Wnt signaling deregulation in the aging and Alzheimer’s brain

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Nusse, R., & Clevers, H. (2017) · Cell · doi:10.1016/j.cell.2017.05.016 · Cited by 4,342 · see citing works

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326 · see citing works

Wnt signaling in cancer

Zhan, T., Rindtorff, N., & Boutros, M. (2017) · Oncogene · doi:10.1038/onc.2016.304 · Cited by 2,626 · see citing works

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

the European Alzheimer's Disease Initiative Investigators, Lambert, J.-C., Heath, S., Even, G., Campion, D., Sleegers, K., Hiltunen, M., Combarros, O., Zelenika, D., Bullido, M. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.439 · Cited by 2,234 · see citing works

Neural mechanisms of ageing and cognitive decline

Bishop, N. A., Lu, T., & Yankner, B. A. (2010) · Nature · doi:10.1038/nature08983 · Cited by 1,323 · see citing works

The ageing cortical synapse: hallmarks and implications for cognitive decline

Morrison, J. H., & Baxter, M. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3200 · Cited by 965 · see citing works

REST and stress resistance in ageing and Alzheimer’s disease

Lu, T., Aron, L., Zullo, J., Pan, Y., Kim, H., Chen, Y., Yang, T.-H., Kim, H., Drake, D., Liu, X., et al. (2014) · Nature · doi:10.1038/nature13163 · Cited by 760 · see citing works

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

Tsukamoto, A. S., Grosschedl, R., Guzman, R. C., Parslow, T. G., & Varmus, H. E. (1988) · Cell · doi:10.1016/0092-8674(88)90220-6 · Cited by 747 · see citing works

Wnt/Ca2+ signaling pathway: a brief overview

De, A. (2011) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmr079 · Cited by 532 · see citing works

Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility

Seifert, J. R. K., & Mlodzik, M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2042 · Cited by 513 · see citing works

Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

Zhang, Z., Hartmann, H., Do, V. M., Abramowski, D., Sturchler, C., Staufenbiel, M., Sommer, B., van de Wetering, M., Clevers, H. C., Säftig, P., et al. (1998) · Nature · doi:10.1038/27208 · Cited by 511 · see citing works

Dysregulation of Wnt/β-Catenin Signaling in Gastrointestinal Cancers

White, B. D., Chien, A. J., & Dawson, D. W. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.12.001 · Cited by 471 · see citing works

Distribution of Active Glycogen Synthase Kinase 3β (GSK-3β) in Brains Staged for Alzheimer Disease Neurofibrillary Changes

Pei, J.-J., Braak, E., Braak, H., Grundke-Iqbal, I., Iqbal, K., Winblad, B., & Cowburn, R. F. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199909000-00011 · Cited by 459 · see citing works

Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony

Forner, S., Baglietto-Vargas, D., Martini, A. C., Trujillo-Estrada, L., & LaFerla, F. M. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.04.002 · Cited by 430 · see citing works

A transcriptional response to Wnt protein in human embryonic carcinoma cells

Willert, J. R., Epping, M. T., Pollack, J. R., Brown, P. O., & Nusse, R. (2002) · BMC Developmental Biology · doi:10.1186/1471-213x-2-8 · Cited by 398 · see citing works

Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain

Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemüller, A. J. M., Caruso, A., Storto, M., Gaviraghi, G., Terstappen, G. C., & Nicoletti, F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1381-04.2004 · Cited by 394 · see citing works

Spatial learning deficit in transgenic mice that conditionally over‐express GSK‐3β in the brain but do not form tau filaments

Hernández, F., Borrell, J., Guaza, C., Avila, J., & Lucas, J. J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01269.x · Cited by 372 · see citing works

Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils

Ferrari, G. V. D., Chacón, M. A., Barría, M. I., Garrido, J., Godoy, J. A., Olivares, G. H., Reyes, A. E., Alvarez, A. R., Bronfman, M., & Inestrosa, N. C. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001208 · Cited by 331 · see citing works

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

Zheng, H., Jia, L., Liu, C.-C., Rong, Z., Zhong, L., Yang, L., Chen, X.-F., Fryer, J. D., Wang, X., Zhang, Y.-W., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2459-16.2017 · Cited by 317 · see citing works

Loss of Dickkopf-1 Restores Neurogenesis in Old Age and Counteracts Cognitive Decline

Seib, D. R., Corsini, N. S., Ellwanger, K., Plaas, C., Mateos, Á., Pitzer, C., Niehrs, C., Celikel, T., & Martín-Villalba, A. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.11.010 · Cited by 294 · see citing works

A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology

Matarin, M., Salih, D. A., Yasvoina, M., Cummings, D. M., Guelfi, S., Liu, W., Nahaboo Solim, M. A., Moens, T. G., Paublete, R. M., Ali, S. S., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.041 · Cited by 290 · see citing works

Mouse models of Alzheimer’s disease

Esquerda-Canals, G., Montoliu-Gaya, L., Güell-Bosch, J., & Villegas, S. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170045 · Cited by 288 · see citing works

Common genetic variation within the Low-Density Lipoprotein Receptor-Related Protein 6 and late-onset Alzheimer's disease

Ferrari, G. V. D., Papassotiropoulos, A., Biechele, T. L., DeVriéze, F. W., Ávila, M. E., Major, M. B., Myers, A., Sáez, K. L., Henríquez, J. P., Zhao, A. S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603523104 · Cited by 266 · see citing works

Wnt signaling during synaptic development and plasticity

Budnik, V., & Salinas, P. C. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.12.002 · Cited by 264 · see citing works

Alzheimer Disease

Apostolova, L. G. (2016) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000307 · Cited by 253 · see citing works

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

Guo, W., Lasky, J. L., Chang, C.-J., Mosessian, S., Lewis, X., Xiao, Y., Yeh, J., Chen, J. Y., Iruela‐Arispe, M. L., Varella‐Garcia, M., et al. (2008) · Nature · doi:10.1038/nature06933 · Cited by 241 · see citing works

Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model

Avrahami, L., Farfara, D., Shaham-Kol, M., Vassar, R. J., Frenkel, D., & Eldar-Finkelman, H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.409250 · Cited by 232 · see citing works

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway

Killick, R., Ribe, E. M., Al-Shawi, R., Malik, B., Hooper, C., Fernandes, C., Dobson, R., Nolan, P. M., Lourdusamy, A., Furney, S., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2012.163 · Cited by 222 · see citing works

Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer’s disease

Liu, C.-C., Tsai, C.-W., Deak, F., Rogers, J., Penuliar, M., Sung, Y. M., Maher, J. N., Fu, Y., Li, X., Xu, H., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.048 · Cited by 222 · see citing works

Wnt-3a overcomes β-amyloid toxicity in rat hippocampal neurons

Alvarez, A. R., Godoy, J. A., Müllendorff, K., Olivares, G. H., Bronfman, M., & Inestrosa, N. C. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.02.028 · Cited by 211 · see citing works

The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss

Purro, S. A., Dickins, E. M., & Salinas, P. C. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4562-11.2012 · Cited by 195 · see citing works

Increased Dickkopf‐1 expression in transgenic mouse models of neurodegenerative disease

Rosi, M. C., Luccarini, I., Grossi, C., Fiorentini, A., Spillantini, M. G., Prisco, A., Scali, C., Gianfriddo, M., Caricasole, A., Terstappen, G. C., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06566.x · Cited by 167 · see citing works

Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis

Okamoto, M., Inoue, K., Iwamura, H., Terashima, K., Soya, H., Asashima, M., & Kuwabara, T. (2011) · The FASEB Journal · doi:10.1096/fj.11-184697 · Cited by 162 · see citing works

Molecular Pathways: Revisiting Glycogen Synthase Kinase-3β as a Target for the Treatment of Cancer

Walz, A. L., Ugolkov, A. V., Chandra, S., Kozikowski, A. P., Carneiro, B. A., O’Halloran, T. V., Giles, F. J., Billadeau, D. D., & Mazar, A. P. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2240 · Cited by 162 · see citing works

Regulation of NMDA-Receptor Synaptic Transmission by Wnt Signaling

Cerpa, W. F., Gambrill, A. C., Inestrosa, N. C., & Barría, A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6311-10.2011 · Cited by 147 · see citing works

Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus

Marzo, A., Galli, S., Lopes, D. M., McLeod, F., Podpolny, M., Segovia‐Roldán, M., Ciani, L., Purro, S. A., Cacucci, F., Gibb, A. J., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.07.024 · Cited by 135 · see citing works

Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?

Marchetti, C., & Marie, H. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.035 · Cited by 133 · see citing works

Communication breakdown: The impact of ageing on synapse structure

Petralia, R. S., Mattson, M. P., & Yao, P. J. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.01.003 · Cited by 133 · see citing works

Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1

Scali, C., Caraci, F., Gianfriddo, M., Diodato, E., Roncarati, R., Pollio, G., Gaviraghi, G., Copani, A., Nicoletti, F., Terstappen, G. C., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.06.016 · Cited by 128 · see citing works

Impaired Wnt Signaling in the Prefrontal Cortex of Alzheimer’s Disease

Folke, J., Pakkenberg, B., & Brudek, T. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1103-z · Cited by 123 · see citing works

Dishevelled Regulates the Metabolism of Amyloid Precursor Protein via Protein Kinase C/Mitogen-Activated Protein Kinase and c-Jun Terminal Kinase

Mudher, A. K., Chapman, S. C., Richardson, J. C., Asuni, A. A., Gibb, G., Pollard, C. C., Killick, R., Iqbal, T. A., Raymond, F. L., Varndell, I. M., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-04987.2001 · Cited by 122 · see citing works

Wnts in action: from synapse formation to synaptic maintenance

Dickins, E. M., & Salinas, P. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00162 · Cited by 121 · see citing works

Wnt-5aoccludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons

Cerpa, W. F., Farı́as, G. G., Godoy, J. A., Fuenzalida, M., Bonansco, C., & Inestrosa, N. C. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-3 · Cited by 118 · see citing works

Activation of the Wnt/β‐catenin pathway represses the transcription of the β‐amyloid precursor protein cleaving enzyme (BACE1) via binding of T‐cell factor‐4 to BACE1 promoter

Parr, C., Mirzaei, N., Christian, M., & Sastre, M. (2014) · The FASEB Journal · doi:10.1096/fj.14-253211 · Cited by 113 · see citing works

Wnt proteins as modulators of synaptic plasticity

McLeod, F., & Salinas, P. C. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.06.003 · Cited by 107 · see citing works

A role for APP in Wnt signalling links synapse loss with β-amyloid production

Elliott, C., Rojo, A. I., Ribé, E. M., Broadstock, M., Xia, W., Morin, P., Semënov, M. V., Baillie, G. S., Cuadrado, A., Al‐Shawi, R., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0231-6 · Cited by 106 · see citing works

Amyloid β synaptotoxicity is Wnt‐PCP dependent and blocked by fasudil

Sellers, K. J., Elliott, C., Jackson, J. D., Ghosh, A., Ribé, E. M., Rojo, A. I., Jarosz-Griffiths, H., Watson, I. A., Xia, W., Semënov, M. V., et al. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.09.008 · Cited by 104 · see citing works

Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells

Caruso, A., Motolese, M., Iacovelli, L., Caraci, F., Copani, A., Nicoletti, F., Terstappen, G. C., Gaviraghi, G., & Caricasole, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03867.x · Cited by 101 · see citing works

Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

Orellana, A. M., Vasconcelos, A. R., Leite, J. A., Lima, L. D. S., Andreotti, D. Z., Munhoz, C. D., Kawamoto, E. M., & Scavone, C. (2015) · Aging · doi:10.18632/aging.100853 · Cited by 96 · see citing works

Frizzled‐1 is involved in the neuroprotective effect of Wnt3a against Aβ oligomers

Chacón, M. A., Varela‐Nallar, L., & Inestrosa, N. C. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21497 · Cited by 87 · see citing works

Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice

Galli, S., Lopes, D. M., Ammari, R., Kopra, J. J., Millar, S. E., Gibb, A. J., & Salinas, P. C. (2014) · Nature Communications · doi:10.1038/ncomms5992 · Cited by 80 · see citing works

Wnt Signaling Mediates LTP-Dependent Spine Plasticity and AMPAR Localization through Frizzled-7 Receptors

McLeod, F., Bossio, A., Marzo, A., Ciani, L., Sibilla, S., Hannan, S. B., Wilson, G. A., Palomer, E., Smart, T. G., Gibb, A. J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.119 · Cited by 79 · see citing works

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

Licht-Murava, A., Paz, R., Vaks, L., Avrahami, L., Plotkin, B., Eisenstein, M., & Eldar-Finkelman, H. (2016) · Science Signaling · doi:10.1126/scisignal.aah7102 · Cited by 77 · see citing works

Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid‐β (Aβ)42 peptides

Tapia‐Rojas, C., Burgos, P. V., & Inestrosa, N. C. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13873 · Cited by 76 · see citing works

The emerging role of Wnt signaling dysregulation in the understanding and modification of age-associated diseases

García‐Velázquez, L., & Arias, C. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.06.001 · Cited by 70 · see citing works

The effects of aging on the expression of Wnt pathway genes in mouse tissues

Hofmann, J. W., McBryan, T., Adams, P. D., & Sedivy, J. M. (2014) · AGE · doi:10.1007/s11357-014-9618-3 · Cited by 69 · see citing works

Downregulation of canonical Wnt signaling in hippocampus of SAMP8 mice

Bayod, S., Felice, P., Andrés‐Benito, P., Rosa, P., Camins, A., Pallàs, M., & Canudas, A.-M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.09.017 · Cited by 63 · see citing works

Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of β‐catenin phosphorylation

Kawamura, Y., Kikuchi, A., Takada, R., Takada, S., Sudoh, S., Shibamoto, S., Yanagisawa, K., & Komano, H. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02197.x · Cited by 36 · see citing works

Susceptibility to GSK3β-Induced Tau Phosphorylation Differs Between the Young and Aged Hippocampus after Wnt Signaling Inhibition

Salcedo‐Tello, P., Hernández‐Ortega, K., & Arias, C. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-130749 · Cited by 28 · see citing works

Long-term estrogen deprivation leads to elevation of Dickkopf-1 and dysregulation of Wnt/β-Catenin signaling in hippocampal CA1 neurons

Scott, E. L., Zhang, Q.-G., Han, D. K., Desai, B. N., & Brann, D. W. (2012) · Steroids · doi:10.1016/j.steroids.2012.11.004 · Cited by 27 · see citing works

Lentiviral Modulation of Wnt/β-Catenin Signaling Affects In Vivo LTP

Ivanova, O., Dobryakova, Y. V., Salozhin, S. V., Aniol, V. A., Onufriev, M. V., Gulyaeva, N. V., & Markevich, V. A. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-016-0455-z · Cited by 15 · see citing works

Grassroots creativity and community in new media environments: Yarn Harlot and the 4000 knitting Olympians

Humphreys, S. (2008) · Continuum · doi:10.1080/10304310801989844 · Cited by 1 · see citing works

Apoptotic Pathways and Alzheimer’s Disease: Probing Therapeutic Potential

Sharma, V., Singh, T. G., Singh, S., Garg, N., & Dhiman, S. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03418-7 · Cited by 197 · see citing works

Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair

Marchetti, B., Tirolo, C., L’Episcopo, F., Caniglia, S., Testa, N., Smith, J. A., Pluchino, S., & Serapide, M. F. (2020) · Aging Cell · doi:10.1111/acel.13101 · Cited by 185 · see citing works

Post-translational modifications: Regulators of neurodegenerative proteinopathies

Gupta, R. V., Sahu, M., Srivastava, D., Tiwari, S., Ambasta, R. K., & Kumar, P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101336 · Cited by 124 · see citing works

Microglia Polarization in Alzheimer’s Disease: Mechanisms and a Potential Therapeutic Target

Wang, Q., Yao, H., Liu, W., Ya, B., Cheng, H., Xing, Z., & Wu, Y. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.772717 · Cited by 109 · see citing works

Recent Scaffold Hopping Applications in Central Nervous System Drug Discovery

Callis, T. B., Garrett, T. R., Montgomery, A. P., Danon, J. J., & Kassiou, M. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00969 · Cited by 99 · see citing works

Wnt pathway modulators in cancer therapeutics: An update on completed and ongoing clinical trials

Neiheisel, A., Kaur, M., Ma, N., Havard, P., & Shenoy, A. K. (2021) · International Journal of Cancer · doi:10.1002/ijc.33811 · Cited by 98 · see citing works

Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery

Ege, D. (2021) · Materials · doi:10.3390/ma14123332 · Cited by 91 · see citing works

Neurodegenerative Pathways in Alzheimer’s Disease: A Review

Ramachandran, A. K., Das, S., Joseph, A., Shenoy, G. G., Alex, A. T., & Mudgal, J. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200807130637 · Cited by 94 · see citing works

Therapeutic targeting of the oncogenic Wnt signaling pathway for treating colorectal cancer and other colonic disorders

Caspi, M., Wittenstein, A., Kazelnik, M., Shor-Nareznoy, Y., & Rosin‐Arbesfeld, R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.010 · Cited by 90 · see citing works

The role of PI3K signaling pathway in Alzheimer’s disease

Pan, J., Yao, Q., Wang, Y., Chang, S., Li, C., Wu, Y., Shen, J., & Yang, R. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1459025 · Cited by 89 · see citing works

Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer’s disease progression

Shi, T., Shen, S., Shi, Y., Wang, Q., Zhang, G., Lin, J., Chen, J., Bai, F., Zhang, L., Wang, Y., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-00989-x · Cited by 87 · see citing works

SFRP1 modulates astrocyte-to-microglia crosstalk in acute and chronic neuroinflammation

Rueda‐Carrasco, J., Martín‐Bermejo, M. J., Pereyra, G., Mateo, M. I., Borroto, A., Brosseron, F., Kummer, M. P., Schwartz, S., López‐Atalaya, J. P., Alarcón, B., et al. (2021) · EMBO Reports · doi:10.15252/embr.202051696 · Cited by 77 · see citing works

Neuropathological Mechanisms Associated with Pesticides in Alzheimer’s Disease

Tang, B. L. (2020) · Toxics · doi:10.3390/toxics8020021 · Cited by 81 · see citing works

Curcumin Improves Neurogenesis in Alzheimer’s Disease Mice via the Upregulation of Wnt/β-Catenin and BDNF

Lou, S.-C., Gong, D., Yang, M., Qiu, Q., Luo, J., & Chen, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105123 · Cited by 75 · see citing works

Dysregulated Wnt Signalling in the Alzheimer’s Brain

Aghaizu, N. D., Jin, H., & Whiting, P. J. (2020) · Brain Sciences · doi:10.3390/brainsci10120902 · Cited by 70 · see citing works

Implicative role of epidermal growth factor receptor and its associated signaling partners in the pathogenesis of Alzheimer’s disease

Jayaswamy, P. K., Vijaykrishnaraj, M., Patil, P., Alexander, L. M., Kellarai, A., & Shetty, P. K. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101791 · Cited by 69 · see citing works

Minutes of PPAR-γ agonism and neuroprotection

Kumar, B. R. P., Kumar, A. P., Jose, J. A., Prabhakaran, P., Yuvaraj, S., Chipurupalli, S., Jeyarani, V., Manisha, C., Banerjee, S., Jeyabalan, J. B., et al. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104814 · Cited by 65 · see citing works

The relationship between adult hippocampal neurogenesis and cognitive impairment in Alzheimer's disease

Geigenmüller, J. N., Tari, A. R., Wisløff, U., & Walker, T. L. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14179 · Cited by 64 · see citing works

The Molecular Basis of Wnt/β-Catenin Signaling Pathways in Neurodegenerative Diseases

Anand, A. A., Khan, M., Monica, V., & Kar, D. (2023) · International Journal of Cell Biology · doi:10.1155/2023/9296092 · Cited by 63 · see citing works

Astragaloside IV Exerts Cognitive Benefits and Promotes Hippocampal Neurogenesis in Stroke Mice by Downregulating Interleukin-17 Expression via Wnt Pathway

Sun, L., Zhang, H., Wang, W., Chen, Z., Wang, S., Li, J., Li, G., Gao, C., & Sun, X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00421 · Cited by 61 · see citing works

Zinc in Cognitive Impairment and Aging

Sun, R., Wang, J., Feng, J., & Cao, B. (2022) · Biomolecules · doi:10.3390/biom12071000 · Cited by 61 · see citing works

Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/β-catenin, AMPK/mTOR signaling pathways

Salem, M. A., Budzyńska, B., Kowalczyk, J., Sayed, N. S. E., & Mansour, S. M. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115697 · Cited by 61 · see citing works

Road traffic noise exposure and its impact on health: evidence from animal and human studies—chronic stress, inflammation, and oxidative stress as key components of the complex downstream pathway underlying noise-induced non-auditory health effects

Arregi, A., Vegas, Ó., Lertxundi, A., Silva, A. I., Ferreira, I., Bereziartua, A., Cruz, M. T., & Lertxundi, N. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-33973-9 · Cited by 70 · see citing works

Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review

Jha, N. K., Chen, W., Kumar, S., Dubey, R., Tsai, L.-W., Kar, R., Jha, S. K., Gupta, P. K., Sharma, A., Gundamaraju, R., et al. (2022) · Open Biology · doi:10.1098/rsob.210289 · Cited by 59 · see citing works

Proteomics of autism and Alzheimer’s mouse models reveal common alterations in mTOR signaling pathway

Mencer, S., Kartawy, M., Lendenfeld, F. V., Soluh, H., Tripathi, M. K., Халиулин, И. Г., & Amal, H. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01578-2 · Cited by 55 · see citing works

The Molecular Effects of Environmental Enrichment on Alzheimer’s Disease

Liew, A. K. Y., Teo, C. H., & Soga, T. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03016-w · Cited by 55 · see citing works

Rare genetic coding variants associated with human longevity and protection against age-related diseases

Lin, J.-R., Sin‐Chan, P., Napolioni, V., Torres, G. G., Mitra, J., Zhang, Q., Jabalameli, M. R., Wang, Z., Nguyen, N., Gao, T., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00108-5 · Cited by 51 · see citing works

LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11‐dependent repression of CDKN2A

Chen, D., Wang, J., Li, Y., Xu, C., Meng, F., Zhang, P., & Liu, L. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1418 · Cited by 45 · see citing works

The multifaceted role of WNT signaling in Alzheimer’s disease onset and age-related progression.

Kostes, W. W., & Brafman, D. A. (2023) · Cells · doi:10.3390/cells12081204 · Cited by 43 · see citing works

Energy Metabolism and Brain Aging: Strategies to Delay Neuronal Degeneration

Na, D., Zhang, Z., Meng, M., Li, M., Gao, J., Kong, J., Zhang, G., & Guo, Y. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01555-z · Cited by 42 · see citing works

Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer’s disease

Pons, V., Lévesque, P., Plante, M.-M., & Rivest, S. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00747-7 · Cited by 43 · see citing works

Wnt signaling pathway dysregulation in the aging brain: lessons from the Octodon degus

Inestrosa, N. C., Tapia-Rojas, C., Lindsay, C. B., & Zolezzi, J. M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00734 · Cited by 43 · see citing works

Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters

Palomer, E., Martín‐Flores, N., Jolly, S., Vargas, P. P., Benvegnù, S., Podpolny, M., Teo, S., Vaher, K., Saito, T., Saido, T. C., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01492-z · Cited by 42 · see citing works

SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease risk

Green, R. J., Mayilsamy, K., McGill, A. R., Martinez, T. E., Chandran, B., Blair, L. J., Bickford, P. C., Mohapatra, S. S., & Mohapatra, S. (2022) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2022.09.007 · Cited by 40 · see citing works

Wnt/β-Catenin Signaling Promotes Differentiation of Ischemia-Activated Adult Neural Stem/Progenitor Cells to Neuronal Precursors

Kriška, J., Janečková, L., Kirdajová, D., Honsa, P., Knotek, T., Džamba, D., Koleničová, D., Butenko, O., Vojtěchová, M., Čapek, M., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.628983 · Cited by 40 · see citing works

Genome-wide DNA methylation analysis of cognitive function in middle and old-aged Chinese monozygotic twins

Wang, W., Li, W., Jiang, W., Lin, H., Wu, Y., Wen, Y., Xu, C., Tian, X., Li, S., Tan, Q., et al. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.10.031 · Cited by 38 · see citing works

Cerebral Organoids for Modeling of HSV-1-Induced-Amyloid β Associated Neuropathology and Phenotypic Rescue

Qiao, H., Zhao, W., Guo, M., Zhu, L., Chen, T., Wang, J., Xu, X., Zhang, Z., Wu, Y., & Chen, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115981 · Cited by 42 · see citing works

Essential Oils for Bone Repair and Regeneration—Mechanisms and Applications

Chircov, C., Miclea, I. I., Grumezescu, V., & Grumezescu, A. M. (2021) · Materials · doi:10.3390/ma14081867 · Cited by 37 · see citing works

A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes

Majumder, P., Chanda, K., Das, D., Singh, B. K., Chakrabarti, P., Jana, N. R., & Mukhopadhyay, D. (2021) · Biochemical Journal · doi:10.1042/bcj20210175 · Cited by 38 · see citing works

Wnt signaling in dental pulp homeostasis and dentin regeneration

Kornsuthisopon, C., Photichailert, S., Nowwarote, N., Tompkins, K. A., & Osathanon, T. (2021) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2021.105322 · Cited by 36 · see citing works

Time is ticking faster for long genes in aging

Soheili‐Nezhad, S., Ibáñez-Solé, O., Izeta, A., Hoeijmakers, J. H. J., & Stoeger, T. (2024) · Trends in Genetics · doi:10.1016/j.tig.2024.01.009 · Cited by 36 · see citing works

Cannabis sativa and Cannabidiol: A Therapeutic Strategy for the Treatment of Neurodegenerative Diseases?

Viana, M. D. B., de Aquino, P. E. A., Estadella, D., Ribeiro, D. A., & Viana, G. S. D. B. (2022) · Medical Cannabis and Cannabinoids · doi:10.1159/000527335 · Cited by 37 · see citing works

Blood-Based Proteomic Profiling Identifies Potential Biomarker Candidates and Pathogenic Pathways in Dementia

Ehtewish, H., Mesleh, A. G., Ponirakis, G., de la Fuente, A., Parray, A., Bensmail, I., Abdesselem, H., Ramadan, M., Khan, S., Chandran, M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098117 · Cited by 36 · see citing works

Recent updates on Wnt signaling modulators: a patent review (2014-2020)

Goswami, V., & Patel, B. (2021) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2021.1940138 · Cited by 34 · see citing works

Altered glia-neuron communication in Alzheimer’s Disease affects WNT, p53, and NFkB Signaling determined by snRNA-seq

Soelter, T. M., Howton, T. C., Clark, A. D., Oza, V. H., & Lasseigne, B. N. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01686-8 · Cited by 34 · see citing works

Boosting Antioxidant Self-defenses by Grafting Astrocytes Rejuvenates the Aged Microenvironment and Mitigates Nigrostriatal Toxicity in Parkinsonian Brain via an Nrf2-Driven Wnt/β-Catenin Prosurvival Axis

Serapide, M. F., L’Episcopo, F., Tirolo, C., Testa, N., Caniglia, S., Giachino, C., & Marchetti, B. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00024 · Cited by 32 · see citing works

Dickkopf-related protein-1 inhibition attenuates amyloid-beta pathology associated to Alzheimer's disease

Menet, R., Bourassa, P., Calon, F., & ElAli, A. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104881 · Cited by 31 · see citing works

Therapeutic Potential of Natural Compounds from Herbs and Nutraceuticals in Alleviating Neurological Disorders: Targeting the Wnt Signaling Pathway

Li, L., Wang, L., & Zhang, L. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c07536 · Cited by 31 · see citing works

On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer’s Disease

Kriška, J., Heřmanová, Z., Knotek, T., Turečková, J., & Anděrová, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189689 · Cited by 33 · see citing works

WNT Signaling Is a Key Player in Alzheimer’s Disease

Inestrosa, N. C., Tapia‐Rojas, C., Cerpa, W. F., Cisternas, P., & Zolezzi, J. M. (2021) · Handbook of experimental pharmacology · doi:10.1007/164_2021_532 · Cited by 28 · see citing works

Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta

Taggi, V., Riera‐Romo, M., Piquette‐Miller, M., zu Schwabedissen, H. E. M., & Neuhoff, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071376 · Cited by 30 · see citing works

APOE3 Christchurch modulates β-catenin/Wnt signaling in iPS cell-derived cerebral organoids from Alzheimer’s cases

Perez-Corredor, P., Vanderleest, T. E., Vacano, G. N., Sanchez, J. S., Villalba-Moreno, N. D., Marino, C., Krasemann, S., Mendivil-Perez, M. A., Aguillón, D., Jiménez-Del-Río, M., et al. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1373568 · Cited by 28 · see citing works

Fragment-based drug discovery for disorders of the central nervous system: designing better drugs piece by piece

Chan, B. W. G. L., Lynch, N. B., Tran, W., Joyce, J. M., Savage, G. P., Meutermans, W. D. F., Montgomery, A. P., & Kassiou, M. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1379518 · Cited by 28 · see citing works

Molecular Insights to the Wnt Signaling During Alzheimer’s Disorder: a Potential Target for Therapeutic Interventions

Nagu, P., Sharma, V., Behl, T., Pathan, A. K., & Mehta, V. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01940-5 · Cited by 28 · see citing works

Oncogenic Pathways in Neurodegenerative Diseases

Varela, L., & García-Rendueles, M. E. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063223 · Cited by 29 · see citing works

From attention-deficit hyperactivity disorder to sporadic Alzheimer’s disease—Wnt/mTOR pathways hypothesis

Grünblatt, E., Homolak, J., Perhoč, A. B., Virag, D., Knezović, A., Barilar, J. O., Riederer, P., Walitza, S., Tackenberg, C., & Šalković‐Petrišić, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1104985 · Cited by 26 · see citing works

Early postnatal defects in neurogenesis in the 3xTg mouse model of Alzheimer’s disease

Liu, Y., Bilen, M., McNicoll, M.-M., Harris, R. A., Fong, B. C., Iqbal, M. A., Paul, S., Mayne, J., Walker, K., Wang, J., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05650-1 · Cited by 26 · see citing works

Impact of micronutrients and nutraceuticals on cognitive function and performance in Alzheimer's disease

Guarnieri, L., Bosco, F., Leo, A., Citraro, R., Palma, E., Sarro, G. D., & Mollace, V. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102210 · Cited by 27 · see citing works

The transcriptional landscape of Alzheimer’s disease and its association with Wnt signaling pathway

Martínez, M., & Inestrosa, N. C. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.029 · Cited by 25 · see citing works

Targeting Wnt signaling pathway by polyphenols: implication for aging and age-related diseases

Dana, P. M., Sadoughi, F., Mansournia, M. A., Mirzaei, H., Asemi, Z., & Yousefi, B. (2021) · Biogerontology · doi:10.1007/s10522-021-09934-x · Cited by 26 · see citing works

Decoding the Role of Astrocytes in the Entorhinal Cortex in Alzheimer’s Disease Using High-Dimensional Single-Nucleus RNA Sequencing Data and Next-Generation Knowledge Discovery Methodologies: Focus on Drugs and Natural Product Remedies for Dementia

Pushparaj, P. N., Gauthaman, K., Sait, K., & Rasool, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.720170 · Cited by 26 · see citing works

The Role of Clusterin Transporter in the Pathogenesis of Alzheimer’s Disease at the Blood–Brain Barrier Interface: A Systematic Review

Fareed, M. M., Qasmi, M., Aziz, S., Völker, E., Förster, C. Y., & Shityakov, S. (2022) · Biomolecules · doi:10.3390/biom12101452 · Cited by 25 · see citing works

Molecular Mechanisms Linking Osteoarthritis and Alzheimer’s Disease: Shared Pathways, Mechanisms and Breakthrough Prospects

Umoh, I. O., Reis, H. J., & de Oliveira, A. C. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25053044 · Cited by 26 · see citing works

The MIND diet, brain transcriptomic alterations, and dementia

Li, J., Capuano, A. W., Agarwal, P., Arvanitakis, Z., Wang, Y., Jager, P. L. D., Schneider, J. A., Tasaki, S., Lopes, K. D. P., Hu, F. B., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14062 · Cited by 24 · see citing works

The neural stem cell secretome across neurodevelopment

Dause, T. J., Denninger, J. K., Smith, B. M., & Kirby, E. D. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114142 · Cited by 24 · see citing works

Alzheimer's disease is associated with disruption in thiamin transport physiology: A potential role for neuroinflammation

Ramamoorthy, K., Yoshimura, R. F., Al-Juburi, S., Anandam, K. Y., Kapadia, R., Alachkar, A., Abbott, G. W., & Said, H. M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105799 · Cited by 25 · see citing works

Structural and Functional Insights into Dishevelled-Mediated Wnt Signaling

Wang, L., Zhu, R., Wen, Z., Fan, H., Norwood-Jackson, T., Jathan, D., & Lee, H. (2024) · Cells · doi:10.3390/cells13221870 · Cited by 23 · see citing works

Mini review: Mitochondrial dysfunction in Alzheimer's disease: Therapeutic implications of lithium

Singulani, M. P., Paula, V. J. R. D., & Forlenza, O. V. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136078 · Cited by 23 · see citing works

Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases

Karabicici, M., Azbazdar, Y., İşcan, E., & Özhan, G. (2021) · Membranes · doi:10.3390/membranes11110844 · Cited by 23 · see citing works

Neurovascular unit pathology is observed very early in disease progression in the mutant SOD1G93A mouse model of amyotrophic lateral sclerosis

Yoshikawa, M., Aizawa, S., Oppenheim, R. W., & Milligan, C. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114084 · Cited by 22 · see citing works

Icariin ameliorates glycolytic dysfunction in Alzheimer's disease models by activating the Wnt/β‐catenin signaling pathway

Liu, J., Wei, A., Liu, T., Ji, X., Zhang, Y., Yan, F., Chen, M., Hu, J., Zhou, S., Shi, J., et al. (2024) · FEBS Journal · doi:10.1111/febs.17099 · Cited by 23 · see citing works

Effect of QTC-4-MeOBnE Treatment on Memory, Neurodegeneration, and Neurogenesis in a Streptozotocin-Induced Mouse Model of Alzheimer’s Disease

Fronza, M. G., Baldinotti, R., Sacramento, M., Gutierres, J. M., Carvalho, F. B., Fernandes, M. D. C., Sousa, F. S. S., Seixas, F. K., Collares, T. V., Alves, D. A. C., et al. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00615 · Cited by 23 · see citing works

Dietary restriction and ageing: Recent evolutionary perspectives

Auley, M. T. M. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111741 · Cited by 22 · see citing works

5‑Phenyl-1,3,4-oxadiazol-2(3 H )‑ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

Mahy, W., Willis, N. J., Zhao, Y., Woodward, H. L., Svensson, F., Sipthorp, J., Vecchia, L., Ruza, R. R., Hillier, J., Kjær, S., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01391 · Cited by 22 · see citing works

Protective role of anticancer drugs in neurodegenerative disorders: A drug repurposing approach

Advani, D., Gupta, R. V., Tripathi, R. S., Sharma, S., Ambasta, R. K., & Kumar, P. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104841 · Cited by 21 · see citing works

Enhancing α-secretase Processing for Alzheimer’s Disease—A View on SFRP1

Tang, B. L. (2020) · Brain Sciences · doi:10.3390/brainsci10020122 · Cited by 20 · see citing works

Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors

Atkinson, B. N., Steadman, D., Mahy, W., Zhao, Y., Sipthorp, J., Bayle, E. D., Svensson, F., Papageorgiou, G., Jeganathan, F., Frew, S., et al. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.126751 · Cited by 20 · see citing works

Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy

Takaichi, Y., CHAMBERS, J. K., Inoue, H., Ano, Y., Takashima, A., Nakayama, H., & Uchida, K. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00969-8 · Cited by 20 · see citing works

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity

Mahy, W., Patel, M., Steadman, D., Woodward, H. L., Atkinson, B. N., Svensson, F., Willis, N. J., Flint, A., Papatheodorou, D., Zhao, Y., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00660 · Cited by 20 · see citing works

From Endoderm to Progenitors: An Update on the Early Steps of Thyroid Morphogenesis in the Zebrafish

Marelli, F., Rurale, G., & Persani, L. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.664557 · Cited by 19 · see citing works

Menopause and development of Alzheimer’s disease: Roles of neural glucose metabolism and Wnt signaling

Villaseca, P., Cisternas, P., & Inestrosa, N. C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1021796 · Cited by 21 · see citing works

TREM2 signalling as a multifaceted player in brain homoeostasis and a potential target for Alzheimer's disease treatment

Ayyubova, G. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15914 · Cited by 20 · see citing works

Blood‐derived microRNAs are related to cognitive domains in the general population

Melas, K., Talevi, V., Imtiaz, M. A., Etteldorf, R., Estrada, S., Krüger, D. M., Centeno, T. P., Aziz, N. A., Fischer, A., & Breteler, M. M. B. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14197 · Cited by 19 · see citing works

MicroRNA-Target Interaction Regulatory Network in Alzheimer’s Disease

Turk, A., Kunej, T., & Peterlin, B. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11121275 · Cited by 19 · see citing works

Melatonin and zinc supplements with physical and mental activities subside neurodegeneration and hepatorenal injury induced by aluminum chloride in rats: Inclusion of GSK-3β-Wnt/β-catenin signaling pathway

Abu‐Elfotuh, K., Hussein, F. H., Abbas, A. N., Al-Rekabi, M. D., Barghash, S. S., Zaghlool, S. S., & El‐Emam, S. Z. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.05.002 · Cited by 20 · see citing works

MST1 selective inhibitor Xmu-mp-1 ameliorates neuropathological changes in a rat model of sporadic Alzheimer’s Disease by modulating Hippo-Wnt signaling crosstalk

Sahu, M. R., Ahmad, M. H., & Mondal, A. C. (2024) · APOPTOSIS · doi:10.1007/s10495-024-01975-0 · Cited by 18 · see citing works

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit

Willis, N. J., Mahy, W., Sipthorp, J., Zhao, Y., Woodward, H. L., Atkinson, B. N., Bayle, E. D., Svensson, F., Frew, S., Jeganathan, F., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00162 · Cited by 18 · see citing works

Aging and senescence: Key players in brain tumor progression and drug resistance

Zhang, C., Neha, N., Zhang, J., Dhaha, P., Li, X., Mishra, S. K., Fleishman, J. S., Parvez, S., Jha, S. K., & Huang, M. (2025) · Drug Resistance Updates · doi:10.1016/j.drup.2025.101228 · Cited by 17 · see citing works

Transcriptome analysis of fasudil treatment in the APPswe/PSEN1dE9 transgenic (APP/PS1) mice model of Alzheimer’s disease

Yan, H., Yan, Y., Gao, Y., Zhang, N., Kumar, G., Fang, Q., Li, Z., Li, J., Zhang, Y., Song, L., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-10554-9 · Cited by 17 · see citing works

Crosstalk between Adult Hippocampal Neurogenesis and Its Role in Alzheimer’s Disease

Tiwari, V., Mishra, A., Singh, S., & Shukla, S. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00119 · Cited by 18 · see citing works

Computational model of brain endothelial cell signaling pathways predicts therapeutic targets for cerebral pathologies

Gorick, C. M., Saucerman, J. J., & Price, R. J. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.11.005 · Cited by 17 · see citing works

Targeting Ferroptosis/Nrf2 Pathway Ameliorates AlCl3-Induced Alzheimer’s Disease in Rats: Neuroprotective Effect of Morin Hydrate, Zeolite Clinoptilolite, and Physical Plus Mental Activities

Abu‐Elfotuh, K., Mahran, Y., Gazzar, W. B. E., Youssef, H. S., Hamdan, A. M., Albalawi, T. M., Alsunbul, M., Alqahtani, R. A., & Mohammed, A. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031260 · Cited by 16 · see citing works

Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease

Huang, X., Xue, L., Chen, T., Huangfu, L., Wang, T., Xiong, L., & Yu, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1080753 · Cited by 16 · see citing works

Upregulation of Wnt2b exerts neuroprotective effect by alleviating mitochondrial dysfunction in Alzheimer's disease

Xu, L.-Z., Li, B.-Q., Li, F.-H., Quan, M.-N., Qin, W., Li, Y., Li, W.-W., Zhao, Y., Wei, Y.-P., & Jia, J.-P. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14139 · Cited by 14 · see citing works

Kai-Xin-San Improves Cognitive Impairment via Wnt/β-Catenin and IRE1/XBP1s Signalings in APP/PS1 Mice

Xu, Y.-M., Lu, F.-M., Xu, H.-C., Zhang, J., Hei, S.-Y., Qiu, Y.-H., Cai, Y.-F., Zhang, S.-J., & Zhao, M. (2023) · Rejuvenation Research · doi:10.1089/rej.2022.0063 · Cited by 15 · see citing works

Inhibition of CXXC5 function rescues Alzheimer’s disease phenotypes by restoring Wnt/β-catenin signaling pathway

Yoon, M., Kim, H., Shin, H., Lee, H., Kang, M., Park, S., Han, G., Kim, Y. S., & Choi, K. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106836 · Cited by 15 · see citing works

Coenzyme Q10 ameliorates cyclophosphamide-induced chemobrain by repressing neuronal apoptosis and preserving hippocampal neurogenesis: Mechanistic roles of Wnt/ β-catenin signaling pathway

Hussein, Z., Michel, H. E., El‐Naga, R. N., El‐Demerdash, E., & Mantawy, E. M. (2024) · NeuroToxicology · doi:10.1016/j.neuro.2024.08.003 · Cited by 16 · see citing works

Upregulated Blood miR-150-5p in Alzheimer’s Disease Dementia Is Associated with Cognition, Cerebrospinal Fluid Amyloid-β, and Cerebral Atrophy

Chia, S. Y., Vipin, A., Ng, K. P., Tu, H., Bommakanti, A. S., Wang, B. Z., Tan, Y. J., Zailan, F. Z., Ng, A. S. L., Ling, S., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220116 · Cited by 15 · see citing works

Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer’s Disease Brains and Mouse Neurodegeneration Models

Aghaizu, N., Jolly, S., Samra, S. K., Kalmar, B., Craessaerts, K., Greensmith, L., Salinas, P., de Strooper, B., & Whiting, P. (2023) · eNeuro · doi:10.1523/eneuro.0306-22.2022 · Cited by 12 · see citing works

High-fat diet feeding triggers a regenerative response in the adult zebrafish brain

Azbazdar, Y., Poyraz, Y. K., Özalp, Ö., Nazli, D., Ipekgil, D., Cucun, G., & Özhan, G. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03210-4 · Cited by 15 · see citing works

Wnt signaling in synaptogenesis of Alzheimer's disease

Zhang, C., Wang, J., & Wang, W. (2023) · Ibrain · doi:10.1002/ibra.12130 · Cited by 23 · see citing works

Dysregulated Wnt Signalling in the Alzheimer’s Brain

Aghaizu, N. D., Jin, H., & Whiting, P. J. (2020) · Brain Sciences · doi:10.3390/brainsci10120902 · Cited by 70 · see citing works

In vivoActivation ofWntSignaling Pathway Enhances Cognitive Function of Adult Mice and Reverses Cognitive Deficits in an Alzheimer's Disease Model

Vargas, J., Fuenzalida, M., & Inestrosa, N. C. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0862-13.2014 · Cited by 147 · see citing works

Wnts in adult brain: from synaptic plasticity to cognitive deficiencies

Oliva, C. A., Vargas, J. Y., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00224 · Cited by 162 · see citing works

Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease

Jia, L., Piña-Crespo, J., & Li, Y. (2019) · Molecular Brain · doi:10.1186/s13041-019-0525-5 · Cited by 288 · see citing works