Awakening Neuropsychiatric Research Into the Stria Medullaris: Development of a Diffusion-Weighted Imaging Tractography Protocol of This Key Limbic Structure
Open accessAbstract
The Stria Medullaris Thalami is a discrete white matter tract that directly connects frontolimbic areas to the habenula, allowing the forebrain to influence midbrain monoaminergic output. Habenular dysfunction has been shown in various neuropsychiatric conditions. However, there exists a paucity of research into the habenula’s principal afferent tract, the stria medullaris. Diffusion-weighted tractography may provide insights into the properties of the stria medullaris in vivo, opening up investigation of this tract in conditions of monoamine dysregulation such as depression, schizophrenia, addiction, and pain. We present a reliable method for reconstructing the stria medullaris using diffusion-weighted imaging, and examine the effects of age and gender on tract diffusion metrics. We also investigate reproducibility of the method through inter-rater comparisons. In consultation with neuroanatomists, a Boolean logic gate protocol was developed for use in ExploreDTI to extract the stria medullaris from constrained spherical deconvolution based whole brain tractography. Particular emphasis was placed on the reproducibility of the tract, attention to crossing white matter tract proximity and anatomical consistency of anterior and posterior boundaries. The anterior commissure, pineal gland and mid point of the thalamus were defined as anatomical fixed points used for reconstruction. Fifty subjects were scanned using High Angular Resolution Diffusion Imaging (61 directions, b-value 1500 mm3). Following constrained spherical deconvolution whole brain tractography, two independent raters isolated the stria medullaris. Each output was checked, examined and cleaned for extraneous streamlines inconsistent with known anatomy of the tract by the rater and a neuroanatomist. A second neuroanatomist assessed tracts for face validity. The stria medullaris was reconstructed with excellent inter-rater reliability for dimensions and diffusion metrics. Gender had no effect on the dimensions or diffusion metrics, however radial diffusivity showed a positive correlation with age. Reliable identification and quantification of diffusion metrics of the stria medullaris invites further exploration of this key habenula linked structure in neuropsychiatric disorders such as depression, anxiety, chronic pain, and addiction. The accurate anatomical localization of the stria medullaris may also aid preoperative stereotactic localization of the tract for deep brain stimulation treatment.
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The cingulate cortex projects to stress inhibitory areas (dorsomedial hypothalamus and the paraventricular hypothalamic nucleus), whilst the infralimbic cortex projects to stress excitatory areas (stria medullaris and amygdala).
“The cingulate cortex projects to stress inhibitory (dorsomedial hypothalamus and the paraventricular hypothalamic nucleus), whilst the infralimbic cortex projects to stress excitatory areas (stria medullaris and amygdala) (125–128).”
From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [127]
The Introduction (page not available) identifies dorsal anterior cingulate fibers as part of a pathway that forms the stria medullaris, supporting only a general cingulate connection to that tract. It does not describe cingulate projections to the dorsomedial or paraventricular hypothalamus, infralimbic projections to the stria medullaris or amygdala, or the proposed stress-inhibitory and stress-excitatory classification. (LLM, conf=0.82)
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Self-citationThe brain of the tree pangolin ( Manis tricuspis ). VIII. The subpallial telencephalon
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Self-citationTopographical anatomy of the septum verum and its white matter connections
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- Authors
- Roddy, D. W., Roman, E., Rooney, S., Andrews, S., Farrell, C., Doolin, K., Levins, K. J., Tozzi, L., Tierney, P., Barry, D., Frodl, T., O’Keane, V., & O’Hanlon, E.
- Affiliations
- Trinity College Dublin (IE)
- St. Vincent's University Hospital (IE)
- University Hospital Magdeburg (DE)
- Corresponding author
- Roddy, Darren W.
- ORCID
- Venue
- Frontiers in Neuroanatomy
- Publisher
- Frontiers Media SA
- Published
- 2018-05-08
- Volume
- 12
- Pages
- 39-39
- ISSN
- 1662-5129 (ISSN-L)
- PMC
- PMC5952041
- OpenAlex
- W2799469200
- Cited by
- 16
- References
- 84
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 2 · 2020: 2 · 2019: 1
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Neuroanatomy (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Health Research Board (201651.12553)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- habenula, constrained spherical deconvolution, radial diffusivity, inter-rater reliability, monoaminergic systems, depression, addiction, chronic pain, deep brain stimulation, stereotactic localization
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