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Cited by 99T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

Regulation of γδ T Cell Effector Diversification in the Thymus

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Parker, Morgan E., Ciofani, Maria·2020·Frontiers in Immunology
DOI 10.3389/fimmu.2020.00042PMC PMC6992645
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Abstract

γδ T cells are the first T cell lineage to develop in the thymus and take up residence in a wide variety of tissues where they can provide fast, innate-like sources of effector cytokines for barrier defense. In contrast to conventional αβ T cells that egress the thymus as naïve cells, γδ T cells can be programmed for effector function during development in the thymus. Understanding the molecular mechanisms that determine γδ T cell effector fate is of great interest due to the wide-spread tissue distribution of γδ T cells and their roles in pathogen clearance, immunosurveillance, cancer, and autoimmune diseases. In this review, we will integrate the current understanding of the role of the T cell receptor, environmental signals, and transcription factor networks in controlling mouse innate-like γδ T cell effector commitment.

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  • γδ T cells that develop without pre-programming in the thymus and receive the TCR signal in the periphery develop as adaptive types, whereas γδ T subsets that receive the signal in the thymus are innate types, and those which receive the TCR signal in the periphery but during an early phase of life get converted into innate-like γδ T cells.

    “γδ T cells that develop without pre-programming in the thymus and receive the TCR signal in the periphery develop as adaptive types, whereas γδ T subsets that receive the signal in the thymus are innate types, and those which receive the TCR signal in the periphery but during an early phase of life get converted into innate-like γδ T cells (12).”

    From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [12]

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Cited by

Sorted by citations

Authors
Parker, M. E., & Ciofani, M.
Affiliations
Duke Medical Center (US)
Corresponding author
Ciofani, Maria
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2020-01-24
Volume
11
Pages
42-42
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2020.00042
PMC
PMC6992645
OpenAlex
W3003135424
Cited by
99
References
4
Citations by year
2026: 9 · 2025: 14 · 2024: 16 · 2023: 16 · 2022: 18 · 2021: 19 · 2020: 6 · 2019: 1
FWCI
1.44
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health
  • National Human Genome Research Institute (UM1HG009428)
  • National Institute of General Medical Sciences (R01GM115474)
  • National Institute of Allergy and Infectious Diseases (T32AI052077)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords
γδ T cells, thymus, T cell receptor, transcriptional regulatory networks, environmental cues, thymus development, immune surveillance
MeSH terms
Intraepithelial Lymphocytes, Animals, Cell Differentiation, Immunity, Innate, Thymus Gland, Signal Transduction, Cytokines, Receptors, Antigen, T-Cell, gamma-delta, Cell Lineage, Mice, Gene Regulatory Networks

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