Disrupted neural synchronization in toddlers with autism
Open accessAbstract
Autism is often described as a disorder of neural synchronization. However, it is unknown how early in development synchronization abnormalities emerge and whether they are related to the development of early autistic behavioral symptoms. Here, we show that disrupted synchronization is evident in the spontaneous cortical activity of naturally sleeping toddlers with autism, but not in toddlers with language delay or typical development. Toddlers with autism exhibited significantly weaker interhemispheric synchronization (i.e., weak "functional connectivity" across the two hemispheres) in putative language areas. The strength of synchronization was positively correlated with verbal ability and negatively correlated with autism severity, and it enabled identification of the majority of autistic toddlers (72%) with high accuracy (84%). Disrupted cortical synchronization, therefore, appears to be a notable characteristic of autism neurophysiology that is evident at very early stages of autism development.
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Altered connectivity in developing language circuits is an early and potentially causal feature of ASD, which could not be inferred from studies of older children or adults.
“This study is particularly important, as it shows altered connectivity in developing language circuits to be an early (and thus potentially causal) feature of the disorder, which could not be inferred from studies of older children or adults.”
From Genetics of autism spectrum disorders (2011) · cites this paper as [54]
Many subsequent studies provide strong support for the connectivity model, including a recent study showing weak interhemispheric functional connectivity in young toddlers with ASD.
“Since the general connectivity model was proposed, many subsequent studies provide strong supporting data, including a recent study showing weak interhemispheric functional connectivity in young toddlers with ASD [54].”
From Genetics of autism spectrum disorders (2011) · cites this paper as [54]
The degree of reduced interhemispheric connectivity in toddlers with ASDs correlates with verbal ability and severity of ASD symptoms.
“the degree of reduced interhemispheric connectivity correlated with verbal ability and severity of ASD symptoms”
From Neuronal Dynamics and Neuropsychiatric Disorders: Toward a Translational Paradigm for Dysfunctional Large-Scale Networks (2012) · cites this paper as Dinstein et al., 2011
Toddlers with ASDs exhibit significantly reduced interhemispheric connectivity between language areas relative to normally developing children and toddlers with language delay.
“Toddlers with ASDs exhibited significantly reduced connectivity between language areas of the two hemispheres relative to normally developing children and toddlers with language delay.”
From Neuronal Dynamics and Neuropsychiatric Disorders: Toward a Translational Paradigm for Dysfunctional Large-Scale Networks (2012) · cites this paper as Dinstein et al., 2011
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ResultPrecentral gyrus functional connectivity signatures of autism
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- Authors
- Dinstein, I., Pierce, K., Eyler, L., Solso, S., Malach, R., Behrmann, M., & Courchesne, E.
- Affiliations
- University of California San Diego (US)
- Weizmann Institute of Science (IL)
- Carnegie Mellon University (US)
- Corresponding author
- Dinstein, Ilan
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 70
- Issue
- 6
- Pages
- 1218-1225
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3119852
- OpenAlex
- W1979877610
- Semantic Scholar
- ac21943249c38c7c945fa415f217836d54408cec
- Cited by
- 384
- References
- 40
- Citations by year
- 2026: 11 · 2025: 7 · 2024: 17 · 2023: 16 · 2022: 16 · 2021: 34 · 2020: 31 · 2019: 34 · 2018: 13 · 2017: 23 · 2016: 30 · 2015: 36 · 2014: 34 · 2013: 46 · 2012: 25
- FWCI
- 16.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- KiltHub Repository (submittedVersion)
- Figshare (submittedVersion, cc-by)
- KiltHub Repository
- Funders
- National Institute of Mental Health (F31MH080457, R01MH036840, R01MH080134, P50MH081755)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- autism spectrum disorder, neuronal synchronization, toddlers, spontaneous cortical activity, sleep, interhemispheric synchronization, functional connectivity, language areas, language delay, verbal ability, autism severity, autism diagnosis, early development
- MeSH terms
- Adaptation, Psychological, Age Factors, Autistic Disorder, Cerebral Cortex, Child Development, Child, Preschool, Cortical Synchronization, Humans, Infant, Language Development Disorders, Functional Laterality, Neurons, Reference Values, Sleep, Case-Control Studies, Polysomnography
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