The DOI matches its Crossref record; 209 of the 209 references it cites were found in a registry or an index.
Antimicrobial Photodynamic Therapy to Control Clinically Relevant Biofilm Infections
Open accessAbstract
Biofilm describes a microbially-derived sessile community in which microbial cells are firmly attached to the substratum and embedded in extracellular polymeric matrix. Microbial biofilms account for up to 80% of all bacterial and fungal infections in humans. Biofilm-associated pathogens are particularly resistant to antibiotic treatment, and thus novel antibiofilm approaches needed to be developed. Antimicrobial Photodynamic therapy (aPDT) had been recently proposed to combat clinically relevant biofilms such as dental biofilms, ventilator associated pneumonia, chronic wound infections, oral candidiasis, and chronic rhinosinusitis. aPDT uses non-toxic dyes called photosensitizers (PS), which can be excited by harmless visible light to produce reactive oxygen species (ROS). aPDT is a multi-stage process including topical PS administration, light irradiation, and interaction of the excited state with ambient oxygen. Numerous in vitro and in vivo aPDT studies have demonstrated biofilm-eradication or substantial reduction. ROS are produced upon photo-activation and attack adjacent targets, including proteins, lipids and nucleic acids present within the biofilm matrix, on the cell surface and inside the microbial cells. Damage to non-specific targets leads to the destruction of both planktonic cells and biofilms. The review aims to summarize the progress of aPDT in destroying biofilms and the mechanisms mediated by ROS. Finally, a brief section provides suggestions for future research.
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Cites
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Background
Cited by
Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review
Mulani, M. S., Kamble, E. E., Kumkar, S. N., Tawre, M. S., & Pardesi, K. R. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00539 · Cited by 1,644
Li, H., Zhou, X., Huang, Y., Liao, B., Cheng, L., & Ren, B. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.622534 · Cited by 284
Self-citationPhotodynamic therapy: Innovative approaches for antibacterial and anticancer treatments
Kolarikova, M., Hosikova, B., Dilenko, H., Barton‐Tomankova, K., Valkova, L., Bajgar, R., Malina, L., & Kolarova, H. (2023) · Medicinal Research Reviews · doi:10.1002/med.21935 · Cited by 282
Advancing antimicrobial strategies for managing oral biofilm infections
Jiao, Y., Tay, F. R., Niu, L.-N., & Chen, J.-H. (2019) · International Journal of Oral Science · doi:10.1038/s41368-019-0062-1 · Cited by 280
Natural Photosensitizers in Antimicrobial Photodynamic Therapy
Polat, E., & Kang, K. (2021) · Biomedicines · doi:10.3390/biomedicines9060584 · Cited by 235
Metadata
- Authors
- Hu, X., Huang, Y.-Y., Wang, Y., Wang, X., & Hamblin, M. R.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2018-06-27
- Volume
- 9
- Pages
- 1299-1299
- ISSN
- 1664-302X (ISSN-L)
- OpenAlex
- W2806055322
- Cited by
- 502
- References
- 209
- FWCI
- 27.05
- Type
- journal article
- Language
- en
- Open access
- gold
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