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Cited by 137Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityAdipose Tissue and Metabolism

Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels

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Abbenhardt, C., McTiernan, A., Alfano, C. M., Wener, M. H., Campbell, K. L., Duggan, C., Foster‐Schubert, K. E., Kong, A. +7 more·2013·Journal of Internal Medicine
DOI 10.1111/joim.12062PMC PMC3738194
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Abstract

Background: Excess body weight and a sedentary lifestyle are associated with the development of several diseases, including cardiovascular disease, diabetes and cancer in women. One proposed mechanism linking obesity to chronic diseases is an alteration in adipose‐derived adiponectin and leptin levels. We investigated the effects of 12‐month reduced calorie, weight loss and exercise interventions on adiponectin and leptin concentrations. Methods: Overweight/obese postmenopausal women (n = 439) were randomized as follows: (i) a reduced calorie, weight‐loss diet (diet; N = 118), (ii) moderate‐to‐vigorous intensity aerobic exercise (exercise; N = 117), (iii) a combination of a reduced calorie, weight‐loss diet and moderate‐to‐vigorous intensity aerobic exercise (diet + exercise; N = 117), and (iv) control (N = 87). The reduced calorie diet had a 10% weight‐loss goal. The exercise intervention consisted of 45 min of moderate‐to‐vigorous aerobic activity 5 days per week. Adiponectin and leptin levels were measured at baseline and after 12 months of intervention using a radioimmunoassay. Results: Adiponectin increased by 9.5% in the diet group and 6.6% in the diet + exercise group (both P ≤ 0.0001 vs. control). Compared with controls, leptin decreased with all interventions (diet + exercise, −40.1%, P < 0.0001; diet, −27.1%, P < 0.0001; exercise, −12.7%, P = 0.005). The results were not influenced by the baseline body mass index (BMI). The degree of weight loss was inversely associated with concentrations of adiponectin (diet, P‐trend = 0.0002; diet + exercise, P‐trend = 0.0005) and directly associated with leptin (diet, P‐trend < 0.0001; diet + exercise, P‐trend < 0.0001). Conclusion: Weight loss through diet or diet + exercise increased adiponectin concentrations. Leptin concentrations decreased in all of the intervention groups, but the greatest reduction occurred with diet + exercise. Weight loss and exercise exerted some beneficial effects on chronic diseases via effects on adiponectin and leptin.

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  • A study that investigated the effect of diet or diet and exercise interventions in individuals aged 50-79 years with overweight or obesity reported that levels of adiponectin increased (diet 9.5% increase, diet and exercise 6.6% increase) and leptin decreased (27.1% diet, 40.1% diet and exercise).

    “levels of adiponectin increased in individuals with overweight or obesity compared with controls (diet resulted in 9.5% increase in adiponectin (P < 0.001), and diet and exercise resulted in a 6.6% increase in adiponectin (P < 0.001)). Furthermore, levels of leptin in individuals with obesity or overweight decreased by 27.1% in the diet group and 40.1% in the diet and exercise group302.”

    From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [302]

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  • In overweight or obese postmenopausal women, the adiponectin level increased by 9.5% in the diet intervention group but by 6.5% in both diet and exercise groups.

    “In overweight or obese postmenopausal women, the adiponectin level increased by 9.5% in the diet intervention group but by 6.5% in both diet and exercise groups [103].”

    From Sarcopenic obesity, insulin resistance, and their implications in cardiovascular and metabolic consequences (2020) · cites this paper as [103]

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Authors
Abbenhardt, C., McTiernan, A., Alfano, C. M., Wener, M. H., Campbell, K. L., Duggan, C., Foster‐Schubert, K. E., Kong, A., Toriola, A. T., Potter, J. D., Mason, C., Xiao, L., Blackburn, G. L., Bain, C., & Ulrich, C. M.
Affiliations
  • German Cancer Research Center (DE)
  • University of Washington (US)
  • National Institutes of Health (US)
  • University of British Columbia (CA)
  • Fred Hutch Cancer Center (US)
  • University of Illinois Chicago (US)
  • Harvard University (US)
Corresponding author
Ulrich, C. M.
ORCID
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2013-03-29
Volume
274
Issue
2
Pages
163-175
ISSN
  • 0954-6820 (ISSN-L)
  • 1365-2796
DOI
10.1111/joim.12062
PMC
PMC3738194
OpenAlex
W2062526070
Cited by
137
References
46
Citations by year
2026: 4 · 2025: 4 · 2024: 8 · 2023: 11 · 2022: 8 · 2021: 12 · 2020: 9 · 2019: 8 · 2018: 15 · 2017: 17 · 2016: 13 · 2015: 10 · 2014: 13 · 2013: 5
FWCI
9.95
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute at the National Institutes of Health (U54-CA116847, R01 CA102504, 5KL2RR025015-03, R25 CA94880, R25CA057699)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
adiponectin, leptin, weight loss, hypocaloric diet, aerobic exercise, postmenopausal women, obesity, overweight, combined diet and exercise intervention, adipokines, chronic disease risk, body mass index, sedentary lifestyle, cardiovascular disease, diabetes mellitus, cancer risk, adipose tissue hormones, menopause, lifestyle intervention
MeSH terms
Aged, Diet, Reducing, Female, Follow-Up Studies, Humans, Middle Aged, Obesity, Reference Values, Time Factors, Weight Loss, Exercise, Body Mass Index, Treatment Outcome, Postmenopause, Risk Assessment, Leptin, Overweight, Adiponectin

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