Cited by 898Advanced MRI Techniques and ApplicationsVisual perception and processing mechanismsFunctional Brain Connectivity Studies

Negative functional MRI response correlates with decreases in neuronal activity in monkey visual area V1

Shmuel, Amir, Augath, Mark, Oeltermann, Axel, Logothetis, Nikos K·2006·Nature Neuroscience

Abstract

Most functional brain imaging studies use task-induced hemodynamic responses to infer underlying changes in neuronal activity. In addition to increases in cerebral blood flow and blood oxygenation level-dependent (BOLD) signals, sustained negative responses are pervasive in functional imaging. The origin of negative responses and their relationship to neural activity remain poorly understood. Through simultaneous functional magnetic resonance imaging and electrophysiological recording, we demonstrate a negative BOLD response (NBR) beyond the stimulated regions of visual cortex, associated with local decreases in neuronal activity below spontaneous activity, detected 7.15 +/- 3.14 mm away from the closest positively responding region in V1. Trial-by-trial amplitude fluctuations revealed tight coupling between the NBR and neuronal activity decreases. The NBR was associated with comparable decreases in local field potentials and multiunit activity. Our findings indicate that a significant component of the NBR originates in neuronal activity decreases.

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Crossref · 10.1038/nn1675

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Authors
Shmuel, A., Augath, M., Oeltermann, A., & Logothetis, N. K.
Affiliations
Max Planck Society (DE)
Corresponding author
  • Shmuel, Amir
  • Logothetis, Nikos K
Venue
Nature Neuroscience
Published
2006-03-19
Volume
9
Issue
4
Pages
569-577
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W1967825340
Cited by
898
References
51
Citations by year
2026: 19 · 2025: 21 · 2024: 13 · 2023: 15 · 2022: 28 · 2021: 39 · 2020: 34 · 2019: 32 · 2018: 23 · 2017: 45 · 2016: 53 · 2015: 44 · 2014: 58 · 2013: 53 · 2012: 60
FWCI
68.05
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
European Molecular Biology Organization
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
negative BOLD response, neuronal activity, visual cortex, spontaneous activity, local field potentials, multi-unit activity, hemodynamic response, monkeys
MeSH terms
Animals, Cerebrovascular Circulation, Electrophysiology, Macaca mulatta, Magnetic Resonance Imaging, Neurons, Oxygen, Regional Blood Flow, Statistics as Topic, Visual Cortex

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