Downregulation of Fat Mass and Obesity-Related Protein in the Anterior Cingulate Cortex Participates in Anxiety- and Depression-Like Behaviors Induced by Neuropathic Pain
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N6-methyladenosine (m 6 A) is the most abundant methylation modification on mRNA in mammals. Fat mass and obesity-related protein (FTO) is the main RNA m 6 A demethylase. FTO is involved in the occurrence and maintenance of neuropathic pain (NP). NP often induces mental disorders. We found that NP downregulated the expression of FTO in the anterior cingulate cortex (ACC), inhibited the expression of matrix metalloproteinase-9 (MMP-9) in the ACC, maladjusted the brain-derived neurotrophic factor precursor (proBDNF) and mature brain-derived neurotrophic factor (mBDNF) levels in the ACC, and induced anxiety- and depression-like behaviors in mice. Blocking the downregulation of FTO in the ACC induced by peripheral nerve injury could reverse the anxiety- and depression-like behaviors of mice. Contrarily, downregulation of simulated FTO induced anxiety- and depression-like behaviors in mice. After peripheral nerve injury, the binding of FTO to MMP-9 mRNA decreased and the enrichment of m 6 A on MMP-9 mRNA increased. In conclusion, downregulation of FTO in ACC by regulating MMP-9 mRNA methylation level contributes to the occurrence of anxiety- and depression-like behaviors in NP mice.
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Anxiety-like and depression-like behavior induced by peripheral nerve injury could be reversed in mice by blocking FTO downregulation in the anterior cingulate cortex.
“Anxiety-like and depression-like behavior induced by peripheral nerve injury could be reversed in mice by blocking FTO downregulation in the anterior cingulate cortex.362”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [362]
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Cites
Ethical guidelines for investigations of experimental pain in conscious animals.
Zimmermann, M. (1983) · Pain · doi:10.1016/0304-3959(83)90201-4 · Cited by 7,762 · see citing works
Quantitative assessment of tactile allodynia in the rat paw
Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., & Yaksh, T. L. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90144-9 · Cited by 7,740 · see citing works
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376 · see citing works
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155 · see citing works
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
Dominissini, D., Moshitch-Moshkovitz, S., Schwartz, S., Salmon-Divon, M., Ungar, L., Osenberg, S., Cesarkas, K., Jacob-Hirsch, J., Amariglio, N., Kupiec, M., et al. (2012) · Nature · doi:10.1038/nature11112 · Cited by 4,884 · see citing works
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.687 · Cited by 4,106 · see citing works
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.015 · Cited by 3,550 · see citing works
Self-citationThe tail suspension test: A new method for screening antidepressants in mice
Steru, L., Chermat, R., Thierry, B., & Simon, P. (1985) · Psychopharmacology · doi:10.1007/bf00428203 · Cited by 3,534 · see citing works
Depression and Pain Comorbidity: A Literature Review
Bair, M. J., Robinson, R. L., Katon, W., & Kroenke, K. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.20.2433 · Cited by 3,463 · see citing works
A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Liu, J., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1432 · Cited by 3,433 · see citing works
Self-citationEmotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059 · see citing works
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
Ping, X.-L., Sun, B.-F., Wang, L., Xiao, W., Yang, X., Wang, W.-J., Adhikari, S., Shi, Y., Lv, Y., Chen, Y.-S., et al. (2014) · Cell Research · doi:10.1038/cr.2014.3 · Cited by 2,375 · see citing works
Self-citationNeuropathic pain in the general population: A systematic review of epidemiological studies
van Hecke, O., Austin, S. K., Khan, R. A., Smith, B. H., & Torrance, N. (2013) · Pain · doi:10.1016/j.pain.2013.11.013 · Cited by 1,613 · see citing works
An fMRI-Based Neurologic Signature of Physical Pain
Wager, T. D., Atlas, L. Y., Lindquist, M. A., Roy, M., Woo, C.-W., & Kross, E. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1204471 · Cited by 1,597 · see citing works
Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity
Pang, P. T., Teng, H. K., Zaitsev, E., Woo, N. T., Sakata, K., Zhen, S., Teng, K. K., Yung, W.-H., Hempstead, B. L., & Lu, B. (2004) · Science · doi:10.1126/science.1100135 · Cited by 1,136 · see citing works
Chronic pain-associated depression: Antecedent or consequence of chronic pain? A review
Fishbain, D. A., Cutler, R., Rosomoff, H. L., & Rosomoff, R. S. (1997) · The Clinical Journal of Pain · doi:10.1097/00002508-199706000-00006 · Cited by 1,074 · see citing works
Colucci-D’Amato, L., Speranza, L., & Volpicelli, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207777 · Cited by 991 · see citing works
Kawasaki, Y., Xu, Z., Wang, X., Park, J. Y., Zhuang, Z., Tan, P.-H., Gao, Y., Roy, K., Corfas, G., Lo, E. H., et al. (2008) · Nature Medicine · doi:10.1038/nm1723 · Cited by 759 · see citing works
Self-citationMembrane-type matrix metalloproteinases: Their functions and regulations
Itoh, Y. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.03.004 · Cited by 440 · see citing works
Cao, P., Chen, C., Liu, A., Shan, Q., Zhu, X., Jia, C.-H., Peng, X., Zhang, M., Farzinpour, Z., Zhou, W., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.06.012 · Cited by 346 · see citing works
Brain-derived neurotrophic factor in mood disorders and antidepressant treatments
Castrén, E., & Kojima, M. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.010 · Cited by 337 · see citing works
Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis
Li, L., Zang, L., Zhang, F., Chen, J., Shen, H., Shu, L., Liang, F., Feng, C., Chen, D., Tao, H., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx128 · Cited by 328 · see citing works
The Anterior Cingulate Cortex Is a Critical Hub for Pain-Induced Depression
Barthas, F., Sellmeijer, J., Hugel, S., Waltisperger, E., Barrot, M., & Yalçın, İ. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.08.004 · Cited by 326 · see citing works
Matrix metalloproteinases as regulators of inflammatory processes
Fingleton, B. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.05.010 · Cited by 263 · see citing works
Painful Stimuli Evoke Potentials Recorded Over the Human Anterior Cingulate Gyrus
Lenz, F. A., Rios, M., Zirh, A. T., Chau, D. T., Krauss, G., & Lesser, R. P. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.4.2231 · Cited by 236 · see citing works
Matrix metalloproteinases in stem cell regulation and cancer
Kessenbrock, K., Wang, C., & Werb, Z. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.01.022 · Cited by 215 · see citing works
Mochcovitch, M. D., da Rocha Freire, R. C., Garcia, R. F., & Nardi, A. E. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.06.041 · Cited by 206 · cited 1× · see citing works
“ACC has been reported to participate in anxiety- and depression-like behaviors in human and animal studies (Osuch et al., 2000; Etkin et al., 2011; Kim et al., 2011; Mochcovitch et al., 2014; Barthas et al., 2015).”
BackgroundSensory Organ Generation in the Chick Inner Ear
Wu, D. K., & Oh, S. H. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-20-06454.1996 · Cited by 204 · see citing works
Regional cerebral metabolism associated with anxiety symptoms in affective disorder patients
Osuch, E. A., Ketter, T. A., Kimbrell, T. A., George, M. S., Benson, B. E., Herscovitch, M. W. W., & Post, R. M. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00920-3 · Cited by 196 · see citing works
Neurotrophins, synaptic plasticity and dementia
Arancio, O., & Chao, M. V. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.03.013 · Cited by 193 · see citing works
Radat, F., Margot-Duclot, A., & Attal, N. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2013.00334.x · Cited by 187 · see citing works
Agüera-Ortíz, L., Failde, I., Micó, J. A., Cervilla, J. A., & López-Ibor, J. J. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.10.022 · Cited by 168 · see citing works
How to study anxiety and depression in rodent models of chronic pain?
Kremer, M., Becker, L. J., Barrot, M., & Yalçın, İ. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14686 · Cited by 167 · see citing works
FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling
Li, H., Ren, Y., Mao, K., Hua, F., Yang, Y., Wei, N., Yue, C., Li, D., & Zhang, H. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.02.201 · Cited by 142 · see citing works
Skike, C. E. V., Jahrling, J. B., Dorigatti, A. O., Sayre, N. L., Hussong, S. A., Ungvari, Z. I., Lechleiter, J. D., & Galván, V. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00570.2017 · Cited by 140 · see citing works
Sun, L., Ma, L., Zhang, H., Cao, Y., Wang, C., Hou, N., Huang, N., von Deneen, K. M., Zhao, C., Shi, Y., et al. (2019) · Theranostics · doi:10.7150/thno.31562 · Cited by 136 · see citing works
Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases
Smith, A. C. W., Kupchik, Y. M., Scofield, M. D., Gipson, C. D., Wiggins, A., Thomas, C. A., & Kalivas, P. W. (2014) · Nature Neuroscience · doi:10.1038/nn.3846 · Cited by 133 · see citing works
Prevalence and impact of depression and pain in neurology outpatients
Williams, L. S. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.11.1587 · Cited by 132 · see citing works
Sublingual captopril and nifedipine in immediate treatment of hypertensive emergensies
(1992) · Padua Research Archive (University of Padova) · doi:10.1001/archinte · Cited by 130 · see citing works
MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage
Kobayashi, H., Chattopadhyay, S., Kato, K., Dolkas, J., Kikuchi, S., Myers, R. R., & Shubayev, V. I. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.08.008 · Cited by 117 · see citing works
Neuropathic Pain Causes Pyramidal Neuronal Hyperactivity in the Anterior Cingulate Cortex
Zhao, R., Zhou, H., Huang, L., Xie, Z., Wang, J., Gan, W., & Yang, G. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00107 · Cited by 113 · see citing works
Frequency of Painful Physical Symptoms With Major Depressive Disorder in Asia
Lee, P., Zhang, M., Hong, J. P., Chua, H.-C., Chen, K.-P., Tang, S. W., Chan, B. T. M., Lee, M. S., Lee, B., Gallagher, G. L., et al. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04114 · Cited by 112 · see citing works
Hayashita‐Kinoh, H., Kinoh, H., Okada, A., Komori, K., Itoh, Y., Chiba, T., Kajita, M., Yana, I., & Seiki, M. (2001) · PubMed · Cited by 106 · see citing works
Ferreira-Chamorro, P., Redondo, A., Riego, G., Leánez, S., & Pol, O. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01332 · Cited by 95 · see citing works
Li, Y., Guo, X., Sun, L., Xiao, J., Su, S., Du, S., Li, Z., Wu, S., Liu, W., Mo, K., et al. (2020) · Advanced Science · doi:10.1002/advs.201902402 · Cited by 91 · see citing works
Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice
Kim, S. S., Wang, H., Li, X., Chen, T., Mercaldo, V., Descalzi, G., Wu, L., & Zhuo, M. (2011) · Molecular Brain · doi:10.1186/1756-6606-4-6 · Cited by 89 · see citing works
Depressive disorder moderates the effect of the FTO gene on body mass index
Rivera, M., Cohen‐Woods, S., Kapur, K., Breen, G. D., Ng, M. Y., Butler, A. W., Craddock, N. J., Gill, M., Korszun, A., Maier, W., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.45 · Cited by 85 · see citing works
Alaiyed, S., McCann, M., Mahajan, G., Rajkowska, G., Stockmeier, C. A., Kellar, K. J., Wu, J. Y., & Conant, K. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.2387-19.2020 · Cited by 84 · see citing works
Matrix metalloproteinase 14 modulates signal transduction and angiogenesis in the cornea
Chang, J.-H., Huang, Y.-H., Cunningham, C. M., Han, K., Chang, M., Seiki, M., Zhou, Z., & Azar, D. T. (2015) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2015.11.006 · Cited by 75 · see citing works
Cañete-Soler, R., Gui, Y., Linask, K. K., & Muschel, R. J. (1995) · Developmental Brain Research · doi:10.1016/0165-3806(95)00079-s · Cited by 68 · see citing works
von Knorring, L., Perris, C., Eisemann, M. R., Eriksson, U., & Perris, H. (1983) · Pain · doi:10.1016/0304-3959(83)90169-0 · Cited by 65 · see citing works
Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals
Rivera, M., Locke, A. E., Corre, T., Czamara, D., Wolf, C., Ching-López, A., Milaneschi, Y., Kloiber, S. M., Cohen‐Woods, S., Rucker, J., et al. (2017) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.116.183475 · Cited by 65 · see citing works
MeT-DB: a database of transcriptome methylation in mammalian cells
Liu, H., Flores, M. A., Meng, J., Zhang, L., Zhao, X., Rao, M. K., Chen, Y., & Huang, Y. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1024 · Cited by 62 · see citing works
Shen, J., Yang, L., & Wei, W. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113227 · Cited by 56 · see citing works
FTO affects hippocampal function by regulation of BDNF processing
Spychala, A., & Rüther, U. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211937 · Cited by 55 · see citing works
Proteasome inhibition results in increased poly-ADP-ribosylation: Implications for neuron death
Keller, J. N., & Markesbery, W. R. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000815)61:4 · Cited by 54 · see citing works
Wang, Y., Zhang, H., Li, Y., Wang, Z., Fan, Q., Yu, S., Lin, Z., & Xiao, Z. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.07.023 · Cited by 50 · see citing works
Self-citationThomas, A. X., Angel, Y. C. D., González, M. I., Carrel, A. J., Carlsen, J., Lam, P. M., Hempstead, B. L., Russek, S. J., & Brooks‐Kayal, A. R. (2016) · eNeuro · doi:10.1523/eneuro.0020-15.2016 · Cited by 48 · see citing works
Chiou, C.-S., Chen, C., Tsai, T.-C., Huang, C., Chou, D., & Hsu, K. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001237 · Cited by 46 · see citing works
The role of MMP genes in recurrent depressive disorders and cognitive functions
Bobińska, K., Szemraj, J., Gałecki, P., & Talarowska, M. E. (2016) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.72 · Cited by 36 · see citing works
Jiang, H., Ke, B., Liu, J., Ma, G., Hai, K., Gong, D., Yang, Z., & Zhou, C. (2018) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000003563 · Cited by 34 · see citing works
Fu, G.-L., Du, S.-B., Huang, T.-F., Cao, M.-H., Feng, X., Wu, S.-G., Albik, S., Bekker, A., & Tao, Y.-X. (2021) · Stroke · doi:10.1161/strokeaha.121.034173 · Cited by 32 · see citing works
Omori, W., Hattori, K., Kajitani, N., Okada‐Tsuchioka, M., Boku, S., Kunugi, H., Okamoto, Y., & Takebayashi, M. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa049 · Cited by 29 · see citing works
A hierarchical model for clustering m6A methylation peaks in MeRIP-seq data
Cui, X., Meng, J., Zhang, S., Rao, M. K., Chen, Y., & Huang, Y. (2016) · BMC Genomics · doi:10.1186/s12864-016-2913-x · Cited by 21 · see citing works
Lin, L., Luo, S., Al‐Hawwas, M., Herselman, M. F., Zhou, X., & Bobrovskaya, L. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01328-6 · Cited by 20 · see citing works
Randon, G., Pagani, F., & Pietrantonio, F. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-0817 · Cited by 6 · see citing works
Flagged first, then by citations
2 of the 68 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Jaworski D. M. Fager N. (2000). Regulation of tissue inhibitor of metalloproteinase-3 (Timp-3) mRNA expression during rat CNS development. J. Neurosci. Res. 61 396– 408. 10.1002/1097-4547(20000815)61 10931526 · DOI
Cited by
Sorted by citations
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
“Anxiety-like and depression-like behavior induced by peripheral nerve injury could be reversed in mice by blocking FTO downregulation in the anterior cingulate cortex.(362) The m(6)A demethylase gene ALKBH5 variant rs12936694 showed an allelic association and genotypic association with MDD.”
BackgroundSelf-citationJeong, S., Chokkalla, A. K., Davis, C. K., & Vemuganti, R. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02099-8 · Cited by 49 · see citing works
Lv, J., Xing, L., Zhong, X., Li, K., Liu, M., & Du, K. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114583 · Cited by 39 · see citing works
Potential Roles of m6A and FTO in Synaptic Connectivity and Major Depressive Disorder
Mitsuhashi, H., & Nagy, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076220 · Cited by 40 · see citing works
YTHDF1 Attenuates TBI-Induced Brain-Gut Axis Dysfunction in Mice
Huang, P., Liu, M., Zhang, J., Zhong, X., & Zhong, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044240 · Cited by 24 · see citing works
Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries
Tian, M., Mao, L., & Zhang, L. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1013450 · Cited by 22 · see citing works
Jiang, X., Yan, Y., Chen, Z., Xiong, J., Zhang, X., Gu, L., Zhang, Y., Zhu, M., Zhang, D., & Jiang, J. (2025) · Theranostics · doi:10.7150/thno.111130 · Cited by 21 · see citing works
Xu, Z., Zhu, X., Mu, S., Fan, R., Wang, B., Gao, W., & Kang, T. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04719-x · Cited by 17 · see citing works
Shao, L., Chen, B., Wu, Q., Xu, Y., Yi, J., Guo, Z., & Liu, B. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.973979 · Cited by 14 · see citing works
Li, M., Yang, Y., Chen, T., Luo, Y., Zhang, Y., Liu, H., & Maes, M. H. J. (2025) · Behavioral and Brain Functions · doi:10.1186/s12993-025-00280-3 · Cited by 13 · see citing works
Silencing of FTO inhibits oxidative stress to relieve neuropathic pain by m6A modification of GPR177
Liu, L., Liu, M., Song, Z., & Zhang, H. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.1345 · Cited by 10 · see citing works
Bai, X., Batallé, G., Martínez-Martel, I., & Pol, O. (2023) · Antioxidants · doi:10.3390/antiox12061179 · Cited by 9 · see citing works
Wu, L., & Tang, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115398 · Cited by 9 · see citing works
Kanarik, M., Liiver, K., Školnaja, M., Teino, I., Org, T., Laugus, K., Shimmo, R., Karelson, M. M., Saarma, M., & Harro, J. (2024) · Acta Neuropsychiatrica · doi:10.1017/neu.2024.36 · Cited by 8 · see citing works
Soberanes-Chávez, P., Trujillo-Barrera, J., & de Gortari, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115857 · Cited by 7 · see citing works
The Potential Role of m6A in the Regulation of TBI-Induced BGA Dysfunction
Huang, P., Liu, M., Zhang, J., Zhong, X., & Zhong, C. (2022) · Antioxidants · doi:10.3390/antiox11081521 · Cited by 7 · see citing works
N6-methyladenosine methylation: a novel key to unlocking mental disorders
Wang, Y., Liu, M., Liu, M., Xu, X., Ma, Y., Luo, Y., & Wang, Y. (2025) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaf044 · Cited by 6 · see citing works
The genetics of a “femaleness/maleness” score in cardiometabolic traits in the UK biobank
Vosberg, D. E., Pausová, Z., & Paus, T. (2023) · Scientific Reports · doi:10.1038/s41598-023-36132-1 · Cited by 6 · see citing works
Chronic postsurgical pain increases postoperative depression risk
Sun, M., Wang, X., Lu, Z., Yang, Y., Lv, S., Miao, M., Chen, W., Wu, S., & Zhang, J. (2025) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2024-222761 · Cited by 6 · see citing works
Self-citationLan, L., Peng, S., Zhang, R., He, H., Yang, Y., Xi, B., & Zhang, J. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1341374 · Cited by 5 · see citing works
Zhao, L., Song, D., Li, T., Li, Y., Dang, M., Hao, Q., fan, H., Lu, Z., Lu, J., Heyingwang, et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-53788-5 · Cited by 5 · see citing works
Self-citationZhang, K., Zhu, S., Xing, N., Zhou, Z. G., Chen, J., Si, T., Li, M., Jia, L., Rastegar‐Kashkooli, Y., Wang, T. J., et al. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70302 · Cited by 4 · see citing works
Self-citationEpigenetic modifications associated to diabetic peripheral neuropathic pain (Review)
Gao, T., Luo, J., Fan, J., Gong, G., & Yang, H. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13394 · Cited by 3 · see citing works
Hu, J., Fu, J., Cai, Y., Chen, S., Qu, M., Zhang, L., Fan, W., Wang, Z., Zeng, Q., & Zou, J. (2024) · Experimental Biology and Medicine · doi:10.3389/ebm.2024.10129 · Cited by 2 · see citing works
Self-citationChen, J., Wang, Y., Peng, Y., Jia, K., Fan, Z., Jiang, F., Yan, J., & Wang, Q. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70058 · Cited by 2 · see citing works
Xiaofeng, H., Yang, R., Qi, Z., Wang, X., Yin, N., Faiola, F., Liu, S., & Gao, M. (2023) · Environmental Science Nano · doi:10.1039/d2en00734g · Cited by 2 · see citing works
Self-citationIdentification of m1A/m6A/m5C/m7G-related genes and clusters associated with neuropathic pain
Tan, L., Gan, X., Lu, D., Liang, Y., Fu, W., Gan, Z., Wang, K., Tang, H., & Yang, P. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1592545 · Cited by 1 · see citing works
Zheng, Y., Zheng, Y., Chen, P., & Wang, X. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.71051 · Cited by 1 · see citing works
Self-citationKanarik, M., Liiver, K., Školnaja, M., Teino, I., Org, T., Laugus, K., Shimmo, R., Karelson, M. M., Saarma, M., & Harro, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.08.574593
Hao, S., Xu, Y., Guo, J.-B., & Li, T. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1622894
Chronic Postsurgical Pain-induced Postoperative Anxiety Risk
Sun, M., Lu, Z., Wang, X., Liu, L., Yang, Y., Lv, S., Miao, M., Chen, W., Wu, S., & Zhang, J. (2025) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001436
Self-citationKurrikoff, T., Eensoo, D., & Harro, J. (2026) · Journal of Neural Transmission · doi:10.1007/s00702-026-03108-0
Wang, X., Lu, Z., Mao, T., Yang, Y., Zhu, R., Li, W., Zeng, S., Wang, Y., Zhang, L., Xu, Y., et al. (2026) · The Journal of Headache and Pain · doi:10.1186/s10194-026-02439-3
Self-citation周喜丹, Li, S., Guo, C., Wu, S., Wu, X., Wu, M., Wu, C., Li, K., Cui, Y., & Zhou, T. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03840-9
- Authors
- Wang, X.-L., Wei, X., Yuan, J.-J., Mao, Y.-Y., Wang, Z.-Y., Xing, N., Gu, H.-W., Lin, C.-H., Wang, W.-T., Zhang, W., & Xing, F.
- Affiliations
- First Affiliated Hospital of Zhengzhou University (CN)
- Zhengzhou University (CN)
- Corresponding author
- Zhang, Wei
- Xing, Fei
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2022-05-12
- Volume
- 16
- Pages
- 884296-884296
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC9133794
- OpenAlex
- W4280637954
- Cited by
- 34
- References
- 68
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 3
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Zhengzhou University
- First Affiliated Hospital of Zhengzhou University
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- FTO, N6-methyladenosine, mRNA methylation, neuropathic pain, anterior cingulate cortex, anxiety-like behavior, depression-like behavior, MMP-9, proBDNF, brain-derived neurotrophic factor, peripheral nerve injury, RNA demethylation
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