The DOI matches its Crossref record; 201 of the 203 references it cites were found in a registry or an index.
Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint
Open accessAbstract
Growth/differentiation factor-15 (GDF-15), also named macrophage inhibitory cytokine-1, is a divergent member of the transforming growth factor β superfamily. While physiological expression is barely detectable in most somatic tissues in humans, GDF-15 is abundant in placenta. Elsewhere, GDF-15 is often induced under stress conditions, seemingly to maintain cell and tissue homeostasis; however, a moderate increase in GDF-15 blood levels is observed with age. Highly elevated GDF-15 levels are mostly linked to pathological conditions including inflammation, myocardial ischemia, and notably cancer. GDF-15 has thus been widely explored as a biomarker for disease prognosis. Mechanistically, induction of anorexia via the brainstem-restricted GDF-15 receptor GFRAL (glial cell-derived neurotrophic factor [GDNF] family receptor α-like) is well-documented. GDF-15 and GFRAL have thus become attractive targets for metabolic intervention. Still, several GDF-15 mediated effects (including its physiological role in pregnancy) are difficult to explain via the described pathway. Hence, there is a clear need to better understand non-metabolic effects of GDF-15. With particular emphasis on its immunomodulatory potential this review discusses the roles of GDF-15 in pregnancy and in pathological conditions including myocardial infarction, autoimmune disease, and specifically cancer. Importantly, the strong predictive value of GDF-15 as biomarker may plausibly be linked to its immune-regulatory function. The described associations and mechanistic data support the hypothesis that GDF-15 acts as immune checkpoint and is thus an emerging target for cancer immunotherapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Elevated levels of GDF15 have been linked to tumor growth and poor prognosis in cancer patients raising the question as to whether GDF15 serves as a tumor suppressor or promoter and a target for the treatment of cancer (84, 85, 99).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [85]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455
Tissue-based map of the human proteome
Uhlén, M., Fagerberg, L., Hallström, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A., Sivertsson, Å., Kampf, C., Sjöstedt, E., Asplund, A., et al. (2015) · Science · doi:10.1126/science.1260419 · Cited by 15,286
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160
Oncology meets immunology: the cancer-immunity cycle.
Chen, D. S., & Mellman, I. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.012 · Cited by 6,929
PD-1 blockade induces responses by inhibiting adaptive immune resistance
Tumeh, P. C., Harview, C. L., Yearley, J. H., Shintaku, I. P., Taylor, E. J. M., Robert, L., Chmielowski, B., Spasic, M., Henry, G., Ciobanu, V., et al. (2014) · Nature · doi:10.1038/nature13954 · Cited by 6,609
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pagès, C., Tosolini, M., Camus, M., Berger, A., Wind, P., et al. (2006) · Science · doi:10.1126/science.1129139 · Cited by 6,516
Self-citationCancer immunoediting: from immunosurveillance to tumor escape
Dunn, G. P., Bruce, A. T., Ikeda, H., Old, L. J., & Schreiber, R. D. (2002) · Nature Immunology · doi:10.1038/ni1102-991 · Cited by 5,393
Elements of cancer immunity and the cancer–immune set point
Chen, D. S., & Mellman, I. (2017) · Nature · doi:10.1038/nature21349 · Cited by 5,352
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
A pathology atlas of the human cancer transcriptome
Uhlen, M., Zhang, C., Lee, S., Sjöstedt, E., Fagerberg, L., Bidkhori, G., Benfeitas, R., Arif, M., Liu, Z., Edfors, F., et al. (2017) · Science · doi:10.1126/science.aan2507 · Cited by 3,371
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
Havel, J. J., Chowell, D., & Chan, T. A. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0116-x · Cited by 2,286
The immune contexture in cancer prognosis and treatment
Fridman, W. H., Zitvogel, L., Sautès–Fridman, C., & Kroemer, G. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.101 · Cited by 2,263
Self-citationNishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230
The metabolic signature of macrophage responses
Viola, A., Munari, F., Sánchez-Rodríguez, R., Scolaro, T., & Castegna, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01462 · Cited by 2,021
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
Gubin, M. M., Zhang, X., Schuster, H., Caron, E., Ward, J. P., Noguchi, T., Ivanova, Y., Hundal, J., Arthur, C. D., Krebber, W.-J., et al. (2014) · Nature · doi:10.1038/nature13988 · Cited by 1,974
Tertiary lymphoid structures in the era of cancer immunotherapy
Sautès-Fridman, C., Petitprez, F., Calderaro, J., & Fridman, W. H. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0144-6 · Cited by 1,884
Self-citationProceedings of the 8th Workshop on Programming Languages and Operating Systems
Lu, S., California, S. '. A. S. 2. S. O. O. S. P. 2. M., Association for Computing Machinery-Digital Library, ACM Special Interest Group on Operating Systems, & SIGs, A. (2015) · doi:10.1145/2818302 · Cited by 1,629
Clonal replacement of tumor-specific T cells following PD-1 blockade
Yost, K. E., Satpathy, A. T., Wells, D. K., Qi, Y., Wang, C., Kageyama, R., McNamara, K. L., Granja, J. M., Sarin, K. Y., Brown, R. A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0522-3 · Cited by 1,534
Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis
Wu, D., Molofsky, A. B., Liang, H.-E., Ricardo-González, R. R., Jouihan, H. A., Bando, J. K., Chawla, A., & Locksley, R. M. (2011) · Science · doi:10.1126/science.1201475 · Cited by 1,411
Melief, C. J. M., van Hall, T., Arens, R., OSSENDORP, F. A., & van der Burg, S. H. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80009 · Cited by 1,192
MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily
Bootcov, M. R., Bauskin, A. R., Valenzuela, S. M., Moore, A. G., Bansal, M., He, X. Y., Zhang, H. P., Donnellan, M., Mahler, S. M., Pryor, K., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11514 · Cited by 1,180
Cold Tumors: A Therapeutic Challenge for Immunotherapy
Bonaventura, P., Shekarian, T., Alcazer, V., Valladeau‐Guilemond, J., Valsesia‐Wittmann, S., Amigorena, S., Caux, C., & Depil, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00168 · Cited by 1,140
TOX is a critical regulator of tumour-specific T cell differentiation
Scott, A. C., Dündar, F., Zumbo, P., Chandran, S. S., Klebanoff, C. A., Shakiba, M., Trivedi, P., Menocal, L., Appleby, H., Camara, S., et al. (2019) · Nature · doi:10.1038/s41586-019-1324-y · Cited by 1,106
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
Mullican, S. E., Lin-Schmidt, X., Chin, C.-N., Chavez, J. A., Furman, J. L., Armstrong, A. A., Beck, S. C., South, V. J., Dinh, T. Q., Cash-Mason, T. D., et al. (2017) · Nature Medicine · doi:10.1038/nm.4392 · Cited by 774
Control of Metastasis by NK Cells
López‐Soto, A., Gonzalez, S. R., Smyth, M. J., & Galluzzi, L. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.06.009 · Cited by 744
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
Emmerson, P. J., Wang, F., Du, Y., Liu, Q., Pickard, R. T., Gonciarz, M. D., Coskun, T., Hamang, M. J., Sindelar, D. K., Ballman, K. K., et al. (2017) · Nature Medicine · doi:10.1038/nm.4393 · Cited by 675
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
Yang, L., Chang, C.-C., Sun, Z., Madsen, D., Zhu, H., Padkjær, S. B., Wu, X., Huang, T., Hultman, K., Paulsen, S. J., et al. (2017) · Nature Medicine · doi:10.1038/nm.4394 · Cited by 668
Regulation of metabolism by the innate immune system
Lackey, D. E., & Olefsky, J. M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.189 · Cited by 667
Kempf, T., Eden, M., Strelau, J., Naguib, M., Willenbockel, C., Tongers, J., Heineke, J., Kotlarz, D., Xu, J., Molkentin, J. D., et al. (2006) · Circulation Research · doi:10.1161/01.res.0000202805.73038.48 · Cited by 651
Comparison of Biomarker Modalities for Predicting Response to PD-1/PD-L1 Checkpoint Blockade
Lu, S., Stein, J. E., Rimm, D. L., Wang, D. W., Bell, M. A., Johnson, D. B., Sosman, J. A., Schalper, K. A., Anders, R. A., Wang, H., et al. (2019) · JAMA Oncology · doi:10.1001/jamaoncol.2019.1549 · Cited by 627
Non-Homeostatic Body Weight Regulation Through a Brainstem-Restricted Receptor for GDF15
Hsu, J.-Y., Crawley, S., Chen, M., Ayupova, D. A., Lindhout, D. A., Higbee, J., Kutach, A., Joo, W., Gao, Z., Fu, D., et al. (2017) · Nature · doi:10.1038/nature24042 · Cited by 616
Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1
Johnen, H., Lin, S., Kuffner, T., Brown, D. A., Tsai, V. W.-W., Bauskin, A. R., Wu, L., Pankhurst, G., Jiang, L., Junankar, S., et al. (2007) · Nature Medicine · doi:10.1038/nm1677 · Cited by 612
GDF15 mediates the effects of metformin on body weight and energy balance
Coll, A. P., Chen, M., Taskar, P., Rimmington, D., Patel, S., Tadross, J. A., Cimino, I., Yang, M., Welsh, P., Virtue, S., et al. (2020) · Nature · doi:10.1038/s41586-019-1911-y · Cited by 584
Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation
Wang, A., Huen, S. C., Luan, H. H., Yu, S., Zhang, C., Gallezot, J.-D., Booth, C. J., & Medzhitov, R. (2016) · Cell · doi:10.1016/j.cell.2016.07.026 · Cited by 579
Perforin and interferon-γ activities independently control tumor initiation, growth, and metastasis
Street, S. E. A., Cretney, E., & Smyth, M. J. (2001) · Blood · doi:10.1182/blood.v97.1.192 · Cited by 573
GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance
Luan, H. H., Wang, A., Hilliard, B. K., Carvalho, F., Rosen, C. E., Ahasic, A. M., Herzog, E. L., Kang, I., Pisani, M. A., Yu, S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.033 · Cited by 527
Kempf, T., Zarbock, A., Widera, C., Butz, S., Stadtmann, A., Rossaint, J., Bolomini-Vittori, M., Korf-Klingebiel, M., Napp, L. C., Hansen, B., et al. (2011) · Nature Medicine · doi:10.1038/nm.2354 · Cited by 518
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans
Patel, S., Alvarez-Guaita, A., Melvin, A., Rimmington, D., Dattilo, A., Miedzybrodzka, E. L., Cimino, I., Maurin, A.-C., Roberts, G. P., Meek, C. L., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.016 · Cited by 509 · cited 2×
“A recent report on pharmacological GDF-15 administration to mice, which triggered conditioned taste aversion, also links GDF-15 more closely to anorexia than to cachexia and muscle wasting (33).”
BackgroundLarge-Scale Delineation of Secreted Protein Biomarkers Overexpressed in Cancer Tissue and Serum
Welsh, J. B., Sapinoso, L. M., Kern, S. G., Brown, D. A., Liu, T., Bauskin, A. R., Ward, R. L., Hawkins, N. J., Quinn, D. I., Russell, P. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530278100 · Cited by 503
Xu, J., Kimball, T. R., Lorenz, J. N., Brown, D. A., Bauskin, A. R., Klevitsky, R., Hewett, T. E., Breit, S. N., & Molkentin, J. D. (2006) · Circulation Research · doi:10.1161/01.res.0000202804.84885.d0 · Cited by 502
Adela, R., & Banerjee, S. K. (2015) · Journal of Diabetes Research · doi:10.1155/2015/490842 · Cited by 474
Tsai, V. W.-W., Husaini, Y., Sainsbury, A., Brown, D. A., & Breit, S. N. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.018 · Cited by 424
Grönberg, H., Adolfsson, J., Aly, M., Nordström, T., Wiklund, P. N., Brandberg, Y., Thompson, J., Wiklund, F. E., Lindberg, J., Clements, M., et al. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00361-7 · Cited by 410
The Immunoscore: Colon Cancer and Beyond
Angell, H. K., Bruni, D., Barrett, J. C., Herbst, R., & Galon, J. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1851 · Cited by 397
Integrin inside-out signaling and the immunological synapse
Springer, T. A., & Dustin, M. L. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.10.004 · Cited by 392
Hsiao, E. C., Koniaris, L. G., Zimmers-Koniaris, T., Sebald, S. M., Huynh, T. V., & Lee, S.-J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3742-3751.2000 · Cited by 302
Macrophage inhibitory cytokine‐1 (MIC‐1/GDF15): a new marker of all‐cause mortality
Wiklund, F. E., Bennet, A. M., Magnusson, P. K. E., Eriksson, U. K., Lindmark, F., Wu, L., Yaghoutyfam, N., Marquis, C. P., Stattin, P. E., Pedersen, N. L., et al. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00629.x · Cited by 292
MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma.
Brown, D. A., Ward, R. L., Buckhaults, P., Liu, T., Romans, K. E., Hawkins, N. J., Bauskin, A. R., Kinzler, K. W., Vogelstein, B., & Breit, S. N. (2003) · PubMed · Cited by 265
Senovilla, L., Vacchelli, E., Galon, J., Adjemian, S., Eggermont, A. M. M., Fridman, W. H., Sautès‐Fridman, C., Ma, Y., Tartour, É., Zitvogel, L., et al. (2012) · OncoImmunology · doi:10.4161/onci.22009 · Cited by 254
Self-citationNAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism
Chrysovergis, K., Wang, X., Kosak, J., Lee, S.-H., Kim, J. S., Foley, J. F., Travlos, G., Singh, S., Baek, S. J., & Eling, T. E. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.27 · Cited by 241
Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys
Xiong, Y., Walker, K., Min, X., Hale, C., Tran, T., Komorowski, R., Yang, J., Davda, J., Nuanmanee, N., Kemp, D., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aan8732 · Cited by 236
PLAB, a novel placental bone morphogenetic protein
Hromas, R., Hufford, M. B., Sutton, J., Xu, D., Li, Y., & Lu, L. (1997) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(97)00122-x · Cited by 233
Becht, É., Giraldo, N. A., Germain, C., de Reyniès, A., Laurent‐Puig, P., Zucman‐Rossi, J., Dieu‐Nosjean, M., Sautès‐Fridman, C., & Fridman, W. H. (2016) · Advances in immunology · doi:10.1016/bs.ai.2015.12.002 · Cited by 224
Self-citationLi, S., Ma, Y., Zheng, P., & Zhang, P. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0744-0 · Cited by 214
Mimeault, M., & Batra, S. K. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22196 · Cited by 211
Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta
Lawton, L. N., Bonaldo, M. F., Jelenc, P. C., Qiu, L., Baumes, S. A., Marcelino, R. A., de Jesus, G. M., Wellington, S., Knowles, J. A., Warburton, D., et al. (1997) · Gene · doi:10.1016/s0378-1119(97)00485-x · Cited by 209
Lerner, L., Hayes, T. G., Tao, N., Krieger, B., Feng, B., Wu, Z., Nicoletti, R., Chiu, M. I., Gyuris, J., & Garcia, J. M. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12033 · Cited by 208
Moore, A. G., Brown, D. A., Fairlie, W. D., Bauskin, A. R., Brown, P. K., Munier, M. L. C., Russell, P. K., Salamonsen, L. A., Wallace, E. M., & Breit, S. N. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7007 · Cited by 206
Appetite regulation: from the gut to the hypothalamus
Neary, N. M., Goldstone, A. P., & Bloom, S. R. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01839.x · Cited by 203
Zimmers, T. A., Jin, X., Hsiao, E. C., McGrath, S. A., Esquela, A. F., & Koniaris, L. G. (2005) · PubMed · Cited by 199
MAP3K11/GDF15 axis is a critical driver of cancer cachexia
Lerner, L. R., Tao, J., Liu, Q., Nicoletti, R., Feng, B., Krieger, B., Mazsa, E. K., Siddiquee, Z., Wang, R., Huang, L., et al. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12077 · Cited by 199
Komiya, T., & Huang, C. H. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00423 · Cited by 193
GDF-15 Contributes to Proliferation and Immune Escape of Malignant Gliomas
Roth, P., Junker, M., Tritschler, I., Mittelbronn, M. G. A., Dombrowski, Y., Breit, S. N., Tabatabai, G., Wick, W., Weller, M., & Wischhusen, J. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0705 · Cited by 177
Self-citationKempf, T., Guba-Quint, A., Torgerson, J., Magnone, M. C., Haefliger, C., Bobadilla, M., & Wollert, K. C. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0466 · Cited by 176
Baek, S. J., Okazaki, R., Lee, S.-H., Martinez, J., Kim, J.-S., Yamaguchi, K., Mishina, Y., Martin, D. W., Shoieb, A., Mcentee, M. F., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.09.015 · Cited by 175
Reduced oxidative capacity in macrophages results in systemic insulin resistance
Jung, S.-B., Choi, M. J., Ryu, D., Yi, H., Lee, S. E., Chang, J. Y., Chung, H. K., Kim, Y. K., Kang, S., Lee, J. H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03998-z · Cited by 174
NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development
Ratnam, N. M., Peterson, J. M., Talbert, E. E., Ladner, K. J., Rajasekera, P. V., Schmidt, C. R., Dillhoff, M. E., Swanson, B. J., Haverick, E. N., Kladney, R. D., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci91561 · Cited by 173
GDF15 promotes EMT and metastasis in colorectal cancer
Li, C., Wang, J., Kong, J., Tang, J., Wu, Y., Xu, E., Zhang, H., & Lai, M. (2015) · Oncotarget · doi:10.18632/oncotarget.6205 · Cited by 170
GDF15, a Cardioprotective TGF-β Superfamily Protein
Ago, T., & Sadoshima, J. (2006) · Circulation Research · doi:10.1161/01.res.0000207919.83894.9d · Cited by 166
Macrophage Inhibitory Cytokine 1: A New Prognostic Marker in Prostate Cancer
Brown, D. A., Lindmark, F., Stattin, P. E., Bälter, K. A., Adami, H., Zheng, S. L., Xu, J., Isaacs, W. B., Grönberg, H., Breit, S. N., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-3126 · Cited by 152
Böttner, M., Laaff, M., Schechinger, B., Rappold, G., Unsicker, K., & Suter-Crazzolara, C. (1999) · Gene · doi:10.1016/s0378-1119(99)00309-1 · Cited by 144
Helical transformations of Salmonella flagella in vitro
Kamiya, R., & Asakura, S. (1976) · Journal of Molecular Biology · doi:10.1016/0022-2836(76)90306-5 · Cited by 141
Supercharging adoptive T cell therapy to overcome solid tumor–induced immunosuppression
Mardiana, S., Solomon, B., Darcy, P. K., & Beavis, P. A. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw2293 · Cited by 140
Tsai, V. W.-W., Manandhar, R., Jørgensen, S. B., Lee-Ng, K. K. M., Zhang, H. P., Marquis, C. P., Jiang, L., Husaini, Y., Lin, S., Sainsbury, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100370 · Cited by 129
Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15
Bruzzese, F., Hägglöf, C., Leone, A., Sjöberg, E., Roca, M. S., Kiflemariam, S., Sjöblom, T., Hammarsten, P., Egevad, L., Bergh, A., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2259 · Cited by 127
Uniting GDF15 and GFRAL: Therapeutic Opportunities in Obesity and Beyond
Mullican, S. E., & Rangwala, S. M. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2018.05.002 · Cited by 127
Progressive Postnatal Motoneuron Loss in Mice Lacking GDF-15
Strelau, J., Strzelczyk, A., Rusu, P. M., Bendner, G., Wiese, S., Diella, F., Altick, A. L., von Bartheld, C. S., Klein, R., Sendtner, M., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1133-09.2009 · Cited by 126
Bilen, M. A., Shabto, J. M., Martini, D. J., Liu, Y., Lewis, C. M., Collins, H., Akce, M., Kissick, H. T., Carthon, B. C., Shaib, W. L., et al. (2019) · BMC Cancer · doi:10.1186/s12885-019-6073-7 · Cited by 126
Senapati, S., Rachagani, S., Chaudhary, K. R., Johansson, S. L., Singh, R. K., & Batra, S. K. (2009) · Oncogene · doi:10.1038/onc.2009.420 · Cited by 123
H6D Polymorphism in Macrophage-Inhibitory Cytokine-1 Gene Associated With Prostate Cancer
Lindmark, F., Zheng, S. L., Wiklund, F. E., Bensen, J. T., Bälter, K. A., Chang, B., Hedelin, M., Clark, J., Stattin, P., Meyers, D. A., et al. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh227 · Cited by 120
Kim, K.-K., Lee, J. J., Yang, Y. D., You, K., & Lee, J. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn031 · Cited by 119
Nakayasu, E. S., Syed, F., Tersey, S. A., Gritsenko, M. A., Mitchell, H. D., Chan, C. Y., Dirice, E., Turatsinze, J., Cui, Y., Kulkarni, R., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.12.005 · Cited by 116
Growth differentiation factor-15 as a prognostic biomarker in ovarian cancer
Staff, A. C., Bock, A. J., Becker, C., Kempf, T., Wollert, K. C., & Davidson, B. (2010) · Gynecologic Oncology · doi:10.1016/j.ygyno.2010.05.032 · Cited by 115
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
Jy, H., Crawley, S., Chen, M., Ayupova, D. A., Lindhout, D. A., Higbee, J., Kutach, A. K., Joo, W. J., Gao, Z., Fu, D., et al. (2018) · Yearbook of pediatric endocrinology · doi:10.1530/ey.15.15.8 · Cited by 113
Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage
Tong, S. Y. C., Marjono, B., Brown, D. A., Mulvey, S., Breit, S. N., Manuelpillai, U., & Wallace, E. M. (2004) · The Lancet · doi:10.1016/s0140-6736(03)15265-8 · Cited by 112
Growth differentiation factor 15: a prognostic marker for recurrence in colorectal cancer
Wallin, U., Glimelius, B. L. G., Jirström, K., Darmanis, S., Nong, R. Y., Pontén, F., Johansson, C., Påhlman, L., & Birgisson, H. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.112 · Cited by 111
GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury
Chung, H. K., Kim, J. T., Kim, H.-W., Kwon, M., Kim, S. Y., Shong, M., Kim, K. S., & Yi, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-17574-w · Cited by 111
GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis
Zhang, Y., Jiang, M., Nouraie, M. S., Roth, M. G., Tabib, T., Winters, S. A., Chen, X., Sembrat, J., Chu, Y., Cárdenes, N., et al. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00062.2019 · Cited by 111
Artz, A., Butz, S., & Vestweber, D. (2016) · Blood · doi:10.1182/blood-2016-01-696617 · Cited by 110
Bao, X., Borné, Y., Muhammad, I. F., Nilsson, J. Å., Lind, L., Melander, O., Niu, K., Orho‐Melander, M., & Engström, G. (2018) · Diabetologia · doi:10.1007/s00125-018-4751-7 · Cited by 110
Boyle, G. M., Pedley, J., Martyn, A. C., Banducci, K., Strutton, G., Brown, D. A., Breit, S. N., & Parsons, P. G. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.270 · Cited by 109
Tsai, V. W.-W., Lin, S., Brown, D. A., Salis, A., & Breit, S. N. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.242 · Cited by 109
Liu, X., Chi, X., Gong, Q., Gao, L., Niu, Y., Chi, X., Cheng, M., Si, Y., Wang, M., Zhong, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127518 · Cited by 108
Corre, J., Labat, E., Espagnolle, N., Hébraud, B., Avet‐Loiseau, H., Roussel, M., Huynh, A., Gadelorge, M., Cordelier, P., Klein, B., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-0188 · Cited by 106
Shnaper, S., Desbaillets, I., Brown, D. A., Murat, A., Migliavacca, E., Schluep, M., Ostermann, S., Hamou, M., Stupp, R., Breit, S. N., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.24639 · Cited by 100
Liu, Q., Tong, D., Liu, G., Gao, J., Wang, L.-A., Xu, J., Yang, X., Xie, Q., Huang, Y., Pang, J., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0420 · Cited by 100
A Prospective Study of Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) and Risk of Colorectal Cancer
Mehta, R. S., Song, M., Bezawada, N., Wu, K., García‐Albéniz, X., Morikawa, T., Fuchs, C. S., Ogino, S., Giovannucci, E. L., & Chan, A. T. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju016 · Cited by 98
Abulizi, P., Loganathan, N., Zhao, D., Mele, T. S., Zhang, Y., Zwiep, T., Liu, K., & Zheng, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-00902-5 · Cited by 97
GDF15 deficiency promotes high fat diet-induced obesity in mice
Tran, T., Yang, J. O., Gardner, J., & Xiong, Y. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201584 · Cited by 97
TGF-β contamination of purified recombinant GDF15
Olsen, O. E., Skjærvik, A., Størdal, B., Sundan, A., & Holien, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187349 · Cited by 95
Yamaguchi, K., Lee, S., Eling, T. E., & Baek, S. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408796200 · Cited by 94
Selander, K. S., Brown, D. A., Sequeiros, G. B., Hunter, M. I., Desmond, R. A., Parpala, T. M., Risteli, J., Breit, S. N., & Jukkola‐Vuorinen, A. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0841 · Cited by 93
NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway
Min, K.-W., Liggett, J. L., SILVA, G. H. D. O., Wu, W., Wang, R., Shen, R.-F., Eling, T. E., & Baek, S. J. (2015) · Oncogene · doi:10.1038/onc.2015.95 · Cited by 90
Yang, C., Ma, J., Zhu, D., Liu, Y., Montgomery, B. K., Wang, L. Z., Li, J., Zhang, Z. Y., Zhang, C. P., & Zhong, L. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu120 · Cited by 87
Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15
Jones, J. E., Cadena, S. M., Gong, C., Wang, X., Chen, Z., Wang, S. X., Vickers, C., Chen, H., Lach‐Trifilieff, E., Hadcock, J. R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.044 · Cited by 87
Diabetes mellitus related biomarker: The predictive role of growth-differentiation factor-15
Berezin, A. Е. (2015) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2015.09.016 · Cited by 84
Zhou, Z., Li, W., Song, Y., Wang, L., Zhang, K., Yang, J., Zhang, W., Su, H., & Zhang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078618 · Cited by 82
Tanno, T., Lim, Y., Wang, Q., Chesi, M., Bergsagel, P. L., Matthews, G., Johnstone, R. W., Ghosh, N., Borrello, I., Huff, C. A., et al. (2013) · Blood · doi:10.1182/blood-2013-08-524025 · Cited by 82
Targeting Obesity and Cachexia: Identification of the GFRAL Receptor–MIC-1/GDF15 Pathway
Breit, S. N., Tsai, V. W.-W., & Brown, D. A. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.10.005 · Cited by 81
Zhang, Y., Zhang, G., Liu, Y., Chen, R., Zhao, D., McAlister, V. C., Mele, T. S., Liu, K., & Zheng, X. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02407 · Cited by 81
Innate and acquired immune surveillance in the postdissemination phase of metastasis
Velozo, H. G., Robles, I., & Werb, Z. (2017) · FEBS Journal · doi:10.1111/febs.14325 · Cited by 78
Staff, A. C., Trovik, J., Zahl, E. A. G., Wik, E., Wollert, K. C., Kempf, T., & Salvesen, H. B. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0715 · Cited by 77
Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality
Fejzo, M. S., Fasching, P. A., Schneider, M. O., Schwitulla, J., Beckmann, M. W., Schwenke, E., MacGibbon, K., & Mullin, P. (2019) · Geburtshilfe und Frauenheilkunde · doi:10.1055/a-0830-1346 · Cited by 75
Shah, A. H., Tabayoyong, W., KUNDU, S. D., Kim, S. J., Parijs, L. V., Liu, V. C., Kwon, E. D., Greenberg, N. M., & Lee, C. (2002) · PubMed · Cited by 74
Chen, S.-J., Karan, D., Johansson, S. L., Lin, F., Zeckser, J. M., Singh, A. P., Batra, S. K., & Lin, M. (2007) · The Prostate · doi:10.1002/pros.20551 · Cited by 74
NAG-1/GDF15 Transgenic Mouse Has Less White Adipose Tissue and a Reduced Inflammatory Response
Kim, J. K., Kosak, J. P., Kim, J. K., Kissling, G. E., Germolec, D. R., Zeldin, D. C., Bradbury, J. A., Baek, S. J., & Eling, T. E. (2013) · Mediators of Inflammation · doi:10.1155/2013/641851 · Cited by 72
Westhrin, M., Moen, S. H., Holien, T., Mylin, A. K., Heickendorff, L., Olsen, O. E., Sundan, A., Turesson, I., Gimsing, P., Waage, A., et al. (2015) · Haematologica · doi:10.3324/haematol.2015.124511 · Cited by 72
Joshi, J. P., Brown, N. E., Griner, S. E., & Nahta, R. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.082 · Cited by 71
Husaini, Y., Qiu, M. R., Lockwood, G. P., Luo, X. W., Shang, P., Kuffner, T., Tsai, V. W.-W., Jiang, L., Russell, P. J., Brown, D. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043833 · Cited by 70
Bauskin, A. R., Jiang, L., Luo, X., Wu, L., Brown, D. A., & Breit, S. N. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2009.0052 · Cited by 70
Peake, B. F., Eze, S. M., Yang, L. P. H., Castellino, R. C., & Nahta, R. (2017) · Oncotarget · doi:10.18632/oncotarget.21765 · Cited by 68
Cekanova, M., Lee, S., Donnell, R. L., Sukhthankar, M., Eling, T. E., Fischer, S. M., & Baek, S. J. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0057 · Cited by 67
Li, C., Wang, X., Casal, J. I., Wang, J., Li, P., Zhang, W., Xu, E., Lai, M., & Zhang, H. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12830 · Cited by 66
Griner, S. E., Joshi, J. P., & Nahta, R. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.10.007 · Cited by 65
Lee, S. E., Kang, S., Choi, M. J., Jung, S.-B., Ryu, M. J., Chung, H. K., Chang, J. Y., Kim, Y. K., Lee, J. H., Kim, K. S., et al. (2017) · Diabetes · doi:10.2337/db17-0333 · Cited by 65
Xu, Q., Xu, H., Li, J., Wang, S., Fu, Z., Jia, J., Wang, L., Zhu, Z., Lu, R., & Yao, Z. (2017) · Oncotarget · doi:10.18632/oncotarget.15216 · Cited by 64
Identification, expression and functional characterization of the GRAL gene
Li, Z., Wang, B., Wu, X., Cheng, S., Paraoan, L., & Zhou, J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03372.x · Cited by 63
YAP promotes breast cancer metastasis by repressing growth differentiation factor-15
Wang, T., Mao, B., Cheng, C., Zou, Z., Gao, J., Yang, Y., Lei, T., Qi, X., Yuan, Z., Xu, W., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.02.020 · Cited by 63
Blanchette-Farra, N., Kita, D., Konstorum, A., Tesfay, L., Lemler, D. J., Hegde, P., Claffey, K. P., Torti, F. M., & Torti, S. V. (2018) · Oncogene · doi:10.1038/s41388-018-0243-y · Cited by 63
Li, Y.-L., Chang, J., Lee, L., Fan, K., Li, Y., Li, Y., Chiang, C.-H., You, G.-R., Chen, H.-Y., & Cheng, A. (2016) · Oncotarget · doi:10.18632/oncotarget.13649 · Cited by 62
Si, Y., Liu, X., Cheng, M., Wang, M., Gong, Q., Yang, Y., Wang, T., & Yang, W. Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019967 · Cited by 59
Ko, J. K.-S. (2009) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000267 · Cited by 59
Growth Differentiation Factor 15 Maturation Requires Proteolytic Cleavage by PCSK3, -5, and -6
Li, J. J., Liu, J., Lupino, K., Liu, X., Zhang, L., & Pei, L. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00249-18 · Cited by 59
Freeman, C. M., Martinez, C. H., Todt, J. C., Martínez, F. J., Han, M. K., Thompson, D. L., McCloskey, L., & Curtis, J. L. (2015) · Respiratory Research · doi:10.1186/s12931-015-0251-1 · Cited by 58
P38 MAPK Contributes to Resistance and Invasiveness of HER2- Overexpressing Breast Cancer
Donnelly, S.-M., Paplomata, E., Peake, B. M., Sanabria, E., Chen, Z., & Nahta, R. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867320666131119155023 · Cited by 56
Mehta, R. S., Chong, D. Q., Song, M., Meyerhardt, J. A., Ng, K., Nishihara, R., Qian, Z., Morikawa, T., Wu, K., Giovannucci, E. L., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.038 · Cited by 54
Wang, X., Yang, Z., Tian, H.-M., Li, Y., Li, M., Zhao, W., Zhang, C., Wang, T., Liu, J., Zhang, A., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15279 · Cited by 54
Macrophage Inhibitory Cytokine-1 Regulates Melanoma Vascular Development
Huh, S. J., Chung, C.-Y., Sharma, A. K., & Robertson, G. P. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090963 · Cited by 53
GDF 15 as an anti-apoptotic, diagnostic and prognostic marker in oral squamous cell carcinoma
Schiegnitz, E., Kämmerer, P. W., Koch, F. P., Krüger, M., Berres, M., & Al‐Nawas, B. (2012) · Oral Oncology · doi:10.1016/j.oraloncology.2012.01.020 · Cited by 53
Guénancia, C., Kahli, A., Laurent, G., Hachet, O., Malapert, G., Grosjean, S. A., Girard, C., Vergely, C., & Bouchot, O. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.06.012 · Cited by 51
Borner, T., Arnold, M., Ruud, J., Breit, S. N., Langhans, W., Lutz, T. A., Blomqvist, A. G., & Riediger, T. (2016) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12169 · Cited by 50
Ulirsch, J. C., Lacy, J. N., An, X., Mohandas, N., Mikkelsen, T. S., & Sankaran, V. G. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004890 · Cited by 49
Control of glioma cell migration and invasiveness by GDF-15
Codó, P., Weller, M., Kaulich, K., Schraivogel, D., Silginer, M., Reifenberger, G., Meister, G., & Roth, P. (2016) · Oncotarget · doi:10.18632/oncotarget.6816 · Cited by 49
An Automated Assay for Growth Differentiation Factor 15
Wollert, K. C., Kempf, T., Giannitsis, E., Bertsch, T., Braun, S., Maier, H., Reim, M., & Christenson, R. H. (2017) · The Journal of Applied Laboratory Medicine · doi:10.1373/jalm.2016.022376 · Cited by 49
Chen, Q., Wang, Y., Zhao, M., Hyett, J. A., Costa, F. D. S., & Nie, G. (2016) · Cytokine · doi:10.1016/j.cyto.2016.05.002 · Cited by 48
Circulating Levels of GDF15, MMP7 and miR-200c as a Poor Prognostic Signature in Gastric Cancer
Blanco, M., Tarrío, N., Reboredo, M., Haz‐Conde, M., García, J., Quindós, M., Figueroa, A., Antón-Aparicio, L. M., Calvo, L., & Valladares‐Ayerbes, M. (2014) · Future Oncology · doi:10.2217/fon.13.263 · Cited by 47
Weide, B., Schäfer, T., Martens, A., Kuzkina, A., Uder, L., Noor, S., Garbe, C., Harter, P. N., Mittelbronn, M. G. A., & Wischhusen, J. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.07.016 · Cited by 47
Self-citationWang, X., Jiang, X., Yu, X., Wang, L., He, S., Feng, F., Guo, L., Jiang, W. B., & Lu, S. (2013) · Cancer Science · doi:10.1111/cas.12331 · Cited by 46
Shin, D. Y., Kim, G., Kim, N., Jung, J. H., Kim, S., Kang, H. W., & Choi, Y. H. (2008) · Oncology Reports · doi:10.3892/or.19.2.517 · Cited by 46
Tsui, K., Chang, Y., Feng, T., Chung, L., Lee, T.-Y., Chang, P., & Juang, H. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-11-0149 · Cited by 46
Prognostic biomarkers for immunotherapy with ipilimumab in metastatic melanoma
Nyakas, M., Aamdal, E., Jacobsen, K. D., Guren, T. K., Aamdal, S., Thorin‐Hagene, K., Brunsvig, P. F., Yndestad, A., Halvorsen, B. L., Taskén, K. A., et al. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13283 · Cited by 46
Vočka, M., Langer, D., Frýba, V., Petrtýl, J., Hanuš, T., Kalousová, M., Zima, T., & Petruzelka, L. B. (2018) · Cancer Biomarkers · doi:10.3233/cbm-170792 · Cited by 43
GDF-15: a novel serum marker for metastases in uveal melanoma patients
Suesskind, D., Schatz, A., Schnichels, S., Coupland, S. E., Lake, S. L., Wissinger, B., Bartz‐Schmidt, K. U., & Henke‐Fahle, S. (2011) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-011-1786-6 · Cited by 42
Lu, Z., Li, Y., Yu, J., Lü, M., Zhang, X., Li, J., Zhou, J., Wang, X., Gong, J., Gao, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088553 · Cited by 42
Upregulation and secretion of macrophage inhibitory cytokine-1 (MIC-1) in gastric cancers
Baek, K. E., Yoon, S. R., Kim, J., Kim, K. S., Kang, S. H., Yang, Y. D., Lim, J., Choi, I., Nam, M. S., Yoon, M., et al. (2008) · Clinica Chimica Acta · doi:10.1016/j.cca.2008.12.008 · Cited by 41
Park, Y.-J., Lee, H., & Lee, J. (2010) · BMB Reports · doi:10.5483/bmbrep.2010.43.2.091 · Cited by 41
Zhao, D., Wang, X., & Zhang, W. (2018) · BMC Cancer · doi:10.1186/s12885-018-4246-4 · Cited by 41
Growth Differentiation Factor 15 and Its Role in Carcinogenesis: An Update
Modi, A., Dwivedi, S., Roy, D., Khokhar, M., Purohit, P., Vishnoi, J., Pareek, P., Sharma, S., Sharma, P., & Misra, S. (2019) · Growth Factors · doi:10.1080/08977194.2019.1685988 · Cited by 41
Kang, S. U., Shin, Y. S., Hwang, H. S., Baek, S. J., Lee, S., & Kim, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034988 · Cited by 40
Lu, X., He, X., Su, J., Wang, J., Liu, X., Xu, K., De, W., Zhang, E., Guo, R., & Shi, Y. E. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.05.016 · Cited by 39
Plasma Inflammatory Markers and Risk of Advanced Colorectal Adenoma in Women
Song, M., Mehta, R. S., Wu, K., Fuchs, C. S., Ogino, S., Giovannucci, E. L., & Chan, A. T. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-15-0307 · Cited by 37
Ji, H. L., Lü, H., Li, Y., LU, L., Wang, J., Zhang, Y., & SHANG, H. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3867 · Cited by 37
Li, S., Wang, Y., Cao, B., Wu, Y., Ji, L., Li, Y.-X., Li, Y., Zhao, Y., Qiao, J., Wang, H., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1598 · Cited by 37
Kido, L. A., Lamas, C. D. A., Maróstica, M. R., & Cagnon, V. H. A. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.12.002 · Cited by 37
Traeger, L., Ellermann, I., Wiethoff, H., Ihbe, J., Gallitz, I., Eveslage, M., Moritz, R., Herrmann, E., Schrader, A. J., & Steinbicker, A. U. (2019) · BMC Cancer · doi:10.1186/s12885-019-5278-0 · Cited by 37
A multiplex immunoassay of serum biomarkers for the detection of uveal melanoma
Song, J., Merbs, S. L., Sokoll, L. J., Chan, D. W., & Zhang, Z. (2019) · Clinical Proteomics · doi:10.1186/s12014-019-9230-8 · Cited by 37
Ishige, T., Nishimura, M., Satoh, M., Fujimoto, M., Fukuyo, M., Semba, T., Kado, S., Tsuchida, S., Sawai, S., Matsushita, K., et al. (2016) · Scientific Reports · doi:10.1038/srep21681 · Cited by 35
Macrophage Inhibitory Cytokine-1 H6D Polymorphism, Prostate Cancer Risk, and Survival
Hayes, V. M., Severi, G., Southey, M. C., Padilla, E. J. D., English, D. R., Hopper, J. L., Giles, G. G., & Sutherland, R. L. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0063 · Cited by 34
Hogendorf, P., Durczyński, A., Skulimowski, A., Kumor, A., Poznańska, G., & Strzelczyk, J. (2017) · Cancer Biomarkers · doi:10.3233/cbm-170203 · Cited by 34
Growth differentiation factor 15 is increased in stable MS
Amstad, A., Coray, M., Frick, C., Barro, C., Oechtering, J., Amann, M., Wischhusen, J., Kappos, L., Naegelin, Y., Kühle, J., et al. (2020) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000675 · Cited by 34
Self-citationReduced expression of GDF‐15 is associated with atrophic inflammatory lesions of the prostate
Lambert, J. R., Whitson, R. J., Iczkowski, K. A., Rosa, F. G. L., Smith, M. L., Wilson, R. S., Smith, E. E., Torkko, K. C., Gari, H. H., & Lucia, M. S. (2014) · The Prostate · doi:10.1002/pros.22911 · Cited by 31
Tanrıkulu, O., Sarıyıldız, M. A., Batmaz, İ., Yazmalar, L., Polat, N., Kaplan, İ., & Çevik, R. (2017) · PubMed · Cited by 31
MIC1/GDF15 as a Bone Metastatic Disease Biomarker
Windrichová, J., Fuchsová, R., Kučera, R., Topolčan, O., Fiala, O., Fínek, J., & Slipkova, D. (2017) · Anticancer Research · doi:10.21873/anticanres.11477 · Cited by 31
Li, J., Veltri, R. W., Yuan, Z., Christudass, C. S., & Mandecki, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122249 · Cited by 30
Kaitu’u‐Lino, T. J., Bambang, K. N., Onwude, J. L., Hiscock, R. J., Konje, J. C., & Tong, S. Y. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072437 · Cited by 30
Schiegnitz, E., Kämmerer, P. W., Rode, K., Schorn, T. F., Brieger, J., & Al‐Nawas, B. (2015) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12323 · Cited by 30
El‐Aziz, S. H. A., Endo, Y., Miyamaori, H., Takino, T., & Sato, H. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00547.x · Cited by 30
GDF15 promotes epithelial-to-mesenchymal transition in colorectal
Zhang, Y., Wang, X., Zhang, M., Zhang, Z., Jiang, L., & Li, L. (2018) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1466146 · Cited by 30
Growth/differentiation factor-15 is an abundant cytokine in human seminal plasma
Souček, K., Slabáková, E., Ovesná, P., Malenovská, A., Kozubı́k, A., & Hampl, A. (2010) · Human Reproduction · doi:10.1093/humrep/deq264 · Cited by 29
CXXC4 activates apoptosis through up-regulating GDF15 in gastric cancer
Han, M., Dai, D., Yousafzai, N. A., Wang, F., Wang, H., Zhou, Q., Lu, H., Xu, W., Feng, L., Jin, H., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21581 · Cited by 29
Muralidharan, A. R., Maddala, R., Skiba, N. P., & Rao, P. V. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20671 · Cited by 27
Liu, Y., Wang, X., Wang, T., Zhang, C., Zhang, K., Zhi, X., Zhang, W., & Sun, K. (2016) · Chinese Medical Journal · doi:10.4103/0366-6999.189052 · Cited by 26
Meier, J. C., Haendler, B., Seidel, H., Groth, P., Adams, R. A., Ziegelbauer, K. B., Kreft, B., Beckmann, G., Sommer, A., & Kopitz, C. (2014) · Cancer Medicine · doi:10.1002/cam4.354 · Cited by 24
Zhang, X., Kang, Y., Huo, T., Tao, R., Wang, X., Li, Z., Guo, Q., & Zhao, L. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.07.011 · Cited by 24
Yang, C., Ma, J., Luo, Q., Neskey, D. M., Zhu, D., Liu, Y., Myers, J. N., Zhang, C., Zhang, Z., & Zhong, L. (2013) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12091 · Cited by 23
Kim, C. H., Kim, M. Y., Moon, J. Y., Hwang, J. W., Lee, S. Y., Joo, Y. M., Han, S. I., Park, H. G., & Kang, H. S. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.02.002 · Cited by 20
Zhang, Y., Hua, W., Niu, L.-C., Li, S., Wang, Y., Shang, L., Zhang, C., Li, W., Wang, R., Chen, B., et al. (2016) · Tumor Biology · doi:10.1007/s13277-015-4699-x · Cited by 20
MIC-1/GDF15 in Barrett’s oesophagus and oesophageal adenocarcinoma
Fisher, O. M., Levert‐Mignon, A., Lord, S. J., Lee-Ng, K. K. M., Botelho, N. K., Falkenback, D., Thomas, M. L., Bobryshev, Y. V., Whiteman, D. C., Brown, D. A., et al. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.100 · Cited by 19
Bansal, N., Kumar, D., Gupta, A. K., Chandra, D., Sankhwar, S. N., & Mandhani, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-17207-2 · Cited by 17
Wang, J., Li, W., Wang, Y., Li, C., Ding, M., Zhang, H., & Lai, M. (2015) · Pathology - Research and Practice · doi:10.1016/j.prp.2015.08.004 · Cited by 16
Kim, K., Park, S., Do, K. H., Kim, J., Choi, K. U., & Moon, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.12355 · Cited by 16
GDF‐15 in solid vs non‐solid treatment‐naïve malignancies
Arfsten, H., Cho, A., Freitag, C., Raderer, M., Goliasch, G., Bartko, P. E., Wurm, R., Strunk, G., Gisslinger, H., Marosi, C., et al. (2019) · European Journal of Clinical Investigation · doi:10.1111/eci.13168 · Cited by 16
Regulation of Systemic Glucose Homeostasis by T Helper Type 2 Cytokines
Kang, Y. E., Kim, H. J., & Shong, M. (2019) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2019.0157 · Cited by 15
Zhang, Y., Hua, W., Niu, L.-C., Li, S., Wang, Y., Shang, L., Zhang, C., Li, W., Wang, R., Chen, B., et al. (2016) · Tumor Biology · doi:10.1007/s13277-016-5008-z · Cited by 14
GDF15 and Hepcidin as Prognostic Factors in Patients with Prostate Cancer
Boegemann, F. J. W. M. (2014) · Journal of Molecular Biomarkers & Diagnosis · doi:10.4172/2155-9929.1000199 · Cited by 12
Engerud, H., Hope, K., Berg, H. F., Fasmer, K. E., Tangen, I. L., Haldorsen, I. S., Trovik, J., & Krakstad, C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210585 · Cited by 9
Stromal Growth Differentiation Factor 15 and Its Association with Ovarian Cancer
de Lima, C. A., Jammal, M. P., Martins-Filho, A., Silveira, T. P., Micheli, D. C., Tavares‐Murta, B. M., Murta, E. F. C., & Nomelini, R. S. (2017) · Gynecologic and Obstetric Investigation · doi:10.1159/000473891 · Cited by 8
Nazarova, N., Chikhirzhina, G. I., & Tuohimaa, P. (2006) · Molecular Biology · doi:10.1134/s0026893306010110 · Cited by 6
Nazarova, N. I., Chikhirzhina, G. I., & Tuohimaaa, P. (2006) · PubMed · Cited by 3
Cited by
Sorted by citations
Wong, N. D., Budoff, M. J., Ferdinand, K. C., Graham, I. M., Michos, E. D., Reddy, T. K., Shapiro, M. D., & Toth, P. P. (2022) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2022.100335 · Cited by 327
Mohammed, I., Hollenberg, M. D., Ding, H., & Triggle, C. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.718942 · Cited by 278
Hepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252
Role of mitochondrial alterations in human cancer progression and cancer immunity
Wang, S., Tseng, L., & Lee, H. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00956-w · Cited by 225
Central nervous system regulation of organismal energy and glucose homeostasis
Myers, M. G., Affinati, A. H., Richardson, N. E., & Schwartz, M. W. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00408-5 · Cited by 165
Metadata
- Authors
- Wischhusen, J., Melero, I., & Fridman, W. H.
- Affiliations
- University of Würzburg (DE)
- Clinica Universidad de Navarra (ES)
- Inserm (FR)
- Corresponding author
- Wischhusen, Jörg
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2020-05-19
- Volume
- 11
- Pages
- 951-951
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC7248355
- OpenAlex
- W3026163675
- Cited by
- 506
- References
- 203
- Citations by year
- 2026: 79 · 2025: 94 · 2024: 112 · 2023: 79 · 2022: 84 · 2021: 49 · 2020: 9
- FWCI
- 8.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Online Publication Service of Würzburg University (Würzburg University) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › GDF15 and Related Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- GDF15, MIC-1, GFRAL, immune checkpoint, cancer immunotherapy, biomarkers, immunomodulation, pregnancy, myocardial infarction, autoimmune disease, inflammation, anorexia, TGF-beta superfamily
- MeSH terms
- Immune Checkpoint Inhibitors, Animals, Autoimmune Diseases, Female, Homeostasis, Humans, Myocardial Infarction, Neoplasms, Placenta, Pregnancy, Biomarkers, Mice, Growth Differentiation Factor 15, Immunomodulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
