Deletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehavior

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

Niswender, C. M., & Conn, P. J. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.011008.145533 · Cited by 1,889

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., & Gonzalez, F. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00062-3 · Cited by 1,819

Identification of a nuclear receptor that is activated by farnesol metabolites

Forman, B. M., Goode, E., Chen, J., Oro, A. E., Bradley, D. J., Perlmann, T., Noonan, D. J., Burka, L. T., McMorris, T., Lamph, W. W., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90530-8 · Cited by 1,210

Identification of membrane-type receptor for bile acids (M-BAR)

Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Nakamura, T., Itadani, H., & Tanaka, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02550-0 · Cited by 993

The GABAergic deficit hypothesis of major depressive disorder

Luscher, B., Shen, Q., & Sahir, N. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.120 · Cited by 934

Bile acids as regulatory molecules

Hylemon, P. B., Zhou, H., Pandak, W. M., Ren, S., Gil, G., & Dent, P. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r900007-jlr200 · Cited by 694

Nuclear Receptor-Dependent Bile Acid Signaling Is Required for Normal Liver Regeneration

Huang, W., Ma, K., Zhang, J., Qatanani, M., Cuvillier, J., Liu, J., Dong, B., Huang, X., & Moore, D. D. (2006) · Science · doi:10.1126/science.1121435 · Cited by 645

Reduced Cortical γ-Aminobutyric Acid Levels in Depressed Patients Determined by Proton Magnetic Resonance Spectroscopy

Sanacora, G., Mason, G. F., Rothman, D. L., Behar, K. L., Hyder, F., Petroff, O. A. C., Berman, R. M., Charney, D. S., & Krystal, J. H. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.11.1043 · Cited by 627

Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine

Kim, I., Ahn, S.-H., Inagaki, T., Choi, M., Ito, S., Guo, G. L., Kliewer, S. A., & Gonzalez, F. J. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700330-jlr200 · Cited by 589

Magnetic Resonance Spectroscopy Studies of Glutamate-Related Abnormalities in Mood Disorders

Yüksel, Ç., & Öngür, D. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.016 · Cited by 493

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415

Bile acid signaling pathways from the enterohepatic circulation to the central nervous system

Mertens, K. L., Kalsbeek, A., Soeters, M. R., & Eggink, H. M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00617 · Cited by 287

Gut microbial metabolites in depression: understanding the biochemical mechanisms

Caspani, G., Kennedy, S. H., Foster, J. A., & Swann, J. R. (2019) · Microbial Cell · doi:10.15698/mic2019.10.693 · Cited by 289

Effects of bile acids on neurological function and disease

McMillin, M., & DeMorrow, S. (2016) · The FASEB Journal · doi:10.1096/fj.201600275r · Cited by 192

Bile acid signaling in neurodegenerative and neurological disorders

Grant, S. M., & DeMorrow, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175982 · Cited by 185

Bile acids: a communication channel in the gut-brain axis

Monteiro-Cardoso, V. F., Corlianò, M., & Singaraja, R. R. (2021) · NeuroMolecular Medicine · doi:10.1007/s12017-020-08625-z · Cited by 145

Small talk: microbial metabolites involved in the signaling from microbiota to brain

Caspani, G., & Swann, J. R. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.08.001 · Cited by 144

Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity

Jena, P. K., Sheng, L., Di Lucente, J., Jin, L., Maezawa, I., & Wan, Y. Y. (2018) · The FASEB Journal · doi:10.1096/fj.201700984rr · Cited by 134

Bile Acids in Neurodegenerative Disorders

Ackerman, H. D., & Gerhard, G. S. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00263 · Cited by 120

Roles of bile acids signaling in neuromodulation under physiological and pathological conditions

Chen, X., Huang, X., Wang, D., Yu, D., Hou, S., Cui, H., & Song, L. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01053-z · Cited by 128

From dried bear bile to molecular investigation: A systematic review of the effect of bile acids on cell apoptosis, oxidative stress and inflammation in the brain, across pre-clinical models of neurological, neurodegenerative and neuropsychiatric disorders

Huang, F., Pariante, C. M., & Borsini, A. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.09.021 · Cited by 117

Bile acids as key modulators of the brain-Gut-Microbiota axis in alzheimer’s disease

Mulak, A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210608 · Cited by 114

Bile Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Promotes Neuroinflammation during Hepatic Encephalopathy in Mice

McMillin, M., Frampton, G. A., Grant, S. M., Khan, S. H., Diocares, J., Petrescu, A. D., Wyatt, A., Kain, J., Jefferson, B., & DeMorrow, S. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00191 · Cited by 112

Identification of functional farnesoid X receptors in brain neurons

Huang, C., Wang, J., Hu, W., Wang, C., Lu, X., Tong, L., Wu, F., & Zhang, W. (2016) · FEBS Letters · doi:10.1002/1873-3468.12373 · Cited by 103

Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure

Xie, G., Wang, X., Jiang, R., Zhao, A., Yan, J., Zheng, X., Huang, F., Liu, X., Panee, J., Rajani, C., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.10.030 · Cited by 83

Bile acids and neurological disease

Hurley, M. J., Bates, R., Macnaughtan, J., & Schapira, A. H. V. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108311 · Cited by 86

Gut microbiome-linked metabolites in the pathobiology of major depression with or without anxiety-a role for bile acids

MahmoudianDehkordi, S., Bhattacharyya, S., Brydges, C. R., Jia, W., Fiehn, O., Rush, A. J., Dunlop, B. W., & Kaddurah-Daouk, R. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.937906 · Cited by 75

Bile acid receptors and signaling crosstalk in the liver, gut and brain

Ferrell, J. M., & Chiang, J. Y. L. (2021) · Liver Research · doi:10.1016/j.livres.2021.07.002 · Cited by 72

Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling

Zhao, Q., Liu, F., Cheng, Y., Xiao, X.-R., Hu, D., Tang, Y., Bao, W.-M., Yang, J., Jiang, T., Hu, J., et al. (2019) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.000817 · Cited by 68

Nutritional Modulation of Immune and Central Nervous System Homeostasis: The Role of Diet in Development of Neuroinflammation and Neurological Disease

Estrada, J. A., & Contreras, I. (2019) · Nutrients · doi:10.3390/nu11051076 · Cited by 65

Synbiotics Bifidobacterium infantis and milk oligosaccharides are effective in reversing cancer-prone nonalcoholic steatohepatitis using western diet-fed FXR knockout mouse models

Jena, P. K., Sheng, L., Nagar, N., Wu, C., Barile, D., Mills, D. A., & Wan, Y.-J. Y. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.04.007 · Cited by 60

The pathophysiological function of non-gastrointestinal farnesoid X receptor

Yan, N., Yan, T., Xia, Y., Hao, H., Wang, G., & Gonzalez, F. J. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107867 · Cited by 56

Potential gut–brain mechanisms behind adverse mental health outcomes of bariatric surgery

Brown, R. M., Guerrero-Hreins, E., Brown, W. A., le Roux, C. W., & Sumithran, P. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00520-2 · Cited by 49

Gut Microbiota Metabolite Messengers in Brain Function and Pathology at a View of Cell Type-Based Receptor and Enzyme Reaction

Lee, B., Lee, S. M., Song, J. W., & Choi, J. W. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.009 · Cited by 49

Emerging Roles of Bile Acids and TGR5 in the Central Nervous System: Molecular Functions and Therapeutic Implications

Romero‐Ramírez, L., & Mey, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179279 · Cited by 50

Bile Acids in Hepatic Encephalopathy

DeMorrow, S. (2018) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2018.04.011 · Cited by 48

Chaihu-shugan-san alleviates depression-like behavior in mice exposed to chronic unpredictable stress by altering the gut microbiota and levels of the bile acids hyocholic acid and 7-ketoDCA

Ma, C., Yuan, D., Renaud, S. J., Zhou, T., Yang, F., Liou, Y., Qiu, X., Zhou, L., & Guo, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1040591 · Cited by 47

The clinical and mechanistic roles of bile acids in depression, Alzheimer's disease, and stroke

Wu, L., Zhao, M., Li, M., Guo, Q., Zhenxing, R., Xiaojiao, Z., & Chen, T. (2022) · PROTEOMICS · doi:10.1002/pmic.202100324 · Cited by 47

The Role of Bile Acids in the Human Body and in the Development of Diseases

Shulpekova, Y. O., Жаркова, М. С., Tkachenko, P. E., Тихонов, И. Н., Stepanov, A. A., Sinitsyna, A. A., Izotov, A., Butkova, T. V., Shulpekova, N. V., Лапина, Н. В., et al. (2022) · Molecules · doi:10.3390/molecules27113401 · Cited by 46

The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity

Rausch, M., Samodelov, S. L., Visentin, M., & Kullak-Ublick, G. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213967 · Cited by 44

Molecular mechanism and therapeutic strategy of bile acids in Alzheimer’s disease from the emerging perspective of the microbiota–gut–brain axis

Wu, M., Cheng, Y., Zhang, R., Han, W., Jiang, H., Bi, C., Zhang, Z., Ye, M., Lin, X., & Liu, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117228 · Cited by 40

Strategy for an Association Study of the Intestinal Microbiome and Brain Metabolome Across the Lifespan of Rats

Chen, T., You, Y., Xie, G., Zheng, X., Zhao, A., Liu, J., Zhao, Q., Wang, S., Huang, F., Rajani, C., et al. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b02859 · Cited by 35

Metabolic Diffusion in Neuropathologies: The Relevance of Brain-Liver Axis

Vegas‐Suárez, S., Simón, J., Martínez‐Chantar, M. L., & Moratalla, R. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.864263 · Cited by 35

Gut–Brain Axis and Bile Acid Signaling: Linking Microbial Metabolism to Brain Function and Metabolic Regulation

Stanimirov, B., Đanić, M., Pavlović, N., Zaklan, D., Lazarević, S., Mikov, M., & Stankov, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262412167 · Cited by 39

Xanthohumol ameliorates Diet-Induced Liver Dysfunction via Farnesoid X Receptor-Dependent and Independent Signaling

Paraiso, I. L., Tran, T. Q., Magaña, A. A., Kundu, P., Choi, J., Maier, C. S., Bobe, G., Raber, J., Kioussi, C., & Stevens, J. F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.643857 · Cited by 31

Liver’s influence on the brain through the action of bile acids

Yeo, X. Y., Tan, L. Y., Chae, W. R., Lee, D., Lee, Y., Wüestefeld, T., & Jung, S. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1123967 · Cited by 35

Bile acids, bioactive signalling molecules in interoceptive gut‐to‐brain communication

Joyce, S. A., & O'Malley, D. (2022) · The Journal of Physiology · doi:10.1113/jp281727 · Cited by 32

A critical review of bile acids and their receptors in hepatic encephalopathy

Williams, E., Chu, C. S., & DeMorrow, S. (2021) · Analytical Biochemistry · doi:10.1016/j.ab.2021.114436 · Cited by 34

Sex Differences in Molecular Rhythms in the Human Cortex

Logan, R. W., Xue, X., Ketchesin, K. D., Hoffman, G. E., Roussos, P., Tseng, G. C., McClung, C. A., & Seney, M. L. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.03.005 · Cited by 30

Depression-associated gut microbes, metabolites and clinical trials

Wang, M., Song, Z., Lai, S., Tang, F., Dou, L., & Yang, F. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1292004 · Cited by 32

Gut feelings: the microbiota-gut-brain axis on steroids

So, S. Y., & Savidge, T. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00294.2021 · Cited by 29

Liver Steatosis and Steatohepatitis Alter Bile Acid Receptors in Brain and Induce Neuroinflammation: A Contribution of Circulating Bile Acids and Blood-Brain Barrier

Fiaschini, N., Mancuso, M., Tanori, M., Colantoni, E., Vitali, R., Diretto, G., Lorenzo-Rebenaque, L., Stronati, L., & Negroni, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214254 · Cited by 31

Gene Therapy for Progressive Familial Intrahepatic Cholestasis: Current Progress and Future Prospects

Bosma, P. J., Wits, M., & Elferink, R. P. J. O. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010273 · Cited by 27

Evidence and Mechanism of Bile Acid–Mediated Gut-Brain Axis in Anxiety and Depression

Idahosa, S. O., Diarra, R., Ranu, H. K., Nasiri, R. H., & Higuchi, S. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.10.019 · Cited by 31

A Fragment of Adhesion Molecule L1 Binds to Nuclear Receptors to Regulate Synaptic Plasticity and Motor Coordination

Kraus, K., KLEENE, R. B., Henis, M., Braren, I., Kataria, H., Sharaf, A. L., Loers, G., Schachner, M., & Lutz, D. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0901-7 · Cited by 24

A combination of three plasma bile acids as a putative biomarker for schizophrenia

Tao, Y., Zheng, F., Cui, D., Huang, F., & Wu, X. (2020) · Acta Neuropsychiatrica · doi:10.1017/neu.2020.42 · Cited by 23

Bioenhancing effects of piperine and curcumin on triterpenoid pharmacokinetics and neurodegenerative metabolomes from Centella asiatica extract in beagle dogs

Boonyarattanasoonthorn, T., Kongratanapasert, T., Maiuthed, A., Hamlin, R. L., Kijtawornrat, A., & Khemawoot, P. (2022) · Scientific Reports · doi:10.1038/s41598-022-24935-7 · Cited by 22

The role of the gut microbiome in disorders of gut–brain interaction

Gawey, B. J., Mars, R. A. T., & Kashyap, P. (2024) · FEBS Journal · doi:10.1111/febs.17200 · Cited by 30

Research Progress on the Mechanism of Bile Acids and Their Receptors in Depression

Zhao, X., Zheng, I., Huang, W., Tang, D., Zhao, M., Hou, R., Huang, Y., Shi, Y., Zhu, W., & Wang, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094023 · Cited by 25

Exploring the role of a novel postbiotic bile acid: Interplay with gut microbiota, modulation of the farnesoid X receptor, and prospects for clinical translation

Wang, B., Han, D. W., Hu, X., Chen, J., Liu, Y., & Wu, J. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127865 · Cited by 24

Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders

Darmanto, A. G., Yen, T., Jan, J., Linh, T. T. D., Taliyan, R., Yang, C. H., & Sheu, J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107564 · Cited by 23

Farnesoid X Receptor Activation in Brain Alters Brown Adipose Tissue Function via the Sympathetic System

Deckmyn, B., Domenger, D., Blondel, C., Ducastel, S., Nicolas, E., Dorchies, E., Caron, É., Charton, J., Vallez, E., Deprez, B. P., et al. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.808603 · Cited by 23

Pregnane X Receptor and P-glycoprotein: a connexion for Alzheimer’s disease management

Jain, S. K., Rathod, V. P., Prajapati, R., Nandekar, P. P., & Sangamwar, A. T. (2014) · Molecular Diversity · doi:10.1007/s11030-014-9550-6 · Cited by 21

On the Evolution of Bile Salts and the Farnesoid X Receptor in Vertebrates

Frisch, K., & Alstrup, A. K. O. (2017) · Physiological and Biochemical Zoology · doi:10.1086/695810 · Cited by 18

Farnesoid X receptor: a potential therapeutic target in multiple organs.

Zhang, C., Wang, Z., Feng, Q., Chen, W.-D., & Wang, Y.-D. (2021) · Histology and Histopathology · doi:10.14670/hh-18-301 · Cited by 16

Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo

Boussadia, B., Gangarossa, G., Mselli-Lakhal, L., Rousset, M.-C., de Bock, F., Lassere, F., Ghosh, C., Pascussi, J., Janigro, D., & Marchi, N. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.018 · Cited by 17

The Status of Bile Acids and Farnesoid X Receptor in Brain and Liver of Rats with Thioacetamide-Induced Acute Liver Failure

Czarnecka, A. M., Milewski, K., Albrecht, J., & Zielińska, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207750 · Cited by 16

Underneath the Gut–Brain Axis in IBD—Evidence of the Non-Obvious

Boldyreva, L. V., Evtushenko, A. A., Lvova, M. N., Morozova, K. N., & Владимировна, К. Е. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212125 · Cited by 16

Interconnected pathways link faecal microbiota plasma lipids and brain activity to childhood malnutrition related cognition

Portlock, T., Shama, T., Kakon, S. H., Hartjen, B., Pook, C. J., Wilson, B. C., Bhuttor, A., Ho, D., Shennon, I., Engelstad, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55798-3 · Cited by 16

Serotonin/5-HT1A Signaling in the Neurovascular Unit Regulates Endothelial CLDN5 Expression

Sugimoto, K., Ichikawa‐Tomikawa, N., Nishiura, K., Kunii, Y., Sano, Y., Shimizu, F., Kakita, A., Kanda, T., Imura, T., & Chiba, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010254 · Cited by 16

Qing'E formula alleviates the aging process in D-galactose-induced aging mice

Zhong, L., Huang, F., Shi, H., Wu, H., Zhang, B., Wu, X., Wei, X., & Wang, Z. (2016) · Biomedical Reports · doi:10.3892/br.2016.667 · Cited by 16

NR1H4 ameliorates Parkinson’s disease via inhibiting astrocyte activation and neuroinflammation in a CEBPβ/NF-κB dependent manner

Li, J., Liu, H., Hu, X., Zhang, S., Yu, Q., Kuang, G., Liu, L., Yu, D., Huang, J., Xia, Y. F., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113087 · Cited by 16

Bile Acids as Key Mediators of the Gut Microbiota–Immune Axis: Potential Biomarker and Therapeutic Perspectives

Baldi, S., Turrini, M., Cei, F., Menicatti, M., Bartolucci, G., & Amedei, A. (2026) · BioFactors · doi:10.1002/biof.70078 · Cited by 13

The contributions of bacteria metabolites to the development of hepatic encephalopathy

Gilbert, M. C., Setayesh, T., & Wan, Y. Y. (2022) · Liver Research · doi:10.1016/j.livres.2022.11.005 · Cited by 10

Bile acid interactions with neurotransmitter transporters

Romanazzi, T., Zanella, D., Bhatt, M., Iacovo, A. D., Galli, A., & Bossi, E. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1161930 · Cited by 12

The relationship between alterations in plasma metabolites and treatment responses in antipsychotic-naïve female patients with schizophrenia

Wang, X., Xie, J., Ma, H., Li, G., Li, M., Li, S., Sun, X., Zhao, Y., Sun, W., Yang, S., et al. (2023) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2023.2271965 · Cited by 11

The bile acid chenodeoxycholic acid associates with reduced stroke in humans and mice

Monteiro-Cardoso, V. F., Yeo, X. Y., Bae, H., Mayan, D. C., Wehbe, M., Lee, S., Krishna-K, K., Baek, S. H., Palomera, L. F., Wu, L. H., et al. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100712 · Cited by 11

Comparative transcriptomic analysis reveals the gut-brain axis regulatory mechanisms in cold-tolerant pufferfish (Takifugu fasciatus) under cold stress

Wang, J., Han, S., Luo, Y., Zhang, J., Wang, Y., & Chen, L. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.742033 · Cited by 10

Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?

Rosell‐Cardona, C., Cryan, J. F., Clarke, G. A., & Kittel‐Schneider, S. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00749-z · Cited by 11

Mechanisms of the effect of gut microbes on depression through the microbiota-gut-brain axis

Zhou, X., Wang, S., Wang, X., Chen, X., Zhou, P., Ma, K., & Zhang, P. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1634548 · Cited by 14

Bile Acids Gate Dopamine Transporter Mediated Currents

Romanazzi, T., Zanella, D., Cheng, M. H., Smith, B., Carter, A. M., Galli, A., Bahar, İ., & Bossi, E. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.753990 · Cited by 9

Gut microbiome metabolites as key actors in atherosclerosis co-depression disease

Liao, X.-X., Wu, X., Zhou, Y.-L., Li, J., Wen, Y.-L., & Zhou, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.988643 · Cited by 10

Cross-sectional and longitudinal associations of circulating bile acids and dementia: a systematic review

Zhang, Y., Li, J., Li, J., Wang, Y., Cui, M., Li, W., Chen, X., & Jiang, Y. (2025) · GeroScience · doi:10.1007/s11357-025-01790-8 · Cited by 10

Daidzein alleviates chronic restraint stress-induced depression-like behavior by regulating neuroinflammation and synaptic plasticity via microbiota-gut-brain axis

Wang, H., Nie, Y., Luo, Y., Sun, Z., He, Y., & Yang, J. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157394 · Cited by 9

Integrated metabolomics and network pharmacology to reveal the mechanism of areca nut addiction

Li, M., Pang, X., Guo, Z., Yang, Y., Gu, Z., & Zhang, L. (2023) · Addiction Biology · doi:10.1111/adb.13352 · Cited by 9

Microbial Metabolites and the Gut-Brain Axis in Neurological Disorders: Implications for Neuropharmacology and Therapy

Wang, Y., & Zhang, Y. (2025) · Neuropharmacology and Therapy · doi:10.15212/npt-2025-0008 · Cited by 9

Interactions of bile acids and gut microbiota modulate neurological health: a comprehensive review on mechanisms and therapeutic potential of dietary phytochemicals

Wang, J., Zhang, Y., Wu, Q., Zhong, Y., Xu, Z., & Yang, J. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1757551 · Cited by 10

Profile of the bile acid FXR-FGF15 pathway in the glucolipid metabolism disorder of diabetic mice suffering from chronic stress

Cai, W., Li, C., Su, Z., Cao, J., Chen, Z., Chen, Y., Guo, Z., Cai, J., & Xu, F. (2023) · PeerJ · doi:10.7717/peerj.16407 · Cited by 8

Peyer’s Patch: Possible target for modulating the Gut-Brain-Axis through microbiota

Asgari, R., Bazzazan, M. A., Jirandehi, A. K., Yousefzadeh, S., Alaei, M., & Shahbaz, S. K. (2024) · Cellular Immunology · doi:10.1016/j.cellimm.2024.104844 · Cited by 5

Bile Acid Profile Differs Between Brain Regions in Rodents and Is Disrupted in a Rodent Model of Alzheimer's Disease

Reuter, M. A., Moreno, R., Tucker, M., Shishani, R., Bustamante, J. M., Marfori, Z., Richieri, T., Valenzuela, A. E., Taha, A. Y., Lein, P. J., et al. (2025) · Comprehensive physiology · doi:10.1002/cph4.70034 · Cited by 4

Dried bear bile exerts its antidepressant effect by modulating adrenal FXR to reduce peripheral glucocorticoid levels

Tao, Y., Li, Z., Yuan, J., Wu, H., Shi, H., Wu, X., & Huang, F. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100856 · Cited by 4

Aqueous Extract of Lycium ruthenicum Murray Attenuates Neuroinflammation in C57BL/6J Mice Induced by High-Fat and High-Fructose Diet Through Regulating Gut Microbiota and Bile Acid Metabolism

Fan, X., Dong, W., Huang, Y., Shu, Y., Yan, Y., Mi, J., Lu, L., Zeng, X., & Cao, Y. (2024) · Foods · doi:10.3390/foods13233812 · Cited by 4

Farnesoid X receptor activation alleviates hepatic encephalopathy by improving hepatic ammonia metabolism in murine models

Ye, W., Bai, X., Zhao, Y., Du, Z., Liu, F., Wang, Y., & Chen, W. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167750 · Cited by 5

Metabolites from the Gut Microbiota and the Role in the Gut-Brain Axis

Fukushima, K. (2022) · Science Insights · doi:10.15354/si.22.re037 · Cited by 4

Gut microbiome-linked metabolites in the pathobiology of depression and anxiety - a role for bile acidsPreprint

MahmoudianDehkordi, S., Bhattacharyya, S., Brydges, C. R., Jia, W. P., Fiehn, O., Rush, A. J., Dunlop, B. W., & Kaddurah-Daouk, R. F. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.04.485514 · Cited by 4

Identifying novel metabolites in children with attention-deficit hyperactivity disorder through metabolome profiling

Hung, Y.-A., Kuo, T.-C., Tseng, Y. J., Shang, C., & Gau, S. S. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03393-5 · Cited by 3

Post-bariatric surgery quality-of-life decline: analysis of the gut–brain axis

Jiao, Y., Zhu, S., Xue, H., Wang, Y., Wang, Y., & Hou, D. (2025) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-025-01784-7 · Cited by 3

Unveiling the rumen-microbiome-brain circuit: a unique dimension of gut-brain axis in ruminants

Joshi, H., Bernard, B., Lemley, C. O., Wang, Z., & Fan, P. F. (2025) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-025-01289-4 · Cited by 4

Metabolomics and the Gut–Brain Axis

Caspani, G., Harvey, M., & Swann, J. R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00003-5 · Cited by 3

Comprehensive Analysis of the Microbiome and Metabolome: Unveiling Interactions Between Intestinal Flora and Metabolites in Schizophrenia

Chen, L., Li, W., Mo, D., Meng, X., Yao, L., Zhang, X., & Liu, H. (2025) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s523570 · Cited by 2

Bile Acids and Their Value for Central Nervous System

Shulpekova, Y. O., Tkachenko, P. E., Shirokova, E. N., & Damulin, I. V. (2022) · Russian Journal of Gastroenterology Hepatology Coloproctology · doi:10.22416/1382-4376-2021-31-5-7-15 · Cited by 2

Aldicarb disturbed bile acid, steroid hormone and oxylipin homeostasis in C57BL/6 J mice

Liu, X., Tu, P., Zhang, Y., Xu, W., Shan, J., & Gao, B. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116285 · Cited by 1

Fecal microbiota composition and function are associated with anxiety and depression in patients with inflammatory bowel disease

Wang, Z., Zhou, M., Dang, Y., Huang, X., Xu, C., Xu, F., Xu, X., Li, P., Zhang, S., Shi, H., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0337941 · Cited by 1

The bridging role of gut microbiota-derived metabolites in neuropathic pain comorbid with anxiety

Bian, J., & 白金柱 (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1752839 · Cited by 1

TGR5 and FXR receptors in motor degeneration: Molecular mechanism, crosstalk pathways and therapeutic prospects

Banerjee, S., Panjwani, D., Singh, S., & Singh, T. G. (2026) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2026.578942 · Cited by 1

Neurologic Consequences of Liver Disease

McMillin, M., Rhodes, K., & DeMorrow, S. (2026) · American Journal Of Pathology · doi:10.1016/j.ajpath.2026.07.014 · Cited by 1

The Gut Microbiota and NDG: What Is the Interplay

Haiba, S., Idriss, S., & Awad, M. (2024) · Springer eBooks · doi:10.1007/978-981-19-3949-5_30-1 · Cited by 1

Alpha-naphthylisothiocyanate-induced cholestatic mice display anxiety-like behavior closely related with enhanced serotoninergic signaling transduction in central nervous system

Zhou, J., Tao, Y., Zhu, H., Wu, H., Shi, H., Huang, F., & Wu, X. (2020) · Neuroreport · doi:10.1097/wnr.0000000000001437 · Cited by 1

Celastrol通过调制SIRT1-FXR信号传导来保护胆汁淤积肝损伤* [S]

齐泽, 方刘, 闫成, 薛荣萧, 丹胡, 丹., 莹梅唐, 魏民宝, 金辉杨, 陶江, 贾鹏胡, et al. (2019)

Absence of the bile acid enzyme CYP8B1 increases brain chenodeoxycholic acid and reduces neuronal excitotoxicity in micePreprint

Monteiro-Cardoso, V. F., Yeo, X. Y., Bae, H., Mayan, D. C., Wehbe, M., Lee, S., Krishna-K, K., Baek, S. H., Palomera, L. F., Shanmugam, S., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.11.520005

Neuron‐specific knockout of FXR attenuates the neurological complications of chronic liver disease

DeMorrow, S., Grant, S. M., Williams, E., Frampton, G. A., Petrescu, A. D., & McMillin, M. (2019) · The FASEB Journal · doi:10.1096/fasebj.2019.33.1_supplement.662.65 · Cited by 1

Hippocampal FXR plays a role in the pathogenesis of depression: A preliminary study based on lentiviral gene modulation

Chen, W.-G., Zheng, J., Xu, X., Hu, Y., & Ma, Y. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.04.025 · Cited by 47

Farnesoid X Receptor-Mediated Cytoplasmic Translocation of CRTC2 Disrupts CREB-BDNF Signaling in Hippocampal CA1 and Leads to the Development of Depression-Like Behaviors in Mice

Hu, W., Wu, J., Ye, T., Chen, Z., Tao, J., Tong, L., Ma, K., Wen, J., Wang, H., & Huang, C. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa039 · Cited by 41

Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmission

Khlghatyan, J., Evstratova, A., Chamberland, S., Marakhovskaia, A., Bahremand, A., Tóth, K., & Beaulieu, J. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00119 · Cited by 31

Changes in Sensitivity of Reward and Motor Behavior to Dopaminergic, Glutamatergic, and Cholinergic Drugs in a Mouse Model of Fragile X Syndrome

Fish, E. W., Krouse, M. C., Stringfield, S. J., DiBerto, J. F., Robinson, J. E., & Malanga, C. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077896 · Cited by 29