L., van den Berg, W. B., & van de Loo, F. A. J. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24072 · Cited by 31
Overexpression of the suppressor of cytokine signalling 3 (SOCS3) in severe atopic dermatitis.
Horiuchi, Y., Bae, S.-J., & Katayama, I. (2006) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2005.01979.x · Cited by 25
Pituitary Corticotroph SOCS-3: Novel Intracellular Regulation of Leukemia-Inhibitory Factor-Mediated Proopiomelanocortin Gene Expression and Adrenocorticotropin Secretion
Auernhammer, C. J. (1998) · Molecular Endocrinology · doi:10.1210/me.12.7.954 · Cited by 22
gp130 on macrophages/granulocytes modulates inflammation during experimental tuberculosis
Sodenkamp, J., Behrends, J., Förster, I., Müller, W., Ehlers, S., & Hölscher, C. (2010) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.10.010 · Cited by 18
Aberrant IL-4 production by SOCS3-over-expressing T cells during infection with Leishmania major exacerbates disease manifestations
Nakaya, M., Hamano, S., Kawasumi, M., Yoshida, H., Yoshimura, A., & Kobayashi, T. (2011) · International Immunology · doi:10.1093/intimm/dxq472 · Cited by 17
Guidelines for the management of Irritable Bowel Syndrome
Spiller, R., Aziz, Q., Creed, F. H., Emmanuel, A. V., Houghton, L. A., Hungin, A. P., Jones, R., Kumar, D., Rubin, G. P., Trudgill, N., et al. (2007) · Durham Research Online (Durham University) · doi:10.1136/gut.2007 · Cited by 17
Inhibition of SOCS-3 in adipocytes of rats with diet-induced obesity increases leptin-mediated fatty acid oxidation
Gu, H., Liu, L., Ma, S., Liu, Y., Ren, Y., Zhai, L., Yu, F., An, L., & Yang, J. (2009) · Endocrine · doi:10.1007/s12020-009-9253-4 · Cited by 15
Erratum To: Suppressor of cytokine signaling 3 controls lysosomal routing of G‐CSF receptor
Irandoust, M. I., Aarts, L. H. J., Roovers, O., Gits, J., Erkeland, S. J., & Touw, I. P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601709 · Cited by 13
STATus Report on Tetramers
Levy, D. E., & Marié, I. J. (2012) · Immunity · doi:10.1016/j.immuni.2012.04.003 · Cited by 12
Oligodendrocytes exhibit selective expression of suppressor of cytokine signaling genes and signal transducer and activator of transcription 1 independent inhibition of interferon-gamma-induced toxicity in response to leukemia inhibitory factor
Emery, B., Butzkueven, H., Snell, C. E., Binder, M. D., & Kilpatrick, T. J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.022 · Cited by 11
Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3
McQuilten, H. A., Izon, D. J., Chong, M. M. W., Curtis, D. J., Roberts, A. W., Kay, T. W. H., Hilton, D. J., Alexander, W. S., & Starr, R. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.01.024 · Cited by 10
“Suppressor of Cytokine Signalling” Molecules in Infection and Inflammation
Carow, B., & Martin, E. (2012) · InTech eBooks · doi:10.5772/25986 · Cited by 4
Self-citation
Effects of step-wise increases in dietary carbohydrate on circulating saturated fatty acids and palmitoleic acid in adults with metabolic syndrome
(2014) · Institutional Repository University of Antioquia (University of Antioquia) · doi:10.1371/journal.pone

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Effects of immune cells and cytokines on inflammation and immunosuppression in the tumor microenvironment
Li, L., Yu, R., Cai, T., Chen, Z., Lan, M., Zou, T., Wang, B., Wang, Q., Zhao, Y., & Cai, Y. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106939 · Cited by 397
Macrophage and Fibroblast Interactions in Biomaterial‐Mediated Fibrosis
Witherel, C. E., Abebayehu, D., Barker, T. H., & Spiller, K. L. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801451 · Cited by 374
DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases
WHI-EMPC Investigators, Ligthart, S., Disease, C. E. O. C. H., Marzi, C., Aslibekyan, S. W., Mendelson, M., Conneely, K. N., Tanaka, T., Colicino, E., Waite, L. L., et al. (2016) · Genome biology · doi:10.1186/s13059-016-1119-5 · Cited by 317
“The gene product of SOCS3, suppressor of cytokine signaling 3, plays a pivotal role in the innate immune system as a regulator of cytokine signaling [11].”
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T cell exhaustion during persistent viral infections
Kahan, S. M., Wherry, E. J., & Zajac, A. J. (2015) · Virology · doi:10.1016/j.virol.2014.12.033 · Cited by 327
Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures
Sousa, C., Golebiewska, A., Poovathingal, S. K., Kaoma, T., Pires‐Afonso, Y., Martina, S., Coowar, D., Azuaje, F., Skupin, A., Balling, R., et al. (2018) · The EMBO Reports · doi:10.15252/embr.201846171 · Cited by 281
“Specifically, STAT3 and suppressor of cytokine signalling 3 (SOCS3) regulate inflammatory responses [54].”

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Authors: Carow, B., & Rottenberg, M. E.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Carow, Berit
ORCID: Carow, Berit
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2014
Volume: 5
Pages: 58-58
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2014.00058
PMC: PMC3928676
OpenAlex: W2140013858
Cited by: 555
References: 179
Citations by year: 2026: 31 · 2025: 55 · 2024: 65 · 2023: 71 · 2022: 64 · 2021: 58 · 2020: 43 · 2019: 52 · 2018: 31 · 2017: 25 · 2016: 27 · 2015: 24 · 2014: 9
FWCI: 3.22
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: SOCS3, suppressor of cytokine signaling, infection, inflammation, autoimmune disease, STAT3 activation, JAK kinases, cytokine signaling, receptor ubiquitination, proteasomal degradation, immune homeostasis, myeloid cells, lymphoid cells

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SOCS3, a Major Regulator of Infection and Inflammation

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