Cited by 566Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic DiseasesProtein Tyrosine Phosphatases

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SOCS3, a Major Regulator of Infection and Inflammation

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Carow, Berit, Rottenberg, Martin E.·2014·Frontiers in Immunology

DOI 10.3389/fimmu.2014.00058PMC PMC3928676

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Abstract

In this review, we describe the role of suppressor of cytokine signaling-3 (SOCS3) in modulating the outcome of infections and autoimmune diseases as well as the underlying mechanisms. SOCS3 regulates cytokine or hormone signaling usually preventing, but in some cases aggravating, a variety of diseases. A main role of SOCS3 results from its binding to both the JAK kinase and the cytokine receptor, which results in the inhibition of STAT3 activation. Available data also indicate that SOCS3 can regulate signaling via other STATs than STAT3 and also controls cellular pathways unrelated to STAT activation. SOCS3 might either act directly by hampering JAK activation or by mediating the ubiquitination and subsequent proteasome degradation of the cytokine/growth factor/hormone receptor. Inflammation and infection stimulate SOCS3 expression in different myeloid and lymphoid cell populations as well as in diverse non-hematopoietic cells. The accumulated data suggest a relevant program coordinated by SOCS3 in different cell populations, devoted to the control of immune homeostasis in physiological and pathological conditions such as infection and autoimmunity.

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RETRACTED: Suppressors of Cytokine Signaling 2 and 3 Diametrically Control Macrophage Polarization
Spence, S., Fitzsimons, A., Boyd, C. R., Kessler, J., Fitzgerald, D. C., Elliott, J., Gabhann, J. N., Smith, S., Sica, A., Hams, E., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.013 · Cited by 96
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Background
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“SOCS3 has been also suggested to inhibit IL-12-induced STAT4 activation by direct binding to IL-12Rβ2 (37), the IL-12R subunit that is not shared with the IL-23R.”
BackgroundInfluential
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Mycoplasma gallisepticum escapes the host immune response via gga-miR-365-3p/SOCS5/STATs axis
Wang, Y., Han, Y. P., Wang, L., Zou, M., Sun, Y., Sun, H., Guo, Q., & Peng, X. (2022) · Veterinary Research · doi:10.1186/s13567-022-01117-x · Cited by 19
“Carow B, Rottenberg ME (2014) SOCS3, a major regulator of infection and inflammation.”
BackgroundInfluential
Whole Blood DNA Methylation Changes Are Associated with Anti-TNF Drug Concentration in Patients with Crohn’s Disease
Lin, S., Hannon, E. J., Reppell, M., Waring, J. F., Smaoui, N., Pivorunas, V. L., Guay, H., Chanchlani, N., Bewshea, C., Bai, B. Y. H., et al. (2023) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjad133 · Cited by 19
“…with chronological age of participants at study entry [r = 0.95, p <0.001]. the SOCS3 gene, involved in the negative regulation of the JAK-STAT pathway and thought to play a role in modulating the outcome of infections and autoimmune diseases 41 [effect size per week 0.0008, p = 1.91 x 10 -41 ].”
BackgroundInfluential
Optic nerve regeneration: Potential treatment approaches
Lee, J., Nguyen, S., & Bhattacharya, S. K. (2024) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2023.102428 · Cited by 24
Pediatric Crohn disease is characterized by Th1 in the terminal ileum and Th1/Th17 immune response in the colon
Mlakar, A. S., Hojsak, I., Jergović, M., Ćimić, S., & Bendelja, K. (2018) · European Journal of Pediatrics · doi:10.1007/s00431-017-3076-8 · Cited by 18
“In addition, the increase in the expression of SOCS3 was comparable to that of IL-6 in terminal ileum but not in the colon where insufficient upregulation of SOCS3 could potentiate the ongoing IL-6driven inflammation and contribute to enhanced Th17 differentiation [2].”
Background
Nonylphenol attenuates SOCS3 expression and M1 polarization in lipopolysaccharide-treated rat splenic macrophages
Pal, S., Nath, P., Biswas, S., Mukherjee, U., & Maitra, S. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.03.012 · Cited by 20
SOCS3 Silencing Attenuates Eosinophil Functions in Asthma Patients
Zafra, M. P., Cañas, J. A., Mazzeo, C., Gámez, C., Sanz, V., Fernández‐Nieto, M., Quirce, S., Barranco, P., Ruiz‐Hornillos, J., Sastre, J., et al. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16035434 · Cited by 19
Toll-like receptors, triggering receptor expressed on myeloid cells family members and receptor for advanced glycation end-products in allergic airway inflammation
Hall, S. C., & Agrawal, D. K. (2015) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2016.1133303 · Cited by 20
“activation of STAT3 by PI3K is regulated by suppressor of cytokine signaling family members.[68] TREM-1, found highly expressed on monocyte/macro-”
Background
Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis
Kulecka, M., O’Sullivan, J., Fitzgerald, R. S., Velikonja, A., Huseyin, C. E., Mendieta, E. J. L., Ruiz‐Limón, P., Eckenberger, J., Vidal-Marín, M., Truppel, B.-A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62533-z · Cited by 20
“The elevated expression of SOCS3 81 and TSC22D3 82 further suggests that compensatory anti-in ﬂ ammatory pathways are engaged but may be insuf ﬁ cient to resolve in ﬂ ammation in the context of persistent microbial and immune stimulation.”
The influence of chronic IL-6 exposure, in vivo , on rat Achilles tendon extracellular matrix
Katsma, M. S., Patel, S. H., Eldon, E. R., Corbell, K., Shimkus, K. L., Fluckey, J. D., & Carroll, C. C. (2017) · Cytokine · doi:10.1016/j.cyto.2017.04.011 · Cited by 20
Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice
Namiki, T., Terakawa, J., Karakama, H., Noguchi, M., Murakami, H., Hasegawa, Y., Ohara, O., Daikoku, T., Ito, J., & Kashiwazaki, N. (2023) · Scientific Reports · doi:10.1038/s41598-023-27859-y · Cited by 18
Treatment with bergamot (Citrus bergamia) leaves extract attenuates leptin resistance in obese rats
Nakandakare-Maia, E. T., Siqueira, J. S., Ferron, A. J. T., Vieira, T. A., Palacio, T. L. N., Grandini, N. A., Garcia, J. L., Belin, M. A. F., Altomare, A., Baron, G., et al. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.111908 · Cited by 20
The G protein-coupled receptor GPRC5A—a phorbol ester and retinoic acid-induced orphan receptor with roles in cancer, inflammation, and immunity
González, P. A. I., Valdivieso, Á. G., & Santa-Coloma, T. A. (2023) · Biochemistry and Cell Biology · doi:10.1139/bcb-2022-0352 · Cited by 18
Autoimmune lymphoproliferative immunodeficiencies (ALPID) in childhood: breakdown of immune homeostasis and immune dysregulation
Toskov, V., & Ehl, S. R. (2023) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-023-00167-1 · Cited by 19
“Suppressors of cytokine signaling 3 (SOCS3) and protein inhibitors of activated STAT3 (PIAS3) negatively regulate STAT3 function [77].”
Background
STAT3-Mediated Ferroptosis is Involved in Sepsis-Associated Acute Respiratory Distress Syndrome
Lin, S., Yan, J., Wang, W., & Luo, L. (2024) · Inflammation · doi:10.1007/s10753-024-01970-2 · Cited by 20
“…STAT receptor binding, inactivating JAK through N terminal kinase inhibitory structures, and promoting the interaction of signaling proteins with ubiquitin-mediated degradation pathway [54–56], which is essential for maintaining proper levels of STAT 3 in cells and preventing its overactivation.”
Differential Expression of Suppressor of Cytokine Signalling Proteins in Behçet's Disease
Hamedi, M., Bergmeier, L. A., Hagi‐Pavli, E., Vartoukian, S. R., & Fortune, F. (2014) · Scandinavian Journal of Immunology · doi:10.1111/sji.12211 · Cited by 19
Deletion of Suppressor of Cytokine Signaling 3 from Forebrain Neurons Delays Infertility and Onset of Hypothalamic Leptin Resistance in Response to a High Caloric Diet
McEwen, H. J. L., Inglis, M. A., Quennell, J. H., Grattan, D. R., & Anderson, G. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2714-14.2016 · Cited by 18
“SOCS3 is upregulated in the hypothalamus in response to inflammation following a high fat diet (Wu et al., 2014), and is important for restraining inflammation and allowing optimal levels of protective immune responses against infection (Carow and Rottenberg, 2014).”
Background
Hydraulic calcium silicate-based root canal sealers mitigate proinflammatory cytokine synthesis and promote osteogenesis in vitro
Alchawoosh, A., Hashimoto, K., Kawashima, N., Noda, S., Nozaki, K., & Okiji, T. (2023) · Journal of Dental Sciences · doi:10.1016/j.jds.2022.12.019 · Cited by 18
“CaSR/NFAT signaling then induces early growth response 2, which inhibits the mRNA expressions of IL-1a and IL-6, and promotes the expression of IL-10, a typical anti-inflammatory cytokine,(32) and suppressor of cytokine signal 3, a major regulator of inflammation.(33) In addition, Ca2þ released from MTA stimulates CaS…”
Background
Neuroprotective effect of G14-humanin on global cerebral ischemia/reperfusion by activation of SOCS3 – STAT3 – MCL–1 signal transduction pathway in rats
Gao, G., Fan, H., Zhang, X., Zhang, F., Wu, H., Feng, Q., Zhao, L., & Li, Y. (2017) · Neurological Research · doi:10.1080/01616412.2017.1352187 · Cited by 17
Knockout-Induced Pluripotent Stem Cells for Disease and Therapy Modeling of IL-10-Associated Primary Immunodeficiencies
Sens, J., Hoffmann, D., Lange, L., Barbosa, P. V., Morgan, M. A., Falk, C. S., & Schambach, A. (2020) · Human Gene Therapy · doi:10.1089/hum.2020.235 · Cited by 17
“32,33 Both genes are regulated by STAT3 phosphorylation after IL-10 induction.”
SOCS3–microtubule interaction via CLIP-170 and CLASP2 is critical for modulation of endothelial inflammation and lung injury
Karki, P., Ke, Y., Zhang, C.-O., Li, Y., Tian, Y., Son, S., Yoshimura, A., Kaibuchi, K., Birukov, K. G., & Birukova, A. A. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014232 · Cited by 18
“Results SOCS3 knockdown augments EC permeability and inflammatory responses SOCS3 is a known negative regulator of inflammation (10), but its role in modulation of inflammatory lung endothelial barrier dysfunction is not known.”
Background
Transcriptomics of Long-Term Meditation Practice: Evidence for Prevention or Reversal of Stress Effects Harmful to Health
Wenuganen, S., Walton, K. G., Katta, S., Dalgard, C. L., Sukumar, G., Starr, J. M., Travis, F. T., Wallace, R. K., Morehead, P., Lonsdorf, N. K., et al. (2021) · Medicina · doi:10.3390/medicina57030218 · Cited by 18
“SOCS3 also can inhibit STAT3 activation [58], providing another possible route for decreased energy efficiency in mitochondria.”
Background
Binge‐like ethanol drinking activates anaplastic lymphoma kinase signaling and increases the expression of STAT3 target genes in the mouse hippocampus and prefrontal cortex
Hamada, K., Ferguson, L. B., Mayfield, R. D., Krishnan, H. R., Maienschein‐Cline, M., & Lasek, A. W. (2021) · Genes Brain & Behavior · doi:10.1111/gbb.12729 · Cited by 18
“%) compared with wild-type controls and mice lacking both Tnrsf1a and Il1r1 drank significantly less ethanol compared with wild-type mice and did not escalate their drinking in an every-other-day 2-bottle choice protocol with increasing ethanol concentrations.61 STAT3 activity is tightly regulated by SOCS3.”
BackgroundInfluential
Stat3 activation-triggered transcriptional networks govern the early stage of HBV-induced hepatic inflammation
Tang, J., Zhang, J., Zhang, G., Peng, W., Ling, N., Zhou, Y., Xu, H., Ren, H., & Chen, M. (2024) · mBio · doi:10.1128/mbio.03068-23 · Cited by 16
“Intriguingly, the inducible negative regulator of Stat3 signaling (Socs3) (32) displayed significant upregulation, while the endogenous suppressors of Stat3 signaling (Pias3 and Nr0b2) (33, 34) were markedly downregulated in 3-month HBV-Tg mice.”
Background
Silencing SOCS3 Markedly Deteriorates Spondyloarthritis in Mice Induced by Minicircle DNA Expressing IL23
Chen, Y., Ouyang, M. J., Yan, R., Maarouf, M., Wang, X., Chen, B., Liu, S., Hu, J., Guo, G., Zhang, J., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02641 · Cited by 17
Deletion of Socs3 in LysM+ cells and Cx3cr1 resulted in age-dependent development of retinal microgliopathy
Du, X., Peñalva, R. G., Little, K., Kissenpfennig, A., Chen, M., & Xu, H. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00432-9 · Cited by 16
Epigenetic Abnormalities in Chondrosarcoma
Bereza, M., Dembiński, M., Zając, A. E., Piątkowski, J., Dudzisz‐Śledź, M., Rutkowski, P. L., & Czarnecka, A. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054539 · Cited by 18
Curcumin exerts beneficial role on insulin resistance through modulation of SOCS3 and Rac-1 pathways in type 2 diabetic rats
Zaheri, Z., Fahremand, F., Rezvani, M. E., Karimollah, A., & Moradi, A. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103430 · Cited by 16
Aspirin up‐regulates suppressor of cytokine signaling 3 in glial cells via PPARα
Chakrabarti, S., Roy, A., Prorok, T., Patel, D. R., Dasarathi, S., & Pahan, K. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14813 · Cited by 16
“Suppressor of cytokine signaling 3 (SOCS3) is a member of the STAT-induced STAT inhibitor (SSI) family (Carow and Rottenberg 2014).”
Background
Functions of aryl hydrocarbon receptor (AHR) and CD38 in NAD metabolism and nonalcoholic steatohepatitis (NASH)
Bock, K. W. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.08.022 · Cited by 17
Hypothermia: Impact on plasticity following brain injury
Colbourne, F., Kalisvaart, A. C. J., & Prokop, B. (2019) · Brain Circulation · doi:10.4103/bc.bc_21_19 · Cited by 17
“investigated the changes that immediate postinjury cooling to 33°C for 3 h had on GAP‐43 7 days after TBI in rats.[7,98] They found higher levels of GAP‐43 in TH‐treated TBI animals compared to normothermic controls.”
Background
Induction of SOCS Expression by EV71 Infection Promotes EV71 Replication
Gao, W., Hou, M., Liu, X., Li, Z., Yang, Y., & Zhang, W. (2020) · BioMed Research International · doi:10.1155/2020/2430640 · Cited by 16
“STAT3 triggers a variety of gene expressions in response to cytokine (such as IL-6 and IL-10) and growth factor stimulation and plays a critical role in many cellular biological processes involved in anti/proinflammatory responses, cell growth, and cell death [27, 28].”
Background
The Wnt–β-Catenin–IL-10 Signaling Axis in Intestinal APCs Protects Mice from Colitis-Associated Colon Cancer in Response to Gut Microbiota
Swafford, D., Shanmugam, A., Ranganathan, P. V., Manoharan, I., Hussein, M. S., Patel, N., Sifuentes, H., Koni, P. A., Prasad, P. D., Thangaraju, M., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901376 · Cited by 16
Effect of SOCS3 on apoptosis of human trophoblasts via adjustment of the JAK2/STAT3 signaling pathway in preterm birth
Yin, Y., Qu, L., Zhu, D., Wu, Y. S., & Zhou, X. (2021) · Translational Pediatrics · doi:10.21037/tp-21-39 · Cited by 15
“The structural features of SOCS proteins include a conserved motif (termed the SOCS box of C terminal), a central Src homology-2 (SH2) area, and an N-terminal variable area (16-18).”
Background
Preconditioning of physiological cyclic stretch attenuated HMGB1 expression in pathologically mechanical stretch-activated A549 cells and ventilator-induced lung injury rats through inhibition of IL-6/STAT3/SOCS3
Fang, X., Huang, T., Wang, C., Ge, Y., Lin, S., Zhang, Y., & Gao, J. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.12.017 · Cited by 16
Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice
Uhde, A., Ciurkiewicz, M., Herder, V., Khan, M. A., Hensel, N., Claus, P., Beckstette, M., Teich, R., Floess, S., Baumgärtner, W., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-24378-z · Cited by 16
Lutein inhibits IL‑6 expression by inducing PPAR‑γ activation and SOCS3 expression in cerulein‑stimulated pancreatic acinar cells
Ahn, Y., Lim, J. W., & Kim, H. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12818 · Cited by 15
“SOCS proteins are direct targets of STATs that inhibit JAK/STAT activation, and SOCS3 regulates cellular processes, including growth, apoptosis, and inflammatory gene expression (29).”
Background
The Vicious Cycle of Melanoma-Microglia Crosstalk: Inter-Melanoma Variations in the Brain-Metastasis-Promoting IL-6/JAK/STAT3 Signaling Pathway
Izraely, S., Ben‐Menachem, S., Malka, S., Sagi‐Assif, O., Bustos, M. A., Adir, O., Meshel, T., Chelladurai, M., Ryu, S., Ramos, R. I., et al. (2023) · Cells · doi:10.3390/cells12111513 · Cited by 15
“In view of its role as an endogenous regulator of various signaling pathways including the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway [43] and as an immunosuppressor, we focused on the involvement of SOCS3, if any, in the microglia–melanoma crosstalk.”
Background
Wheat germ peptide improves glucose metabolism and insulin resistance in HepG2 hepatocytes via regulating SOCS3/IRS1/Akt pathway
Song, H., Huang, Q., Zhang, Y., & Shen, X. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.10.005 · Cited by 14
Gut-Brain Axis Modulation of Metabolic Disorders: Exploring the Intertwined Neurohumoral Pathways and Therapeutic Prospects
Bhalla, D., Dinesh, S., Sharma, S., & Sathisha, G. J. (2024) · Neurochemical Research · doi:10.1007/s11064-023-04084-7 · Cited by 18
“To stimulate the transcription of targeted genes, notably the one responsible for the suppression of the cytokine signalling family (SOCS3), tyrosine-phosphorylated STAT3 molecules split and are delivered to the nucleus [75].”
Ac2PIM-responsive miR-150 and miR-143 Target Receptor-interacting Protein Kinase 2 and Transforming Growth Factor Beta-activated Kinase 1 to Suppress NOD2-induced Immunomodulators
Prakhar, P., Holla, S., Ghorpade, D. S., Gilleron, M., Puzo, G., Udupa, V., & Balaji, K. N. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.662817 · Cited by 15
“In the current investigation, we ana- OCTOBER 30, 2015•VOLUME 290•NUMBER 44 JOURNAL OF BIOLOGICAL CHEMISTRY 26583 lyzed the crosstalk of two important families of PRR, TLRs, and NLRs. Specifically, a mycobacterial cell wall glycolipid Ac2PIM and component of bacterial peptidoglycan MDP were utilized as cognate ligands…”
BackgroundInfluential
15-Deoxy-Δ12,14-prostaglandin J2Induces Apoptosis and Upregulates SOCS3 in Human Thyroid Cancer Cells
Trindade‐da‐Silva, C. A., Reis, C. F., Vecchi, L., Napimoga, M. H., Sperandio, M., Colombo, B. F. M., Alves, P. T., Ward, L. S., Ueira‐Vieira, C., & Goulart, L. R. (2016) · PPAR Research · doi:10.1155/2016/4106297 · Cited by 15
“It is known that the activation of STAT3 in cancers leads to gene expression promoting cell proliferation and resistance to apoptosis [58], but 15d-PGJ 2 -induced SOCS3 overexpression may have prevented STAT3phosphorylation [50].”
Cooperation between the bacterial‐derived short‐chain fatty acid butyrate and interleukin‐22 detected in human Caco2 colon epithelial/carcinoma cells
Bachmann, M., Meissner, C., Pfeilschifter, J. M., & Mühl, H. (2016) · BioFactors · doi:10.1002/biof.1341 · Cited by 16
Core genes involved in the regulation of acute lung injury and their association with COVID-19 and tumor progression: A bioinformatics and experimental study
Васильевна, С. А., Savin, I. A., Brenner, E. V., Аркадьевна, З. М., & Markov, A. V. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260450 · Cited by 16
“Additionally, the top 10 ALI-associated key nodes also included Socs3, a suppressor of cytokine signalling and negative regulator of JAK1/STAT3 signalling axis [65], and Rtp4, a type I interferon-induced gene involved in immune response and viral defence [66].”
Background
Dynamic immune response to Avian Pathogenic Escherichia coli infection in broiler chickens: Insights into pro-inflammatory and anti-inflammatory cytokine regulation
Ye, X., Hsu, C.-Y., Jia, L., Zhang, X., Magee, C., Whitham, S., Leigh, S. A., Evans, J. D., Zhang, L., & Robinson, K. (2025) · Poultry Science · doi:10.1016/j.psj.2025.105029 · Cited by 14
“Such dual regulatory roles ensure the immune response remains effective and controlled, facilitating a smooth transition to resolution and establishing long-term immune stability (Carow and Rottenberg, 2014; Dalpke et al., 2008).”
Mineral trioxide aggregate suppresses pro‐inflammatory cytokine expression via the calcineurin/nuclear factor of activated T cells/early growth response 2 pathway in lipopolysaccharide‐stimulated macrophages
Kuramoto, M., Kawashima, N., Tazawa, K., Nara, K., Fujii, M., Noda, S., Hashimoto, K., Nozaki, K., & Okiji, T. (2020) · International Endodontic Journal · doi:10.1111/iej.13386 · Cited by 14
Ultrasound targeted microbubble destruction-mediated SOCS3 attenuates biological characteristics and epithelial-mesenchymal transition (EMT) of breast cancer stem cells
Tang, X., Hao, N., Zhou, Y., & Liu, Y. (2022) · Bioengineered · doi:10.1080/21655979.2022.2031384 · Cited by 14
“The previous studies have shown the regulatory effect of SOCS3 on hormone signaling [49,50].”
Background
Common targetable inflammatory pathways in brain transcriptome of autism spectrum disorders and Tourette syndrome
Alshammery, S., Patel, S., Jones, H. F., Han, V. X., Gloss, B., Gold, W. A., & Dale, R. C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.999346 · Cited by 14
MicroRNA expression in apical periodontitis and pulpal inflammation: a systematic review
Gashaamy, Z. J. A., Alomar, T., Al-Sinjary, L., Wazzan, M., Saeed, M. H., & Al-Rawi, N. H. (2023) · PeerJ · doi:10.7717/peerj.14949 · Cited by 14
LPS priming-induced immune tolerance mitigates LPS-stimulated microglial activation and social avoidance behaviors in mice
Charoensaensuk, V., Huang, B., Huang, S.-T., Lin, C., Xie, S.-Y., Chen, C., Chen, Y.-C., Cheng, H., Liu, Y.-S., Lai, S., et al. (2024) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2024.02.006 · Cited by 15
Porphyromonas gingivalis and its lipopolysaccharide differently modulate epidermal growth factor–dependent signaling in human gingival epithelial cells
Elkaïm, R., Bugueno, I. M., Benkirane-Jessel, N., & Tenenbaum, H. (2017) · Journal of Oral Microbiology · doi:10.1080/20002297.2017.1334503 · Cited by 14
Increased M1 macrophages in young miR‐15a/16−/− mice with tumour grafts or dextran sulphate sodium‐induced colitis
Jia, X., Hu, X., Han, S., Miao, X., Liu, H., Li, X., Lin, Z., Wang, Z., & Gong, W. (2018) · Scandinavian Journal of Immunology · doi:10.1111/sji.12703 · Cited by 14
“SOCS3 can be induced by STAT3 activation.(30) Here, the STAT3 inhibitor (Stattic) could almost block SOCS3 expression in LPS‐stimulated macrophages, confirming that STAT3 activation promoted SOCS3 expression.”
Background
Cryptotanshinone protects porcine alveolar macrophages from infection with porcine reproductive and respiratory syndrome virus
Huang, C., Zhu, J., Wang, L., Chu, A., Yin, Y., Vali, K., Garmendia, A. E., & Tang, Y. (2020) · Antiviral Research · doi:10.1016/j.antiviral.2020.104937 · Cited by 14
The Regulatory Roles of Ezh2 in Response to Lipopolysaccharide (LPS) in Macrophages and Mice with Conditional Ezh2 Deletion with LysM-Cre System
Kunanopparat, A., Leelahavanichkul, A., Visitchanakun, P., Kueanjinda, P., Phuengmaung, P., Sae‐khow, K., Boonmee, A., Benjaskulluecha, S., Palaga, T., & Hirankarn, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065363 · Cited by 14
“Among several genes, Ezh1, Ezh2, and suppressor of cytokine signaling 3 (Socs3) were explored due to the possible inhibitory effect on inflammatory responses [49,50].”
BackgroundInfluential
Upregulation of the Suppressors of Cytokine Signaling 1 and 3 Is Associated with Arrest of Phosphorylated-STAT1 Nuclear Importation and Reduced Innate Response in Denguevirus-Infected Macrophages
Estrada-Jiménez, T., Peña, L. M.-P., Flores-Mendoza, L. K., Sedeño-Monge, V., Santos‐López, G., Rosas-Murrieta, N. H., Reyes-Carmona, S. R., Terán-Cabanillas, E., Hernández, J., Camacho, I. H., et al. (2015) · Viral Immunology · doi:10.1089/vim.2014.0136 · Cited by 14
“Of the eight family members, SOCS1 and SOCS3 are the most potent inhibitors of cytokine signaling mediated by the JAK–STAT pathway (10, 13, 18).”
Association Between Active DNA Demethylation and Liver Fibrosis in Individuals with Metabolic-Associated Steatotic Liver Disease (MASLD)
Barchetta, I., Zampieri, M., Cimini, F. A., Dule, S., Sentinelli, F., Passarella, G., Oldani, A., Karpach, K., Bacalini, M. G., Baroni, M. G., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031271 · Cited by 14
“We focused on SOCS3, SREBF1, and TXNIP, genes known to be implicated in inflammatory pathways and liver fibrosis [14–20].”
Protective Effect of Glycomacropeptide on the Inflammatory Response of U937 Macrophages
Córdova-Dávalos, L. E., Cervantes‐García, D., Ballona-Alba, M. F., Santos-López, A., Esquivel-Basaldúa, A. S., Gallegos-Alcalá, P., Jiménez, M., & Salinas, E. (2023) · Foods · doi:10.3390/foods12071528 · Cited by 13
“The SOCS3 protein is involved in the negative regulation of STAT1 and STAT3 activation, decreasing the cytokine expression [54].”
Background
Exploring the heterogeneous transcriptional response of the CNS to systemic LPS and Poly(I:C)
Bormann, D., Copic, D., Klas, K., Direder, M., Riedl, C. J., Testa, G., Kühtreiber, H., Poreba, E., Hametner, S., Golabi, B., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106339 · Cited by 11
“Interestingly, the upregulation of immunomodulators, such as the suppressor of cytokine signalling Socs3 (Carow and Rottenberg, 2014), inhibitor of IFN signalling Usp18 (Honke et al., 2016) and immune checkpoint molecules Cd274 and Cd47 (Marin-Acevedo et al., 2021), suggests a remarkably early immunomodulatory respons…”
Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation
Hansen, S. S. K., Krautz, R., Rago, D., Havelund, J. F., Stigliani, A., Færgeman, N. J., Prézelin, A., Rivière, J., Couturier‐Tarrade, A., Akimov, V., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48492-x · Cited by 13
Keratinocytes drive the epithelial hyperplasia key to sea lice resistance in coho salmon
Salisbury, S. J., Daniels, R. R., Monaghan, S. J., Bron, J. E., Villamayor, P. R., Gervais, O., Fast, M. D., Sveen, L., Houston, R. D., Robinson, N., et al. (2024) · BMC Biology · doi:10.1186/s12915-024-01952-8 · Cited by 12
“For example, we speculate that the upregulation of the inflammation-dampening socs3 [119] in Atlantic salmon T cells may be a result of sea louse immunomodulation.”
Background
Engineered bio-functional material-based nerve guide conduits for optic nerve regeneration: a view from the cellular perspective, challenges and the future outlook
Obeng, E., Shen, B., Wang, W., Xie, Z., Zhang, W., Li, Z., Yao, Q., & Wu, W. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae133 · Cited by 13
Transcriptional abnormalities in induced pluripotent stem cell-derived oligodendrocytes of individuals with primary progressive multiple sclerosis
Plastini, M. J., Desu, H. L., Ascona, M. C., Lang, A. L., Saporta, M., & Brambilla, R. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.972144 · Cited by 12
“Additionally, Socs3, a suppressor of inflammation that negatively regulates cytokine signaling (Carow and Rottenberg, 2014), was downregulated in PPMS OLs indicating the potential failure of a feed-back mechanism designed to keep inflammatory activation in check.”
Background
TCDD-mediated suppression of naïve human B cell IgM secretion involves aryl hydrocarbon receptor-mediated reduction in STAT3 serine 727 phosphorylation and is restored by interferon-γ
Blevins, L. K., Zhou, J., Crawford, R. B., & Kaminski, N. E. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109447 · Cited by 13
“To this end, STAT proteins directly induce expression of their respective repressors, a class of proteins termed Suppressors of cytokine signaling (SOCS), with SOCS3 being transcribed by STAT3 directly [19].”
BackgroundInfluential
Pro-inflammatory cytokines as regulators of protein tyrosine phosphatases and insulin signaling in murine skeletal muscle cells
Stein, V., Geserick, P., Friedrich, K., Brinschwitz, B., Musal, I. M., Ulke, J., Fielitz, J., & Kappert, K. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112037 · Cited by 13
Neuroendocrine and Behavioral Consequences of Hyperglycemia in Cancer
Vasquez, J. H., & Borniger, J. C. (2020) · Endocrinology · doi:10.1210/endocr/bqaa047 · Cited by 12
“One of these genes, Suppressor of cytokine signaling-3 (SOCS3), acts as a negative regulator on sustained STAT3 signaling through its interactions with JAK kinase and cytokine receptors (46).”
Background
Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription
Dinarello, A., Tesoriere, A., Martini, P. G. V., Fontana, C. M., Volpato, D., Badenetti, L., Terrin, F., Facchinello, N., Romualdi, C., Carnevali, O., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052678 · Cited by 12
“socs3a is a Stat3 target gene that represses the Jak/Stat3 pathway and binds Janus Kinases (Jaks), inhibiting their function as an activator of Stat3 [55].”
Background
Downregulation of miR-122 by porcine reproductive and respiratory syndrome virus promotes viral replication by targeting SOCS3
Zhang, J., Li, F., Sun, P., Wang, J., Li, K., Zhao, Z., Bai, X., Cao, Y., Bao, H., Li, D., et al. (2022) · Veterinary Microbiology · doi:10.1016/j.vetmic.2022.109595 · Cited by 12
Decoding systems immunological model of sphingolipids with IL-6/IL-17/IL-23 axes in L. major infection
Jawale, D., Khandibharad, S., & Singh, S. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159261 · Cited by 13
The Interleukin-11/IL-11 Receptor Promotes Glioblastoma Survival and Invasion under Glucose-Starved Conditions through Enhanced Glutaminolysis
Stuart, S. F., Bezawork‐Geleta, A., Areeb, Z., Gomez, J., Tsui, V., Zulkifli, A., Paradiso, L., Jones, J., Nguyen, H. P. T., Putoczki, T. L., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043356 · Cited by 12
Depressive-like Behavior Is Accompanied by Prefrontal Cortical Innate Immune Fatigue and Dendritic Spine Losses after HIV-1 Tat and Morphine Exposure
Nass, S. R., Hahn, Y. K., Ohene‐Nyako, M., McLane, V. D., Damaj, M. I., Thacker, L. R., Knapp, P. E., & Hauser, K. F. (2023) · Viruses · doi:10.3390/v15030590 · Cited by 12
Ozone attenuates chemotherapy-induced peripheral neuropathy via upregulating the AMPK-SOCS3 axis
Zhang, X., Zong, L.-J., Jia, R., Qin, X., Ruan, S., Lu, L., Wang, P., Hu, L., Liu, W., Yang, Y., et al. (2023) · Journal of Cancer Research and Therapeutics · doi:10.4103/jcrt.jcrt_912_23 · Cited by 12
Polysaccharides from Tremella Fuciformis Enhance Glucose and Lipid Metabolism in HepG2 Cells Through Activating the AMPK Signaling Pathway
Song, H., Lü, J., & Deng, R. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202401926 · Cited by 13
A large-scale genome-wide gene expression analysis in peripheral blood identifies very few differentially expressed genes related to antidepressant treatment and response in patients with major depressive disorder
Nøhr, A. K., Lindow, M., Forsingdal, A., Demharter, S., Nielsen, T. T., Buller, R., Moltke, I., Vitezic, M., & Albrechtsen, A. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01002-9 · Cited by 12
“The other significant gene, SOCS3 is a major regulator of inflammation and infection [29].”
Background
Cytotoxic T lymphocyte antigen-4 regulates development of xenogenic graft versus host disease in mice via modulation of host immune responses induced by changes in human T cell engraftment and gene expression
Gao, C., Gardner, D. B., Theobalds, M.-C., Hitchcock, S., Deutsch, H., Amuzie, C. J., Cesaroni, M., Sargsyan, D., Rao, T. S., & Malaviya, R. (2021) · Clinical & Experimental Immunology · doi:10.1111/cei.13659 · Cited by 11
“Among these six genes, interferon regulatory factor 4 (IRF4) [69], suppressor of cytokine signaling (SOCS) 3 [70], CD70 [71], CXCL13 [72] and CD24 [73] are associated with T cell signaling and differentiation, whereas SPl1 is responsible for epigenetic and transcriptional regulation [69].”
Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033)
Machuka, E., Juma, J., Muigai, A. W. T., Amimo, J. O., Pellé, R., & Abworo, E. O. (2022) · BMC Genomics · doi:10.1186/s12864-022-08754-8 · Cited by 13
Betaine regulates adipogenic and osteogenic differentiation of hAD-MSCs
Jing, Y., Zhou, J. P., Guo, F., Yu, L., Ren, X., & Yin, X. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08404-6 · Cited by 13
Suppressor of cytokine signalling 3 is crucial for interleukin‐7 receptor re‐expression after T‐cell activation and interleukin‐7 dependent proliferation
Güler, A., Venegas, M. L., Adankwah, E., Mayatepek, E., Nausch, N., & Jacobsen, M. (2019) · European Journal of Immunology · doi:10.1002/eji.201948302 · Cited by 12
Commonly disrupted pathways in brain and kidney in a pig model of systemic endotoxemia
Olney, K. C., de Ávila, C., Todd, K. T., Tallant, L., Barnett, J. H., Gibson, K. A., Hota, P., Pandian, A. S., Cay-Durgun, P., Serhan, M., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-023-03002-6 · Cited by 11
“2a and Additional file 3: Table S2); SOCS3 downregulates cytokine signaling due to binding to both the Janus Kinase (JAK) and the cytokine receptor, which results in the inhibition of STAT3 activation [40].”
Background
The Role of Phthalocyanine-Gold Nanoconjugates (Pc-Au NCs) in Ameliorating the Hepatic and Renal Toxicity-Induced by Silver Nanoparticles (Ag NPs) in Male Rats
Elhameed, H. A. H. A., Attia, M. S., Mohamed, A. A.-S., Alexeree, S. M. I., behery, E. I. E., Alagawany, M. M., Farag, M. R., Cerbo, A. D., Azzam, M. M., & Mawed, S. A. (2024) · Biological Trace Element Research · doi:10.1007/s12011-024-04209-1 · Cited by 11
“Total protein(g/dL) 7 ± 0.20 a 6.9 ± 0.10 a 6.90 ± 0.50 On the other hand, inflammation and toxicants could stimulate the suppressor of cytokine signaling 3 ( socs3 ) expressions in different myeloid and lymphoid tissues as a result of activation of the JAK/STAT3 pathway [39, 40].”
Influential
Translational Relevance of Secondary Intracellular Signaling Cascades Following Traumatic Spinal Cord Injury
Zavvarian, M.-M., Modi, A. D., Sadat, S., Hong, J., & Fehlings, M. G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115708 · Cited by 12
“…regulator of the JAK/STAT pathway and plays an important role SOCS3 is a negative regulator of the JAK/STAT pathway and plays an important role in modulating inflammation and the cellular response to cytokines [197,198]. in modulating in ﬂ ammation and the cellular response to cytokines [197,198].”
Background
STAT3 is involved in IL-6-Mediated Downregulation of Hepatic Transporters in Mice
Abualsunun, W. A., & Piquette‐Miller, M. (2018) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/jpps30241 · Cited by 11
“Selective in vivo inhibition of STAT3 activation has been previously demonstrated in rodents with more than 3-fold selectivity for STAT3 over STAT1 [24].”
Background
MerTK negatively regulates Staphylococcus aureus induced inflammatory response via SOCS1/SOCS3 and Mal
Zahoor, A., Yang, C., Yang, Y., Akhtar, M. F., Umar, T., Khan, M. A., Ahmad, S., Deng, G., & Guo, M. (2020) · Immunobiology · doi:10.1016/j.imbio.2020.151960 · Cited by 11
Monocyte Differentiation into Destructive Macrophages on In Vitro Administration of Gingival Crevicular Fluid from Periodontitis Patients
Fageeh, H. I., Fageeh, H. N., & Patil, S. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11060555 · Cited by 11
Combinational silencing of components involved in JAK/STAT signaling pathway
Bousoik, E., Mahdipoor, P., Alhazza, A., & Aliabadi, H. M. (2022) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2022.106233 · Cited by 11
Adrenoceptors as Potential Target for Add-On Immunomodulatory Therapy in Multiple Sclerosis
Pilipović, I., Stojić-Vukanić, Z., & Leposavić, G. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108358 · Cited by 11
Xiaoyaosan ameliorates depressive-like behavior and susceptibility to glucose intolerance in rat: involvement of LepR-STAT3/PI3K pathway in hypothalamic arcuate nucleus
Qiu, W., Wu, Q., Zhang, K., Da, X., Tang, K., Yuan, N., Deng, L., Wu, M.-S., Zhang, Y., Quan, J., et al. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-03942-9 · Cited by 12
“Meanwhile, there is a negative feedback mechanism in leptin-induced STAT3 signaling through the induction of SOCS3 [55].”
Background
Identification of Transcriptional Modules and Key Genes in Chickens Infected with Salmonella enterica Serovar Pullorum Using Integrated Coexpression Analyses
Liu, B., & Cai, J. (2017) · BioMed Research International · doi:10.1155/2017/8347085 · Cited by 11
“15), is a major regulator of infection and inflammation and controls immune homeostasis in physiological and pathological conditions such as infection and autoimmunity [43].”
Background
Intestinal Dysbiosis and Development of Cardiometabolic Disorders in Childhood Cancer Survivors: A Critical Review
Morel, S., DELVIN, E. E., Marcil, V., & Levy, E. H. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8102 · Cited by 11
“The SOCS3 impairs insulin action by binding to the insulin receptor and its substrates (IRS-1 and IRS-2), leading to their ubiquitination and degradation (28).”
Myeloid SOCS3 Deficiency Regulates Angiogenesis via Enhanced Apoptotic Endothelial Cell Engulfment
Korovina, I., Neuwirth, A., Sprott, D., Troullinaki, M., Poitz, D. M., Deußen, A., & Ameln, A. K. (2019) · Journal of Innate Immunity · doi:10.1159/000502645 · Cited by 11
DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood
Issarapu, P., Arumalla, M., Elliott, H., Nongmaithem, S., Sankareswaran, A., Betts, M., Sajjadi, S., Kessler, N. J., Bayyana, S., Mansuri, S. R., et al. (2022) · bioRxiv · doi:10.1038/s41467-023-40607-0 · Cited by 8
Suppressor of cytokine signaling-3 expression and its regulation in relation to inflammation in Chronic Obstructive Pulmonary Disease
Tinè, M., Balestro, E., Carpi, S., Neri, T., Biondini, D., Conti, M., Casara, A., Bernardinello, N., Cocconcelli, E., Turato, G., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1320077 · Cited by 11
Enrichment and purification of Torreya grandis peptides by macroporous resin and its hypoglycemic mechanism revealed by transcriptome analysis
Xue, J., Wu, S., Zhu, Q., Liu, X., He, Z., Ye, W., Wang, P., & Wu, F. (2024) · Industrial Crops and Products · doi:10.1016/j.indcrop.2024.118445 · Cited by 10
Tocilizumab in combination with corticosteroids: potential for managing cancer cachexia with systemic hyperinflammation
Chen, P., Wang, D., Zhan, Z., Chen, L., & Chen, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1477310 · Cited by 10
Exploring key molecular signatures of immune responses and pathways associated with tuberculosis in comorbid diabetes mellitus: a systems biology approach
Gnanasekaran, T. S., Gollapalli, P., Shetty, P. K., & Kumari, S. (2022) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-022-00257-5 · Cited by 10
Socs3b regulates the development and function of innate immune cells in zebrafish
Sobah, M. L., Scott, A. C., Laird, M., Koole, C., Liongue, C., & Ward, A. C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1119727 · Cited by 10
Ohwia caudata extract relieves the IL‐17A ‐induced inflammatory response of synoviocytes through modulation of SOCS3 and JAK2 / STAT3 activation
Lu, C., Kuo, C., Kuo, W., Hsieh, D. J., Wang, T., Shih, C.-Y., Lin, P., Lin, S., Ho, T., & Huang, C. (2023) · Environmental Toxicology · doi:10.1002/tox.23818 · Cited by 10
Less Severe Sepsis in Cecal Ligation and Puncture Models with and without Lipopolysaccharide in Mice with Conditional Ezh2-Deleted Macrophages (LysM-Cre System)
Phuengmaung, P., Khiewkamrop, P., Makjaroen, J., Issara-Amphorn, J., Boonmee, A., Benjaskulluecha, S., Ritprajak, P., Nita‐Lazar, A., Palaga, T., Hirankarn, N., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108517 · Cited by 10
“Indeed, cytosolic Socs3 inhibits the NF-κB-dependent inflammatory genes through enhanced ubiquitination and proteasomal degradation [44,59].”
BackgroundResult
Early-phase Innate Immune Suppression in Murine Severe Sepsis Is Restored with Systemic Interferon-β
Kusakabe, Y., Uchida, K., Yamamura, Y., Hiruma, T., Totsu, T., Tamai, Y., Tsuyuzaki, H., Hasegawa, K., Chang, K., & Yamada, Y. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002185 · Cited by 10
Molecular evolution and functional characterization of SOCS3a and SOCS3b in miiuy croaker (Miichthys miiuy)
Huo, R., Chu, Q., Zhao, X., Liu, X., & Xu, T. (2020) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2020.103723 · Cited by 10
Intestinal epithelial suppressor of cytokine signaling 3 (SOCS3) impacts on mucosal homeostasis in a model of chronic inflammation
Shaw, E. J., Smith, E. E., Whittingham‐Dowd, J., Hodges, M., Else, K. J., & Rigby, R. J. (2017) · Immunity Inflammation and Disease · doi:10.1002/iid3.171 · Cited by 10
“This may be because the products of IDO degradation are not fulfilling a negative feedback loop, or because several transcription factors aremore active in the absence of SOCS3 [28].”
Background
P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?
Klaver, D., & Thurnher, M. (2023) · Purinergic Signalling · doi:10.1007/s11302-023-09932-3 · Cited by 9
“P2Y11 induced and rolipram enhanced the expression of suppressor of cytokine signaling 3 (SOCS3) [20], a well established regulator of inflammation [52].”
Background

Authors: Carow, B., & Rottenberg, M. E.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Carow, Berit
ORCID: Carow, Berit
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2014
Volume: 5
Pages: 58-58
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2014.00058
PMC: PMC3928676
OpenAlex: W2140013858
Cited by: 555
References: 179
Citations by year: 2026: 31 · 2025: 55 · 2024: 65 · 2023: 71 · 2022: 64 · 2021: 58 · 2020: 43 · 2019: 52 · 2018: 31 · 2017: 25 · 2016: 27 · 2015: 24 · 2014: 9
FWCI: 3.22
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: SOCS3, suppressor of cytokine signaling, infection, inflammation, autoimmune disease, STAT3 activation, JAK kinases, cytokine signaling, receptor ubiquitination, proteasomal degradation, immune homeostasis, myeloid cells, lymphoid cells

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SOCS3, a Major Regulator of Infection and Inflammation

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