Inflammation and cardiovascular disease: From mechanisms to therapeutics
Open accessAbstract
Inflammation constitutes a complex, highly conserved cascade of molecular and cellular events. Inflammation has been labeled as "the fire within," is highly regulated, and is critical to host defense and tissue repair. In general, inflammation is beneficial and has evolved to promote survival. However, inflammation can also be maladaptive when chronically activated and sustained, leading to progressive tissue injury and reduced survival. Examples of a maladaptive response include rheumatologic disease and atherosclerosis. Despite evidence gathered by Virchow over 100 years ago showing that inflammatory white cells play a role in atherogenesis, atherosclerosis was until recently viewed as a disease of passive cholesterol accumulation in the subendothelial space. This view has been supplanted by considerable basic scientific and clinical evidence demonstrating that every step of atherogenesis, from the development of endothelial cell dysfunction to foam cell formation, plaque formation and progression, and ultimately plaque rupture stemming from architectural instability, is driven by the cytokines, interleukins, and cellular constituents of the inflammatory response. Herein we provide an overview of the role of inflammation in atherosclerotic cardiovascular disease, discuss the predictive value of various biomarkers involved in inflammation, and summarize recent clinical trials that evaluated the capacity of various pharmacologic interventions to attenuate the intensity of inflammation and impact risk for acute cardiovascular events.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Inflammation contributes to insulin resistance, endothelial dysfunction, lipid accumulation, and vascular injury, thereby accelerating disease progression.
“Among these, inflammation plays a central role by contributing to insulin resistance, endothelial dysfunction, lipid accumulation, and vascular injury, thereby accelerating disease progression [36,37].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [37]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482 · see citing works
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J., Gotto, A. M., Kastelein, J. J. P., Koenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0807646 · Cited by 6,674 · see citing works
Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease
Sabatine, M. S., Giugliano, R. P., Keech, A. C., Honarpour, N., Wiviott, S. D., Murphy, S. A., Kuder, J. F., Wang, H., Liu, T., Wasserman, S. M., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1615664 · Cited by 6,138 · cited 1× · see citing works
“The Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk (FOURIER) trial showed significant LDL-C lowering and improvement in CVD events with evolocumab in statin treated or statin intolerant patients with ASCVD who had LDL-C 70 mg/dL [192].”
BackgroundRidker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850 · see citing works
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287 · see citing works
Arnett, D. K., Blumenthal, R. S., Albert, M. A., Buroker, A. B., Goldberger, Z. D., Hahn, E. J., Himmelfarb, C. D., Khera, A., Lloyd-Jones, D., McEvoy, J. W., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000678 · Cited by 4,536 · see citing works
Self-citation(2019) · doi:10.1161/cir.0000000000000677 · Cited by 4,501 · see citing works
Self-citationInflammation in Atherosclerosis
Libby, P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179705 · Cited by 3,748 · see citing works
Rosuvastatin to Prevent Vascular Events in Men and Women With Elevated C-Reactive Protein
Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J. J., Gotto, A. M., Kastelein, J. J. P., Köenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2009) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000344393.60303.0a · Cited by 3,641 · see citing works
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia
Bhatt, D. L., Steg, P. G., Miller, M., Brinton, E. A., Jacobson, T. A., Ketchum, S. B., Doyle, R. T., Juliano, R. A., Jiao, L., Granowitz, C., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1812792 · Cited by 3,317 · see citing works
Efficacy and safety of low-dose colchicine after myocardial infarction
Tardif, J.-C., Kouz, S., Waters, D. D., Bertrand, O. F., Diaz, R., Maggioni, A. P., Pinto, F. J., Ibrahim, R., Gamra, H., Kiwan, G. S., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1912388 · Cited by 3,159 · cited 1× · see citing works
“cantly reduced ASCVD-related events in patients with high ASCVD risk [17].”
BackgroundResolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932 · see citing works
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429 · see citing works
Colchicine in Patients with Chronic Coronary Disease
Nidorf, S. M., Fiolet, A. T. L., Mosterd, A., Eikelboom, J. W., Schut, A., Opstal, T. S. J., The, S. H. K., Xu, X.-F., Ireland, M. A., Lenderink, T., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2021372 · Cited by 2,299 · see citing works
C-Reactive Protein Levels and Outcomes after Statin Therapy
Ridker, P. M., Cannon, C. P., Morrow, D., Rifai, N., Rose, L. M., McCabe, C. H., Pfeffer, M. A., & Braunwald, E. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042378 · Cited by 2,292 · see citing works
CD4+ Count–Guided Interruption of Antiretroviral Treatment
The Strategies for Management of Antiretroviral Therapy (SMART) Study Group (2006) · New England Journal of Medicine · doi:10.1056/nejmoa062360 · Cited by 2,230 · see citing works
Esposito, K., Marfella, R., Ciotola, M., Di Palo, C., Giugliano, F., Giugliano, G., D'Armiento, M., D'Andrea, F., & Giugliano, D. (2004) · JAMA · doi:10.1001/jama.292.12.1440 · Cited by 2,126 · see citing works
Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
Zhu, W., Gregory, J. C., Org, E., Buffa, J. A., Gupta, N., Wang, Z., Li, L., Fu, X., Wu, Y., Mehrabian, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.011 · Cited by 1,968 · see citing works
Effect of Statin Therapy on C-Reactive Protein Levels
Albert, M. A., Danielson, E., Rifai, N., Ridker, P. M., & for the PRINCE Investigators (2001) · JAMA · doi:10.1001/jama.286.1.64 · Cited by 1,642 · see citing works
Ridker, P. M., Rifai, N., Clearfield, M., Downs, J. R., Weis, S. E., Miles, J. S., & Gotto, A. M. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106283442601 · Cited by 1,557 · see citing works
Fried, S. K., Bunkin, D. A., & Greenberg, A. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4660 · Cited by 1,528 · see citing works
Esposito, K., Pontillo, A., Di Palo, C., Giugliano, G., Masella, M., Marfella, R., & Giugliano, D. (2003) · JAMA · doi:10.1001/jama.289.14.1799 · Cited by 1,511 · see citing works
Symptomatic atherosclerosis is associated with an altered gut metagenome
Karlsson, F. H., Fåk, F., Nookaew, I., Tremaroli, V., Fagerberg, B., Petranovic, D., Bäckhed, F., & Nielsen, J. (2012) · Nature Communications · doi:10.1038/ncomms2266 · Cited by 1,371 · cited 1× · see citing works
“A study comparing patients with symptomatic CAD to healthy controls found a negative correlation between bacterial genetic markers associated with the production of butyrate in the gut and blood hsCRP levels in humans [222].”
HIV Infection and the Risk of Acute Myocardial Infarction
Freiberg, M. S., Chang, C.-C. H., Kuller, L. H., Skanderson, M., Lowy, E., Kraemer, K. L., Butt, A. A., Goetz, M. B., Leaf, D. A., Oursler, K. A., et al. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.3728 · Cited by 1,340 · see citing works
Peters, M. J. L., Symmons, D. P. M., McCarey, D., Dijkmans, B. A. C., Nicola, P., Kvien, T. K., McInnes, I. B., Haentzschel, H., Gonzalez-Gay, M. A., Provan, S., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.113696 · Cited by 1,325 · see citing works
Wang, Z., Roberts, A. B., Buffa, J. A., Levison, B. S., Zhu, W., Org, E., Gu, X., Huang, Y., Zamanian-Daryoush, M., Culley, M. K., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.055 · Cited by 1,317 · see citing works
Otto, C. M., Kuusisto, J., Reichenbach, D. D., Gown, A. M., & O’Brien, K. D. (1994) · Circulation · doi:10.1161/01.cir.90.2.844 · Cited by 1,315 · see citing works
Hammond, S. M. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.05.001 · Cited by 1,291 · see citing works
Oxidative Stress in Atherosclerosis
Kattoor, A. J., Pothineni, N. V. K., Palagiri, D. R., & Mehta, J. L. (2017) · Current Atherosclerosis Reports · doi:10.1007/s11883-017-0678-6 · Cited by 1,276 · see citing works
Utilization of Nutrients by Isolated Epithelial Cells of the Rat Colon
Roediger, W. E. W. (1982) · Gastroenterology · doi:10.1016/s0016-5085(82)80339-9 · Cited by 1,201 · see citing works
Oikonomou, E. K., Marwan, M., Desai, M. Y., Mâncio, J., Alashi, A., Hutt, E., Thomas, S., Herdman, L., Kotanidis, C. P., Thomas, K. E. H., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31114-0 · Cited by 1,193 · see citing works
C-reactive protein, fibrinogen, and cardiovascular disease prediction
The Emerging Risk Factors Collaboration (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1107477 · Cited by 1,150 · see citing works
Fried, S. K. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.3.847 · Cited by 1,146 · see citing works
Detecting human coronary inflammation by imaging perivascular fat
Antonopoulos, A. S., Sanna, F., Sabharwal, N. K., Thomas, S., Oikonomou, E. K., Herdman, L., Margaritis, M., Shirodaria, C. C., Kampoli, A., Akoumianakis, I., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal2658 · Cited by 1,108 · see citing works
Steensberg, A., van Hall, G., Osada, T., Sacchetti, M., Saltin, B., & Pedersen, B. K. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00237.x · Cited by 1,095 · see citing works
Inflammation and cardiovascular disease mechanisms
Libby, P. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.456s · Cited by 1,095 · see citing works
Myocardial infarction accelerates atherosclerosis
Dutta, P., Courties, G., Wei, Y., Leuschner, F., Gorbatov, R., Robbins, C. S., Iwamoto, Y., Thompson, B. D., Carlson, A. L., Heidt, T., et al. (2012) · Nature · doi:10.1038/nature11260 · Cited by 1,084 · see citing works
Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease
Nidorf, S. M., Eikelboom, J. W., Budgeon, C. A., & Thompson, P. L. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.10.027 · Cited by 1,059 · see citing works
Bone Formation and Inflammation in Cardiac Valves
Mohler, E. R., Gannon, F. H., Reynolds, C. A., Zimmerman, R. A., Keane, M. G., & Kaplan, F. S. (2001) · Circulation · doi:10.1161/01.cir.103.11.1522 · Cited by 1,053 · see citing works
Transcriptional control of the inflammatory response
Medzhitov, R., & Horng, T. (2009) · Nature Reviews Immunology · doi:10.1038/nri2634 · Cited by 1,035 · see citing works
Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase
Laufs, U., & Liao, J. K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.24266 · Cited by 1,035 · see citing works
Pro‐ and anti‐inflammatory cytokine balance in strenuous exercise in humans
Ostrowski, K., Rohde, T., Asp, S., Schjerling, P., & Pedersen, B. K. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.287ad.x · Cited by 1,014 · see citing works
Ridker, P. M., Danielson, E., Fonseca, F. A., Genest, J., Gotto, A. M., Kastelein, J. J., Koenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60447-5 · Cited by 1,010 · see citing works
Ridker, P. M. (2016) · Circulation Research · doi:10.1161/circresaha.115.306656 · Cited by 1,002 · see citing works
Lipoprotein(a), PCSK9 Inhibition, and Cardiovascular Risk: Insights From the FOURIER Trial
O’Donoghue, M. L., Fazio, S., Giugliano, R. P., Stroes, E. S. G., Kanevsky, E., Gouni-Berthold, I., Im, K., Lira Pineda, A., Wasserman, S. M., Češka, R., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.037184 · Cited by 984 · cited 1× · see citing works
“However, unlike statins, PCSK9 inhibitors have the benefit of lowering lipoprotein (a), a lipoprotein known to potentiate vascular calcification [38,39].”
BackgroundEffects of tobacco smoke on immunity, inflammation and autoimmunity
Arnson, Y., Shoenfeld, Y., & Amital, H. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.12.003 · Cited by 966 · see citing works
microRNA Regulation of Inflammatory Responses
O’Connell, R. M., Rao, D. S., & Baltimore, D. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075013 · Cited by 957 · see citing works
Joshi, N. V., Vesey, A. T., Williams, M. C., Shah, A. S. V., Calvert, P. A., Craighead, F., Yeoh, S. E., Wallace, W. A., Salter, D. M., Fletcher, A. M., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61754-7 · Cited by 953 · see citing works
Low-grade inflammation, diet composition and health: current research evidence and its translation
Minihane, A. M., Vinoy, S., Russell, W. R., Baka, A., Roche, H. M., Tuohy, K. M., Teeling, J. L., Blaak, E. E., Fenech, M. F., Vauzour, D., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002093 · Cited by 919 · see citing works
Seldin, M. M., Meng, Y., Qi, H., Zhu, W., Wang, Z., Hazen, S. L., Lusis, A. J., & Shih, D. M. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002767 · Cited by 911 · see citing works
Mast Cell: A Multi-Functional Master Cell
Krystel‐Whittemore, M., Dileepan, K. N., & Wood, J. G. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00620 · Cited by 892 · see citing works
Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
FEBBRAIO, M. A., & PEDERSEN, B. K. (2002) · The FASEB Journal · doi:10.1096/fj.01-0876rev · Cited by 875 · see citing works
(2012) · The Lancet · doi:10.1016/s0140-6736(11)61931-4 · Cited by 823 · see citing works
Inflammation and plaque vulnerability
Hansson, G. K., Libby, P., & Tabas, I. A. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12406 · Cited by 809 · see citing works
Vascular Adhesion Molecules in Atherosclerosis
Galkina, E., & Ley, K. F. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.149179 · Cited by 804 · see citing works
Myeloperoxidase and Cardiovascular Disease
Nicholls, S. J., & Hazen, S. L. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000163262.83456.6d · Cited by 803 · see citing works
Ridker, P. M., Thuren, T., Zalewski, A., & Libby, P. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.06.012 · Cited by 799 · see citing works
Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans
Starkie, R., Ostrowski, S. R., Jauffred, S., Febbraio, M., & Pedersen, B. K. (2003) · The FASEB Journal · doi:10.1096/fj.02-0670fje · Cited by 790 · see citing works
Proudfoot, D., Skepper, J. N., Hegyi, L., Bennett, M. R., Shanahan, C. M., & Weissberg, P. L. (2000) · Circulation Research · doi:10.1161/01.res.87.11.1055 · Cited by 719 · see citing works
Monocyte-macrophages and T cells in atherosclerosis
Tabas, I., & Lichtman, A. H. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.008 · Cited by 646 · see citing works
Gielen, S., Adams, V., Möbius-Winkler, S., Linke, A., Erbs, S., Yu, J., Kempf, W., Schubert, A., Schuler, G., & Hambrecht, R. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00848-9 · Cited by 613 · see citing works
Schwingshackl, L., & HOFFMANN, G. E. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.03.003 · Cited by 590 · see citing works
Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease
The STABILITY Investigators (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1315878 · Cited by 579 · see citing works
Impact of Statins on Serial Coronary Calcification During Atheroma Progression and Regression
Puri, R., Nicholls, S. J., Shao, M., Kataoka, Y., Uno, K., Kapadia, S. R., Tuzcu, E. M., & Nissen, S. E. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.01.036 · Cited by 571 · see citing works
Relationship Between Interleukin 6 and Mortality in Patients With Unstable Coronary Artery Disease
Lindmark, E., Diderholm, E., Wallentin, L. C., & Siegbahn, A. (2001) · JAMA · doi:10.1001/jama.286.17.2107 · Cited by 557 · see citing works
Heianza, Y., Ma, W., Manson, J. E., Rexrode, K. M., & Qi, L. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004947 · Cited by 544 · cited 1× · see citing works
“In a systematic review of 19 prospective studies, elevated TMAO and its precursors were associated with all-cause mortality andmajor adverse CV events [139].”
BackgroundZhao, G., Etherton, T. D., Martin, K. R., West, S. G., Gillies, P. J., & Kris‐Etherton, P. M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.11.2991 · Cited by 529 · see citing works
Tumor Necrosis Factor-α Promotes In Vitro Calcification of Vascular Cells via the cAMP Pathway
Tintut, Y., Patel, J., Parhami, F., & Demer, L. L. (2000) · Circulation · doi:10.1161/01.cir.102.21.2636 · Cited by 528 · see citing works
Martin, S. S., Qasim, A., & Reilly, M. P. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.060 · Cited by 516 · see citing works
Self-citationTrimethylamine N-oxide: the good, the bad and the unknown.
Velasquez, M., Ramezani, A., Manal, A., & Raj, D. (2016) · Toxins · doi:10.3390/toxins8110326 · Cited by 504 · see citing works
Serruys, P. W. J. C., García‐García, H. M., Buszman, P. E., Erné, P., Verheye, S., Aschermann, M., Duckers, H., Bleie, Ø., Dudek, D., Bøtker, H. E., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.771899 · Cited by 503 · see citing works
Genetics of Human Cardiovascular Disease
Kathiresan, S., & Srivastava, D. (2012) · Cell · doi:10.1016/j.cell.2012.03.001 · Cited by 496 · see citing works
Baer, D. J., Judd, J. T., Clevidence, B. A., & Tracy, R. P. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.969 · Cited by 476 · see citing works
Role of Lipoprotein-Associated Phospholipase A 2 in Atherosclerosis
Zalewski, A. A., & Macphee, C. H. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000160551.21962.a7 · Cited by 473 · see citing works
Bermudez, E. A., Rifai, N., Buring, J. E., Manson, J. E., & Ridker, P. M. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000029781.31325.66 · Cited by 469 · see citing works
Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study
Naranjo, A., Sokka, T., Descalzo, M. Á., Alén, J. C., Hørslev‐Petersen, K., Luukkainen, R., Combe, B. G., Burmester, G. R., Devlin, J., Ferraccioli, G., et al. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2383 · Cited by 464 · see citing works
Dietary pattern, inflammation, and incidence of type 2 diabetes in women
Schulze, M. B., Hoffmann, K., Manson, J. E., Willett, W. C., Meigs, J. B., Weikert, C., Heidemann, C., Colditz, G. A., & Hu, F. B. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.3.675 · Cited by 462 · see citing works
Estrogen alters thresholds for B cell apoptosis and activation
Grimaldi, C. M., Cleary, J., Dagtas, A. S., Moussai, D., & Diamond, B. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14873 · Cited by 461 · see citing works
Dietary pattern, inflammation, and incidence of type 2 diabetes in women
Schulze, M. B., Hoffmann, K., Manson, J. E., Willett, W. C., Meigs, J. B., Weikert, C., Heidemann, C., Colditz, G. A., & Hu, F. B. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.3.675 · Cited by 457 · see citing works
Myeloperoxidase – A bridge linking inflammation and oxidative stress with cardiovascular disease
Ndrepepa, G. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.02.022 · Cited by 452 · see citing works
Meuwese, M. C., Stroes, E. S. G., Hazen, S. L., van Miert, J. N. I., Kuivenhoven, J. A., Schaub, R. G., Wareham, N. J., Luben, R., Kastelein, J. J. P., Khaw, K., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.03.033 · Cited by 444 · see citing works
Sampson, U. K., Fazio, S., & Linton, M. F. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-011-0219-7 · Cited by 439 · cited 1× · see citing works
“ence residual cardiovascular (CV) risk [1].”
Antonopoulos, A. S., Margaritis, M., Lee, R., Channon, K. M., & Antoniades, C. A. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799504803 · Cited by 432 · see citing works
Wannamethee, S. G., Lowe, G. D. O., Shaper, A. G., Rumley, A., LENNON, L. T., & Whincup, P. H. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi183 · Cited by 430 · see citing works
Physical activity and modulation of systemic low-level inflammation
Bruunsgaard, H. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0505247 · Cited by 429 · see citing works
Estrogen alters thresholds for B cell apoptosis and activation
Grimaldi, C. M., Cleary, J., Dagtas, A. S., Moussai, D., & Diamond, B. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214873 · Cited by 427 · see citing works
Oei, H.-H. S., van der Meer, I. M., Albert Hofman, D., Koudstaal, P. J., Stijnen, T., Breteler, M. M. B., & Witteman, J. C. M. (2005) · Circulation · doi:10.1161/01.cir.0000154553.12214.cd · Cited by 423 · see citing works
Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques
Hutcheson, J. D., Goettsch, C., Bertazzo, S., Maldonado, N., Ruiz, J. L., Goh, W., Yabusaki, K., Faits, T., Bouten, C., Franck, G., et al. (2016) · Nature Materials · doi:10.1038/nmat4519 · Cited by 419 · see citing works
Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid
Mason, R. P., Libby, P., & Bhatt, D. L. (2020) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.119.313286 · Cited by 407 · see citing works
Trøseid, M., Andersen, G. Ø., Broch, K., & Hov, J. R. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102649 · Cited by 406 · see citing works
GlycA: A Composite Nuclear Magnetic Resonance Biomarker of Systemic Inflammation
Otvos, J. D., SHALAUROVA, I. Y., Wolak, J. E., Connelly, M. A., Mackey, R. H., Stein, J. H., & Tracy, R. P. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2014.232918 · Cited by 401 · see citing works
Physical training reduces peripheral markers of inflammation in patients with chronic heart failure
Adamopoulos, S. N. (2001) · European Heart Journal · doi:10.1053/euhj.2000.2285 · Cited by 373 · see citing works
Schoenfeld, S. R., Kasturi, S., & Costenbader, K. H. (2013) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2012.12.002 · Cited by 370 · see citing works
Exercise training modulates cytokines activity in coronary heart disease patients
Goldhammer, E., Tanchilevitch, A., Maor, I., Beniamini, Y., Rosenschein, U., & Sagiv, M. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.08.073 · Cited by 363 · see citing works
Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries
Kelly-Arnold, A., Maldonado, N., Laudier, D. M., Aikawa, E. R., Cardoso, L., & Weinbaum, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308814110 · Cited by 356 · see citing works
Anti-Inflammatory MicroRNAs and Their Potential for Inflammatory Diseases Treatment
Tahamtan, A., Teymoori‐Rad, M., Nakstad, B., & Salimi, V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01377 · Cited by 355 · see citing works
Martínez, G. J., Celermajer, D. S., & Patel, S. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.12.027 · Cited by 346 · see citing works
Exercise, inflammation and aging.
(2012) · Europe PMC (PubMed Central) · Cited by 345 · see citing works
Self-citationOrtego, M., Bustos, C., Hernández-Presa, M. Á., Tuñón, J., Díaz, C., Hernández, G., & Egido, J. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00193-8 · Cited by 342 · see citing works
Bohula, E. A., Giugliano, R. P., Cannon, C. P., Zhou, J., Murphy, S. A., White, J. A., Tershakovec, A. M., Blazing, M. A., & Braunwald, E. (2015) · Circulation · doi:10.1161/circulationaha.115.018381 · Cited by 340 · see citing works
Coronary atherosclerosis in indigenous South American Tsimane: a cross-sectional cohort study
Kaplan, H., Thompson, R. C., Trumble, B. C., Wann, L. S., Allam, A. H., Beheim, B., Frohlich, B., Sutherland, M. L., Sutherland, J. D., Stieglitz, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30752-3 · Cited by 338 · see citing works
Hypoxia But Not Inflammation Augments Glucose Uptake in Human Macrophages
Folco, E. J. E., Sheikine, Y., Rocha, V. Z., Christen, T., Shvartz, E., Sukhova, G. K., Carli, M. F. D., & Libby, P. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.03.044 · Cited by 326 · see citing works
Bouabdallaoui, N., Tardif, J., Waters, D. D., Pinto, F. J., Maggioni, A. P., Díaz, R., Berry, C., Köenig, W., López-Sendón, J., Gamra, H., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa659 · Cited by 319 · see citing works
Foxo1 mediates insulin action on apoC-III and triglyceride metabolism
Altomonte, J., Lin, C., Harbaran, S., Richter, A. M., Xu, J., Meseck, M. L., & Dong, H. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19992 · Cited by 310 · see citing works
Fedewa, M. V., Hathaway, E. D., & Ward-Ritacco, C. L. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-095999 · Cited by 309 · see citing works
Nizri, E., Irony-Tur-Sinai, M., Lory, O., Orr‐Urtreger, A., Lavi, E., & Brenner, T. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902212 · Cited by 308 · see citing works
Morrow, D. A., de Lemos, J. A., Sabatine, M. S., Wiviott, S. D., Blazing, M. A., Shui, A. M., Rifai, N., Califf, R. M., & D, E. B. M. (2006) · Circulation · doi:10.1161/circulationaha.106.628909 · Cited by 304 · see citing works
Pryor, W. A., Stone, K., Zang, L., & Bermúdez, E. (1998) · Chemical Research in Toxicology · doi:10.1021/tx970159y · Cited by 302 · see citing works
Sanford, J. A., Nogiec, C. D., Lindholm, M. E., Adkins, J., Amar, D., Dasari, S., Drugan, J. K., Fernández, F. M., Radom‐Aizik, S., Schenk, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.004 · Cited by 300 · see citing works
Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway
Geng, J., Yang, C., Wang, B., Zhang, X., Hu, T., Gu, Y., & Li, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.11.016 · Cited by 297 · see citing works
Adiponectin - Its Role in Metabolism and Beyond
Stefan, N., & Stümvoll, M. (2002) · Hormone and Metabolic Research · doi:10.1055/s-2002-34785 · Cited by 293 · see citing works
Casas, R. M., Sacanella, E., & Estruch, R. (2014) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530314666140922153350 · Cited by 291 · see citing works
The role of efferocytosis in atherosclerosis
Kojima, Y., Weissman, I. L., & Leeper, N. J. (2017) · Circulation · doi:10.1161/circulationaha.116.025684 · Cited by 289 · see citing works
Targeting inflammation in metabolic syndrome
Welty, F. K., Alfaddagh, A., & Elajami, T. K. (2016) · Translational Research · doi:10.1016/j.trsl.2015.06.017 · Cited by 287 · see citing works
Self-citationCirculating interferon-α levels and hypertriglyceridemia in the acquired immunodeficiency syndrome
Grünfeld, C., Kotler, D. P., Shigenaga, J. K., Doerrler, W. T., Tierney, A. R., Wang, J., Pierson, R. N., & Feingold, K. R. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)80154-e · Cited by 286 · see citing works
Circulating interferon-α levels and hypertriglyceridemia in the acquired immunodeficiency syndrome.
Grunfeld, C., Kotler, D. P., Shigenaga, J. K., Doerrler, W., Tierney, A., Wang, J., Pierson, R. N., & Feingold, K. R. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90536-7 · Cited by 286 · see citing works
Inflammatory and Cholesterol Risk in the FOURIER Trial
Bohula, E. A., Giugliano, R. P., Leiter, L. A., Verma, S., Park, J.-G., Sever, P. S., Lira Pineda, A., Honarpour, N., Wang, H., Murphy, S. A., et al. (2018) · Circulation · doi:10.1161/circulationaha.118.034032 · Cited by 280 · see citing works
Senthong, V., Wang, Z., Li, X. S., Fan, Y., Wu, Y., Wilson Tang, W. H., & Hazen, S. L. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002816 · Cited by 270 · see citing works
Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex
Huang, Y., Wu, Z., Riwanto, M., Gao, S., Levison, B. S., Gu, X., Fu, X., Wagner, M. A., Besler, C., Gerstenecker, G., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67478 · Cited by 269 · cited 8× · see citing works
“Abbreviations: AGEs, Advanced glycation end products; FA, free fatty acids; TNF-α chemoattractant protein-1; ROS, reactive oxygen species; SCFA, short-chain fatty aci low-density lipoprotein; HDL, high-density lipoprotein; ApoC III, apolipoprotein C II (Fig.”
BackgroundInfluentialBrites, F. D., Martín, M., Guillas, I., & Kontush, A. (2017) · BBA Clinical · doi:10.1016/j.bbacli.2017.07.002 · Cited by 265 · see citing works
Splenic Metabolic Activity Predicts Risk of Future Cardiovascular Events
Emami, H., Singh, P., MacNabb, M. H., Vucic, E., Lavender, Z. R., Rudd, J. H. F., Fayad, Z. A., Lehrer‐Graiwer, J., Korsgren, M., Figueroa, A. L., et al. (2015) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2014.10.009 · Cited by 264 · see citing works
Foxo1 mediates insulin action on apoC-III and triglyceride metabolism
Altomonte, J., Lin, C., Harbaran, S., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419992 · Cited by 260 · see citing works
Residual Inflammatory Risk on Treatment With PCSK9 Inhibition and Statin Therapy
Pradhan, A. D., Aday, A. W., Rose, L. M., & Ridker, P. M. (2018) · Circulation · doi:10.1161/circulationaha.118.034645 · Cited by 258 · see citing works
Effects of Physical Activity on Cardiovascular Disease
Ahmed, H. M., Blaha, M. J., Nasir, K., Rivera, J. J., & Blumenthal, R. S. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.08.042 · Cited by 253 · see citing works
Self-citationThe Chemical Components of Tobacco and Tobacco Smoke
Cooke, M. (2010) · Chromatographia · doi:10.1365/s10337-010-1556-3 · Cited by 250 · see citing works
Ross, A. C., Rizk, N., O’Riordan, M. A., Dogra, V. S., El‐Bejjani, D., Storer, N. J., Harrill, D., Tungsiripat, M., Adell, J., & McComsey, G. A. (2009) · Clinical Infectious Diseases · doi:10.1086/605578 · Cited by 248 · see citing works
Senthong, V., Li, X. S., Hudec, T., Coughlin, J., Wu, Y., Levison, B., Wang, Z., Hazen, S. L., & Tang, W. H. W. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.03.546 · Cited by 242 · see citing works
Infections, atherosclerosis, and coronary heart disease
Pothineni, N. V. K., Subramany, S., Kuriakose, K., Shirazi, L. F., Romeo, F., Shah, P. K., & Mehta, J. L. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx362 · Cited by 241 · see citing works
Ridker, P. M., MacFadyen, J. G., Thuren, T. Y., & Libby, P. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz542 · Cited by 241 · see citing works
PCSK9 and inflammation: role of shear stress, pro-inflammatory cytokines, and LOX-1
Ding, Z., Pothineni, N. V. K., Goel, A., Lüscher, T. F., & Mehta, J. L. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz313 · Cited by 240 · see citing works
Relationship of Cigarette Smoking With Inflammation and Subclinical Vascular Disease
McEvoy, J. W., Nasir, K., DeFilippis, A. P., Lima, J. A. C., Bluemke, D. A., Hundley, W. G., Barr, R. G., Budoff, M. J., Szklo, M., Navas‐Acién, A., et al. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304960 · Cited by 239 · see citing works
Self-citationRidker, P. M., Morrow, D. A., Rose, L. M., Rifai, N., Cannon, C. P., & D, E. B. M. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.080 · Cited by 235 · see citing works
High Density Lipoproteins (HDL) Interrupt the Sphingosine Kinase Signaling Pathway
Xia, P., Vadas, M. A., Rye, K., Barter, P. J., & Gamble, J. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.33143 · Cited by 234 · see citing works
The Relationship between Lung Inflammation and Cardiovascular Disease
van Eeden, S. F., Leipsic, J. A., Man, S. F. P., & Sin, D. D. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201203-0455pp · Cited by 231 · see citing works
Bakhru, A., & Erlinger, T. P. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020160 · Cited by 229 · see citing works
Sedentary Time and Markers of Chronic Low-Grade Inflammation in a High Risk Population
Henson, J. J., Yates, T. E., Edwardson, C. L., Khunti, K. K., Talbot, D. C. S., Gray, L. J., Leigh, T. M., Carter, P., & Davies, M. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078350 · Cited by 219 · see citing works
Antoniades, C., Bakogiannis, C., Leeson, P., Guzik, T. J., Zhang, M.-H., Tousoulis, D., Antonopoulos, A. S., Demosthenous, M., Marinou, K., Hale, A., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.985150 · Cited by 219 · see citing works
Colchicine in Patients with Chronic Coronary Disease
Lucijanić, M., Javor, E., & Skelin, M. (2021) · New England Journal of Medicine · doi:10.1056/nejmc2034992 · Cited by 219 · see citing works
Trans fatty acids – Effects on systemic inflammation and endothelial function
Mozaffarian, D. (2006) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2006.04.007 · Cited by 214 · see citing works
Nicotine Strongly Activates Dendritic Cell–Mediated Adaptive Immunity
Aicher, A., Heeschen, C., Mohaupt, M., Cooke, J. P., Zeiher, A. M., & Dimmeler, S. (2003) · Circulation · doi:10.1161/01.cir.0000047279.42427.6d · Cited by 213 · see citing works
Nidorf, M., & Thompson, P. L. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.10.039 · Cited by 202 · see citing works
Inflammation and Atherothrombosis
Libby, P., & Ridker, P. M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.08.011 · Cited by 200 · see citing works
HDL-mediated mechanisms of protection in cardiovascular disease
Kontush, A. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu147 · Cited by 194 · see citing works
Upregulation of CD40 and CD40 Ligand (CD154) in Patients With Moderate Hypercholesterolemia
Garlichs, C. D., John, S., Schmeißer, A., Eskafi, S., Stumpf, C., Karl, M., Goppelt‐Struebe, M., Schmieder, R. E., & Daniel, W. G. (2001) · Circulation · doi:10.1161/hc4501.099312 · Cited by 194 · see citing works
Gonçalves, I., Edsfeldt, A., Ko, N. Y., Grufman, H., Berg, K. E., Björkbacka, H., Nitulescu, M., Persson, A. F., Nilsson, M., Prehn, C. P., et al. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.249854 · Cited by 188 · see citing works
Dickinson, S., Hancock, D. P., Petocz, P., Ceriello, A., & Brand-Miller, J. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1188 · Cited by 184 · see citing works
High dose and long-term statin therapy accelerate coronary artery calcification
Henein, M., Granåsen, G., Wiklund, U., Schmermund, A., Guerci, A., Erbel, R., & Raggi, P. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.02.072 · Cited by 181 · see citing works
Paraoxonase-1 inhibits oxidised LDL-induced MCP-1 production by endothelial cells
Mackness, B., Hine, D. G., Liu, Y., Mastorikou, M., & Mackness, M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.04.056 · Cited by 178 · see citing works
Ahlehoff, O., Skov, L., Gislason, G., Lindhardsen, J., Kristensen, S. L., Iversen, L., Lasthein, S., Gniadecki, R., Dam, T. N., Torp-Pedersen, C. T., et al. (2012) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02593.x · Cited by 177 · see citing works
Panagiotakos, D. B., Pitsavos, C. S., Chrysohoou, C. A., Kavouras, S. A., & Stefanadis, C. (2004) · Preventive Medicine · doi:10.1016/j.ypmed.2004.07.010 · Cited by 174 · see citing works
Plasma and erythrocyte biomarkers of dairy fat intake and risk of ischemic heart disease
Sun, Q., Ma, J., Campos, H., & Hu, F. B. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.4.929 · Cited by 171 · see citing works
Shao, B., Pennathur, S., & Heinecke, J. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.337345 · Cited by 170 · see citing works
Vascular Inflammation in Subclinical Atherosclerosis Detected by Hybrid PET/MRI
Fernández‐Friera, L., Fuster, V., López‐Melgar, B., Oliva, B., Sánchez‐Gonzalez, J., Macías, A., Pérez-Asenjo, B., Zamudio, D., Farto, J. C. A., España, S., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.12.075 · Cited by 168 · see citing works
Andreotti, F., Porto, I., Crea, F., & Maseri, A. (2002) · Heart · doi:10.1136/heart.87.2.107 · Cited by 156 · see citing works
The Western lifestyle has lasting effects on metaflammation
Christ, A., & Latz, E. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0156-1 · Cited by 156 · see citing works
Dietary fiber, inflammation, and cardiovascular disease
King, D. E. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200400112 · Cited by 155 · see citing works
Shah, B., Newman, J., Woolf, K., Ganguzza, L., Guo, Y., Allen, N., Zhong, J., Fisher, E., & Slater, J. (2018) · Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease · doi:10.1161/jaha.118.011367 · Cited by 155 · see citing works
Relations of glycemic index and glycemic load with plasma oxidative stress markers
Hu, Y., Block, G., Norkus, E. P., Morrow, J. D., Dietrich, M., & Hudes, M. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.70 · Cited by 154 · see citing works
Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis
Dweck, M. R., Aikawa, E. R., Newby, D. E., Tarkin, J. M., Rudd, J. H. F., Narula, J., & Fayad, Z. A. (2016) · Circulation Research · doi:10.1161/circresaha.116.307971 · Cited by 150 · see citing works
Novel Insights Into the NLRP3 Inflammasome in Atherosclerosis
Jin, Y. H., & Fu, J. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012219 · Cited by 148 · see citing works
Chemokines are elevated in plasma after strenuous exercise in humans
Ostrowski, K., Rohde, T., Asp, S., Schjerling, P., & Pedersen, B. K. (2001) · European Journal of Applied Physiology · doi:10.1007/s004210170012 · Cited by 146 · see citing works
Paraoxonase-1 inhibits oxidised LDL-induced MCP-1 production by endothelial cells
Mackness, B. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(04)00780-6 · Cited by 145 · see citing works
Smoking status and differential white cell count in men and women in the EPIC-Norfolk population
Smith, M. R., Kinmonth, A., Luben, R., Bingham, S. A., Day, N., Wareham, N. J., Welch, A. A., & Khaw, K. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00200-4 · Cited by 144 · see citing works
Turner, N. A., O'Regan, D. J., Ball, S. G., & Porter, K. E. (2005) · The FASEB Journal · doi:10.1096/fj.04-2852fje · Cited by 143 · see citing works
Skagen, K., Trøseid, M., Ueland, T., Holm, S., Abbas, A., Gregersen, I., Kummen, M., Bjerkeli, V., Reier-Nilsen, F., Russell, D., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.01.033 · Cited by 139 · see citing works
Duprez, D. A., Otvos, J. D., Sanchez, O. A., Mackey, R. H., Tracy, R. P., & Jacobs, D. R. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2016.255828 · Cited by 137 · see citing works
Statins and Inflammation: New Therapeutic Opportunities in Psychiatry
Kim, S., Kang, H., Jhon, M., Kim, J., Lee, J., Walker, A. J., Agustini, B., Kim, J., & Berk, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00103 · Cited by 137 · see citing works
† (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00034-0 · Cited by 133 · see citing works
Corte, K. W. D., Perrar, I., Penczynski, K. J., Schwingshackl, L., Herder, C., & Buyken, A. E. (2018) · Nutrients · doi:10.3390/nu10050606 · Cited by 131 · see citing works
Guedeney, P., Claessen, B. E. P. M., Kalkman, D. N., Aquino, M. B., Sorrentino, S., Giustino, G., Farhan, S., Vogel, B., Sartori, S., Montalescot, G., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.01.077 · Cited by 131 · see citing works
PCSK9 inhibition and inflammation: A narrative review
Ruscica, M., Tokgözoğlu, L. S., Corsini, A., & Sirtori, C. R. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.07.015 · Cited by 130 · see citing works
Tsimané: Das gesündeste Volk der Welt
(2017) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0043-106661 · Cited by 127 · see citing works
Askarpour, M., Khani, D., Sheikhi, A., Ghaedi, E., & Alizadeh, S. (2019) · Obesity Surgery · doi:10.1007/s11695-019-03926-0 · Cited by 120 · see citing works
Pitsavos, C., Panagiotakos, D. B., Chrysohoou, C. A., Kavouras, S. A., & Stefanadis, C. (2005) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000164690.50200.43 · Cited by 117 · see citing works
Raggi, P., Gadiyaram, V., Zhang, C., Chen, Z., Lopaschuk, G., & Stillman, A. E. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.013104 · Cited by 113 · see citing works
Glynn, R. J., MacFadyen, J. G., & Ridker, P. M. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2008.120642 · Cited by 107 · see citing works
Kianoush, S., Yakoob, M. Y., Al‐Rifai, M., DeFilippis, A. P., Bittencourt, M. S., Duncan, B. B., Benseñor, I. M., Bhatnagar, A., Lotufo, P. A., & Blaha, M. J. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.005088 · Cited by 104 · see citing works
Self-citationMedical Therapy for Long-Term Prevention of Atherothrombosis Following an Acute Coronary Syndrome
Gallone, G., Baldetti, L., Pagnesi, M., Latib, A., Colombo, A., Libby, P., & Giannini, F. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.09.052 · Cited by 104 · see citing works
Cigarette Smoking and Cardiovascular Events
McEvoy, J. W., Blaha, M. J., DeFilippis, A. P., Lima, J. A. C., Bluemke, D. A., Hundley, W. G., Min, J. K., Shaw, L. J., Lloyd‐Jones, D. M., Barr, R. G., et al. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304562 · Cited by 101 · see citing works
Self-citationRifai, M. A., DeFilippis, A. P., McEvoy, J. W., Hall, M. E., Acien, A. N., Jones, M. R., Keith, R. J., Magid, H. S. A., Rodríguez, C. J., Barr, R. G., et al. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.01.021 · Cited by 101 · see citing works
Self-citationJoshi, N. V., Toor, I. S., Shah, A. S. V., Carruthers, K. F., Vesey, A. T., Alam, S. R., Sills, A., Hoo, T. Y., Melville, A. J., Langlands, S. P., et al. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.001956 · Cited by 98 · see citing works
Cytokine SNPs: Comparison of Allele Frequencies by Race & Implications for Future Studies
Dyke, A. L. V., Cote, M., Wenzlaff, A., Land, S., & Schwartz, A. (2009) · Cytokine · doi:10.1016/j.cyto.2009.02.003 · Cited by 97 · see citing works
Treatment With Methotrexate Inhibits Atherogenesis in Cholesterol-Fed Rabbits
Bulgarelli, A., Dias, A. A. M., Caramelli, B., & Maranhão, R. C. (2011) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318241c385 · Cited by 95 · see citing works
Thresholds for Arterial Wall Inflammation Quantified by 18F-FDG PET Imaging
van der Valk, F. M., Verweij, S. L., Zwinderman, A. H., Strang, A. C., Kaiser, Y., Marquering, H. A., Nederveen, A. J., Stroes, E. S. G., Verberne, H. J., & Rudd, J. H. F. (2016) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2016.04.007 · Cited by 93 · see citing works
Pearson, T. A., Ballantyne, C. M., Veltri, E. P., Shah, A. K., Bird, S. R., Lin, J., Rosenberg, E., & Tershakovec, A. M. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.09.090 · Cited by 91 · see citing works
Ogawa, M., Nakamura, S., Saito, Y., Kosugi, M., & Magata, Y. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.092866 · Cited by 88 · see citing works
Aldaham, S. A., Foote, J. A., Chow, H. ‐. S., & Hakim, I. A. (2015) · International Journal of Inflammation · doi:10.1155/2015/439396 · Cited by 86 · see citing works
Negative Risk Markers for Cardiovascular Events in the Elderly
Mortensen, M. B., Fuster, V., Muntendam, P., Mehran, R., Baber, U., Sartori, S., & Falk, E. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.04.049 · Cited by 84 · see citing works
Hoogeveen, R. M., Opstal, T. S. J., Kaiser, Y., Stiekema, L. C. A., Kroon, J., Knol, R. J. J., Bax, W. A., Verberne, H. J., Cornel, J. H., & Stroes, E. S. G. (2019) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2019.06.022 · Cited by 83 · see citing works
Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes
Falconer, C., Cooper, A. R., Walhin, J., Thompson, D., Page, A. S., Peters, T. J., Montgomery, A. A., Sharp, D., Dayan, C. M., & Andrews, R. C. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.03.009 · Cited by 76 · see citing works
Leucker, T. M., Gerstenblith, G., Schär, M., Brown, T. T., Jones, S. R., Afework, Y., Weiss, R. G., & Hays, A. G. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.016263 · Cited by 75 · see citing works
Self-citationKing, C. C., Piper, M. E., Gepner, A. D., Fiore, M. C., Baker, T. B., & Stein, J. H. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308728 · Cited by 72 · see citing works
Pirro, M., Simental‐Mendía, L. E., Bianconi, V., Watts, G. F., Banach, M., & Sahebkar, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8010118 · Cited by 70 · see citing works
Polymorphisms in the TNF‐α and TNF‐receptor genes in patients with coronary artery disease
Allen, R., Lee, E. M., Roberts, D. H., Park, B. K., & Pirmohamed, M. (2001) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2001.00907.x · Cited by 68 · see citing works
Toll-like receptor 2/4 links to free fatty acid-induced inflammation and β-cell dysfunction
Yin, J., Peng, Y., Wu, J., Wang, Y., & Yao, L. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0313143 · Cited by 67 · see citing works
Effects of Biochemically Confirmed Smoking Cessation on White Blood Cell Count
Abel, G. A., Hays, J. T., Decker, P. A., Croghan, G. A., Kuter, D. J., & Rigotti, N. A. (2005) · Mayo Clinic Proceedings · doi:10.4065/80.8.1022 · Cited by 66 · see citing works
Veeranna, V., ZALAWADIYA, S. K., Niraj, A., Kumar, A., Ference, B. A., & Afonso, L. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.11.034 · Cited by 65 · see citing works
Flagged first, then by citations
2 of the 239 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
NF-κB in biology and targeted therapy: new insights and translational implications
Guo, Q., Jin, Y., Chen, X., Ye, X., Shen, X., Lin, M., Zeng, C., Zhou, T., & Zhang, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01757-9 · Cited by 2,267 · see citing works
Khan, J., Deb, P. K., Priya, S., Damian-Medina, K., Devi, R., Walode, S. G., & Rudrapal, M. (2021) · Molecules · doi:10.3390/molecules26134021 · Cited by 350 · see citing works
Makover, M. E., Shapiro, M. D., & Toth, P. P. (2022) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2022.100371 · Cited by 133 · see citing works
Self-citationIL-6 and Cardiovascular Risk: A Narrative Review
Mehta, N. N., deGoma, E. M., & Shapiro, M. D. (2024) · Current Atherosclerosis Reports · doi:10.1007/s11883-024-01259-7 · Cited by 133 · see citing works
The Brain–Heart Axis: Neuroinflammatory Interactions in Cardiovascular Disease
Hu, J., Abdullah, A., Nanna, M. G., & Soufer, R. (2023) · Current Cardiology Reports · doi:10.1007/s11886-023-01990-8 · Cited by 115 · see citing works
Long-Term Cardiovascular Effects of COVID-19: Emerging Data Relevant to the Cardiovascular Clinician
Tobler, D. L., Pruzansky, A. J., Naderi, S., Ambrosy, A. P., & Slade, J. J. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01032-8 · Cited by 94 · see citing works
Metabolic syndrome: epidemiology, mechanisms, and current therapeutic approaches
Hamooya, B. M., Siame, L., Muchaili, L., Masenga, S. K., & Kirabo, A. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1661603 · Cited by 88 · see citing works
Liu, F., Wu, J., Gong, L.-J., Yang, H.-S., & Chen, H. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1490300 · Cited by 80 · see citing works
NF-κB, A Potential Therapeutic Target in Cardiovascular Diseases
Cheng, W. T. K., Cui, C., Liu, G., Ye, C., Fang, S., Bagchi, A. K., Mehta, J. L., & Wang, X. (2022) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-022-07362-8 · Cited by 83 · see citing works
Wada, Y., Jensen, C., Meyer, A., Zonoozi, A. A. M., & Honda, H. (2023) · Journal of Cardiology · doi:10.1016/j.jjcc.2023.05.006 · Cited by 77 · see citing works
Tryptophan: From Diet to Cardiovascular Diseases
Melhem, N. J., & Taleb, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189904 · Cited by 72 · see citing works
Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk
Berisha, H., Hattab, R., Comi, L., Giglione, C., Migliaccio, S., & Magni, P. (2025) · Nutrients · doi:10.3390/nu17050776 · Cited by 75 · see citing works
Revitalizing T cells: breakthroughs and challenges in overcoming T cell exhaustion
Wu, Y., Wu, Y., Gao, Z., Yu, W., Zhang, L., & Zhou, F. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02327-3 · Cited by 69 · see citing works
Innate Immunity System in Patients With Cardiovascular and Kidney Disease
Zoccali, C., & Mallamaci, F. (2023) · Circulation Research · doi:10.1161/circresaha.122.321749 · Cited by 60 · see citing works
Lipoprotein (a), Inflammation, and Atherosclerosis
Fusco, S. A. D., Maggioni, A. P., Scicchitano, P., Zuin, M., D’Elia, E., & Colivicchi, F. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12072529 · Cited by 57 · see citing works
Cardiovascular health and cancer risk associated with plant based diets: An umbrella review
Capodici, A., Mocciaro, G., Gori, D., Landry, M. J., Masini, A., Sanmarchi, F., Fiore, M., Coa, A. A., Castagna, G., Gardner, C. D., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300711 · Cited by 62 · see citing works
Triple Hybrid Cellular Nanovesicles Promote Cardiac Repair after Ischemic Reperfusion
Lai, J., Pan, Q., Chen, G., Liu, Y., chen, C., Pan, Y., Liu, L., Zeng, B., Yu, L., Xu, Y., et al. (2024) · ACS Nano · doi:10.1021/acsnano.3c10784 · Cited by 54 · see citing works
Autoimmune diseases and new-onset atrial fibrillation: a UK Biobank study
Tilly, M. J., Geurts, S., Zhu, F., Bos, M. M., Ikram, M. A., de Maat, M. P. M., de Groot, N. M. S., & Kavousi, M. (2022) · EP Europace · doi:10.1093/europace/euac244 · Cited by 52 · see citing works
Antza, C., Gallo, A., Boutari, C., Ershova, A. I., Gürses, K. M., Lewek, J., Mirmaksudov, M., Silbernagel, G., Sandstedt, J., & Lebedeva, А. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117272 · Cited by 64 · see citing works
Involving machine learning techniques in heart disease diagnosis: a performance analysis
Shukur, B. S., & Mijwil, M. M. (2022) · International Journal of Power Electronics and Drive Systems/International Journal of Electrical and Computer Engineering · doi:10.11591/ijece.v13i2.pp2177-2185 · Cited by 50 · see citing works
Hillary, R. F., Ng, H. K., McCartney, D. L., Elliott, H. R., Walker, R. M., Campbell, A., Huang, F., Direk, K., Welsh, P. I., Sattar, N. A., et al. (2024) · Cell Genomics · doi:10.1016/j.xgen.2024.100544 · Cited by 49 · see citing works
Elliott, P. S., Kharaty, S. S., & Phillips, C. M. (2022) · Nutrients · doi:10.3390/nu14245371 · Cited by 51 · see citing works
Brewer, L. C., Bowie, J. V., Slusser, J. P., Scott, C. G., Cooper, L. A., Hayes, S. N., Patten, C. A., & Sims, M. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.024974 · Cited by 45 · see citing works
Franssen, W. M. A., Nieste, I., Verboven, K., & Eijnde, B. O. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156320 · Cited by 54 · see citing works
Role of Chemerin in Cardiovascular Diseases
Mačvanin, M., Rizzo, M., Radovanović, J., Sönmez, A., Paneni, F., & Isenović, E. R. (2022) · Biomedicines · doi:10.3390/biomedicines10112970 · Cited by 43 · see citing works
Katsi, V. K., Papakonstantinou, I. P., & Tsioufis, K. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411786 · Cited by 42 · see citing works
Citrus flavonoids and adhesion molecules: Potential role in the management of atherosclerosis
Ebrahimi, F., Ghazimoradi, M. M., Fatima, G., & Bahramsoltani, R. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e21849 · Cited by 46 · see citing works
Oral health as a modifiable risk factor for cardiovascular diseases
Altamura, S., Pinto, R. D., Pietropaoli, D., & Ferri, C. (2023) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2023.03.003 · Cited by 41 · see citing works
Fazio, S., Mercurio, V., Tibullo, L., Fazio, V., & Affuso, F. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1380506 · Cited by 39 · see citing works
Roles of mushroom polysaccharides in chronic disease management
Zhang, S., Lei, L., Zhou, Y., Ye, F., & Guo-hua, Z. H. A. O. (2022) · Journal of Integrative Agriculture · doi:10.1016/s2095-3119(21)63871-6 · Cited by 38 · see citing works
PAI-1: A Major Player in the Vascular Dysfunction in Obstructive Sleep Apnea?
Badran, M., & Gozal, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105516 · Cited by 36 · see citing works
PTSD, Immune System, and Inflammation
Pivac, N., Vuić, B., Šagud, M., Erjavec, G. N., Perković, M. N., Konjevod, M., Tudor, L., Štrac, D. Š., Uzun, S., Kozumplik, O., et al. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_11 · Cited by 38 · see citing works
Dzaye, O. D. A., Berning, P., Dardari, Z., Mortensen, M. B., Marshall, C. H., Nasir, K., Budoff, M. J., Blumenthal, R. S., Whelton, S. P., & Blaha, M. J. (2021) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeab099 · Cited by 35 · see citing works
Self-citationNair, A., Rani, M. R. P., Raj, P. S., Ranjit, S., Rajankutty, K., & Raghu, K. G. (2022) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23215 · Cited by 35 · see citing works
Liu, X., Sun, X.-B., Zhang, Y.-K., Jiang, W., Lai, M., Wiggins, K., Raffield, L., Bielak, L., Zhao, W., Pitsillides, A., et al. (2023) · Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease · doi:10.1161/jaha.122.029090 · Cited by 19 · see citing works
Sex Differences Define the Vulnerability to Atherosclerosis
Poznyak, A. V., Sukhorukov, V. N., Guo, S., Postnov, A. Y., & Orekhov, A. N. (2023) · Clinical Medicine Insights Cardiology · doi:10.1177/11795468231189044 · Cited by 32 · see citing works
Diao, W., Zhou, C., Zhang, Z., Cao, Y., Li, Y., Tang, J., & Liu, G. (2024) · ACS Sensors · doi:10.1021/acssensors.4c01306 · Cited by 32 · see citing works
Mehta, A., Blumenthal, R. S., Gluckman, T. J., Feldman, D. I., & Kohli, P. (2025) · US Cardiology Review · doi:10.15420/usc.2024.25 · Cited by 32 · see citing works
Dietary polyphenols maintain human health through modulation of gut microbiota
Rudrapal, M., de Oliveira, A. M., & Singh, R. P. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1710088 · Cited by 36 · see citing works
Friuli, M., Eramo, B., Valenza, M., Scuderi, C., Provensi, G., & Romano, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910250 · Cited by 32 · see citing works
Charles‐Schoeman, C., Choy, E., McInnes, I. B., Mysler, E., Nash, P. T., Yamaoka, K., Lippe, R., Khan, N., Shmagel, A., Palac, H., et al. (2023) · RMD Open · doi:10.1136/rmdopen-2023-003392 · Cited by 31 · see citing works
Vagus nerve stimulation for cardiovascular diseases: Is there light at the end of the tunnel?
Zafeiropoulos, S., Ahmed, U., Bikou, A., Mughrabi, I. T., Stavrakis, S., & Zanos, S. P. (2023) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2023.07.003 · Cited by 29 · see citing works
Stratakis, N., Anguita‐Ruiz, A., Fabbri, L., Maître, L., González, J. R., Andrušaitytė, S., Basagaña, X., Borràs, E., Keun, H. C., Chatzi, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56013-7 · Cited by 30 · see citing works
Association Between Cigarette Smoking and Subclinical Markers of Cardiovascular Harm
Yao, Z., Tasdighi, E., Dardari, Z., Jha, K. K., Osuji, N., Rajan, T., Boakye, E., Rodríguez, C. J., Matsushita, K., Simonsick, E. M., et al. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.12.032 · Cited by 29 · see citing works
Self-citationChiou, S., Clarke, E., Lam, C., Harvey, T., & Nightingale, T. E. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.831372 · Cited by 29 · see citing works
Trentini, A., Manfrinato, M. C., Castellazzi, M., & Bellini, T. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12081196 · Cited by 30 · see citing works
Georgoulis, M., Damigou, E., Chrysohoou, C. A., Barkas, F., Anastasiou, G., Kravvariti, E., Tsioufis, C. P., Liberopoulos, E. N., Sfikakis, P. P., Pitsavos, C. S., et al. (2023) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2023.09.019 · Cited by 28 · see citing works
Sha, S., Gwenzi, T., Chen, L., Brenner, H., & Schöttker, B. (2023) · European Journal of Epidemiology · doi:10.1007/s10654-023-01023-2 · Cited by 28 · see citing works
Novel Perspectives in Chronic Kidney Disease-Specific Cardiovascular Disease
Xu, C., Tsihlis, G., Chau, K., Trinh, K., Rogers, N. M., & Julovi, S. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052658 · Cited by 27 · see citing works
Review on Emerging Therapeutic Strategies for Managing Cardiovascular Disease
Narkhede, M., Pardeshi, A., Bhagat, R., & Dharme, G. (2024) · Current Cardiology Reviews · doi:10.2174/011573403x299265240405080030 · Cited by 27 · see citing works
Macrì, F., Vigorito, I., Castiglione, S., Faggiano, S., Casaburo, M., Fanotti, N., Piacentini, L., Vigetti, D., Vinci, M. C., & Raucci, A. (2023) · Biomolecules · doi:10.3390/biom14010029 · Cited by 26 · see citing works
Kurt, B., Rex, K., Reugels, M., Fordyce, C. B., Fudim, M., Sharma, A., Berger, M., Marx, N., Marx-Schütt, K., & Kahles, F. (2025) · Current Heart Failure Reports · doi:10.1007/s11897-025-00710-3 · Cited by 26 · see citing works
Targeting Macrophage Dysregulation for Viral Infections: Novel Targets for Immunomodulators
Reece, M. D., Taylor, R. R., Song, C., & Gavegnano, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.768695 · Cited by 26 · see citing works
Swiderski, J., Gadanec, L. K., Apostolopoulos, V., Moore, G. J., Kelaidonis, K., Matsoukas, J., & Zulli, A. (2023) · Biomolecules · doi:10.3390/biom13050787 · Cited by 25 · see citing works
Life’s Essential 8 is inversely associated with high-sensitivity C-reactive protein
Hebib, L., Herráiz-Adillo, Á., Higueras‐Fresnillo, S., Berglind, D., Daka, B., Wennberg, P., Hagström, E., Lenander, C., Ahlqvist, V. H., Östgren, C. J., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-65977-3 · Cited by 24 · see citing works
Al‐Masri, A. A., & Ameén, F. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105628 · Cited by 25 · see citing works
Targeting Inflammation in the Diagnosis, Management, and Prevention of Cardiovascular Diseases
Matsumori, A. (2022) · Global Heart · doi:10.5334/gh.1156 · Cited by 23 · see citing works
Nattokinase attenuates endothelial inflammation through the activation of SRF and THBS1
Chiu, H., Chou, C., Lee, K.-T., Shih, C.-C., Huang, T.-H., & Sung, L. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131779 · Cited by 23 · see citing works
Nuszkiewicz, J., Kukulska-Pawluczuk, B., Piec, K., Jarek, D. J., Motolko, K., Szewczyk‐Golec, K., & Woźniak, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13144258 · Cited by 23 · see citing works
Raadsen, R., Hansildaar, R., Pouw, L. C., Hooijberg, F., Boekel, L., Wolbink, G., van Kuijk, A. W. R., & Nurmohamed, M. T. (2023) · RMD Open · doi:10.1136/rmdopen-2023-003485 · Cited by 22 · see citing works
Acupuncture in Traditional Chinese Medicine: A Complementary Approach for Cardiovascular Health
Wang, S., Fang, R., Huang, L., Zhou, L., Liu, H., Cai, M., Sha’aban, A., Yu, C., & Akkaif, M. A. (2024) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s476319 · Cited by 22 · see citing works
Assessment of N/L ratio and subclinical atherosclerosis in FH subjects with or without LDLR mutation
Barbagallo, F. D. G., Bosco, G., Marco, M. D., Scilletta, S., Miano, N., Martedì, M., Privitera, I., Papa, M., Piazza, C., Valenza, F., et al. (2026) · Journal of the Endocrine Society · doi:10.1210/jendso/bvag001 · Cited by 22 · see citing works
Guha, A., Wang, X., Harris, R. A., Nelson, A.-G., Stepp, D. W., Klaassen, Z. W. A., Raval, P., Cortes, J. E., Coughlin, S. S., Bogdanov, V. Y., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.761488 · Cited by 22 · see citing works
Lycopene Modulates Oxidative Stress and Inflammation in Hypercholesterolemic Rats
Albrahim, T. I. (2022) · Pharmaceuticals · doi:10.3390/ph15111420 · Cited by 22 · see citing works
Sweeney, T. E., Quispe, R., Das, T. M., Juraschek, S. P., Martin, S. S., & Michos, E. D. (2021) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2021.1930531 · Cited by 23 · see citing works
Self-citationAlgae-derived compounds: Bioactivity, allergenicity and technologies enhancing their values
Mirzapour‐Kouhdasht, A., García‐Vaquero, M., & Huang, J. (2024) · Bioresource Technology · doi:10.1016/j.biortech.2024.130963 · Cited by 22 · see citing works
Wang, Q., Zhi, T., Han, P., Li, S., Xia, J., Chen, Z., Wang, C., Wu, Y.-L., Jia, Y., & Ma, A. (2021) · Food and Agricultural Immunology · doi:10.1080/09540105.2021.1982870 · Cited by 21 · see citing works
Extra Virgin Olive Oil and Cardiovascular Protection in Chronic Kidney Disease
Marrone, G., Urciuoli, S., Lauro, M. D., Ruzzolini, J., Ieri, F., Vignolini, P., Daniele, F. D., Guerriero, C., Nediani, C., Daniele, N. D., et al. (2022) · Nutrients · doi:10.3390/nu14204265 · Cited by 22 · see citing works
Serhiyenko, V. A., Serhiyenko, L. M., Sehin, V. B., & Serhiyenko, A. A. (2022) · Endocrine Regulations · doi:10.2478/enr-2022-0031 · Cited by 21 · see citing works
Cardiovascular Manifestations of the Long COVID Syndrome
Ros, M. L., Das, S., Elias, J., Frishman, W. H., & Aronow, W. S. (2023) · Cardiology in Review · doi:10.1097/crd.0000000000000552 · Cited by 20 · see citing works
Nowak, K. L., & Chonchol, M. (2025) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2025.06.019 · Cited by 20 · see citing works
Watral, J., Formanowicz, D., Perek, B., Kostka-Jeziorny, K., Podkowińska, A., Tykarski, A., & Łuczak, M. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1229648 · Cited by 20 · see citing works
Cozac, D. A., Halațiu, V.-B., & Scridon, A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1630410 · Cited by 22 · see citing works
Sava, A., Buron, F., Routier, S., Panainte, A. D., Bibire, N., Constantin, S. M., Lupaşcu, F., Focșa, A., & Profire, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137079 · Cited by 19 · see citing works
Protective Potential of Maresins in Cardiovascular Diseases
Liu, M., He, H., & Chen, L. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.923413 · Cited by 19 · see citing works
Men, B., Li, Y., & Jiang, S. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s449661 · Cited by 21 · see citing works
Chen, X., Yang, Y., Zhou, Z., Yu, H., Zhang, S., Huang, S., Wei, Z., Ren, K., & Jin, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112930 · Cited by 19 · see citing works
Gut microbiota-derived metabolites: Potential targets for cardiorenal syndrome
Lai, Y.-C., Zhu, Y., Zhang, X., Ding, S., Wang, F., Hao, J., Wang, Z., Shi, C., Xu, Y., Zheng, L., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107672 · Cited by 21 · see citing works
Sava, A., Buron, F., Routier, S., Panainte, A. D., Bibire, N., & Profire, L. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111678 · Cited by 18 · see citing works
The Ocean’s Pharmacy: Health Discoveries in Marine Algae
Silva, M., Avni, D., Varela, J. C. S., & Barreira, L. A. (2024) · Molecules · doi:10.3390/molecules29081900 · Cited by 18 · see citing works
Oncom: A Nutritive Functional Fermented Food Made from Food Process Solid Residue
Wijaya, C. H., Nuraida, L., Nuramalia, D. R., Hardanti, S., & Świąder, K. (2024) · Applied Sciences · doi:10.3390/app142210702 · Cited by 23 · see citing works
Rethinking of phosphodiesterase 5 inhibition: the old, the new and the perspective in human health
Paronetto, M. P., & Crescioli, C. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1461642 · Cited by 17 · see citing works
Alshahrani, A. A., Kontopantelis, E., Morgan, C., Ravindrarajah, R., Martin, G. P., & Mamas, M. A. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003419 · Cited by 21 · see citing works
The Link between Stroke Risk and Orodental Status—A Comprehensive Review
Shahi, S., Farhoudi, M., Dizaj, S. M., Sharifi, S., Sadigh‐Eteghad, S., Goh, K. W., Ming, L. C., Dhaliwal, J. S., & Salatin, S. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11195854 · Cited by 17 · see citing works
Skeletal muscle as a reservoir for nitrate and nitrite: The role of xanthine oxidase reductase (XOR)
de Zevallos, J. O., Woessner, M. N., & Kelley, E. E. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.10.004 · Cited by 19 · see citing works
Mo, Q., Deng, X., Zhou, Z., & Yin, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104777 · Cited by 16 · see citing works
Raut, S., & Cucullo, L. (2025) · Antioxidants · doi:10.3390/antiox14121490 · Cited by 16 · see citing works
Associations of genetic and infectious risk factors with coronary heart disease
Hodel, F., Xu, Z. M., Thorball, C. W., Harpe, R. D. L., Letang-Mathieu, P., Brenner, N., Butt, J., Bender, N., Waterboer, T., Marques-Vidal, P. M., et al. (2023) · eLife · doi:10.7554/elife.79742 · Cited by 16 · see citing works
Almeida, C., Nobre, J. G., Costa, D. A., & Barata, P. (2023) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2023.1235126 · Cited by 18 · see citing works
Zahid, S., Mohamed, M. S., Rajendran, A., Minhas, A., Khan, M. Z., Nazir, N. T., Ocon, A. J., Weber, B., Isiadinso, I., & Michos, E. D. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae108 · Cited by 16 · see citing works
Self-citationWang, M., Zhu, Z., Wu, X., Cheong, K., Li, X., Yu, W., Yao, Y., Wu, J., & Cao, Z. (2024) · Foods · doi:10.3390/foods13172782 · Cited by 16 · see citing works
Cheung, J., Cheung, B. M. Y., Yiu, K., Tse, H., & Chan, Y. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1573841 · Cited by 15 · see citing works
Boukhers, I., Morel, S., Kongolo, J., Domingo, R., Servent, A., Ollier, L., Kodja, H., Petit, T., & Poucheret, P. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45090440 · Cited by 15 · see citing works
Genetics in Ischemic Stroke: Current Perspectives and Future Directions
Zhang, K., Loong, S. S. E., Yuen, L. Z., Venketasubramanian, N., Chin, H.-L. L., Lai, P. S., & Tan, B. Y. (2023) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd10120495 · Cited by 16 · see citing works
Sarıkaya, B., Kolay, E., Guney-Coskun, M., Yiğit, A., & Aktaç, Ş. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae143 · Cited by 15 · see citing works
Dzaye, O. D. A., Berning, P., Dardari, Z., Berman, D. S., Budoff, M. J., Miedema, M. D., Nasir, K., Rozanski, A., Rumberger, J. A., Shaw, L. J., et al. (2021) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2021.10.007 · Cited by 15 · see citing works
Self-citationGut microbiota on cardiovascular diseases-a mini review on current evidence
Zhang, S., Li, J., Li, L., & Yuan, X. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1690411 · Cited by 14 · see citing works
Bioactives and exercise synergize to modulate AMPK and inflammation
Sheng, Z., Luo, Q., LIU, X., & Yang, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1670379 · Cited by 17 · see citing works
Zhou, C., Tan, Y., Xu, B., Wang, Y., & Cheang, W. S. (2022) · Antioxidants · doi:10.3390/antiox11071286 · Cited by 14 · see citing works
Association between parity and markers of inflammation: The multi-ethnic study of atherosclerosis
Ezeigwe, A. K., Ogunmoroti, O., Minhas, A., Rodriguez, C. P., Kazzi, B. E., Fashanu, O. E., Osibogun, O. I., Kovell, L. C., Harrington, C. M., & Michos, E. D. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.922367 · Cited by 14 · see citing works
Self-citation
- Authors
- Alfaddagh, A., Martin, S. S., Leucker, T. M., Michos, E. D., Blaha, M. J., Lowenstein, C. J., Jones, S. R., & Toth, P. P.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Toth, Peter P.
- ORCID
- Venue
- American Journal of Preventive Cardiology
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 4
- Pages
- 100130
- ISSN
- 2666-6677 (ISSN-L)
- PMC
- PMC8315628
- OpenAlex
- W3109720983
- Cited by
- 473
- References
- 239
- Citations by year
- 2026: 94 · 2025: 137 · 2024: 98 · 2023: 75 · 2022: 49 · 2021: 20
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- American Journal of Preventive Cardiology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- inflammation, atherosclerosis, atherogenesis, cardiovascular disease, chronic inflammation, endothelial dysfunction, foam cell formation, plaque rupture, cytokines, interleukins, inflammatory markers, anti-inflammatory therapy, acute cardiovascular events, plaque vulnerability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review