Meningeal mast cells as key effectors of stroke pathology.

Heart disease and stroke statistics-2018 update: a report from the american heart association

Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146 · see citing works

Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

Nogueira, R. G., Jadhav, A. P., Haussen, D. C., Bonafé, A., Budzik, R. F., Bhuva, P., Yavagal, D. R., Ribó, M., Cognard, C., Hanel, R. A., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1706442 · Cited by 5,667 · see citing works

Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

Albers, G. W., Marks, M. P., Kemp, S. M., Christensen, S., Tsai, J. P.-C., Ortega‐Gutiérrez, S., McTaggart, R., Torbey, M., Kim‐Tenser, M. A., Leslie‐Mazwi, T. M., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1713973 · Cited by 4,966 · see citing works

Structural and functional features of central nervous system lymphatic vessels

Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413 · see citing works

The immunology of stroke: from mechanisms to translation

Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596 · see citing works

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

Aspelund, A., Antila, S., Proulx, S. T., Karlsen, T. V., Karaman, S., Detmar, M., Wiig, H., & Alitalo, K. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142290 · Cited by 2,198 · see citing works

The Science of Stroke: Mechanisms in Search of Treatments

Moskowitz, M. A., Lo, E. H., & Iadecola, C. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.002 · Cited by 1,930 · see citing works

IgE and mast cells in allergic disease

Galli, S. J., & Tsai, M. (2012) · Nature Medicine · doi:10.1038/nm.2755 · Cited by 1,799 · see citing works

MAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances

Galli, S. J., Kalesnikoff, J., Grimbaldeston, M. A., Piliponsky, A. M., Williams, C. M. M., & Tsai, M. M. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141025 · Cited by 1,231 · see citing works

Debris clearance by microglia: an essential link between degeneration and regeneration

Neumann, H., Kotter, M. R., & Franklin, R. J. M. (2008) · Brain · doi:10.1093/brain/awn109 · Cited by 1,111 · see citing works

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

Liesz, A., Suri-Payer, E., Veltkamp, C., Doerr, H., Sommer, C., Rivest, S., Giese, T., & Veltkamp, R. (2009) · Nature Medicine · doi:10.1038/nm.1927 · Cited by 1,059 · see citing works

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

Galli, S. J., Borregaard, N., & Wynn, T. A. (2011) · Nature Immunology · doi:10.1038/ni.2109 · Cited by 1,055 · see citing works

Inflammation and Stroke: An Overview

Anrather, J., & Iadecola, C. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0483-x · Cited by 966 · see citing works

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.

Louveau, A., Herz, J., Alme, M. N., Salvador, A. F., Dong, M. Q., Viar, K. E., Herod, S. G., Knopp, J., Setliff, J. C., Lupi, A. L., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0227-9 · Cited by 956 · see citing works

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

Shichita, T., Sugiyama, Y., Ooboshi, H., Sugimori, H., Nakagawa, R., Takada, I., Iwaki, T., Okada, Y., Iida, M., Cua, D. J., et al. (2009) · Nature Medicine · doi:10.1038/nm.1999 · Cited by 842 · see citing works

Regulation of learning and memory by meningeal immunity: a key role for IL-4

Derecki, N. C., Cardani, A. N., Yang, C. H., Quinnies, K. M., Crihfield, A., Lynch, K. R., & Kipnis, J. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091419 · Cited by 800 · see citing works

Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

Galli, S. J., Grimbaldeston, M. A., & Tsai, M. M. (2008) · Nature reviews. Immunology · doi:10.1038/nri2327 · Cited by 738 · see citing works

Role of T Lymphocytes and Interferon-γ in Ischemic Stroke

Yilmaz, G., Arumugam, T. V., Stokes, K. Y., & Granger, D. N. (2006) · Circulation · doi:10.1161/circulationaha.105.593046 · Cited by 722 · see citing works

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

Knowland, D., Arac, A., Sekiguchi, K. J., Hsu, M., Lutz, S. E., Perrino, J., Steinberg, G. K., Barres, B. A., Nimmerjahn, A., & Agalliu, D. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.003 · Cited by 703 · see citing works

Mast cells as sources of cytokines, chemokines, and growth factors

Mukai, K., Tsai, M. M., Saito, H., & Galli, S. J. (2018) · Immunological Reviews · doi:10.1111/imr.12634 · Cited by 687 · see citing works

Revisiting the Mechanisms of CNS Immune Privilege

Louveau, A., Harris, T. H., & Kipnis, J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.006 · Cited by 682 · see citing works

Targeting Neutrophils in Ischemic Stroke: Translational Insights from Experimental Studies

Jickling, G. C., Liu, D., Ander, B. P., Stamova, B., Zhan, X., & Sharp, F. R. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.45 · Cited by 644 · see citing works

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

Herisson, F., Frodermann, V., Courties, G., Rohde, D., Sun, Y., Vandoorne, K., Wojtkiewicz, G. R., Masson, G. S., Vinegoni, C., Kim, J., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0213-2 · Cited by 610 · see citing works

Mast Cell-Deficient W-sash c-kit Mutant KitW-sh/W-sh Mice as a Model for Investigating Mast Cell Biology in Vivo

Grimbaldeston, M. A., Chen, C., Piliponsky, A. M., Tsai, M. M., Tam, S., & Galli, S. J. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62055-x · Cited by 594 · see citing works

Enhanced Expression of Iba1, Ionized Calcium-Binding Adapter Molecule 1, After Transient Focal Cerebral Ischemia In Rat Brain

Ito, D., Tanaka, K., Suzuki, S., Dembo, T., & Fukuuchi, Y. (2001) · Stroke · doi:10.1161/01.str.32.5.1208 · Cited by 593 · see citing works

Stroke and the immune system: from pathophysiology to new therapeutic strategies

Macrez, R., Ali, C., Toutirais, O., Mauff, B. L., Defer, G. L., Dirnagl, U., & Vivien, D. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70066-7 · Cited by 559 · see citing works

Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice

Perego, C., Fumagalli, S., & Simoni, M. G. D. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-174 · Cited by 504 · see citing works

Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity

Supajatura, V., Ushio, H., Nakao, A., Akira, S., Okumura, K., Ra, C., & Ogawa, H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14704 · Cited by 491 · see citing works

Mast cell–derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B

Grimbaldeston, M. A., Nakae, S., Kalesnikoff, J., Tsai, M. M., & Galli, S. J. (2007) · Nature Immunology · doi:10.1038/ni1503 · Cited by 486 · see citing works

Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells.

Nakano, T., Sonoda, T., Hayashi, C., Yamatodani, A., Kanayama, Y., Yamamura, T., Asai, H., Yonezawa, T., Kitamura, Y., & Galli, S. J. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.162.3.1025 · Cited by 483 · see citing works

Post-stroke inflammation—target or tool for therapy?

Lambertsen, K. L., Finsen, B. R., & Clausen, B. H. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1930-z · Cited by 466 · see citing works

Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens

Dudeck, A., Dudeck, J., Scholten, J., Petzold, A., Surianarayanan, S., Köhler, A., Peschke, K., Voehringer, D., Waskow, C., Krieg, T. M., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.028 · Cited by 455 · see citing works

Neutrophil recruitment to the brain in mouse and human ischemic stroke

Perez-de-Puig, I., Miró-Mur, F., Ferrer-Ferrer, M., Gelpi, E., Pedragosa, J., Justicia, C., Urra, X., Chamorro, A., & Planas, A. M. (2015) · Acta Neuropathologica · doi:10.1007/s00401-014-1381-0 · Cited by 420 · see citing works

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

Liesz, A., Zhou, W., Mracsko, E. Z., Karcher, S., Bauer, H., Schwarting, S., Sun, L., Bruder, D., Stegemann‐Koniszewski, S., Cerwenka, A., et al. (2011) · Brain · doi:10.1093/brain/awr008 · Cited by 410 · see citing works

Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity

Supajatura, V., Ushio, H., Nakao, A., Akira, S., Okumura, K., Ra, C., & Ogawa, H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214704 · Cited by 404 · see citing works

Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates

Shechter, R., London, A., & Schwartz, M. (2013) · Nature reviews. Immunology · doi:10.1038/nri3391 · Cited by 399 · see citing works

Novel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical Treatments

George, P. M., & Steinberg, G. K. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.041 · Cited by 394 · see citing works

VEGF-A recruits a proangiogenic MMP-9–delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue

Christoffersson, G., Vågesjö, E., Vandooren, J., Lidén, M., Massena, S., Reinert, R. B., Briššová, M., Powers, A. C., Opdenakker, G., & Phillipson, M. (2012) · Blood · doi:10.1182/blood-2012-04-421040 · Cited by 384 · see citing works

Mast Cells Can Enhance Resistance to Snake and Honeybee Venoms

Metz, M., Piliponsky, A. M., Chen, C., Lammel, V., Åbrink, M., Pejler, G., Tsai, M. M., & Galli, S. J. (2006) · Science · doi:10.1126/science.1128877 · Cited by 381 · see citing works

Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor

Lambertsen, K. L., Clausen, B. H., Babcock, A. A., Gregersen, R., Fenger, C., Nielsen, H. H., Haugaard, L. S., Wirenfeldt, M., Nielsen, M., Dagnæs‐Hansen, F., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5505-08.2009 · Cited by 364 · see citing works

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

Wattananit, S., Tornero, D., Graubardt, N., Memanishvili, T., Monni, E., Tatarishvili, J., Miskinyte, G., Ge, R., Ahlenius, H., Lindvall, O., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4317-15.2016 · Cited by 354 · see citing works

Phagocytosis executes delayed neuronal death after focal brain ischemia

Neher, J. J., Emmrich, J., Fricker, M., Mander, P. K., Théry, C., & Brown, G. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308679110 · Cited by 350 · see citing works

N2 Neutrophils, Novel Players in Brain Inflammation After Stroke

Cuartero, M. I., Ballesteros, I., Moraga, A., Nombela, F., Vivancos, J., Hamilton, J. A., Corbí, A. L., Lizasoaín, I., & Moro, M. Á. (2013) · Stroke · doi:10.1161/strokeaha.113.002470 · Cited by 345 · see citing works

B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke

Doyle, K. P., Quach, L. N., Solé, M., Axtell, R. C., Nguyen, T. V., Soler-Llavina, G. J., Jurado, S., Han, J., Steinman, L., Longo, F. M., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4098-14.2015 · Cited by 338 · see citing works

Cre-Mediated Cell Ablation Contests Mast Cell Contribution in Models of Antibody- and T Cell-Mediated Autoimmunity

Feyerabend, T. B., Weiser, A., Tietz, A., Stassen, M., Harris, N. L., Köpf, M., Radermacher, P., Möller, P., Benoist, C. O., Mathis, D. J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.015 · Cited by 335 · see citing works

Advances in Meningeal Immunity

Rua, R., & McGavern, D. B. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.04.003 · Cited by 326 · see citing works

Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice

Clausen, B. H., Lambertsen, K. L., Babcock, A. A., Holm, T. H., Dagnæs‐Hansen, F., & Finsen, B. R. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-46 · Cited by 315 · see citing works

Regulatory B Cells Limit CNS Inflammation and Neurologic Deficits in Murine Experimental Stroke

Ren, X. S., Akiyoshi, K., Dziennis, S., Vandenbark, A. A., Herson, P. S., Hurn, P. D., & Offner, H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1623-11.2011 · Cited by 298 · see citing works

Mast cells can promote the development of multiple features of chronic asthma in mice

Yu, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25702 · Cited by 281 · see citing works

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke

Neumann, J. H. L., Riek‐Burchardt, M., Herz, J., Doeppner, T. R., König, R., Hütten, H., Etemire, E., Männ, L., Grüneboom, A., Fischer, T., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1355-2 · Cited by 276 · see citing works

Neutrophil Cerebrovascular Transmigration Triggers Rapid Neurotoxicity through Release of Proteases Associated with Decondensed DNA

Allen, C., Thornton, P., Dénes, Á., McColl, B. W., Pierozynski, A., Monestier, M., Pinteaux, E., Rothwell, N. J., & Allan, S. M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200409 · Cited by 245 · see citing works

Boosting Regulatory T Cells Limits Neuroinflammation in Permanent Cortical Stroke

Liesz, A., Zhou, W., Na, S., Hämmerling, G. J., Garbi, N., Karcher, S., Mracsko, E. Z., Backs, J., Rivest, S., & Veltkamp, R. C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4901-12.2013 · Cited by 220 · see citing works

Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice

Lilla, J. N., Chen, C., Mukai, K., BenBarak, M. J., Franco, C. B., Kalesnikoff, J., Yu, M., Tsai, M. M., Piliponsky, A. M., & Galli, S. J. (2011) · Blood · doi:10.1182/blood-2011-03-343962 · Cited by 217 · see citing works

Mast Cells as Early Responders in the Regulation of Acute Blood–Brain Barrier Changes after Cerebral Ischemia and Hemorrhage

Lindsberg, P. J., Strbian, D., & Karjalainen‐Lindsberg, M. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.282 · Cited by 190 · see citing works

Future directions of acute ischaemic stroke therapy

Fisher, M., & Saver, J. L. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00054-x · Cited by 180 · see citing works

Meningeal Mast Cells Affect Early T Cell Central Nervous System Infiltration and Blood-Brain Barrier Integrity through TNF: A Role for Neutrophil Recruitment?

Sayed, B. A., Christy, A. L., Walker, M. E., & Brown, M. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000126 · Cited by 163 · see citing works

Effect of cromolyn on S100P interactions with RAGE and pancreatic cancer growth and invasion in mouse models

Arumugam, T., Ramachandran, V., & Logsdon, C. D. (2006) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djj498 · Cited by 159 · see citing works

Immune responses in stroke: how the immune system contributes to damage and healing after stroke and how this knowledge could be translated to better cures?

Rayasam, A., Hsu, M., Kijak, J. A., Kissel, L. T., Hernandez, G. L., Sándor, M., & Fábry, Z. (2018) · Immunology · doi:10.1111/imm.12918 · Cited by 157 · see citing works

Cerebral Mast Cells Regulate Early Ischemic Brain Swelling and Neutrophil Accumulation

Strbian, D., Karjalainen‐Lindsberg, M., Tatlisumak, T., & Lindsberg, P. J. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600228 · Cited by 153 · see citing works

A Quantitative Study of Microglial—Macrophage Synthesis of Tumor Necrosis Factor during Acute and Late Focal Cerebral Ischemia in Mice

Lambertsen, K. L., Meldgaard, M., Ladeby, R., & Finsen, B. R. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600014 · Cited by 145 · see citing works

Requirement of Interaction between Mast Cells and Skin Dendritic Cells to Establish Contact Hypersensitivity

Otsuka, A., Kubo, M., Honda, T., Egawa, G., Nakajima, S., Tanizaki, H., Kim, B., Matsuoka, S., Watanabe, T., Nakae, S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025538 · Cited by 144 · see citing works

Meningeal T cells associate with diffuse axonal loss in multiple sclerosis spinal cords

Androdias, G., Reynolds, R., Chanal, M., Ritleng, C., Confavreux, C., & Nataf, S. (2010) · Annals of Neurology · doi:10.1002/ana.22054 · Cited by 142 · see citing works

Mast Cells Are Early Responders After Hypoxia-Ischemia in Immature Rat Brain

Jin, Y., Silverman, A.-J., & Vannucci, S. J. (2009) · Stroke · doi:10.1161/strokeaha.109.549691 · Cited by 141 · see citing works

Systemic augmentation of αB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation

Arac, A., Brownell, S. E., Rothbard, J. B., Chen, C., Ko, R. M., Pereira, M. P., Albers, G. W., Steinman, L., & Steinberg, G. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107368108 · Cited by 140 · see citing works

Evidence questioning cromolyn's effectiveness and selectivity as a ‘mast cell stabilizer' in mice

Oka, T., Kalesnikoff, J., Starkl, P. M., Tsai, M. M., & Galli, S. J. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.116 · Cited by 131 · see citing works

Mast Cells and Immunoregulation/Immunomodulation

Tsai, M. M., Grimbaldeston, M. A., & Galli, S. J. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9533-9_11 · Cited by 121 · see citing works

Antigen Dependently Activated Cluster of Differentiation 8-Positive T Cells Cause Perforin-Mediated Neurotoxicity in Experimental Stroke

Mracsko, E. Z., Liesz, A., Stojanovic, A., Lou, W. P.-K., Osswald, M., Zhou, W., Karcher, S., Winkler, F., Martín-Villalba, A., Cerwenka, A., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1867-14.2014 · Cited by 119 · see citing works

Spatio-temporal profile, phenotypic diversity, and fate of recruited monocytes into the post-ischemic brain

García‐Bonilla, L., Faraco, G., Moore, J. M. R., Murphy, M., Racchumi, G., Srinivasan, J., Brea, D., Iadecola, C., & Anrather, J. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0750-0 · Cited by 119 · see citing works

Evidence that vitamin D3 promotes mast cell–dependent reduction of chronic UVB-induced skin pathology in mice

Biggs, L., Yu, C., Fedoric, B., Lopez, A. F., Galli, S. J., & Grimbaldeston, M. A. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091725 · Cited by 116 · see citing works

T-bet-dependent NKp46+ innate lymphoid cells regulate the onset of TH17-induced neuroinflammation

Kwong, B., Rua, R., Gao, Y., Flickinger, J. C., Wang, Y., Kruhlak, M. J., Zhu, J., Vivier, É., McGavern, D. B., & Lazarevic, V. (2017) · Nature Immunology · doi:10.1038/ni.3816 · Cited by 114 · see citing works

Amplification of Regulatory T Cells Using a CD28 Superagonist Reduces Brain Damage After Ischemic Stroke in Mice

Na, S., Mracsko, E., Liesz, A., Hünig, T., & Veltkamp, R. (2015) · Stroke · doi:10.1161/strokeaha.114.007756 · Cited by 108 · see citing works

T cell–derived interleukin (IL)-21 promotes brain injury following stroke in mice

Clarkson, B. D. S., Ling, C., Shi, Y., Harris, M. G., Rayasam, A., Sun, D., Salamat, M. S., Kuchroo, V. K., Lambris, J. D., Sándor, M., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131377 · Cited by 106 · see citing works

Approaches for Analyzing the Roles of Mast Cells and Their Proteases In Vivo

Galli, S. J., Tsai, M. M., Marichal, T., Tchougounova, E., Reber, L. L., & Pejler, G. (2015) · Advances in immunology · doi:10.1016/bs.ai.2014.11.002 · Cited by 105 · see citing works

FTY720 Reduces Post-Ischemic Brain Lymphocyte Influx but Does Not Improve Outcome in Permanent Murine Cerebral Ischemia

Liesz, A., Sun, L., Zhou, W., Schwarting, S., Mracsko, E. Z., Zorn, M., Bauer, H., Sommer, C., & Veltkamp, R. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021312 · Cited by 104 · see citing works

Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice

Schäfer, B., Piliponsky, A. M., Oka, T., Song, C. H., Gerard, N. P., Gerard, C. J., Tsai, M. M., Kalesnikoff, J., & Galli, S. J. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.05.009 · Cited by 103 · see citing works

Cerebral Mast Cells Mediate Blood-Brain Barrier Disruption in Acute Experimental Ischemic Stroke Through Perivascular Gelatinase Activation

Mattila, O. S., Strbian, D., Saksi, J., Pikkarainen, T. O., Rantanen, V., Tatlisumak, T., & Lindsberg, P. J. (2011) · Stroke · doi:10.1161/strokeaha.111.632224 · Cited by 98 · see citing works

Mast Cell Stabilization Reduces Hemorrhage Formation and Mortality After Administration of Thrombolytics in Experimental Ischemic Stroke

Strbian, D., Karjalainen‐Lindsberg, M., Kovanen, P. T., Tatlisumak, T., & Lindsberg, P. J. (2007) · Circulation · doi:10.1161/circulationaha.106.655423 · Cited by 97 · see citing works

CD28 Superagonist-Mediated Boost of Regulatory T Cells Increases Thrombo-Inflammation and Ischemic Neurodegeneration during the Acute Phase of Experimental Stroke

Schuhmann, M. K., Kraft, P., Stoll, G., Lorenz, K., Meuth, S. G., Wiendl, H., Nieswandt, B., Sparwasser, T. D., Beyersdorf, N., Kerkau, T., et al. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.175 · Cited by 94 · see citing works

Linear arrays of homogenous mast cells in the dura mater of the rat

Dimlich, R. V. W., Keller, J. T., Strauss, T. A., & Fritts, M. J. (1991) · Journal of Neurocytology · doi:10.1007/bf01252276 · Cited by 85 · see citing works

B cells do not have a major pathophysiologic role in acute ischemic stroke in mice

Schuhmann, M. K., Langhauser, F., Kraft, P., & Kleinschnitz, C. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0890-x · Cited by 84 · see citing works

Mast Cells Promote Blood Brain Barrier Breakdown and Neutrophil Infiltration in a Mouse Model of Focal Cerebral Ischemia

McKittrick, C. M., Lawrence, C. E., & Carswell, H. V. O. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.239 · Cited by 81 · see citing works

Contribution of Mast Cell–Derived Interleukin‐1β to Uric Acid Crystal–Induced Acute Arthritis in Mice

Reber, L. L., Marichal, T., Sokolove, J. B., Starkl, P. M., Gaudenzio, N., Iwakura, Y., Karasuyama, H., Schwartz, L. B., Robinson, W. H., Tsai, M. M., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38747 · Cited by 76 · see citing works

Evidence that Meningeal mast cells can worsen stroke pathology in mice.

Arac, A., Grimbaldeston, M. A., Nepomuceno, A. R. B., Olayiwola, O., Pereira, M. P., Nishiyama, Y., Tsykin, A., Goodall, G. J., Schlecht, U., Vogel, H., et al. (2014) · The American Journal of Pathology · doi:10.1016/j.ajpath.2014.06.003 · Cited by 74 · see citing works

The Mast Cell Degranulator Compound 48/80 Directly Activates Neurons

Schemann, M., Kugler, E. M., Bühner, S., Eastwood, C., Donovan, J., Jiang, W. Y., & Grundy, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052104 · Cited by 73 · see citing works

Intrastriatal B-cell administration limits infarct size after stroke in B-cell deficient mice

Chen, Y., Bodhankar, S., Murphy, S. J., Vandenbark, A. A., Alkayed, N. J., & Offner, H. (2012) · Metabolic Brain Disease · doi:10.1007/s11011-012-9317-7 · Cited by 73 · see citing works

Stroke Induces Histamine Accumulation and Mast Cell Degranulation in the Neonatal Rat Brain

Biran, V., Cochois, V., Karroubi, A., Arrang, J., Charriaut‐Marlangue, C., & Héron, A. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00092.x · Cited by 72 · see citing works

Immune and Inflammatory Responses to Stroke: Good Or Bad?

McCombe, P., & Read, S. J. (2008) · International Journal of Stroke · doi:10.1111/j.1747-4949.2008.00222.x · Cited by 70 · see citing works

Meningeal Whole Mount Preparation and Characterization of Neural Cells by Flow Cytometry

Louveau, A., Filiano, A. J., & Kipnis, J. (2018) · Current Protocols in Immunology · doi:10.1002/cpim.50 · Cited by 70 · see citing works

The meningeal and choroidal infiltration routes for leukocytes in stroke

Benakis, C., Llovera, G., & Liesz, A. (2018) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286418783708 · Cited by 62 · see citing works

Targeting Different Monocyte/Macrophage Subsets Has No Impact on Outcome in Experimental Stroke

Schmidt, A., Strecker, J., Hucke, S., Bruckmann, N. M., Herold, M. V. B., Mack, M., Diederich, K., Schäbitz, W., Wiendl, H., Klotz, L., et al. (2017) · Stroke · doi:10.1161/strokeaha.116.015577 · Cited by 57 · see citing works

Pivotal role of innate myeloid cells in cerebral post-ischemic sterile inflammation

Tsuyama, J., Nakamura, A., Ooboshi, H., Yoshimura, A., & Shichita, T. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0707-8 · Cited by 45 · see citing works

Spectratype analysis of clonal T cell expansion in murine experimental stroke

Liesz, A., Karcher, S., & Veltkamp, R. C. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.01.013 · Cited by 36 · see citing works

Targeting mast cell as a neuroprotective strategy

Ocak, U., Ocak, P. E., Wang, A., Zhang, J. H., Boling, W., Wu, P., Mo, J., Zhang, T., & Huang, L. (2018) · Brain Injury · doi:10.1080/02699052.2018.1556807 · Cited by 35 · see citing works

Mast cells in the human dura: effects of age and dural bleeding

Varatharaj, A., Mack, J. A., Davidson, J. R., Gutnikov, A., & Squier, W. (2012) · Child s Nervous System · doi:10.1007/s00381-012-1699-7 · Cited by 22 · see citing works

COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation

Kempuraj, D., Selvakumar, G. P., Ahmed, M. E., Raikwar, S. P., Thangavel, R., Khan, A. C., Zaheer, S. A., Iyer, S. S., Burton, C., James, D., et al. (2020) · The Neuroscientist · doi:10.1177/1073858420941476 · Cited by 294 · see citing works

Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease

Derk, J., Jones, H. E., Como, C., Pawlikowski, B., & Siegenthaler, J. A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.703944 · Cited by 120 · see citing works

Meningeal CGRP ‐Prolactin Interaction Evokes Female‐Specific Migraine Behavior

Avona, A., Mason, B. N., Burgos-Vega, C., Hovhannisyan, A. H., Belugin, S., Mecklenburg, J. M., Goffin, V., Wajahat, N., Price, T. J., Akopian, A. N., et al. (2021) · Annals of Neurology · doi:10.1002/ana.26070 · Cited by 97 · see citing works

Basophils and Mast Cells in COVID-19 Pathogenesis

Murdaca, G., Gioacchino, M. D., Greco, M., Borro, M., Paladin, F., Petrarca, C., & Gangemi, S. (2021) · Cells · doi:10.3390/cells10102754 · Cited by 78 · see citing works

Neuroimmunology of depression

Sarno, E., Moeser, A. J., & Robison, A. J. (2021) · Advances in pharmacology · doi:10.1016/bs.apha.2021.03.004 · Cited by 80 · see citing works

Microglia and mast cells generate proinflammatory cytokines in the brain and worsen inflammatory state: Suppressor effect of IL-37

Conti, P., Lauritano, D., Caraffa, A., Gallenga, C. E., Kritas, S. K., Ronconi, G., & Martinotti, S. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173035 · Cited by 71 · see citing works

The Role of Mast Cells in Stroke

Parrella, E., Porrini, V., Benarese, M., & Pizzi, M. (2019) · Cells · doi:10.3390/cells8050437 · Cited by 65 · see citing works

Mast Cells in Gut and Brain and Their Potential Role as an Emerging Therapeutic Target for Neural Diseases

Traina, G. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00345 · Cited by 69 · see citing works

Intervention of neuroinflammation in the traumatic brain injury trajectory: In vivo and clinical approaches

Prabhakar, N. K., Khan, H., Grewal, A. K., & Singh, T. G. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108902 · Cited by 58 · see citing works

The underlying mechanisms of cold exposure-induced ischemic stroke

Chen, Z., Liu, P., Xia, X., Wang, L., & Li, X. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155514 · Cited by 54 · see citing works

Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain Injury

Kempuraj, D., Ahmed, M. E., Selvakumar, G., Thangavel, R., Raikwar, S., Zaheer, S. A., Iyer, S., Burton, C., James, D., & Zaheer, A. (2020) · Mediators of Inflammation · doi:10.1155/2020/4243953 · Cited by 43 · see citing works

Acute traumatic brain injury-induced neuroinflammatory response and neurovascular disorders in the brain

Kempuraj, D., Ahmed, M. E., Selvakumar, G. P., Thangavel, R., Raikwar, S. P., Zaheer, S. A., Iyer, S. S., Govindarajan, R., Nattanmai Chandrasekaran, P., Burton, C., et al. (2021) · Neurotoxicity Research · doi:10.1007/s12640-020-00288-9 · Cited by 43 · see citing works

Meningeal immunity: Structure, function and a potential therapeutic target of neurodegenerative diseases

Ma, T., Wang, F., Xu, S., & Huang, J. H. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.01.028 · Cited by 37 · see citing works

Investigating the AC079305/DUSP1 Axis as Oxidative Stress‐Related Signatures and Immune Infiltration Characteristics in Ischemic Stroke

Fan, J., Cao, S., Chen, M., Yao, Q., Zhang, X., Du, S., Qu, H., Cheng, Y., Ma, S., Zhang, M., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8432352 · Cited by 30 · see citing works

Interactions between the Autonomic Nervous System and the Immune System after Stroke

Zhu, L., Huang, L., Le, A. C. T., Wang, T. J., Zhang, J., Chen, X., Wang, J., Wang, J., & Jiang, C. Q. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210047 · Cited by 34 · see citing works

Immune conversations at the border: meningeal immunity in health and disease

Patel, P. U., Regmi, A., Dass, A. I., & Rojas, O. L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1531068 · Cited by 16 · see citing works

GPR18 Agonist Resolvin D2 Reduces Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage by Multiple Protective Mechanisms

Zhang, T., Zuo, G., & Zhang, H. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01114-2 · Cited by 15 · see citing works

Intracranial mast cells contribute to the control of social behavior in male mice

Tanioka, D., Chikahisa, S., Shimizu, N., Shiuchi, T., Sakai, N., Nishino, S., & Séi, H. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113143 · Cited by 14 · see citing works

Cellular and Molecular Roles of Immune Cells in the Gut-Brain Axis in Migraine

Zhou, Y., Pang, M., Ma, Y., Lu, L., Zhang, J., Wang, P., Li, Q., & Yang, F. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03623-1 · Cited by 12 · see citing works

Interactions between the Autonomic Nervous System and the Immune System after Stroke

Zhu, L., Huang, L., Le, A. C. T., Wang, T. J., Zhang, J., Chen, X., Wang, J., Wang, J., & Jiang, C. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00227.x · Cited by 10 · see citing works

Living on the border of the CNS: Dural immune cells in health and disease

Chen, Z., Liu, P., Xia, X., Wang, L., & Li, X. (2022) · Cellular Immunology · doi:10.1016/j.cellimm.2022.104545 · Cited by 8 · see citing works

The meninges as a neuroimmune interface: structure, barriers and roles in CNS disease

Joost, S., Kaddatz, H., Vankriekelsvenne, E., & Brandenburg, L. (2026) · Fluids and Barriers of the CNS · doi:10.1186/s12987-026-00795-5 · Cited by 7 · see citing works

Neuropsychiatric disorders in the course to SARS-CoV-2 virus infection, including biological pathomechanisms, psychosocial factors and long COVID-19 associated with “brain fog”

Sadowski, J., Ostrowska, S. A., Klaudel, T., Zaborska, M., Chruszcz, M., Sztangreciak-Lehun, A., & Bułdak, R. J. (2025) · Journal of NeuroVirology · doi:10.1007/s13365-025-01242-1 · Cited by 4 · see citing works

Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges

Li, Q., Chen, W., Sun, M., Ni, X., Ran, Q., Hu, X., Cao, F., & Zeng, W. (2025) · Advanced Science · doi:10.1002/advs.202514842 · Cited by 3 · see citing works

The dura mater: A hub for immune surveillance at the central nervous system borders

Neish, K., Wang, Q., Richoz, N., & Clatworthy, M. R. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkaf344 · Cited by 3 · see citing works

Purinergic Regulation of Neuroinflammation in Traumatic Brain Injury

Serebryanaya, N. B., Fomicheva, E. E., & Павлович, Я. П. (2022) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-022-01337-w · Cited by 1 · see citing works

GPR18 Agonist Resolvin D2 Reduces the Early Brain Injury in A Rat Model of Subarachnoid Hemorrhage by Multi-Mechanisms of ProtectionPreprint

Zhang, T., Zuo, G., & Zhang, H. (2021) · Research Square · doi:10.21203/rs.3.rs-398477/v1 · Cited by 1 · see citing works

Faculty Opinions recommendation of Mast cells in gut and brain and their potential role as an emerging therapeutic target for neural diseases.

Kawakami, T. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736437714.793571859

Characterization of non-human primate dura in health and neurodegenerationPreprint

Janson, C., Hauser, K., Muller, S., Hansen, E., Lam, C. H., Kordower, J. H., & Romanova, L. G. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.03.477517

Papel dos neutrófilos nas meninges para o desenvolvimento da dor neuropática

Castro, R. D. S. (2024) · doi:10.11606/d.17.2024.tde-04042025-103110

Role of neutrophils in the meninges for the development of neuropathic pain

Castro, R. D. S. (2024) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Targeting Soluble VCAM1 and GSK3β Improves Cerebrovascular Function and Reduces Stroke Pathology in Diabetic Mice

Brishti, M. A., Mandal, M., Singh, U. P., Ishrat, T., & Leo, M. D. (2026) · Cells · doi:10.3390/cells15050455

Presence of innate lymphoid cells in the ischemic stroke brain

Wang, S. (2021) · theses.fr (ABES) · doi:10.70675/89448768z5d25z40b6za25az2dcf35abe6db

Mast Cells in the Developing Brain

Bruce, M. R., Maximova, A. A., Engel, K., Allee, A. W., & McCarthy, M. M. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.0452-26.2026

SHIP1 Restrains Hypoxia/Reoxygenation‐Induced Cytokine Secretion in Mouse Bone Marrow–Derived Mast Cells

Gubeljak, L., Pes, J., Arik, E., Fehr, A. T., Schietinger, M., Wilhelm, T., Capellmann, S., Huber, M., & Habib, P. (2026) · European Journal of Immunology · doi:10.1002/eji.70274

Mast Cells in Neuroimmune Interactions: Mechanisms, Pathophysiological Roles, and Therapeutic Implications

Hasan, A., Asfour, A. A. R., Qaba, H., AL-Sharabi, A. A., ASFOOR, A., Sarhan ONDOKUZ MAYIS UNIVERSITY MOHAMMED, Al-Adhreai, A., Güner, S., & Saeedy, M. A. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06173-4

Evidence that Meningeal mast cells can worsen stroke pathology in mice.

Arac, A., Grimbaldeston, M. A., Nepomuceno, A. R. B., Olayiwola, O., Pereira, M. P., Nishiyama, Y., Tsykin, A., Goodall, G. J., Schlecht, U., Vogel, H., et al. (2014) · The American Journal of Pathology · doi:10.1016/j.ajpath.2014.06.003 · Cited by 74 · see citing works

Abstract TP100: Meningeal Mast Cells Can Exacerbate Stroke Pathology In Mice

Arac, A., Grimbaldeston, M. A., Nepomuceno, A., Olayiwola, O., Pereira, M. P., Vogel, H. S., Tsai, M. M., Galli, S. J., Bliss, T. M., & Steinberg, G. K. (2013) · Stroke · doi:10.1161/str.44.suppl_1.atp100

201 Meningeal Mast Cell-Dependent Exacerbation of Brain Injury After Stroke in Mice

Arac, A., Grimbaldeston, M. A., Nepomuceno, A., Olayiwola, O., Pereira, M. P., Nishiyama, Y., Vogel, H. S., Tsai, M. M., Galli, S. J., Bliss, T. M., et al. (2013) · Neurosurgery · doi:10.1227/01.neu.0000432791.83504.8a · Cited by 1 · see citing works

The Role of Mast Cells in Stroke

Parrella, E., Porrini, V., Benarese, M., & Pizzi, M. (2019) · Cells · doi:10.3390/cells8050437 · Cited by 65 · see citing works

Abstract T P71: Meningeal-Derived IL-6 Exacerbates Post-Stroke Inflammation and Pathology

Arac, A., Grimbaldeston, M. A., Olayiwoya, O., Tsai, M. M., Galli, S. J., Bliss, T. M., & Steinberg, G. K. (2014) · Stroke · doi:10.1161/str.45.suppl_1.tp71