A theoretical comparison between two ruminal electron sinks

Ungerfeld, Emilio M.

doi:10.3389/fmicb.2013.00319

Cited by 85Ruminant Nutrition and Digestive PhysiologyAnaerobic Digestion and Biogas ProductionAnimal Nutrition and Physiology

A theoretical comparison between two ruminal electron sinks

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Ungerfeld, Emilio M.·2013·Frontiers in Microbiology

DOI 10.3389/fmicb.2013.00319PMC PMC3812538

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Abstract

Dihydrogen accumulation resulting from methanogenesis inhibition in the rumen is an energy loss and can inhibit fermentation. The objective of this analysis was to compare the energetic and nutritional consequences of incorporating H2 into reductive acetogenesis or additional propionate production beyond the acetate to propionate shift occurring along with methanogenesis inhibition. Stoichiometric consequences were calculated for a simulated fermentation example. Possible nutritional consequences are discussed. Incorporating H2 into reductive acetogenesis or additional propionate production resulted in equal heat of combustion output in volatile fatty acids (VFA). Incorporation of H2 into reductive acetogenesis could result in moderate decrease in ruminal pH, although whole-animal buffering mechanisms make pH response difficult to predict. Research would be needed to compare the microbial protein production output. There could be post-absorptive implications due to differences in VFA profile. Electron incorporation into reductive acetogenesis could favor energy partition toward milk, but increase risk of ketosis in high-producing dairy cows on ketogenic diets. Greater propionate production could favor milk protein production, but may be less desirable in animals whose intake is metabolically constrained, like feedlot steers. Because of the different nutritional implications, and because practical solutions to incorporate H2 into either pathway are not yet available, it is recommended to research both alternatives.

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These findings suggest that the cecum favors reductive acetogenesis over hydrogenotrophic respiration, consistent with the higher concentration of dH2 in the cecum, which can enhance the competitiveness of reductive acetogenesis.
“Altogether, these findings suggest that the cecum favors reductive acetogenesis over hydrogenotrophic respiration, consistent with the higher concentration of dH2 in the cecum (Fig. 1D), which can enhance the competitiveness of reductive acetogenesis [42, 43].”
From Reductive acetogenesis is a dominant process in the ruminant hindgut (2025) · cites this paper as [42]

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Additional file 4 of Disruption of ruminal homeostasis by malnutrition involved in systemic ruminal microbiota-host interactions in a pregnant sheep model
Xue, Y., Lin, L., Hu, F., Zhu, W., & Mao, S. (2020) · Figshare · doi:10.6084/m9.figshare.13004071
Additional file 2 of Disruption of ruminal homeostasis by malnutrition involved in systemic ruminal microbiota-host interactions in a pregnant sheep model
Xue, Y., Lin, L., Hu, F., Zhu, W., & Mao, S. (2020) · Figshare · doi:10.6084/m9.figshare.13004065
Additional file 3 of Disruption of ruminal homeostasis by malnutrition involved in systemic ruminal microbiota-host interactions in a pregnant sheep model
Xue, Y., Lin, L., Hu, F., Zhu, W., & Mao, S. (2020) · Figshare · doi:10.6084/m9.figshare.13004068
Additional file 6 of Disruption of ruminal homeostasis by malnutrition involved in systemic ruminal microbiota-host interactions in a pregnant sheep model
Xue, Y., Lin, L., Hu, F., Zhu, W., & Mao, S. (2020) · Figshare · doi:10.6084/m9.figshare.13004077
Additional file 5 of Disruption of ruminal homeostasis by malnutrition involved in systemic ruminal microbiota-host interactions in a pregnant sheep model
Xue, Y., Lin, L., Hu, F., Zhu, W., & Mao, S. (2020) · Figshare · doi:10.6084/m9.figshare.13004074
Additional file 7 of Disruption of ruminal homeostasis by malnutrition involved in systemic ruminal microbiota-host interactions in a pregnant sheep model
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Additional file 1 of Disruption of ruminal homeostasis by malnutrition involved in systemic ruminal microbiota-host interactions in a pregnant sheep model
Xue, Y., Lin, L., Hu, F., Zhu, W., & Mao, S. (2020) · Figshare · doi:10.6084/m9.figshare.13004062
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Limits to Dihydrogen Incorporation into Electron Sinks Alternative to Methanogenesis in Ruminal Fermentation
Ungerfeld, E. M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01272 · Cited by 58 · see citing works
Self-citation
Biochemical constraints to the incorporation of dihydrogen into alternative electron acceptors in in vitro ruminal fermentationPreprint
Ungerfeld, E. M., Samoluk, M. F., Cancino‐Padilla, N., Jaurena, G., & Hackmann, T. J. (2026) · Research Square · doi:10.21203/rs.3.rs-10501563/v1
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Shifts in metabolic hydrogen sinks in the methanogenesis-inhibited ruminal fermentation: a meta-analysis
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— Invited Review — Hydrogen production and hydrogen utilization in the rumen: key to mitigating enteric methane production
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Authors: Ungerfeld, E. M.
Affiliations: Austral University of Chile (CL)
Corresponding author: Ungerfeld, Emilio M.
ORCID: Ungerfeld, Emilio M.
Venue: Frontiers in Microbiology
Publisher: Frontiers Media SA
Published: 2013
Volume: 4
Pages: 319-319
ISSN: 1664-302X (ISSN-L)
DOI: 10.3389/fmicb.2013.00319
PMC: PMC3812538
OpenAlex: W2103899509
Cited by: 85
References: 98
Citations by year: 2026: 5 · 2025: 7 · 2024: 3 · 2023: 4 · 2022: 13 · 2021: 7 · 2020: 13 · 2019: 9 · 2018: 10 · 2017: 4 · 2016: 8 · 2015: 2
FWCI: 7.08
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Microbiology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Ruminant Nutrition and Digestive Physiology
Physical Sciences › Engineering › Building and Construction › Anaerobic Digestion and Biogas Production
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords: hydrogen incorporation, methanogenesis inhibition, reductive acetogenesis, propionate production, volatile fatty acids, calorific value, rumen pH, microbial protein production, ketosis, milk protein yield, energy allocation, dairy cattle, feedlot steers, rumen fermentation

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A theoretical comparison between two ruminal electron sinks

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