Cited by 356Thermal Regulation in MedicineThermoregulation and physiological responsesTraumatic Brain Injury and Neurovascular Disturbances

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Brain temperature and its fundamental properties: a review for clinical neuroscientists

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Wang, Huan, Wang, Bonnie, Normoyle, Kieran P., Jackson, Kevin, Spitler, Kevin, Sharrock, Matthew F., Miller, Claire M., Best, Catherine, Llano, Daniel, Du, Rose·2014·Frontiers in Neuroscience

DOI 10.3389/fnins.2014.00307PMC PMC4189373

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Abstract

Brain temperature, as an independent therapeutic target variable, has received increasingly intense clinical attention. To date, brain hypothermia represents the most potent neuroprotectant in laboratory studies. Although the impact of brain temperature is prevalent in a number of common human diseases including: head trauma, stroke, multiple sclerosis, epilepsy, mood disorders, headaches, and neurodegenerative disorders, it is evident and well recognized that the therapeutic application of induced hypothermia is limited to a few highly selected clinical conditions such as cardiac arrest and hypoxic ischemic neonatal encephalopathy. Efforts to understand the fundamental aspects of brain temperature regulation are therefore critical for the development of safe, effective, and pragmatic clinical treatments for patients with brain injuries. Although centrally-mediated mechanisms to maintain a stable body temperature are relatively well established, very little is clinically known about brain temperature's spatial and temporal distribution, its physiological and pathological fluctuations, and the mechanism underlying brain thermal homeostasis. The human brain, a metabolically "expensive" organ with intense heat production, is sensitive to fluctuations in temperature with regards to its functional activity and energy efficiency. In this review, we discuss several critical aspects concerning the fundamental properties of brain temperature from a clinical perspective.

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Figure 1 Thermal map of the brain. The results of measurements of the temperature difference between arterial blood and 100 brain and subarachnoid sites in 16 monkeys during 347 experiments. Values expressed are Ti–Ta temperature of intracranial site minus the temperature of the aortic arterial blood measured simultaneously, and are all positive values). The major regions which have been studied in the primate brain have been placed on two representative frontal sections, A, frontal 14.5 and B, front 0.3. Values are expressed to the nearest 0.1 C. Reprinted with permission from The American Journal of Physiology, Hayward and Baker (1969).CC BY · PubMed Central

Figure 2 Local brain temperature change during activity and active cooling. Example studies documenting localized phasic temperature changes after an increase in activity or a stimulus presentation (plotted over red background) or to external cooling (plotted over blue background). Brief experiment description, species, and brain area written inside oval and reference displayed on opposite side of abscissa.CC BY · PubMed Central

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Authors: Wang, H., Wang, B., Normoyle, K. P., Jackson, K., Spitler, K., Sharrock, M. F., Miller, C. M., Best, C., Llano, D., & Du, R.
Affiliations: Carle Foundation Hospital (US)
University of Illinois Urbana-Champaign (US)
Brigham and Women's Hospital (US)
Corresponding author: Wang, Huan
ORCID: Wang, Bonnie
Normoyle, Kieran P.
Jackson, Kevin
Spitler, Kevin
Sharrock, Matthew F.
Llano, Daniel
Du, Rose
Venue: Frontiers in Neuroscience
Publisher: Frontiers Media SA
Published: 2014-10-08
Volume: 8
Pages: 307-307
ISSN: 1662-453X (ISSN-L)
DOI: 10.3389/fnins.2014.00307
PMC: PMC4189373
OpenAlex: W2166795165
Cited by: 356
References: 237
Citations by year: 2026: 29 · 2025: 33 · 2024: 38 · 2023: 37 · 2022: 42 · 2021: 40 · 2020: 40 · 2019: 32 · 2018: 25 · 2017: 22 · 2016: 11 · 2015: 7
FWCI: 2.09
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Neuroscience (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: brain temperature, therapeutic hypothermia, neuroprotection, brain temperature regulation, brain injury, cardiac arrest, hypoxic-ischemic encephalopathy, head trauma, stroke, multiple sclerosis, epilepsy, neurodegenerative diseases, brain energy metabolism

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Brain temperature and its fundamental properties: a review for clinical neuroscientists

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