Negative functional MRI response correlates with decreases in neuronal activity in monkey visual area V1
Abstract
Most functional brain imaging studies use task-induced hemodynamic responses to infer underlying changes in neuronal activity. In addition to increases in cerebral blood flow and blood oxygenation level-dependent (BOLD) signals, sustained negative responses are pervasive in functional imaging. The origin of negative responses and their relationship to neural activity remain poorly understood. Through simultaneous functional magnetic resonance imaging and electrophysiological recording, we demonstrate a negative BOLD response (NBR) beyond the stimulated regions of visual cortex, associated with local decreases in neuronal activity below spontaneous activity, detected 7.15 +/- 3.14 mm away from the closest positively responding region in V1. Trial-by-trial amplitude fluctuations revealed tight coupling between the NBR and neuronal activity decreases. The NBR was associated with comparable decreases in local field potentials and multiunit activity. Our findings indicate that a significant component of the NBR originates in neuronal activity decreases.
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The model does not account for negative BOLD responses or changes in spontaneous activity.
“However, this model fails to account for negative BOLD responses (153), or changes in spontaneous activity (154).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [153]
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Febo, M. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00043 · Cited by 43 · see citing works
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Epp, S. M., Castrillón, G., Yuan, B., Andrews-Hanna, J., Preibisch, C., & Riedl, V. (2026) · Nature Neuroscience · doi:10.1038/s41593-025-02132-9 · Cited by 41 · see citing works
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Nguyen‐Duc, J., de Riedmatten, I., Spencer, A. P. C., Perot, J., Olszowy, W., & Jelescu, I. (2025) · Human Brain Mapping · doi:10.1002/hbm.70110 · Cited by 11 · see citing works
- Authors
- Shmuel, A., Augath, M., Oeltermann, A., & Logothetis, N. K.
- Affiliations
- Max Planck Society (DE)
- Corresponding author
- Shmuel, Amir
- Logothetis, Nikos K
- Venue
- Nature Neuroscience
- Published
- 2006-03-19
- Volume
- 9
- Issue
- 4
- Pages
- 569-577
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1967825340
- Cited by
- 898
- References
- 51
- Citations by year
- 2026: 19 · 2025: 21 · 2024: 13 · 2023: 15 · 2022: 28 · 2021: 39 · 2020: 34 · 2019: 32 · 2018: 23 · 2017: 45 · 2016: 53 · 2015: 44 · 2014: 58 · 2013: 53 · 2012: 60
- FWCI
- 68.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- European Molecular Biology Organization
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- negative BOLD response, neuronal activity, visual cortex, spontaneous activity, local field potentials, multi-unit activity, hemodynamic response, monkeys
- MeSH terms
- Animals, Cerebrovascular Circulation, Electrophysiology, Macaca mulatta, Magnetic Resonance Imaging, Neurons, Oxygen, Regional Blood Flow, Statistics as Topic, Visual Cortex
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