The role of teichoic acids of bifidobacteria in driving the interaction with the human host
Open accessAbstract
An in silico survey carried out in this study, performed on more than 3,000 publicly available bifidobacterial genome sequences, revealed clear differences in genes predicted to be involved in teichoic acid (TA) biosynthesis at inter-species level, indicating that only a small number of species possess a specific cluster for the production and assembly of these cell envelope-associated structures. Among these, Bifidobacterium bifidum represents a key member of the human gut microbiota at the early stages of life. Here, we show differences in the transcriptomic profiles of genes predicted to be involved in TA biosynthesis of three different strains of B. bifidum PRL2010 following exposure to human intestinal epithelial cells, suggesting a strain-specific and host-mediated molecular response. Notably, such data were further corroborated by in vitro experiments with isogenic derivatives of B. bifidum PRL2010 carrying mutations located in one of the genetic loci putatively responsible for TA synthesis, which suggests that TAs of PRL2010 are involved in establishing microbe-host cross talk by modulating adhesion to epithelial intestinal cells, as well as by affecting the interaction with human macrophages. We furthermore revealed that some of the key genes implicated in TA synthesis by PRL2010 are overexpressed under in vivo conditions when the microorganism is colonizing the murine gut, which further confirms a host modulatory effect on the production of these extracellular structures in bifidobacteria.
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These functions support survival in the infant gut.
“Specifically, 25 unique COGs are implicated in the import and processing of human milk sugars [84] , while others are associated with host-immune interactions [85] and osmotic and pH regulation [86] , i.e., functions that support survival in the infant gut [23,87,88] .”
From Genome-scale insights into the metabolic landscape and evolutionary development of Bifidobacterium bifidum (2026) · cites this paper as [23]
The Introduction (page unavailable) links carbohydrate-metabolism genes and host-interacting surface structures to bifidobacterial colonization and persistence in the intestine. The Conclusion (page unavailable) also links teichoic-acid-mediated immune interactions to persistence in the human gut. These passages support the general survival point, but do not establish that osmotic and pH regulation support survival specifically in the infant gut. (LLM, conf=0.82)
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Reid, G. (2023) · Microbiome Research Reports · doi:10.20517/mrr.2022.17 · Cited by 3 · see citing works
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Occurrence and applications of CRISPR-Cas systems in bifidobacteria
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Self-citationSelleri, E., Longhi, G., Tarracchini, C., Carolis, E. D., Petraro, S., Mancabelli, L., Milani, C., Turroni, F., Ventura, M., & Lugli, G. A. (2026) · Microbiome Research Reports · doi:10.20517/mrr.2026.19
Self-citationQu, D., Feng, S., Wang, S., Yu, L., Tian, F., Zhang, H., Chen, W., & Zhai, Q. (2026) · Food Science and Human Wellness · doi:10.26599/fshw.2026.9251015
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Bifidobacteria: biogeography, host adaptation and ecological functions
Tarracchini, C., Milani, C., Jones, C. N. L., Turroni, F., Burgess, G., Mahony, J., Hall, L. J., Ventura, M., & van Sinderen, D. (2026) · Nature Reviews Microbiology · doi:10.1038/s41579-026-01367-y
Self-citation
- Authors
- Longhi, G., Vergna, L. M., Lugli, G. A., Bianchi, M. G., Tarracchini, C., Milani, C., Turroni, F., Bussolati, O., van Sinderen, D., & Ventura, M.
- Affiliations
- University of Parma (IT)
- Corresponding author
- Ventura, Marco
- ORCID
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2025-07-10
- Volume
- 16
- Pages
- 1616397-1616397
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC12286996
- OpenAlex
- W4412141588
- Cited by
- 6
- References
- 90
- Citations by year
- 2026: 6
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Science Foundation Ireland (SFI/12/RC/2273‐412‐P1, SFI/12/RC/, 12/RC/2273, SFI/12/RC/ 2273_P2, 12/RC/, 12/RC/2273_P2, SFI/12/RC/2273.)
- Università degli Studi di Parma
- APC Microbiome Institute (SFI/12/RC/2273_P2, SFI/12/RC/2273)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- teichoic acid, Bifidobacterium, Bifidobacterium bifidum, teichoic acid biosynthesis, gut microbiota, host-microbe interactions, intestinal epithelial cell adhesion, macrophage interaction, strain-specific gene expression, isogenic mutants
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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