Cited by 189Bone Tissue Engineering MaterialsAdditive Manufacturing and 3D Printing Technologies3D Printing in Biomedical Research

Additive manufacturing methods for producing hydroxyapatite and hydroxyapatite-based composite scaffolds: a review

Open access
Kumar, Anuj, Kargozar, Saeid, Baino, Francesco, Han, Sung Soo·2019·Frontiers in Materials

Abstract

Hydroxyapatite (HAp) has been considered for decades an ideal biomaterial for bone repair due to its compositional and crystallographic similarity to bio-apatites in hard tissues. However, fabrication of porous HAp acting as a template (scaffold) for supporting bone regeneration and growth has been a challenge to biomaterials scientists. The introduction of additive manufacturing technologies, which provide the advantages of a relatively fast, precise, controllable and potentially scalable fabrication process, has opened new horizons in the field of bioceramic scaffolds. This review focuses on 3D-printed HAp scaffolds and related composite systems, where the calcium phosphate phase is combined with other ceramics or polymers improving the mechanical properties and/or imparting special extra-functionalities. The main applications of 3D-printed HAp scaffolds in bone tissue engineering are presented and discussed; furthermore, this review also emphasizes the most recent achievements towards the development and testing of multifunctional HAp-based systems combining multiple properties for advanced therapy (e.g. bone regeneration, antibacterial effect, angiogenesis and cancer treatment).

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Crossref · 10.3389/fmats.2019.00313

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  • Additive manufacturing is a widely used technique that can develop scaffolds with a controllable shape having required porosity.

    “Additive manufacturing is one of the widely used techniques that can develop scaffolds with a controllable shape having required porosity [77,78].”

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2 of the 182 references couldn’t be matched to a known paper.

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  1. 9b00893 · DOI
  2. Sumer, M., Keles, G. C., Cetinkaya, B. O., Balli, U., Pamuk, F., and Uckan, S. (2013). Autogenous cortical bone and bioactive glass grafting for treatment of intraosseous periodontal defects. Eur. J. Dent. 7, 6-14. doi: 10.1055/s-009-44516 · DOI
  3. 8b12784 · DOI

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Authors
Kumar, A., Kargozar, S., Baino, F., & Han, S. S.
Affiliations
  • Yeungnam University (KR)
  • Mashhad University of Medical Sciences (IR)
  • Politecnico di Torino (IT)
Corresponding author
  • Kumar, Anuj
  • Baino, Francesco
  • Han, Sung Soo
Venue
Frontiers in Materials
Published
2019-12-17
Volume
6
ISSN
2296-8016 (ISSN-L)
OpenAlex
W2995341222
Cited by
189
References
182
Citations by year
2026: 18 · 2025: 20 · 2024: 34 · 2023: 31 · 2022: 33 · 2021: 38 · 2020: 15
FWCI
1.73
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Materials (publishedVersion, cc-by)
  • PORTO@Iris (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • INFM-OAR (INFN Catania) (submittedVersion, cc-by)
  • Zenodo (CERN European Organization for Nuclear Research)
Funders
  • National Research Foundation
  • Yeungnam University
  • National Research Foundation of Korea
  • Ministry of Education, Science and Technology (2017R1D1A3B03036276)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Engineering › Automotive Engineering › Additive Manufacturing and 3D Printing Technologies
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords
hydroxyapatite, 3D printing, bioceramic scaffolds, composite scaffolds, bone tissue engineering, bone regeneration, porous scaffolds, calcium phosphate, antibacterial scaffolds, angiogenesis, cancer therapy, multifunctional biomaterials

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