Cited by 229Alzheimer's disease research and treatmentsMicrobial Metabolites in Food BiotechnologyGut microbiota and health

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Prebiotic Effect of Fructooligosaccharides from Morinda officinalis on Alzheimer’s Disease in Rodent Models by Targeting the Microbiota-Gut-Brain Axis

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Chen, Diling, Yang, Xin, Yang, Jian, Lai, Guoxiao, Yong, Tianqiao, Tang, Xiaocui, Shuai, Ou, Zhou, Gailian, Xie, Yizhen, Wu, Qingping·2017·Frontiers in Aging Neuroscience

DOI 10.3389/fnagi.2017.00403PMC PMC5727096

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Abstract

Gut microbiota influences the central nervous system disorders such as Alzheimer’s disease (AD). The prebiotics and probiotics can improve the host cognition. A previous study demonstrated that fructooligosaccharides from Morinda officinalis (OMO) exert effective memory improvements in AD-like animals, thereby considered as potential prebiotics; however, the underlying mechanism still remains enigma. Thus, the present study investigated whether OMO is effective in alleviating AD by targeting the microbiota-gut-brain axis. OMO was administered in rats with AD-like symptoms (D-galactose- and Aβ 1-42-induced deficient rats). Significant and systematic deterioration in AD-like animals were identified, including learning and memory abilities, histological changes, production of cytokines, and microbial community shifts. Behavioral experiments demonstrated that OMO administration can ameliorate the learning and memory abilities in both AD-like animals significantly. AD parameters showed that OMO administration cannot only improve oxidative stress and inflammation disorder, but also regulate the synthesis and secretion of neurotransmitter. Histological changes indicated that OMO administration ameliorates the swelling of brain tissues, neuronal apoptosis, and down-regulation of the expression of AD intracellular markers (Tau and Aβ 1-42). 16S rRNA sequencing of gut microbiota indicated that OMO administration maintains the diversity and stability of the microbial community. In addition, OMO regulated the composition and metabolism of gut microbiota in inflammatory bowel disease (IBD) mice model treated by overdosed antibiotics and thus showed the prebiotic potential. Moreover, gut microbiota plays a major role in neurodevelopment, leading to alterations in gene expression in critical brain and intestinal regions, thereby resulting in perturbation to the programming of normal cognitive behaviors. Taken together, our findings suggest that the therapeutic effect of the traditional medicine, M. officinalis, on various neurological diseases such as AD, is at least partially contributed by its naturally occurring chemical constituent, OMO, via modulating the interaction between gut ecology and brain physiology.

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Self-citation
Retracted
Cerebral small vessel disease burden is associated with decreased abundance of gut Barnesiella intestinihominis bacterium in the Framingham Heart Study
Fongang, B., Satizábal, C. L., Kautz, T. F., Wadop, Y. N., Muhammad, J. A. S., Vasquez, E. L., Mathews, J. J., Gireud, M., Saklad, A. R., Himali, J. J., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-40872-5 · Cited by 31
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Authors: Chen, D., Yang, X., Yang, J., Lai, G., Yong, T., Tang, X., Shuai, O., Zhou, G., Xie, Y., & Wu, Q.
Affiliations: Chinese Academy of Sciences (CN)
Guangzhou Medical University (CN)
Guangxi University of Chinese Medicine (CN)
Corresponding author: Chen, Diling
Xie, Yizhen
ORCID: Chen, Diling
Yang, Xin
Yang, Jian
Yong, Tianqiao
Tang, Xiaocui
Zhou, Gailian
Xie, Yizhen
Wu, Qingping
Venue: Frontiers in Aging Neuroscience
Publisher: Frontiers Media SA
Published: 2017-12-08
Volume: 9
Pages: 403-403
ISSN: 1663-4365 (ISSN-L)
DOI: 10.3389/fnagi.2017.00403
PMC: PMC5727096
OpenAlex: W2775686313
Cited by: 227
References: 70
Citations by year: 2026: 16 · 2025: 28 · 2024: 31 · 2023: 29 · 2022: 42 · 2021: 36 · 2020: 23 · 2019: 13 · 2018: 9
FWCI: 9.11
Type: journal article
Language: en
Update notices: corrigendum (2025-05-14)
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Aging Neuroscience (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Guangzhou Medical University (2016C28)
Guangdong Academy of Sciences (2016GDASRC-0102)
Guangzhou Municipal Science and Technology Project
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: fructooligosaccharides, Morinda officinalis, Alzheimer's disease, prebiotics, microbiota-gut-brain axis, gut microbiota, learning and memory, oxidative stress, neuroinflammation, amyloid-beta, tau protein, neuronal apoptosis, antibiotic-induced dysbiosis, inflammatory bowel disease, traditional medicine

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Prebiotic Effect of Fructooligosaccharides from Morinda officinalis on Alzheimer’s Disease in Rodent Models by Targeting the Microbiota-Gut-Brain Axis

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