Neuroplasticity Failure in Alzheimer's Disease
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Synapses are major sites of Aβ pathology and generation.
“Synapses have long been viewed as critical sites of AD pathology [6, 28, 112, 119, 168] and diverse evidence had supported that synapses are major sites of Aβ pathology and also generation.”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [119]
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- Authors
- Mesulam, M.-M.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Mesulam, M.-Marsel
- ORCID
- Mesulam, M.-Marsel
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 24
- Issue
- 3
- Pages
- 521-529
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1986900475
- Semantic Scholar
- f8177bff0d24b9b2570968f01cc6fce6a4d02ffd
- Cited by
- 449
- References
- 111
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 8 · 2023: 13 · 2022: 12 · 2021: 11 · 2020: 14 · 2019: 12 · 2018: 12 · 2017: 13 · 2016: 18 · 2015: 20 · 2014: 21 · 2013: 23 · 2012: 13
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns020285-15)
- National Institute on Aging (AG13854, P30AG013854)
- National Institute of Neurological Disorders and Stroke (NS 20285)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Alzheimer's disease, neuroplasticity, amyloid plaques, neurofibrillary tangles, synaptic loss, neuronal loss, cholinergic depletion, cognitive impairment
- MeSH terms
- Alzheimer Disease, Brain, Humans, Neuronal Plasticity, Neurofibrillary Tangles, Plaque, Amyloid
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