Intrinsic functional network organization in high-functioning adolescents with autism spectrum disorder
Open accessAbstract
Converging theories and data suggest that atypical patterns of functional and structural connectivity are a hallmark neurobiological feature of autism. However, empirical studies of functional connectivity, or, the correlation of MRI signal between brain regions, have largely been conducted during task performance and/or focused on group differences within one network [e.g., the default mode network (DMN)]. This narrow focus on task-based connectivity and single network analyses precludes investigation of whole-brain intrinsic network organization in autism. To assess whole-brain network properties in adolescents with autism, we collected resting-state functional connectivity MRI (rs-fcMRI) data from neurotypical (NT) adolescents and adolescents with autism spectrum disorder (ASD). We used graph theory metrics on rs-fcMRI data with 34 regions of interest (i.e., nodes) that encompass four different functionally defined networks: cingulo-opercular, cerebellar, fronto-parietal, and DMN (Fair etal., 2009). Contrary to our hypotheses, network analyses revealed minimal differences between groups with one exception. Betweenness centrality, which indicates the degree to which a seed (or node) functions as a hub within and between networks, was greater for participants with autism for the right lateral parietal (RLatP) region of the DMN. Follow-up seed-based analyses demonstrated greater functional connectivity in ASD than NT groups between the RLatP seed and another region of the DMN, the anterior medial prefrontal cortex. Greater connectivity between these regions was related to lower ADOS (Autism Diagnostic Observation Schedule) scores (i.e., lower impairment) in autism. These findings do not support current theories of underconnectivity in autism, but, rather, underscore the need for future studies to systematically examine factors that can influence patterns of intrinsic connectivity such as autism severity, age, and head motion.
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Children with ASD have not shown altered cingulo-opercular connectivity.
“but not altered cingulo-operuclar connectivity 59”
From Subtyping cognitive profiles in Autism Spectrum Disorder using a Functional Random Forest algorithm (2018) · cites this paper as [59]
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- Authors
- Redcay, E., Moran, J. M., Mavros, P. L., Tager-Flusberg, H., Gabrieli, J. D. E., & Whitfield-Gabrieli, S.
- Affiliations
- University of Maryland, College Park (US)
- Harvard University (US)
- Massachusetts Institute of Technology (US)
- Boston University (US)
- McGovern Institute for Brain Research (US)
- Corresponding author
- Redcay, Elizabeth
- Venue
- Frontiers in Human Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 573-573
- ISSN
- 1662-5161 (ISSN-L)
- PMC
- PMC3777537
- OpenAlex
- W2012274058
- Cited by
- 158
- References
- 18
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 8 · 2023: 12 · 2022: 16 · 2021: 12 · 2020: 6 · 2019: 8 · 2018: 15 · 2017: 16 · 2016: 19 · 2015: 20 · 2014: 12
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Human Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- OpenBU (Boston University) (submittedVersion, cc-by)
- OpenBU (Boston University) (submittedVersion, other-oa)
- Frontiers Research Foundation
- Funders
- Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital
- McGovern Institute for Brain Research, Massachusetts Institute of Technology
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, adolescents, resting-state functional connectivity, intrinsic brain networks, default mode network, betweenness centrality, graph theory, cerebellar network, cingulo-opercular network, frontoparietal network, anterior medial prefrontal cortex, autism severity
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