Cited by 566Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic DiseasesProtein Tyrosine Phosphatases

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SOCS3, a Major Regulator of Infection and Inflammation

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Carow, Berit, Rottenberg, Martin E.·2014·Frontiers in Immunology

DOI 10.3389/fimmu.2014.00058PMC PMC3928676

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Abstract

In this review, we describe the role of suppressor of cytokine signaling-3 (SOCS3) in modulating the outcome of infections and autoimmune diseases as well as the underlying mechanisms. SOCS3 regulates cytokine or hormone signaling usually preventing, but in some cases aggravating, a variety of diseases. A main role of SOCS3 results from its binding to both the JAK kinase and the cytokine receptor, which results in the inhibition of STAT3 activation. Available data also indicate that SOCS3 can regulate signaling via other STATs than STAT3 and also controls cellular pathways unrelated to STAT activation. SOCS3 might either act directly by hampering JAK activation or by mediating the ubiquitination and subsequent proteasome degradation of the cytokine/growth factor/hormone receptor. Inflammation and infection stimulate SOCS3 expression in different myeloid and lymphoid cell populations as well as in diverse non-hematopoietic cells. The accumulated data suggest a relevant program coordinated by SOCS3 in different cell populations, devoted to the control of immune homeostasis in physiological and pathological conditions such as infection and autoimmunity.

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RETRACTED: Suppressors of Cytokine Signaling 2 and 3 Diametrically Control Macrophage Polarization
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A Clinical Predictive Model Based on SOCS3 Promoter Methylation to Predict the Prognosis of Acute-on-Chronic Hepatitis B Liver Failure
Li, J., Tang, Y., Wang, J., Wei, X.-F., Wang, N., Wang, J., Lyu, H., Jiang, X., Liu, H.-H., & Wang, K. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s506050 · Cited by 4
“17,18 19–22 SOCS3 is correlated with the severity of inflammation in patients with ACHBLF and in mouse hepatitis virus strain 3-induced acute liver failure.”
Interception Targets of Angelica Gigas Nakai Root Extract versus Pyranocoumarins in Prostate Early Lesions and Neuroendocrine Carcinomas in TRAMP Mice
Tang, S., Jiang, P., Kim, S., Zhang, J., Jiang, C., & Lü, J. (2021) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-20-0589 · Cited by 3
“Socs3 plays a major role in inflammation and infection signaling, likely through JAK kinase and STAT3 signaling (63).”
Background
COVID-19 and Tuberculosis: Two Knives in a Sheath
Bupesh, G., Saravanan, K. M., Sundaram, K. K. M., Kumar, A. V., Alphonsa, T., Rajendran, S., Rajamanickam, K., Alemtoshi, Balachandar, V., & Bharali, P. (2022) · Coronaviruses · doi:10.2174/2666796703666220705144250 · Cited by 3
Distinct human skeletal muscle-derived CD90 progenitor subsets for myo-fibro-adipogenic disease modeling and treatment in multiplexed conditions
Li, A., Anbuchelvan, M., Fathi, A. T., Abu-Zahra, M., Evseenko, D. A., Petrigliano, F. A., & Dar, A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1173794 · Cited by 3
“demonstrates that 423F/gp130 signaling antagonizes TGF-β1mediated expression of collagen I and III, as well as insulininduced adipogenesis, suggesting that 423F/gp130 signaling promotes downstream activation of SOCS3 that has been shown to negatively regulate gp130 (Carow and Rottenberg, 2014), TGFβ1 (Ogata et al.”
Background
How do deer respiratory epithelial cells weather the initial storm of SARS-CoV-2 WA1/2020 strain?
Davila, K. M. S., Nelli, R. K., Phadke, K. S., Ruden, R. M., Sang, Y., Bellaire, B. H., Gimenez-Lirola, L. G., & Miller, L. C. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.02524-23 · Cited by 3
“…types (47) Another transcription factor of Jak-STAT signaling associated with IL-6 production during virus infection is SOCS3 (48), a negative feedback regulator in cytokine signaling, which also plays an important role during apoptosis, inflammation, T-cell development, and viral infection (49).”
Background
A loss of function mutation in SOCS2 results in increased inflammatory response of macrophages to TLR ligands and Staphylococcus aureus
Guzylack‐Piriou, L., Gausserès, B., Tasca, C., Hassel, C., Tabouret, G., & Foucras, G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1397330 · Cited by 5
“The expression of SOCS2 was shown to increase in macrophages infected with mycobacteria, and SOCS2 -de ﬁ cient mice exhibit higher sensitivity to the in ﬂ ammation induced by Mycobacterium bovis (24).”
Background
Integrated gene expression and alternative splicing analysis in human and mouse models of Rett syndrome
Gioiosa, S., Gasparini, S., Presutti, C., Rinaldi, A., Castrignanò, T., & Mannironi, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-86114-8 · Cited by 3
Characterizing the expression profile of 3R tau pathology in Pick’s disease
Tamvaka, N., Soto‐Beasley, A. I., Gavrielatos, M., Heckman, M. G., Ren, Y., Udine, E., Quicksall, Z., Liskey, D., Castanedes‐Casey, M., Wszołek, Z. K., et al. (2025) · Science Advances · doi:10.1126/sciadv.adt6105 · Cited by 4
“Similarly, the SOCS3 gene, which encodes for the suppressor of cytokine signaling 3 protein, is also involved in inflammation and immunity by regulating cytokine signaling and has been shown to be up-regulated in the brain of patients with AD ( 18 , 24 ).”
Immunomodulatory effect of thymopentin on lymphocytes from supramammary lymph nodes of dairy cows
Guan, R., Xu, W., Yuan, L., Wang, Y., Cui, X., & Hu, S. (2019) · Immunology Letters · doi:10.1016/j.imlet.2019.09.002 · Cited by 3
Expression of mycobacterium tuberculosis induced SOCS3 and STAT3 and the implications on innate immunity in TB patients vs healthy contacts in high TB/HIV endemic setting: A cross-sectional analytical study
Lungu, P., Kabaso, M., Njelesani, E., Sukwa, T. Y., Lakhi, S., & Mwaba, P. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263624 · Cited by 3
MicroRNA-155 acts as a potential prognostic and diagnostic factor in patients with ankylosing spondylitis by modulating SOCS3
Jahangir, M., Kahrizi, M. S., Natami, M., Pour, R. M., Ghoreishizadeh, S., Hemmatzadeh, M., Mohammadi, H., Shomali, N., & Shotorbani, S. S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-08033-5 · Cited by 4
“It also regulates STAT3 activation kinetics and determines the transcriptional pattern of proand anti-inflammatory cytokines [21, 49].”
Background
Differing coronavirus genres alter shared host signaling pathways upon viral infection
Cruz-Pulido, D., Ouma, W. Z., & Kenney, S. P. (2022) · Scientific Reports · doi:10.1038/s41598-022-13396-7 · Cited by 3
Transcriptomic profiles of Plasmodium falciparum and Plasmodium vivax -infected individuals in IndonesiaPreprint
Bobowik, K., Syafruddin, D., Darusallam, C. C., Sudoyo, H., Wells, C. A., & Romero, I. G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.07.425684 · Cited by 3
“Inflammation, a pathway which mediates parasite clearance [64], was evident by the upregulation of IRAK3, S100A8, and SOCS3, all known inflammatory markers and mediators [52, 65, 66].”
Background
Utilising Nanopore direct RNA sequencing of blood from patients with sepsis for discovery of co- and post-transcriptional disease biomarkersPreprint
He, J., Ganesamoorthy, D., Chang, J. J. ‐., Zhang, J., Trevor, S. L., GIBBONS, K. S., McPherson, S. J., Kling, J. C., Schlapbach, L. J., Blumenthal, A., et al. (2024) · medRxiv · doi:10.1101/2024.12.13.24318230 · Cited by 3
Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice
Pramanik, R., Chattopadhyay, S., & Bishayi, B. (2025) · Immunologic Research · doi:10.1007/s12026-024-09586-2 · Cited by 2
“…thus inhibiting inflammation; deletion of SOCS 3 has been linked with enhanced phosphorylation of STAT 3 and increased production of IL-17 [92]. mTOR is a major driver of inflammation and its maximum expression in splenic lymphocytes was observed in the SA group, but the TGF-β and IL-21…”
Borrelia burgdorferi sensu lato inhibits CIITA transcription through pSTAT3 activation and enhanced SOCS1 and SOCS3 expression leading to limited IFN-γ production
Brouwer, M. A. E., Karami, Z., Keating, S. T., Vrijmoeth, H. D., Lemmers, H., Dijkstra, H., van de Veerdonk, F. L., Lupșe, M. S., ter Hofstede, H. J. M., Netea, M. G., et al. (2025) · Ticks and Tick-borne Diseases · doi:10.1016/j.ttbdis.2025.102442 · Cited by 2
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Song, H., Lü, J., Zhang, Y., & Shen, X. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202402446 · Cited by 2
“SOCS3 plays a crucial role in energy homeostasis by inhibiting hormones such as insulin and leptin [20].”
Understanding immunological insights of liver transplantation: a practice for attaining operational tolerance
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Valizadeh, A., Veenhuis, R. T., Bradley, B. A., & Xu, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062598 · Cited by 2
“THC downregulated multiple pro-inflammatory genes as well as genes involved in the negative regulation of inflammation, such as SOCS3 , NR1D1 , and MRC1 , all of which are typically induced by inflammatory stimuli to help modulate or restrain the immune response [65–67].”
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Yan, C., Li, W., Cai, Y.-M., Cai, W.-Y., Hu, N., Song, Y., Li, W., Sun, Z., & Geng, Q. (2025) · Current Medical Science · doi:10.1007/s11596-025-00083-7 · Cited by 2
Transcriptional responses in different mouse models of septic liver injury differ from those in patients with septic liver injury
Yan, Q., Fan, W. J., He, X., Shi, Z., & Zhong, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1556392 · Cited by 2
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Herrera-Uribe, J., & Stevenson, N. J. (2025) · European Journal of Immunology · doi:10.1002/eji.202451645 · Cited by 2
“Wunderlichetal.2013[80]andCarow&Rottenbergetal.2014[81] previously demonstrated that SOCS3-mediated feedback inhibition of leptin receptor (Ob-Rb) signaling in macrophages and other immune cells results in impaired cytokine production and immune cell metabolism, thereby compromising early antiviral…”
IL-1β–induced STAT3 activation drives IL-17–producing CD8+ tissue-resident memory T cells and exacerbates chronic psoriasis
Kim, T., Lee, C. R., Lee, S.-Y., Lee, A. R., Lee, Y. J., Bang, C. H., & Cho, M.-L. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07446-7 · Cited by 3
A modular transcriptomic signature paired with machine learning reveals core immune pathways in sepsis diagnosis
Johari, T., & Chicco, D. (2026) · Discover Computing · doi:10.1007/s10791-026-09974-2 · Cited by 2
“SOCS3, induced by IL10 and other cytokines, inhibits JAK/STAT signaling and contributes to the phenomenon of endotoxin tolerance in monocytes and macrophages [98, 99].”
IL-10–STAT3-Dependent Transcriptional Regulation in Microglia: Alzheimer’s Disease and Neuroinflammation
Kim, M. E., & Lee, J. S. (2026) · Biomedicines · doi:10.3390/biomedicines14040826 · Cited by 2
“SOCS3 regulates STAT3 phosphorylation and nuclear STAT3 binding during IL-10 signaling [56–58].”
JAK-STAT signaling pathway in cancer: from molecular mechanisms to clinical intervention
Zhang, X., Li, P., Ma, F., Wang, T., Chu, Q., Wei, S., Xue, C., Wang, Z., & Lu, J. J. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02692-9 · Cited by 3
“SOCS3-medi-ated inhibition of JAK1/STAT3 signaling has also been implicated in regulating inflammatory responses in the central nervous system, highlighting broader homeostatic roles for this regulatory network [68, 69].”
Lentivirus-mediated overexpression of suppressor of cytokine signaling-3 reduces neutrophilic airway inflammation by suppressing T-helper 17 responses in mice with chronic Pseudomonasï¿½aeruginosa lung infections
Ding, F., Zhang, X., Chen, Y., Liao, R., Xie, G., Zhang, P., Shao, P., & Zhang, M. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3417 · Cited by 2
“A previous study reported that SOcS3 serves a critical role in restricting inflammation and regulating protective immune responses against infection in multiple mouse models (24).”
Topical Clonidine Accelerates Cutaneous Wound Healing in Diabetic Rats by Regulating the Expression of Related Cytokine Signaling
Phan, T.-C.-L., Chiang, Y.-S., Su, M., Liang, Y.-J., & Juang, S.-J. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46060339 · Cited by 2
“Its primary function stems from its ability to bind to both the JAK kinase and the cytokine receptor, leading to the suppression of STAT3 activation [31].”
Background
TLR-4Ab and IFNγAb with exogenous IL-10 treated LPS induced mice shown differential inflammatory response upon RANKL-M-CSF stimulation in resident bone marrow cells
Mukherjee, G., Samanta, S., & Bishayi, B. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107416 · Cited by 2
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Tabaa, M. M. E., Harty, M. E. E., Mohsen, M. A., Rashad, E., Negm, W. A., elmorshedy, K., & Abu-Risha, S. E.-S. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.109934 · Cited by 3
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Meesilpavikkai, K., Kaikaew, K., Zhou, Z., Dalm, V. A. S. H., Kaiser, F. M. P., Schliehe, C., Swagemakers, S. M. A., van der Spek, P. J., Schrijver, B., Vasic, P., et al. (2025) · Immune Network · doi:10.4110/in.2025.25.e18 · Cited by 2
“In addition to its role in STAT3 regulation, SOCS3 modulates the signaling of other STAT proteins and pathways unrelated to STAT thus affecting infection and inflammatory responses (20,22,23).”
Intermittent food restriction upregulates critical hypothalamic genes involved in energy regulation imbalance
Fernández, M. A. R., Vilca, C. M. C., Batista, L. O., do Carmo, M. D. G. T., & de Albuquerque, K. T. (2023) · Nutrition · doi:10.1016/j.nut.2023.112006 · Cited by 2
Tissue levels of suppressor of cytokine signaling-3 (SOCS-3) in mycosis fungoides
Nada, H. R., Rashed, L. A., Salman, O. O., Abdallah, N., & Abdelhady, M. M. (2022) · Archives of Dermatological Research · doi:10.1007/s00403-022-02339-x · Cited by 2
“Still, its exact role played in the disease has not yet been thoroughly investigated [2].”
Background
The loss-of-function of SOCS2 increases the inflammatory response to Staphylococcus aureus infectionPreprint
Guzylack‐Piriou, L., Gausserès, B., Tasca, C., Hassel, C., Tabouret, G., & Foucras, G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.22.554270 · Cited by 2
“SOCS3 has already been shown to negatively regulate STAT-3 activation in response to several cytokines, such as those of the gp130-containing IL-6 receptor family (Carow & Rottenberg, 2014).”
A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory target gene expressionPreprint
Gaggioli, M. R., Jones, A. G., Panagi, I., Washington, E., Loney, R. E., Muench, J. H., Brennan, R. G., Thurston, T. L. M., & Ko, D. C. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.14.580367 · Cited by 2
“36 It has also been shown that deletion of SOCS3 or mutation of its binding site in gp130 results in IL-6 displaying an anti-inflammatory bias similar to IL-10 signaling.”
Background
Identification of functional pathways and potential genes associated with interferon signaling during human adenovirus type 7 infection by weighted gene coexpression network analysis
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“For example, influenza A virus [25], HSV [38], and RSV [47] can suppresses IFN-I production and response by stimulating SOCS3 expression [2], consistent with our data showing that SOCS3 was upregulated after adenovirus infection.”
Result
GAB1 attenuates lipopolysaccharide‑mediated endothelial dysfunction via regulation of SOCS3
Ren, G., Liu, R., Mai, H., Yin, G., Ding, F., Wang, C., Chen, S., & Lan, X. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12689 · Cited by 1
“SOCS3 is a novel intracellular regulator that negatively regulates the sustained activation of multiple cytokine‑asso‑ ciated signaling pathways, which in turn participates in biological processes such as inflammation, oxidative stress, cell proliferation and apoptosis (22,23).”
Background
Neutralization of TLR2 in combination with either TNF-α or IL-1β antibody reduces the severity of septic arthritis through STAT3/mTOR signalling in lymphocytes
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“24 SOCS3 is suggested as a potential therapeutic target molecule to keep the function of photoreceptor cells during the inflammation.”
Background
The Role of Sex Hormones and Gender Differences in the Immunity of Cancer
Cosci, I., Fiore, P. D., D, S. M. M., & Ferlin, A. (2024) · Springer eBooks · doi:10.1007/978-3-030-80962-1_377-1 · Cited by 1
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“Inflammatory regulatory markers SOCS3 [32] and VCAM1 [33] were upregulated in VAOs.”
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DNA methylation predicts lung function and pulmonary exacerbation in sputum samples from patients with cystic fibrosis
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“SOCS3 encodes a protein that either blocks or promotes inflammation depending on the cellular context [26].”
Receptor engineering constitutes feedback control and robustness of IL-23R signaling and highlights importance of intracellular cytokine receptor signaling motifs
Kashtanjeva, L., Ruhland, C., Horstmeier, F. C., Thives-Kurenbach, F., Ettich, J., Padrini, G., Streuber, S., Scheller, J., Dittrich, A., & Floss, D. M. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-025-02593-2 · Cited by 2
“The SOCS protein family consists of eight members, SOCS1 – SOCS7 and the cytokine-inducible Src homology 2 (SH2) containing protein (CIS), which inhibit STAT activation by many, but not all, JAK–STAT activating receptors [3].”
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“This nuanced regulation may allow SOCS3 to fine-tune hepcidin production without completely abolishing STAT3 activation, thereby preserving IL-6’s beneficial metabolic effects, such as macrophage reprogramming and anti-inflammatory signaling [44,45].”
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“SOCS3, a core negative regulator of cytokine signaling [45, 46], critically constrains Th1 polarization by suppressing IL-12 signaling [47] and modulates Th17/Treg balance [48–50].”
Docosahexaenoic acid supplementation inhibits monocyte exhaustion memory formation during sepsis
Caldwell, B. A., Wu, Y., Ie, S., Lucas, A., Conacher, B., Zhang, Y., Razani, B., & Li, L. (2026) · Inflammation Research · doi:10.1007/s00011-026-02194-w · Cited by 1
“SOCS3, by contrast, is a well-characterized suppressor of inflammatory cytokine sig - naling that operates in a STAT-or cytokine-induced negative feedback loop [71].”
Spatially structured inflammatory response in the presence of a uniform stimulus
Jerison, E. R., Romeo, N., & Quake, S. R. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2507102123 · Cited by 1
“1 (27), and the inflammatory repressor socs3a (28, 29).”
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Peters, L. D., Seay, H. R., Smith, J. A., Posgai, A. L., Berkowitz, R. L., Wasserfall, C. H., Atkinson, P. M. A., Bacher, R. L., Brusko, M., & Brusko, T. M. (2026) · Journal of Clinical Investigation · doi:10.1172/jci196445 · Cited by 1
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“In contrast, suppressor of cytokine signaling 3 ( Socs3 ), a negative regulator of the JAK/STAT signaling pathway (32), was increased to a greater degree in myeloid cells and T cells of P. melaninogenica - exposed mice compared to S. pneumoniae –infected mice (Fig.”
Triple-negative breast cancer: new potential therapeutics derived from SOCS3 protein
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Etitiological Relationship between Hyperlipidemia and Acute Pancreatitis
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Lack of maternal exposure to somatostatin leads to diet-induced insulin and leptin resistance in mouse male offspring
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Elevating Jak-STAT signaling via SOCS3 deletion sustains photoreceptor viability and visual function in mouse models of retinitis pigmentosa
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“…in response to cytokine signaling, SOCS3 acts as a negative feedback inhibitor by binding to the complex of the cytokine receptor and its associated JAK kinase, either hampering JAK activation or mediating the ubiquitination and subsequent proteasome degradation of cytokine receptors [23–25].”
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Investigation of the Molecular Mechanisms by Which Endothelin-3 Stimulates Preadipocyte Growth
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“Previous studies have indicated that SOCS3 negatively regulates STAT3 gene expression (49).”
Background
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M. tuberculosis infection in diabetics is associated with increased inflammatory cytokine but decreased Suppressor of cytokine signaling (SOCS)-3 responsesPreprint
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Self-citation
Reply:Ex vivoSOCS3 gene responsiveness to alarmins in eosinophils of mepolizumab-treated patients is as yet of unknown biological significance
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“…cell types 48 Another transcription factor of Jak-STAT signaling associated with IL-6 production during virus infection is SOCS3 49 , a negative feedback regulator in cytokine signaling, which also plays an important role during apoptosis, inflammation, T-cell development, and viral infection 50 .”
Background
Low albumin status accompanies multi-layered immunosuppressive phenotypes in metastatic breast cancer patientsPreprint
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Tendon fibroblast inflammatory responses depend on NF-κβ and JAK/STAT signaling and alter mechanotransduction pathwaysPreprint
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“Upregulation of Sod3 and Socs3 was also observed, suggesting that the TFs were increasing protective mechanisms against inflammation in response to M1-CM 44,45 .”
ROLE OF STAT3 IN HUMAN NK CELL FUNCTIONS
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Efeito da ghrelina sobre o eixo GH/IGF-1 em animais submetidos à endotoxemia
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Peer Review #1 of "Comprehensive analysis of an lncRNA-miRNA-mRNA competing endogenous RNA network in pulpitis (v0.2)"
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Peer Review #1 of "Comprehensive analysis of an lncRNA-miRNA-mRNA competing endogenous RNA network in pulpitis (v0.1)"
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Upregulation of suppressor of cytokine signaling 3 ameliorates spinal degenerative disease in adolescents by mediating leptin and tumor necrosis factor‑α levels
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“Consequently a role of CV-B4 on IGF2 presentation in the thymus cannot be excluded, indeed it was shown that CV-B3 is able to alter class I antigen presentation (32).”
BackgroundInfluential
Methylation Pattern of the SOCS3 and IL6R Promoters in Rheumatoid Arthritis
Cieśla, M., Kolarz, B., Majdan, M., & Darmochwał-Kolarz, D. (2020) · International Journal of Inflammation · doi:10.1155/2020/8394659
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Background
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Suppressor of cytokine signaling proteins 1 and 3 and hepatitis B virus infection
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Enfermedad de Castleman versus tuberculosis generalizada: un caso de fiebre de origen desconocido
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Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death by Activating a TGFβ3/TFEB/STAT3 Pathway Early during Mammary Gland InvolutionPreprint
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Amphiregulin and Growth Differentiation Factor 11 Promote Retinal Ganglion Cell Survival In Vivo through Activation of Smad3
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A INTELIGÊNCIA ARTIFICIAL E SUAS IMPLICAÇÕES NO CAMPO DA GENÉTICA
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OBESIDADE MONOGÊNICA NÃO SINDRÔMICA: DOS GENES À TERAPIA
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Genética: Molecular, humana e médica 3
Neto, B. R. D. S. (2023) · doi:10.22533/at.ed.793230501
O PAPEL DE SOCS3 EM DISTÚRBIOS METABÓLICOS NA HEPATITE C CRÔNICA: REVISÃO DA LITERATURA
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Peer Review #1 of "MicroRNA expression in apical periodontitis and pulpal inflammation: a systematic review (v0.1)"
(2023) · PeerJ · doi:10.7287/peerj.14949v0.1/reviews/1
Peer Review #1 of "MicroRNA expression in apical periodontitis and pulpal inflammation: a systematic review (v0.3)"
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Peer Review #3 of "MicroRNA expression in apical periodontitis and pulpal inflammation: a systematic review (v0.1)"
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Pulmonary maternal immune activation does not extend through the placenta but leads to fetal metabolic adaptationPreprint
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Authors: Carow, B., & Rottenberg, M. E.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Carow, Berit
ORCID: Carow, Berit
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2014
Volume: 5
Pages: 58-58
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2014.00058
PMC: PMC3928676
OpenAlex: W2140013858
Cited by: 555
References: 179
Citations by year: 2026: 31 · 2025: 55 · 2024: 65 · 2023: 71 · 2022: 64 · 2021: 58 · 2020: 43 · 2019: 52 · 2018: 31 · 2017: 25 · 2016: 27 · 2015: 24 · 2014: 9
FWCI: 3.22
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: SOCS3, suppressor of cytokine signaling, infection, inflammation, autoimmune disease, STAT3 activation, JAK kinases, cytokine signaling, receptor ubiquitination, proteasomal degradation, immune homeostasis, myeloid cells, lymphoid cells

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SOCS3, a Major Regulator of Infection and Inflammation

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