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Cited by 7Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersFunctional Brain Connectivity Studies

Late fMRI Response Components Are Altered in Autism Spectrum Disorder

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Murray, Scott O., Kolodny, Tamar, Schallmo, Michael-Paul, Gerdts, Jennifer, Bernier, Raphael A.·2020·Frontiers in Human Neuroscience
DOI 10.3389/fnhum.2020.00241PMC PMC7338757
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Abstract

Disrupted cortical neural inhibition has been hypothesized to be a primary contributor to the pathophysiology of autism spectrum disorder (ASD). This hypothesis predicts that ASD will be associated with an increase in neural responses. We tested this prediction by comparing fMRI response magnitudes to simultaneous visual, auditory, and motor stimulation in ASD and neurotypical (NT) individuals. No increases in the initial transient response in any brain region were observed in ASD, suggesting that there is no increase in overall cortical neural excitability. Most notably, there were widespread fMRI magnitude increases in the ASD response following stimulation offset, approximately 6-8 s after the termination of sensory and motor stimulation. In some regions, the higher fMRI offset response in ASD could be attributed to a lack of an "undershoot"-an often observed feature of fMRI responses believed to reflect inhibitory processing. Offset response magnitude was associated with reaction times (RT) in the NT group and may explain an overall reduced RT in the ASD group. Overall, our results suggest that increases in neural responsiveness are present in ASD but are confined to specific components of the neural response, are particularly strong following stimulation offset, and are linked to differences in RT.

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Cited by

Sorted by citations

Authors
Murray, S. O., Kolodny, T., Schallmo, M.-P., Gerdts, J., & Bernier, R. A.
Affiliations
  • University of Washington (US)
  • University of Minnesota (US)
Corresponding author
Murray, Scott O.
ORCID
Venue
Frontiers in Human Neuroscience
Publisher
Frontiers Media SA
Published
2020-06-30
Volume
14
Pages
241-241
ISSN
1662-5161 (ISSN-L)
DOI
10.3389/fnhum.2020.00241
PMC
PMC7338757
OpenAlex
W3037395630
Cited by
7
References
9
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2022: 2
FWCI
0.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Human Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institute of Mental Health
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
autism spectrum disorder, neural inhibition, cortical excitability, undershoot, reaction time, sensory stimulation, motor stimulation

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