A new translational target for deep brain stimulation to treat depression
Open accessAbstract
Depression is a common, severe psychiatric illness with an enormous individual and societal burden and limited therapeutic options. Unfortunately, between about 10 and 30% of depressed patients taking antidepressants and receiving psychotherapy are partially or totally resistant to these treatments, and even with electroconvulsive therapy, a significant number remain refractory between about 10 and 30% of depressed patients taking antidepressants and receiving psychotherapy are partially or totally resistant to these treatments, and even with electroconvulsive therapy, a significant number remain refractory. Thus, there is an urgent need for more effective treatments, especially for the most severely affected fraction of patients. > …between about 10 and 30% of depressed patients taking antidepressants and receiving psychotherapy are partially or totally resistant to these treatments, and even with electroconvulsive therapy, a significant number remain refractory. For the treatment of neurological symptoms, such as essential tremor, dystonia and Parkinson Disease, deep brain stimulation (DBS) has become a routine treatment. Given this success, the last decade has seen its application in small case series and individual cases to treat depression. Most of these studies have described successful treatment rates of around 30–50% in patients who had previously been characterised as treatment resistant. Such an approach in treatment resistant depression (TRD) of course depends on the selection of suitable targets in the complex neural circuits mediating this brain disease. To be able to translate preclinical findings into human research, a valid animal model and a tool for translation are required. In our search for an appropriate target, we have used the congenital Learned Helpless (cLH) model, which uniquely models TRD. Inter alia , our established genetic …
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In the Keining et al 2013 open-label study of two patients with treatment-resistant depression, lateral habenula deep brain stimulation yielded a 100% remission rate, measured by HDRS.
“| | Keining et al | 2013 Open label | N = 2 | N/A | 100.0% | 100.0% | HDRS |”
From Deep brain stimulation for depression. (2022) · cites this paper as [46]
Across the four pooled lateral habenula deep brain stimulation studies totaling 11 patients, the response rate was 85.7%.
“Total* | | | N = 11 | | 85.7% | 53.6% | |”
From Deep brain stimulation for depression. (2022) · cites this paper as [46]
Across the four pooled lateral habenula deep brain stimulation studies totaling 11 patients, the remission rate was 53.6%.
“Total* | | | N = 11 | | 85.7% | 53.6% | |”
From Deep brain stimulation for depression. (2022) · cites this paper as [46]
In the Keining et al 2013 open-label study of two patients with treatment-resistant depression, lateral habenula deep brain stimulation yielded a 100% response rate, measured by HDRS.
“| | Keining et al | 2013 Open label | N = 2 | N/A | 100.0% | 100.0% | HDRS |”
From Deep brain stimulation for depression. (2022) · cites this paper as [46]
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- Authors
- Kiening, K., & Sartorius, A.
- Affiliations
- University Hospital Heidelberg (DE)
- Heidelberg University (DE)
- Corresponding author
- Kiening, Karl
- ORCID
- Sartorius, Alexander
- Venue
- EMBO Molecular Medicine
- Published
- 2013-07-04
- Volume
- 5
- Issue
- 8
- Pages
- 1151-1153
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- PMC
- PMC3944457
- OpenAlex
- W2112694709
- Cited by
- 70
- References
- 10
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 10 · 2017: 9 · 2016: 10 · 2015: 6 · 2014: 3 · 2013: 3
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- EMBO Molecular Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Bundesministerium für Bildung und Forschung (01EW1110)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- deep brain stimulation, treatment-resistant depression, depression, animal models of depression, neural circuits
- MeSH terms
- Animals, Cerebrovascular Circulation, Depressive Disorder, Disease Models, Animal, Helplessness, Learned, Humans, Phenotype, Treatment Outcome, Rats, Sprague-Dawley, Habenula, Deep Brain Stimulation, Rats, Translational Research, Biomedical
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