Single-Cell RNA-Seq of Mouse Olfactory Bulb Reveals Cellular Heterogeneity and Activity-Dependent Molecular Census of Adult-Born Neurons
Open accessAbstract
Cellular heterogeneity within the mammalian brain poses a challenge toward understanding its complex functions. Within the olfactory bulb, odor information is processed by subtypes of inhibitory interneurons whose heterogeneity and functionality are influenced by ongoing adult neurogenesis. To investigate this cellular heterogeneity and better understand adult-born neuron development, we utilized single-cell RNA sequencing and computational modeling to reveal diverse and transcriptionally distinct neuronal and nonneuronal cell types. We also analyzed molecular changes during adult-born interneuron maturation and uncovered developmental programs within their gene expression profiles. Finally, we identified that distinct neuronal subtypes are differentially affected by sensory experience. Together, these data provide a transcriptome-based foundation for investigating subtype-specific neuronal function in the olfactory bulb (OB), charting the molecular profiles that arise during the maturation and integration of adult-born neurons and how they dynamically change in an activity-dependent manner.
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As immature OB neurons exit the RMS, they express markers such as Sox11 and S100a6, whereas mature OB neurons are marked by expression of Frmd7.
“As the immature OB neurons exit the RMS, they express markers such as Sox11 and S100a687, whereas the mature OB neurons are marked by the expression of Frmd7.”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [87]
The Results section, “Transcriptome-Based Clustering of Neurons Identifies Markers of Neuronal Subtypes” (page unavailable), identifies Sox11-enriched cells in the rostral migratory stream as immature migrating adult-born neurons. It does not establish that they express Sox11 as they exit the stream; searches of our copy for S100a6 and Frmd7 found no support for those proposed markers. (LLM, conf=0.86)
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Olfactory information processing viewed through mitral and tufted cell-specific channels
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- Authors
- Tepe, B., Hill, M. C., Pekarek, B. T., Hunt, P. J., Martin, T. J., Martin, J. F., & Arenkiel, B. R.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Martin, James F.
- Arenkiel, Benjamin R.
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 25
- Issue
- 10
- Pages
- 2689-2703.e3
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC6342206
- OpenAlex
- W2903487479
- Cited by
- 183
- References
- 88
- Citations by year
- 2026: 19 · 2025: 41 · 2024: 30 · 2023: 28 · 2022: 20 · 2021: 20 · 2020: 18 · 2019: 7
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion, other-oa)
- PubMed Central (acceptedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- McNair Medical Institute (U54 HD083092, R01NS078294-05, DE023177, HL127717, HL130804, HL118761)
- The Vivian L. Smith Foundation
- LeDucq Foundation Transatlantic Networks of Excellence in Cardiovascular Research (14CVD01, F31HL136065)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- olfactory bulb, adult neurogenesis, inhibitory interneurons, cellular heterogeneity, neuronal cell types, interneuron maturation, activity-dependent gene expression, sensory experience, transcriptome, mice
- MeSH terms
- Aging, Animals, Base Sequence, Interneurons, Mice, Inbred C57BL, Neurons, Olfactory Bulb, Transcription, Genetic, Biomarkers, Sequence Analysis, RNA, Gene Regulatory Networks, Neurogenesis, Single-Cell Analysis, Transcriptome
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