Acupuncture treatment modulates the corticostriatal reward circuitry in major depressive disorder
Open accessAbstract
Major depressive disorder (MDD) is a common disorder with a high prevalence and significant social and economic impacts. Nevertheless, the treatment of MDD is far from satisfactory. Acupuncture treatment has emerged as a promising method for treating MDD. However, the neural mechanism by which acupuncture reduces depressive symptoms is not fully understood. Studies have shown that the corticostriatal reward circuitry is associated with the pathophysiology of MDD; thus, we investigated the corticostriatal resting-state functional connectivity (rsFC) before and after real and sham acupuncture treatments combined with the antidepressant fluoxetine. Forty-six female major depressive patients were assigned to either verum acupuncture plus fluoxetine (n = 22) or sham acupuncture plus fluoxetine (n = 24) treatment for 8 weeks, and resting state functional magnetic resonance imaging (fMRI) data were collected before the first and after the last treatment sessions. The results showed that compared with sham acupuncture, the verum acupuncture group showed: (1) significantly increased rsFC between inferior ventral striatum and medial prefrontal cortex, ventral rostral putamen and amygdala/parahippocampus, as well as dorsal caudate and middle temporal gyrus; (2) significantly decreased rsFC between right ventral rostral putamen and right dorsolateral prefrontal cortex, and right dorsal caudate and bilateral cerebellar tonsil. The increased rsFC between the inferior ventral striatum and medial prefrontal cortex, ventral rostral putamen and amygdala/parahippocampus were significantly positively associated with decreased clinical scores (Montgomery-Åsberg Depression Rating Scale and Self-Rating Depression Scale scores) at the end of the eight-week treatment. Our findings suggest that acupuncture may achieve treatment effects by modulating the corticostriatal reward/motivation circuitry in MDD patients.
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Acupuncture may achieve therapeutic effects by modulating the corticostriatal reward/motivation circuit in patients with severe depression.
“The results of an 8-week clinical study involving 46 female patients with severe depression suggested that acupuncture may achieve therapeutic effects by modulating the corticostriatal reward/motivation circuit in patients with severe depression. 433”
From Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024) · cites this paper as [433]
The Abstract says acupuncture may achieve treatment effects by modulating corticostriatal reward/motivation circuitry in patients with major depressive disorder. The Methods (Participants) do not establish that all patients had severe depression; the Results (Patient characteristics) say 46 were recruited but only 36 completed the eight-week study and were analyzed. Thus the proposed mechanism is supported, but the severity and sample description overstate the evidence. (LLM, conf=0.88)
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Cited by
Sorted by citations
Major depressive disorder: hypothesis, mechanism, prevention and treatment
Cui, L., Li, S., Wang, S., Wu, X., Liu, Y., Yu, W., Wang, Y., Tang, Y., Xia, M., & Li, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01738-y · Cited by 1,061 · see citing works
- Authors
- Wang, Z., Wang, X., Liu, J., Chen, J., Liu, X., Nie, G., Jorgenson, K., Sohn, K. C., Huang, R., Liu, M., Liu, B., & Kong, J.
- Affiliations
- Harvard University (US)
- Guangzhou University of Chinese Medicine (CN)
- Daegu Catholic University (KR)
- South China Normal University (CN)
- Corresponding author
- Liu, Bo
- Kong, Jian
- ORCID
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 84
- Pages
- 18-26
- ISSN
- 0022-3956 (ISSN-L)
- PMC
- PMC5125902
- OpenAlex
- W2520169676
- Cited by
- 108
- References
- 132
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 14 · 2023: 8 · 2022: 16 · 2021: 20 · 2020: 7 · 2019: 14 · 2018: 6 · 2017: 5 · 2016: 1
- FWCI
- 17.82
- Type
- journal article
- Language
- en
- Update notices
- erratum (2017-04-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- South Korean Health Ministry (CIMI-13-01-32)
- NIH/NCCIH (R01AT006364, R01 R01AT008563, R21AT008707, P01 AT006663)
- Natural Science Foundation of China (31371049)
- Planned Science and Technology Project of Guangdong Province (2014B020212022)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Acupuncture Treatment Research Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- major depressive disorder, acupuncture, resting-state functional connectivity, fluoxetine, sham acupuncture, medial prefrontal cortex, amygdala, caudate nucleus, dorsolateral prefrontal cortex, cerebellar tonsil, motivation, depression treatment
- MeSH terms
- Adult, Cerebral Cortex, Combined Modality Therapy, Corpus Striatum, Depressive Disorder, Major, Major Depressive Disorder, Female, Fluoxetine, Humans, Magnetic Resonance Imaging, Middle Aged, Neural Pathways, Psychiatric Status Rating Scales, Rest, Reward, Acupuncture Therapy, Treatment Outcome, Antidepressive Agents, Second-Generation
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