A specific olfactory bulb interneuron subtype Tpbg/5T4 generated at embryonic and neonatal stages
Open accessAbstract
Various mammals have shown that sensory stimulation plays a crucial role in regulating the development of diverse structures, such as the olfactory bulb (OB), cerebral cortex, hippocampus, and retina. In the OB, the dendritic development of excitatory projection neurons like mitral/tufted cells is influenced by olfactory experiences. Odor stimulation is also essential for the dendritic development of inhibitory OB interneurons, such as granule and periglomerular cells, which are continuously produced in the ventricular-subventricular zone throughout life. Based on the morphological and molecular features, OB interneurons are classified into several subtypes. The role for each interneuron subtype in the control of olfactory behavior remains poorly understood due to lack of each specific marker. Among the several OB interneuron subtypes, a specific granule cell subtype, which expresses the oncofetal trophoblast glycoprotein (Tpbg or 5T4) gene, has been reported to be required for odor detection and discrimination behavior. This review will primarily focus on elucidating the contribution of different granule cell subtypes, including the Tpbg/5T4 subtype, to olfactory processing and behavior during the embryonic and adult stages.
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Neonatal-born granule cells have been primarily associated with innate olfactory responses.
“neonatal-born GCs have been primarily associated with innate olfactory responses [14,20,21,53,54].”
From Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system (2026) · cites this paper as [54]
The Perspectives section (page unavailable) hypothesizes that embryonic-born granule cells are involved in fundamental olfactory responses, while adult-born cells are more associated with learned behaviors. It also reports that a subtype generated during embryonic and perinatal periods is required for basic odor detection and discrimination. It does not establish the same association for neonatal-born granule cells generally, or describe them as primarily associated with innate responses. (LLM, conf=0.86)
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Cites
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572 · see citing works
Molecular Architecture of the Mouse Nervous System
Zeisel, A., Hochgerner, H., Lönnerberg, P., Johnsson, A., Memic, F., van der Zwan, J., Häring, M., Braun, E., Borm, L. E., La Manno, G., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.021 · Cited by 2,995 · see citing works
Spatially resolved, highly multiplexed RNA profiling in single cells
Chen, K. H., Boettiger, A. N., Moffitt, J. R., Wang, S., & Zhuang, X. (2015) · Science · doi:10.1126/science.aaa6090 · Cited by 2,969 · see citing works
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Yao, Z., van Velthoven, C. T. J., Kunst, M., Zhang, M., McMillen, D., Lee, C., Jung, W., Goldy, J., Abdelhak, A., Aitken, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06812-z · Cited by 1,194 · see citing works
Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics
Shekhar, K., Lapan, S. W., Whitney, I. E., Tran, N. M., Macosko, E. Z., Kowalczyk, M., Adiconis, X., Levin, J. Z., Nemesh, J., Goldman, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.07.054 · Cited by 1,176 · see citing works
Mosaic Organization of Neural Stem Cells in the Adult Brain
Merkle, F. T., Mirzadeh, Z., & Álvarez-Buylla, A. (2007) · Science · doi:10.1126/science.1144914 · Cited by 821 · see citing works
Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain
Obernier, K., & Alvarez-Buylla, A. (2019) · Development · doi:10.1242/dev.156059 · Cited by 578 · see citing works
Cortical representations of olfactory input by trans-synaptic tracing
Miyamichi, K., Amat, F., Moussavi, F., Wang, C., Wickersham, I. R., Wall, N. R., Taniguchi, H., Tasic, B., Huang, Z. J., He, Z., et al. (2010) · Nature · doi:10.1038/nature09714 · Cited by 546 · see citing works
Embryonic origin of postnatal neural stem cells
Fuentealba, L. C., Rompani, S. B., Parraguez, J. I., Obernier, K., Romero, R., Cepko, C. L., & Alvarez-Buylla, A. (2015) · Cell · doi:10.1016/j.cell.2015.05.041 · Cited by 488 · cited 6× · see citing works
“…in superficial GCs nearby the MC layer (G IIIM ) based on their location and dendritic morphology (Imamura et al., 2006; Yoshihara et al., 2012; Fuentealba et al., 2015), while CalR GCs are in the other superficial GCs (G III ) with a different cell lineage from Tpbg/5T4 (Merkle et al., 2014;…”
BackgroundInfluentialLong‐term survival and cell death of newly generated neurons in the adult rat olfactory bulb
Winner, B., Cooper‐Kuhn, C. M., Aigner, R., Winkler, J., & Kuhn, H. G. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02238.x · Cited by 412 · see citing works
Neuronal organization of olfactory bulb circuits
Nagayama, S., Homma, R., & Imamura, F. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00098 · Cited by 411 · see citing works
Igarashi, K. M., Ieki, N., An, M., Yamaguchi, Y., Nagayama, S., Kobayakawa, K., Kobayakawa, R., Tanifuji, M., Sakano, H., Chen, W. R., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0154-12.2012 · Cited by 390 · see citing works
How Is the Olfactory Map Formed and Interpreted in the Mammalian Brain?
Mori, K., & Sakano, H. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-112210-112917 · Cited by 350 · see citing works
Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells
Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, K. I., Hirabayashi, Y., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3989 · Cited by 329 · see citing works
Mouse Retinal Cell Atlas: Molecular Identification of over Sixty Amacrine Cell Types
Yan, W., Laboulaye, M. A., Tran, N. M., Whitney, I. E., Benhar, I., & Sanes, J. R. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0471-20.2020 · Cited by 329 · see citing works
Neural stem cells in mammalian development
Merkle, F. T., & Álvarez-Buylla, A. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.09.008 · Cited by 312 · see citing works
The Distinct Temporal Origins of Olfactory Bulb Interneuron Subtypes
Batista‐Brito, R., Close, J., Machold, R. P., & Fishell, G. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5625-07.2008 · Cited by 285 · see citing works
Adult neural stem cells in distinct microdomains generate previously unknown interneuron types
Merkle, F. T., Fuentealba, L. C., Sanders, T. A., Magno, L., Kessaris, N., & Álvarez-Buylla, A. (2013) · Nature Neuroscience · doi:10.1038/nn.3610 · Cited by 277 · see citing works
Yamaguchi, M., & Mori, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406082102 · Cited by 270 · see citing works
Synaptic Inhibition in the Olfactory Bulb Accelerates Odor Discrimination in Mice
Abraham, N. M., Egger, V., Shimshek, D. R., Renden, R., Fukunaga, I., Sprengel, R., Seeburg, P. H., Klugmann, M., Margrie, T. W., Schaefer, A. T., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.009 · Cited by 252 · see citing works
Spatial atlas of the mouse central nervous system at molecular resolution
Shi, H., He, Y., Zhou, Y., Huang, J., Maher, K., Wang, B., Tang, Z., Luo, S., Tan, P., Wu, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06569-5 · Cited by 244 · see citing works
An Extracellular Interactome of Immunoglobulin and LRR Proteins Reveals Receptor-Ligand Networks
Özkan, E., Carrillo, R. A., Eastman, C., Weiszmann, R., Waghray, D., Johnson, K. G., Zinn, K., Celniker, S., & García, K. C. (2013) · Cell · doi:10.1016/j.cell.2013.06.006 · Cited by 232 · see citing works
Lemasson, M., Saghatelyan, A., Olivo-Marin, J.-C., & Lledo, P.-M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1114-05.2005 · Cited by 218 · see citing works
Activation of adult-born neurons facilitates learning and memory
Alonso, M., Lepousez, G., Wagner, S., Bardy, C., Gabellec, M., Torquet, N., & Lledo, P. (2012) · Nature Neuroscience · doi:10.1038/nn.3108 · Cited by 215 · see citing works
Continuous neurogenesis in the adult forebrain is required for innate olfactory responses
Sakamoto, M., Imayoshi, I., Ohtsuka, T., Yamaguchi, M., Mori, K., & Kageyama, R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018782108 · Cited by 198 · see citing works
Tepe, B., Hill, M. C., Pekarek, B. T., Hunt, P. J., Martin, T. J., Martin, J. F., & Arenkiel, B. R. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.034 · Cited by 183 · see citing works
The olfactory granule cell: From classical enigma to central role in olfactory processing
Shepherd, G. M., Chen, W. R., Willhite, D. C., Migliore, M., & Greer, C. A. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.03.005 · Cited by 171 · see citing works
The Impact of Adult Neurogenesis on Olfactory Bulb Circuits and Computations
Lepousez, G., Valley, M. T., & Lledo, P. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183731 · Cited by 168 · see citing works
Adult Olfactory Bulb NeurogenesisPreprint
Lledo, P., & Valley, M. T. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018945 · Cited by 156 · see citing works
Mechanisms of neuronal migration in the adult brain
Kaneko, N., Sawada, M., & Sawamoto, K. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14002 · Cited by 150 · see citing works
Sakamoto, M., Ieki, N., Miyoshi, G., Mochimaru, D., Miyachi, H., Imura, T., Yamaguchi, M., Fishell, G., Mori, K., Kageyama, R., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.0674-14.2014 · Cited by 131 · see citing works
Olfactory Circuitry and Behavioral Decisions
Mori, K., & Sakano, H. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-031820-092824 · Cited by 120 · see citing works
The subiculum is a patchwork of discrete subregions
Cembrowski, M. S., Wang, L., Lemire, A. L., Copeland, M., DiLisio, S. F., Clements, J., & Spruston, N. (2018) · eLife · doi:10.7554/elife.37701 · Cited by 98 · see citing works
Kagermeier-Schenk, B., Wehner, D., Özhan, G., Yamamoto, H., Li, J., Kirchner, K., Hoffmann, C., Stern, P. L., Kikuchi, A., Schambony, A., et al. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.10.015 · Cited by 97 · see citing works
Imamura, F., Nagao, H., Naritsuka, H., Murata, Y., Taniguchi, H., & Mori, K. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20896 · Cited by 75 · see citing works
Disinhibition of olfactory bulb granule cells accelerates odour discrimination in mice
Nunes, D., & Kuner, T. (2015) · Nature Communications · doi:10.1038/ncomms9950 · Cited by 73 · see citing works
Geramita, M. A., Burton, S. D., & Urban, N. N. (2016) · eLife · doi:10.7554/elife.16039 · Cited by 73 · see citing works
Myers, K. A., RAHI-SAUND, V., Davison, M. D., et al. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37110-7 · Cited by 70 · see citing works
How, When, and Where New Inhibitory Neurons Release Neurotransmitters in the Adult Olfactory Bulb
Bardy, C., Alonso, M., Bouthour, W., & Lledo, P. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4543-10.2010 · Cited by 64 · see citing works
Intrinsic Mechanisms Regulating Neuronal Migration in the Postnatal Brain
Bressan, C., & Saghatelyan, A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.620379 · Cited by 54 · see citing works
Zhao, Y., Malinauskas, T., Harlos, K., & Jones, E. Y. (2014) · Structure · doi:10.1016/j.str.2014.01.009 · Cited by 49 · see citing works
Yoshihara, S.-I., Takahashi, H., Nishimura, N., Naritsuka, H., Shirao, T., Hirai, H., Yoshihara, Y., Mori, K., Stern, P. L., & Tsuboi, A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5907-11.2012 · Cited by 45 · see citing works
Self-citationA Subtype of Olfactory Bulb Interneurons Is Required for Odor Detection and Discrimination Behaviors
Takahashi, H., Ogawa, Y., Yoshihara, S.-I., Asahina, R., Kinoshita, M., Kitano, T., Kitsuki, M., Tatsumi, K., Okuda, M., Tatsumi, K., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2783-15.2016 · Cited by 45 · see citing works
Self-citationKing, K. W., Sheppard, F. C. D., Westwater, C., et al. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(99)00055-x · Cited by 35 · see citing works
Egger, V., & Kuner, T. (2021) · Cell and Tissue Research · doi:10.1007/s00441-020-03402-7 · Cited by 33 · see citing works
Fourcaud‐Trocmé, N., Courtiol, E., & Buonviso, N. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00088 · Cited by 30 · see citing works
Correlated firing in tufted cells of mouse olfactory bulb
Ma, J., & Lowe, G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.033 · Cited by 29 · see citing works
Yoshizawa, M., Hoshino, M., Sone, M., & Nabeshima, Y. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00650-5 · Cited by 26 · see citing works
Malvaut, S., Gribaudo, S., Hardy, D., David, L. S., Daroles, L., Labrecque, S., Lebel‐Cormier, M., Chaker, Z., Côté, D. C., Koninck, P. D., et al. (2017) · Current Biology · doi:10.1016/j.cub.2017.09.058 · Cited by 25 · see citing works
The role of calretinin-expressing granule cells in olfactory bulb functions and odor behavior
Hardy, D., Malvaut, S., Breton‐Provencher, V., & Saghatelyan, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-27692-8 · Cited by 20 · see citing works
Gribaudo, S., Bovetti, S., Garzotto, D., Fasolo, A., & Marchis, S. D. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22177 · Cited by 19 · see citing works
The Stem Cell Marker Lgr5 Defines a Subset of Postmitotic Neurons in the Olfactory Bulb
Yu, Y., Moberly, A. H., Bhattarai, J. P., Duan, C., Zheng, Q., Li, F., Huang, H. H., Olson, W. P., Luo, W., Wen, T., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0500-17.2017 · Cited by 16 · see citing works
Gribaudo, S., Saraulli, D., Nato, G., Bonzano, S., Gambarotta, G., Luzzati, F., Costanzi, M., Peretto, P., Bovetti, S., & Marchis, S. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084269 · Cited by 9 · see citing works
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Dejou, J., Athanassi, A., Brunel, T., Thevenet, M., Didier, A., & Mandairon, N. (2026) · PLOS Biology · doi:10.1371/journal.pbio.3003845 · Cited by 1 · see citing works
“At the neuronal level, while adult-born GCs are well-known to support flexible olfactory behaviors in adulthood [19,50–52], neonatal-born GCs have been primarily associated with innate olfactory responses [14,20,21,53,54].”
- Authors
- Tsuboi, A.
- Affiliations
- The University of Osaka (JP)
- Corresponding author
- Tsuboi, Akio
- ORCID
- Tsuboi, Akio
- Venue
- Frontiers in Neural Circuits
- Publisher
- Frontiers Media SA
- Published
- 2024-06-12
- Volume
- 18
- Pages
- 1427378-1427378
- ISSN
- 1662-5110 (ISSN-L)
- PMC
- PMC11203798
- OpenAlex
- W4399569518
- Cited by
- 3
- References
- 53
- Citations by year
- 2026: 2 · 2025: 1
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Neural Circuits (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Agency for Medical Research and Development (JP22ym0126809j0001)
- Ministry of Education, Culture, Sports, Science and Technology
- Nara Medical University
- Japan Society for the Promotion of Science (24K22168, 23K23996)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- olfactory bulb, interneuron subtypes, granule cells, periglomerular cells, mitral/tufted cells, odor detection, odor discrimination, olfactory behavior, dendritic development, embryonic development, neonatal development, olfactory processing
- MeSH terms
- Animals, Humans, Interneurons, Olfactory Bulb, Neurogenesis
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