The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.
Dendritic Cells and Their Role in Immunotherapy
Open accessAbstract
Despite significant advances in the field of cancer immunotherapy, the majority of patients still do not benefit from treatment and must rely on traditional therapies. Dendritic cells have long been a focus of cancer immunotherapy due to their role in inducing protective adaptive immunity, but cancer vaccines have shown limited efficacy in the past. With the advent of immune checkpoint blockade and the ability to identify patient-specific neoantigens, new vaccines, and combinatorial therapies are being evaluated in the clinic. Dendritic cells are also emerging as critical regulators of the immune response within tumors. Understanding how to augment the function of these intratumoral dendritic cells could offer new approaches to enhance immunotherapy, in addition to improving the cytotoxic and targeted therapies that are partially dependent upon a robust immune response for their efficacy. Here we will discuss the role of specific dendritic cell subsets in regulating the anti-tumor immune response, as well as the current status of dendritic cell-based immunotherapies, in order to provide an overview for future lines of research and clinical trials.
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Cites
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Cited by
Lu, P., Ruan, D., Huang, M., Tian, M., Zhu, K., Gan, Z., & Xiao, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01852-x · Cited by 667
Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
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JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens
Hu, Q., Bian, Q., Rong, D., Wang, L., Song, J., Huang, H.-S., Zeng, J., Mei, J., & Wang, P.-Y. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1110765 · Cited by 339
Hydrogen sulfide: An endogenous regulator of the immune system
Dilek, N., Papapetropoulos, A., Toliver-Kinsky, T., & Szabo, C. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105119 · Cited by 292
Liu, J., Liu, Z., Pang, Y., & Zhou, H. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01343-7 · Cited by 219
Metadata
- Authors
- Gardner, A., de Mingo Pulido, Á., & Ruffell, B.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2020-05-21
- Volume
- 11
- Pages
- 924-924
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W3028510355
- Cited by
- 485
- References
- 150
- FWCI
- 19.00
- Type
- journal article
- Language
- en
- Open access
- gold
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