CoChat
Sign Up
Cited by 34

Glia and zinc in ageing and Alzheimer’s disease: a mechanism for cognitive decline?

Hancock, Sara M., Finkelstein, David I., Adlard, Paul A.·2014·Frontiers in Aging Neuroscience
DOI 10.3389/fnagi.2014.00137PMC PMC4069481
Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fnagi.2014.00137

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 48

  1. Adlard P. A. Parncutt J. M. Finkelstein D. I. Bush A. I. (2010). Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits in Alzhimer’s disease? J. Neurosci. 30, 1631– 1636 10.1523/JNEUROSCI.5255-09.2010 20130173 PMC6633978 · DOI
  2. Adlard P. A. Sedjahtera A. Gunawan L. Bray L. Hare D. Lear J. (2014). A novel approach to rapidly prevent age-related cognitive decline. Aging Cell 13, 351– 359 10.1111/acel.12178 24305557 PMC4331782 · DOI
  3. Beyer N. Coulson D. T. R. Heggarty S. Ravid R. Irvine G. B. Hellemans J. (2009). ZnT3 mRNA levels are reduced in Alzheimer’s disease post-mortem brain. Mol. Neurodegen. 4: 53 10.1186/1750-1326-4-53 20030848 PMC2806356 · DOI
  4. Bishop G. M. Scheiber I. V. Dringen R. Robinson S. R. (2010). Synergistic accumulation of iron and zinc by cultured astrocytes. J. Neural. Transm. 117, 809– 817 10.1007/s00702-010-0420-9 20549524 · DOI
  5. Deary I. J. Corley J. Gow A. J. Harris S. E. Houlihan L. M. Marioni R. E. (2009). Age-associated cognitive decline. Br. Med. Bull. 92, 135– 152 10.1093/bmb/ldp033 19776035 · DOI · Paper page
  6. Desphande A. Kawai H. Metherate R. Glabe C. G. Busciglio J. (2009). A role for synapse zinc in activity-dependent Aβ oligomer formation and accumulation at excitatory synapses. J. Neurosci. 29, 4004– 4015 10.1523/JNEUROSCI.5980-08.2009 19339596 PMC6665357 · DOI · Paper page
  7. Erickson J. C. Hollopeter G. Thomas S. A. Froelick G. J. Palmiter R. D. (1997). Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behaviour and neuron vulnerability to metals, aging and seizures. J. Neurosci. 17, 1271– 1281 9006971 PMC6793742
  8. Grabrucker A. M. Rowan A. Garner C. C. (2011). Brain-delivery of zinc-ions as potential treatment for neurological diseases: mini review. Drug Deliv. Lett. 1, 13– 23 10.2174/2210303111101010013 22102982 PMC3220161 · DOI
  9. Greenough M. A. Camakaris J. Bush A. I. (2013). Metal dyshomeostasis and oxidative stress in Alzheimer’s disease. Neurochem. Int. 62, 540– 555 10.1016/j.neuint.2012.08.014 22982299 · DOI
  10. Han X. Chen M. Wang F. Windrem M. Wang S. Shanz S. (2013). Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell Stem Cell 12, 342– 353 10.1016/j.stem.2012.12.015 23472873 PMC3700554 · DOI · Paper page
  11. Hennigar S. R. Kelleher S. L. (2012). Zinc networks: the cell-specific compartmentalization of zinc for specialised functions. Biol. Chem. 393, 565– 578 10.1515/hsz-2012-0128 22944660 · DOI
  12. Higashi Y. Segawa S. Matsuo T. Nakamura S. Kikkawa Y. Nishida K. (2011). Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia. Glia 59, 1933– 1945 10.1002/glia.21235 22253048 · DOI
  13. Jeong J. Eide D. J. (2013). The SLC39 family of zinc transporters. Mol. Aspects Med. 34, 612– 619 10.1016/j.mam.2012.05.011 23506894 PMC3602797 · DOI
  14. Kaindl A. M. Degos V. Peineau S. Gouadon E. Chhor V. Loron G. (2012). Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain. Ann. Neurol. 72, 536– 549 10.1002/ana.23626 23109148 · DOI
  15. Kaindl A. M. Degos V. Peineau S. Gouadon E. Loron G. Lombet A. (2008). Microglia express functional NMDA receptors: a novel finding and a promise for innovative treatment of excitotoxic and inflammatory brain disease. Neuropediatrics 39, V23 10.1055/s-0029-1215736 · DOI
  16. Karol N. Brodski C. Bibi Y. Kaisman T. Forberg M. Hershfinkel M. (2010). Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc. J. Cell. Physiol. 224, 567– 574 10.1002/jcp.22168 20432464 · DOI
  17. Kettenmann H. Verkhratsky A. (2008). Neuroglia: the 150 years after. Trends Neurosci. 31, 653– 659 10.1016/j.tins.2008.09.003 18945498 · DOI
  18. Knoch M. E. Hartnett K. A. Hara H. Kandler K. Aizenman E. (2008). Microglia induce neurotoxicity via intraneuronal Zn2+ release and a K+ current surge. Glia 56, 89– 96 10.1002/glia.20592 17955552 PMC2561170 · DOI
  19. Lee J.-Y. Cho E. Seo J.-W. Hwang J. J. Koh J.-Y. (2012). Alteration of the cerebral zinc pool in a mouse model of Alzheimer disease. J. Neuropathol. Exp. Neurol. 71, 211– 222 10.1097/NEN.0b013e3182417387 22318122 · DOI
  20. Lee C. J. Mannaioni G. Yuan H. Woo D. H. Gingrich M. B. Traynelis S. F. (2007). Astrocytic control of synaptic NMDA receptors. J. Physiol. 581, 1057– 1081 10.1113/jphysiol.2007.130377 17412766 PMC2170820 · DOI
  21. Lopez O. L. Zivkovic S. Smith G. Becker J. T. Meltzer C. DeKosky S. T. (2001). Psychiatric symptoms associated with cortical-subcortical dysfunction in Alzheimer’s disease. J. Neuropsychiatry Clin. Neurosci. 13, 56– 60 10.1176/appi.neuropsych.13.1.56 11207330 · DOI
  22. Manso Y. Adlard P. A. Carrasco J. Vasak M. Hidalgo J. (2011). Metallothionein and brain inflammation. J. Biol. Inorg. Chem. 16, 1103– 1113 10.1007/s00775-011-0802-y 21678079 · DOI
  23. Mesulam M.-M. (1999). Neuroplasticity failure in Alzheimer’s disease; bridging the gap between plaques and tangles. Neuron 24, 521– 529 10.1016/s0896-6273(00)81109-5 10595506 · DOI · Paper page
  24. Meunier D. Stamatakis E. A. Tyler L. K. (2014). Age-related functional reorganisation, structural changes and preserved cognition. Neurobiol. Aging 35, 42– 54 10.1016/j.neurobiolaging.2013.07.003 23942392 · DOI
  25. Mocchegiani E. Giaconni R. Cipriano C. Muzzioli M. Fattoretti P. Bertoni-Freddari C. (2001). Zinc-bound metallothioneins as potential biological markers of ageing. Brain Res. Bull. 55, 147– 153 10.1016/s0361-9230(01)00468-3 11470310 · DOI
  26. Morris D. R. Levenson C. W. (2012). Ion channels and zinc: mechanisms of neurotoxicity and neurodegeneration. J. Toxicol. 2012: 785647 10.1155/2012/785647 22645609 PMC3356718 · DOI
  27. Morris G. P. Clark I. A. Zinn R. Vissel B. (2013). Microglia: a new frontier for synaptic plasticity, learning and memory and neurodegenerative disease research. Neurobiol. Learn. Mem. 105, 40– 53 10.1016/j.nlm.2013.07.002 23850597 · DOI · Paper page
  28. Nimmerjahn A. Kirchhoff F. Helmchen F. (2005). Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314– 1318 10.1126/science.1110647 15831717 · DOI · Paper page
  29. Nolte C. Gore A. Sekler I. Kresse W. Hershfinkel M. Hoffman A. (2004). ZnT1 expression in astroglial cells protects against zinc toxicity and slows the accumulation of intracellular zinc. Glia 43, 145– 155 10.1002/glia.20065 15378655 · DOI
  30. Paoletti P. Vergnano A. M. Barbour B. Casado M. (2009). Zinc at glutamatergic synapses. Neuroscience 158, 126– 136 10.1016/j.neuroscience.2008.01.061 18353558 · DOI
  31. Reitz C. Brayne C. Mayeux R. (2011). Epidemiology of Alzheimer’s disease. Nat. Rev. Neurol. 7, 137– 152 10.1038/nrneurol.2011.2 21304480 PMC3339565 · DOI · Paper page
  32. Religa D. Strozyk D. Cherny R. A. Volitakis I. Haroutunian V. Winblad B. (2006). Elevated cortical zinc in Alzheimer disease. Neurology 67, 69– 75 10.1212/01.wnl.0000223644.08653.b5 16832080 · DOI
  33. Roberts B. R. Ryan T. M. Bush A. I. Masters C. L. Duce J. A. (2012). The role of metallobiology and amyloid-β peptides in Alzheimer’s disease. J. Neurochem. 120(Suppl. 1), 149– 166 10.1111/j.1471-4159.2011.07500.x 22121980 · DOI · Paper page
  34. Salazar G. Craige B. Love R. Kalman D. Faundez V. (2005). Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells. J. Cell Sci. 118, 1911– 1921 10.1242/jcs.02319 15860731 · DOI
  35. Sensi S. L. Paoletti P. Bush A. I. Sekler I. (2009). Zinc in the physiology and pathology of the CNS. Nat. Rev. Neurosci. 10, 780– 791 10.1038/nrn2734 19826435 · DOI · Paper page
  36. Sirrieh R. E. MacLean D. M. Jayaraman V. (2013). Amino-terminal domain tetramer organisation and structural effects of zinc binding in the N-methyl-D-aspartate (NMDA) receptor. J. Biol. Chem. 288, 22555– 22564 10.1074/jbc.M113.482356 23792960 PMC3829342 · DOI
  37. Stollg G. Jander S. (1999). The role of microglia and macrophages in the pathophysiology of the CNS. Prog. Neurobiol. 58, 233– 247 10.1016/s0301-0082(98)00083-5 10341362 · DOI
  38. Sun X.-Y. Wei Y.-P. Xiong Y. Wang X.-C. Xie A.-J. Wang X.-L. (2012). Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatise 2A (PP2A). J. Biol. Chem. 287, 11174– 11182 10.1074/jbc.M111.309070 22334661 PMC3322889 · DOI
  39. Takeda A. (2000). Zinc homeostasis and functions of zinc in the brain. Biometals 14, 343– 351 10.1023/A:1012982123386 11831464 · DOI
  40. Takeda A. Tamano H. (2012). Proposed glucocorticoid-mediated zinc signalling in the hippocampus. Metallomics 4, 614– 618 10.1039/c2mt20018j 22610492 · DOI
  41. Talantova M. Sanz-Blasco S. Zhang X. Xia P. Akhtar M. W. Okamoto S.-I. (2013). Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation and synaptic loss. Proc. Natl. Acad. Sci. U S A 110, E2518– E2527 10.1073/pnas.1306832110 23776240 PMC3704025 · DOI · Paper page
  42. Theusen O. B. Wei Z. Jorgen C. Ole V. Erik H. P. (2010). Effect of paraquat and amyloid-β-peptide on the metabolism in primary astrocytes studied by 1H-NMR. Open Mag. Res. J. 3, 1– 13 10.2174/1874769801003010001 · DOI
  43. Vasto S. Candore G. Listi F. Balistreri C. R. Colonna-Romano G. Malavolta M. (2008). Inflammation, genes and zinc in Alzheimer’s disease. Brain Res. Rev. 58, 96– 105 10.1016/j.brainresrev.2007.12.001 18190968 · DOI
  44. Volterra A. Bezzi P. (2002). “ Release of transmitters from glial cells,” in The Tripartite Synapse: Glia in Synaptic Transmission, ed Volterra A. (Oxford: University Press), 164– 184
  45. Wake H. Moorhouse A. J. Jinno S. Kohsaka S. Nabekura J. (2009). Resting microglia directly monitor the functional state of synapses in vivo and determine the face of ischemic terminals. J. Neurosci. 29, 3974– 3980 10.1523/JNEUROSCI.4363-08.2009 19339593 PMC6665392 · DOI · Paper page
  46. Wang Z.-Y. Stoltenberg M. Huang L. Danscher G. Dahlstrom A. Shi Y. (2005). Abundant expression of zinc transporters in Bergman glia of mouse cerebellum. Brain Res. Bull. 64, 441– 448 10.1016/j.brainresbull.2004.10.001 15607832 · DOI
  47. Wong W. T. (2013). Microglial aging in the healthy CNS: phenotypes, drivers and rejuvenation. Front. Cell. Neurosci. 7: 22 10.3389/fncel.2013.00022 23493481 PMC3595516 · DOI
  48. Yeh C.-Y. Verkhratsky A. Terzieva S. Rodriguez J. J. (2013). Glutamine synthetise in astrocytes from entorhinal cortex of the triple transgenic animal model of Alzheimer’s disease is not affected by pathological progression. Biogerontology 14, 777– 787 10.1007/s10522-013-9456-1 23990215 · DOI

Cited by

Sorted by citations

Authors
Hancock, S. M., Finkelstein, D. I., & Adlard, P. A.
Venue
Frontiers in Aging Neuroscience
Publisher
Frontiers Media SA
Published
2014-06-25
Volume
6
ISSN
1663-4365
DOI
10.3389/fnagi.2014.00137
PMC
PMC4069481
Cited by
34
References
5

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review