Development and characterization of PEDOT:PSS/alginate soft microelectrodes for application in neuroprosthetics
Open accessAbstract
Reducing the mechanical mismatch between the stiffness of a neural implant and the softness of the neural tissue is still an open challenge in neuroprosthetics. The emergence of conductive hydrogels in the last few years has considerably widened the spectrum of possibilities to tackle this issue. Nevertheless, despite the advancements in this field, further improvements on the fabrication of conductive hydrogel-based electrodes are still required. In this work, we report the fabrication of a conductive hydrogel-based microelectrode array for neural recording using a hybrid material composed of poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) and alginate. The mechanical properties of the conductive hydrogel have been investigated using imaging techniques, while the electrode arrays have been electrochemically characterized at each fabrication step and successfully validated both in-vitro and in-vivo. The presence of the conductive hydrogel, selectively electrodeposited onto the platinum microelectrodes, allowed achieving superior electrochemical characteristics, leading to a lower electrical noise during recordings. These findings represent an advancement in the design of soft conductive electrodes for neuroprosthetic applications.
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Conductive polymers are considerably softer than metals, flexible and conformable, and have a high charge injection capacity.
“Conductive polymers have been widely used in implantable devices for research as they are considerably softer than metals, flexible and conformable, and have a high charge injection capacity [166][167][168][169][170].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [167]
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Cites
Alginate: Properties and biomedical applications
Lee, K. Y., & Mooney, D. J. (2011) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.06.003 · Cited by 8,218 · see citing works
Biomedical applications of hydrogels: A review of patents and commercial products
Caló, E., & Khutoryanskiy, V. V. (2015) · European Polymer Journal · doi:10.1016/j.eurpolymj.2014.11.024 · Cited by 2,634 · see citing works
Conductive polymers: Towards a smart biomaterial for tissue engineering
Balint, R., Cassidy, N. J., & Cartmell, S. H. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.02.015 · Cited by 1,777 · see citing works
Classification, processing and application of hydrogels: A review
Ullah, F., Othman, M. B. H., Javed, F. T., Ahmad, Z., & Akil, H. M. (2015) · Materials Science and Engineering C · doi:10.1016/j.msec.2015.07.053 · Cited by 1,566 · see citing works
Hydrogels in a historical perspective: From simple networks to smart materials
Buwalda, S. J., Boere, K. W. M., Dijkstra, P. J., Feijen, J., Vermonden, T., & Hennink, W. E. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.03.052 · Cited by 994 · see citing works
Structural control of mixed ionic and electronic transport in conducting polymers
Rivnay, J., Inal, S., Collins, B. A., Sessolo, M., Stavrinidou, E., Strakosas, X., Tassone, C. J., DeLongchamp, D. M., & Malliaras, G. G. (2016) · Nature Communications · doi:10.1038/ncomms11287 · Cited by 950 · see citing works
NeuroGrid: recording action potentials from the surface of the brain
Khodagholy, D., Gelinas, J. N., Thesen, T., Doyle, W., Devinsky, O., Malliaras, G. G., & Buzsáki, G. (2015) · Nature Neuroscience · doi:10.1038/nn.3905 · Cited by 938 · see citing works
Materials and technologies for soft implantable neuroprostheses
Lacour, S. P., Courtine, G., & Guck, J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.63 · Cited by 738 · see citing works
Glial responses to implanted electrodes in the brain
Salatino, J. W., Ludwig, K. A., Kozai, T. D. Y., & Purcell, E. K. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0154-1 · Cited by 642 · see citing works
Organic Bioelectronics: Bridging the Signaling Gap between Biology and Technology
Simon, D. T., Gabrielsson, E. O., Tybrandt, K., & Magnus Berggren, A. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00146 · Cited by 573 · see citing works
Abidian, M. R., Corey, J. M., Kipke, D. R., & Martin, D. C. (2010) · Small · doi:10.1002/smll.200901868 · Cited by 405 · see citing works
Conducting polymer-hydrogels for medical electrode applications
Green, R. A., Baek, S., Poole-Warren, L. A., & Martens, P. J. (2010) · Science and Technology of Advanced Materials · doi:10.1088/1468-6996/11/1/014107 · Cited by 268 · see citing works
Kim, D., Wiler, J. A., Anderson, D. J., Kipke, D. R., & Martin, D. C. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.07.034 · Cited by 206 · see citing works
Conductive Hydrogels: Mechanically Robust Hybrids for Use as Biomaterials
Green, R. A., Hassarati, R. T., Goding, J. A., Baek, S., Lovell, N. H., Martens, P. J., & Poole-Warren, L. A. (2012) · Macromolecular Bioscience · doi:10.1002/mabi.201100490 · Cited by 203 · see citing works
Low-cost, μm-thick, tape-free electronic tattoo sensors with minimized motion and sweat artifacts
Wang, Y., Qiu, Y., Ameri, S. K., Jang, H., Dai, Z., Huang, Y., & Lu, N. (2018) · npj Flexible Electronics · doi:10.1038/s41528-017-0019-4 · Cited by 192 · see citing works
Spencer, K. C., Sy, J. C., Ramadi, K. B., Graybiel, A. M., Langer, R., & Cima, M. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-02107-2 · Cited by 184 · see citing works
Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis
Ferlauto, L., Airaghi Leccardi, M. J. I., Chenais, N. A. L., Gilliéron, S. C. A., Vagni, P., Bevilacqua, M., Wolfensberger, T. J., Sivula, K., & Ghezzi, D. (2018) · Nature Communications · doi:10.1038/s41467-018-03386-7 · Cited by 183 · see citing works
Self-citationMechanism of anodic electrodeposition of calcium alginate
Cheng, Y., Luo, X., Betz, J. F., et al. (2011) · Soft Matter · doi:10.1039/c1sm05210a · Cited by 118 · see citing works
Xiang, Z., Yen, S., Sheshadri, S., Wang, J., Lee, S., Liu, Y., Liao, L., Thakor, N. V., & Lee, C. (2016) · Advanced Materials · doi:10.1002/adma.201503423 · Cited by 116 · see citing works
Interpenetrating Conducting Hydrogel Materials for Neural Interfacing Electrodes
Goding, J. A., Gilmour, A. D., Martens, P. J., Poole-Warren, L. A., & Green, R. A. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201601177 · Cited by 113 · see citing works
Conducting polymer coated neural recording electrodes
Harris, A. R., Morgan, S. J., Chen, J., Kapsa, R. M. I., Wallace, G. G., & Paolini, A. G. (2012) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/1/016004 · Cited by 112 · see citing works
Tattoo Conductive Polymer Nanosheets for Skin‐Contact Applications
Zucca, A., Cipriani, C., Sudha, Tarantino, S., Ricci, D., Mattoli, V., & Greco, F. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201400761 · Cited by 97 · see citing works
Light-evoked hyperpolarization and silencing of neurons by conjugated polymers
Feyen, P., Colombo, E., Endeman, D., Nova, M., Laudato, L., Martino, N., Antognazza, M. R., Lanzani, G., Benfenati, F., & Ghezzi, D. (2016) · Scientific Reports · doi:10.1038/srep22718 · Cited by 97 · see citing works
Self-citationKleber, C., Brüns, M., Lienkamp, K., Rühe, J., & Asplund, M. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.05.056 · Cited by 92 · see citing works
Heo, D. N., Song, S.-J., Kim, H., Lee, Y. J., Ko, W., Lee, S. J., Lee, D., Park, S. J., Zhang, L. G., Kang, J. Y., et al. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.05.009 · Cited by 90 · see citing works
Bryant, S. J., & Vernerey, F. J. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700605 · Cited by 83 · see citing works
Interfacing Electronic and Ionic Charge Transport in Bioelectronics
Martin, D. C., & Malliaras, G. G. (2016) · ChemElectroChem · doi:10.1002/celc.201500555 · Cited by 80 · see citing works
Chronic intracortical neural recordings using microelectrode arrays coated with PEDOT–TFB
Charkhkar, H., Knaack, G. L., McHail, D. G., Mandal, H. S., Peixoto, N., Rubinson, J. F., Dumas, T. C., & Pancrazio, J. J. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.12.022 · Cited by 68 · see citing works
Conductive Hydrogel Electrodes for Delivery of Long-Term High Frequency Pulses
Staples, N. A., Goding, J. A., Gilmour, A. D., Aristovich, K. Y., Byrnes-Preston, P., Holder, D. S., Morley, J. W., Lovell, N. H., Chew, D. J., & Green, R. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00748 · Cited by 45 · see citing works
Shedding Light on Living Cells
Antognazza, M. R., Martino, N., Ghezzi, D., Feyen, P., Colombo, E., Endeman, D., Benfenati, F., & Lanzani, G. (2014) · Advanced Materials · doi:10.1002/adma.201403513 · Cited by 42 · see citing works
Self-citationConducting polymer electrodes for auditory brainstem implants
Guex, A., Vachicouras, N., Hight, A. E., Brown, M. C., Lee, D. J., & Lacour, S. P. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb00099h · Cited by 41 · see citing works
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Gulino, M., Kim, D., Pané, S., Santos, S. D., & Pêgo, A. P. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00689 · Cited by 159 · see citing works
Advances in visual prostheses: engineering and biological challenges
Borda, E., & Ghezzi, D. (2022) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ac812c · Cited by 44 · see citing works
Self-citationChenais, N. A. L., Leccardi, M. J. I. A., & Ghezzi, D. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab3913 · Cited by 24 · see citing works
Organic electronics for neuroprosthetics
Airaghi Leccardi, M. J. I., & Ghezzi, D. (2020) · Healthcare Technology Letters · doi:10.1049/htl.2019.0108 · Cited by 12 · see citing works
- Authors
- Ferlauto, L., D’Angelo, A. N., Vagni, P., Airaghi Leccardi, M. J. I., Mor, F. M., Cuttaz, E. A., Heuschkel, M. O., Stoppini, L., & Ghezzi, D.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- HES-SO University of Applied Sciences and Arts Western Switzerland (CH)
- Corresponding author
- Ghezzi, Diego
- ORCID
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2018-09-19
- Volume
- 12
- Pages
- 648-648
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC6156361
- OpenAlex
- W2891215663
- Cited by
- 74
- References
- 31
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 7 · 2023: 15 · 2022: 14 · 2021: 12 · 2020: 7 · 2019: 7 · 2018: 1
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- ArODES (HES-SO (https://www.hes-so.ch/)) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- H2020 Marie Skłodowska-Curie Actions (701632)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Keywords
- PEDOT:PSS, alginate, conductive hydrogels, neural recording, neuroprosthetics, neural implants, mechanical mismatch, electrodeposition, platinum microelectrodes, electronic noise, in vivo validation
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