The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance
Open accessAbstract
It is well-established that the nutritional deficiency or inadequacy can impair immune functions. Growing evidence suggests that for certain nutrients increased intake above currently recommended levels may help optimize immune functions including improving defense function and thus resistance to infection, while maintaining tolerance. This review will examine the data representing the research on prominent intervention agents n-3 polyunsaturated fatty acids (PUFA), micronutrients (zinc, vitamins D and E), and functional foods including probiotics and tea components for their immunological effects, working mechanisms, and clinical relevance. Many of these nutritive and non-nutritive food components are related in their functions to maintain or improve immune function including inhibition of pro-inflammatory mediators, promotion of anti-inflammatory functions, modulation of cell-mediated immunity, alteration of antigen-presenting cell functions, and communication between the innate and adaptive immune systems. Both animal and human studies present promising findings suggesting a clinical benefit of vitamin D, n-3 PUFA, and green tea catechin EGCG in autoimmune and inflammatory disorders, and vitamin D, vitamin E, zinc, and probiotics in reduction of infection. However, many studies report divergent and discrepant results/conclusions due to various factors. Chief among them, and thus call for attention, includes more standardized trial designs, better characterized populations, greater consideration for the intervention doses used, and more meaningful outcome measurements chosen.
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“Probiotics have been found to modify the population of the gut microflora and have been shown to increase some aspects of mucosal and systemic immunity in healthy humans such as altered cytokine production, increased natural killer cell cytotoxic activity, increased secretory immunoglobulin A (IgA) levels, and enhanced resistance to infections [282].”
From Nutrition for Older Athletes: Focus on Sex-Differences (2021) · cites this paper as [282]
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Cites
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
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Pro-resolving lipid mediators are leads for resolution physiology
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Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
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“The most significant breakthrough in n-3 PUFA research is perhaps the discovery that n-3 PUFA are pro-resolution agents by serving as the precursors for several families of pre-resolving mediators, which at least include EPA-derived E-series resolvins, DHA-derived D-series resolvins, and DHA-derived protectins and mar…”
Vitamin effects on the immune system: Vitamins A and D take centre stage
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Omega-3 fatty acids and inflammatory processes: from molecules to man
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Antibody response to influenza vaccination in the elderly: A quantitative review
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The immune system and the impact of zinc during aging
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Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults
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“It is worth noting that the effect of probiotics on cytokine production may be straindependent given the mixed results showing that consuming probiotics induces IFN-α [B. lactis HN019, (197)], reduces TNFα [L. rhamnosus GG, (198)] and IL-2 [B. animalis ssp. Lactis Bb12, (198)], and has no effect on IFN-γ, IL-1β, and I…”
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Cited by
A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection
Gombart, A. F., Pierre, A., & Maggini, S. (2020) · Nutrients · doi:10.3390/nu12010236 · Cited by 1,358
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693
Effects of Omega-3 Fatty Acids on Immune Cells
Gutiérrez, S., Svahn, S. L., & Johansson, M. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205028 · Cited by 525
Nutrition, immunity and COVID-19
Calder, P. C. (2020) · BMJ Nutrition, Prevention & Health · doi:10.1136/bmjnph-2020-000085 · Cited by 426
The Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review
James, P. T., Ali, Z., Armitage, A. E., Bonell, A., Cerami, C., Drakesmith, H., Jobe, M., Jones, K. S., Liew, Z., Moore, S. E., et al. (2021) · The Journal of Nutrition · doi:10.1093/jn/nxab059 · Cited by 147
Metadata
- Authors
- Wu, D., Lewis, E. D., Pae, M., & Meydani, S. N.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-01-15
- Volume
- 9
- Pages
- 3160-3160
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2908597227
- Cited by
- 481
- References
- 15
- FWCI
- 58.45
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
