A hitchhiker's guide to diffusion tensor imaging
Open accessAbstract
Diffusion Tensor Imaging (DTI) studies are increasingly popular among clinicians and researchers as they provide unique insights into brain network connectivity. However, in order to optimize the use of DTI, several technical and methodological aspects must be factored in. These include decisions on: acquisition protocol, artifact handling, data quality control, reconstruction algorithm, and visualization approaches, and quantitative analysis methodology. Furthermore, the researcher and/or clinician also needs to take into account and decide on the most suited software tool(s) for each stage of the DTI analysis pipeline. Herein, we provide a straightforward hitchhiker's guide, covering all of the workflow's major stages. Ultimately, this guide will help newcomers navigate the most critical roadblocks in the analysis and further encourage the use of DTI.
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In mouse models, reductions in AxD are seen during acute axonal degeneration.
“In mouse models, Reductions in AxD are also seen during acute axonal degeneration 25, 57.”
From Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model (2019) · cites this paper as [57]
The Application fields section says axial diffusivity is related to structural changes that can indicate axonal injury. It does not say that axial diffusivity decreases during acute axonal degeneration in mouse models; those condition, population, and direction details are unsupported by this source. (LLM, conf=0.82)
Experimental — accuracy not yet measured
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Roddy, D. W., Roman, E., Rooney, S., Andrews, S., Farrell, C., Doolin, K., Levins, K. J., Tozzi, L., Tierney, P., Barry, D., et al. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00039 · Cited by 16 · see citing works
Magnetic resonance imaging of the dopamine system in schizophrenia – A scoping review
Schulz, J., Zimmermann, J., Sorg, C., Menegaux, A., & Brandl, F. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.925476 · Cited by 14 · see citing works
Wang, S., Zuo, L., Jiang, T., Peng, P., Chu, S., & Xiao, D. (2017) · Neurological Research · doi:10.1080/01616412.2017.1379277 · Cited by 12 · see citing works
- Authors
- Soares, J. M., Marques, P., Alves, V., & Sousa, N.
- Affiliations
- University of Minho (PT)
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 31-31
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC3594764
- OpenAlex
- W2172006631
- Cited by
- 893
- References
- 13
- Citations by year
- 2026: 42 · 2025: 85 · 2024: 91 · 2023: 83 · 2022: 113 · 2021: 106 · 2020: 92 · 2019: 102 · 2018: 61 · 2017: 54 · 2016: 29 · 2015: 17 · 2014: 11 · 2013: 4 · 2012: 1
- FWCI
- 15.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Funders
- FP7 Health
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- diffusion tensor imaging, artifact handling, data quality control, brain network connectivity
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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