Cited by 143Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityEating Disorders and Behaviors

The DOI matches its Crossref record; 302 of the 305 references it cites were found in a registry or an index.

Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources

Open access

Beeler, Jeff A., Frazier, Cristianne R. M., Zhuang, Xiaoxi·2012·Frontiers in Integrative Neuroscience

DOI 10.3389/fnint.2012.00049PMC PMC3400936

Open this paper in CoChat — free account Open PDF

Abstract

Accumulating evidence indicates integration of dopamine function with metabolic signals, highlighting a potential role for dopamine in energy balance, frequently construed as modulating reward in response to homeostatic state. Though its precise role remains controversial, the reward perspective of dopamine has dominated investigation of motivational disorders, including obesity. In the hypothesis outlined here, we suggest instead that the primary role of dopamine in behavior is to modulate activity to adapt behavioral energy expenditure to the prevailing environmental energy conditions, with the role of dopamine in reward and motivated behaviors derived from its primary role in energy balance. Dopamine has long been known to modulate activity, exemplified by psychostimulants that act via dopamine. More recently, there has been nascent investigation into the role of dopamine in modulating voluntary activity, with some investigators suggesting that dopamine may serve as a final common pathway that couples energy sensing to regulated voluntary energy expenditure. We suggest that interposed between input from both the internal and external world, dopamine modulates behavioral energy expenditure along two axes: a conserve-expend axis that regulates generalized activity and an explore-exploit axes that regulates the degree to which reward value biases the distribution of activity. In this view, increased dopamine does not promote consumption of tasty food. Instead increased dopamine promotes energy expenditure and exploration while decreased dopamine favors energy conservation and exploitation. This hypothesis provides a mechanistic interpretation to an apparent paradox: the well-established role of dopamine in food seeking and the findings that low dopaminergic functions are associated with obesity. Our hypothesis provides an alternative perspective on the role of dopamine in obesity and reinterprets the "reward deficiency hypothesis" as a perceived energy deficit. We propose that dopamine, by facilitating energy expenditure, should be protective against obesity. We suggest the apparent failure of this protective mechanism in Western societies with high prevalence of obesity arises as a consequence of sedentary lifestyles that thwart energy expenditure.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fnint.2012.00049

Cites

302 of 305 references verified3 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Items 201–305 of 305

Dopamine Scales Performance in the Absence of New Learning
Cagniard, B., Beeler, J. A., Britt, J. P., McGehee, D. S., Marinelli, M., & Zhuang, X. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.026 · Cited by 129
Self-citation
Reward circuitry dopaminergic activation regulates food and drug craving behavior
Blum, K., Liu, Y., Shriner, R., & S. Gold, M. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211795656819 · Cited by 128
Cocaine Cues Drive Opposing Context-Dependent Shifts in Reward Processing and Emotional State
Wheeler, R. A., Aragona, B. J., Fuhrmann, K. A., Jones, J. L., Day, J. J., Cacciapaglia, F., Wightman, R. M., & Carelli, R. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.014 · Cited by 127
Ventral Tegmental Area Leptin Receptor Neurons Specifically Project to and Regulate Cocaine- and Amphetamine-Regulated Transcript Neurons of the Extended Central Amygdala
Leshan, R. L., Opland, D. M., Louis, G. W., Leinninger, G. M., Patterson, C. M., Rhodes, C. J., Münzberg, H., & Myers, M. G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1001-10.2010 · Cited by 127
Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors
Moran, T. H., & Bi, S. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1857 · Cited by 126
Public transit, obesity, and medical costs: Assessing the magnitudes
Edwards, R. D. (2008) · Preventive Medicine · doi:10.1016/j.ypmed.2007.10.004 · Cited by 125
Eating for pleasure or calories
Zheng, H., & Berthoud, H. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.10.011 · Cited by 121
Energy regulatory signals and food reward
Figlewicz, D. P., & Sipols, A. J. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.03.002 · Cited by 116
The functional anatomy of disorders of the basal ganglia
Albin, R. L. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93872-u · Cited by 116
Insulin acts at different CNS sites to decrease acute sucrose intake and sucrose self-administration in rats
Figlewicz, D. P., Bennett, J. L., Aliakbari, S., Zavosh, A., & Sipols, A. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90334.2008 · Cited by 115
Exercise: it's the real thing!
Hawley, J. A., & Holloszy, J. O. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00185.x · Cited by 112
Modulation of the mesolimbic dopamine system by leptin
Opland, D. M., Leinninger, G. M., & Myers (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.028 · Cited by 111
Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury
Horikawa, Y. T., Patel, H. H., Tsutsumi, Y. M., et al. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.10.003 · Cited by 109
The neurobiology of appetite: hunger as addiction.
Dagher, A. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.69 · Cited by 108
Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacity
Novak, C. M., Escande, C., Burghardt, P. R., Zhang, M., Barbosa, M. T., Chini, E. N., Britton, S. L., Koch, L. G., Akil, H., & Levine, J. A. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.013 · Cited by 106
Is dopamine required for natural reward?
Cannon, C. M., & BSEIKRI, M. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.04.020 · Cited by 106
Influence of Methylphenidate on Eating in Obese Men
Leddy, J. J., Epstein, L. H., Jaroni, J. L., Roemmich, J. N., Paluch, R. A., Goldfield, G. S., & Lerman, C. E. (2004) · Obesity Research · doi:10.1038/oby.2004.29 · Cited by 105
Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonism
Salamone, J. D., Farrar, A. M., Font, L., Patel, V. B., Schlar, D. E., Nunes, E. J., Collins, L. E., & Sager, T. N. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.02.021 · Cited by 105
Differential expression of dopamine D2 and D4 receptor and tyrosine hydroxylase mRNA in mice prone, or resistant, to chronic high-fat diet-induced obesity
Huang, X., Yu, Y., Zavitsanou, K., Han, M., & Storlien, L. H. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.12.013 · Cited by 105
Nucleus accumbens neurons encode predicted and ongoing reward costs in rats
Day, J. J., Jones, J. L., & Carelli, R. M. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07531.x · Cited by 104
Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling
Patterson, C. M., Bouret, S. G., Dunn-Meynell, A. A., & Levin, B. E. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90859.2008 · Cited by 101
Role of Amygdalo-Nigral Circuitry in Conditioning of a Visual Stimulus Paired with Food
Lee, H. J., Groshek, F., Petrovich, G. D., Cantalini, J. P., Gallagher, M., & Holland, P. C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0416-05.2005 · Cited by 101
Dopaminergic dysregulation in mice selectively bred for excessive exercise or obesity
Mathes, W. F., Nehrenberg, D. L., Gordon, R. R., Hua, K., Garland, T., & Pomp, D. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.02.016 · Cited by 98
The Effects of Exercise on Food Intake and Body Fatness: A Summary of Published Studies
Elder, S. J., & Roberts, S. B. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00263.x · Cited by 95
Extracellular dopamine levels in striatal subregions track shifts in motivation and response cost during instrumental conditioning
Ostlund, S. B., Wassum, K. M., Murphy, N. P., Balleine, B. W., & Maidment, N. T. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4759-10.2011 · Cited by 94
Adenylyl Cyclase Type 5 Contributes to Corticostriatal Plasticity and Striatum-Dependent Learning
Kheirbek, M. A., Britt, J. P., Beeler, J. A., Ishikawa, Y., McGehee, D. S., & Zhuang, X. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3343-09.2009 · Cited by 93
Self-citation
Acute changes in the response to peripheral leptin with alteration in the diet composition
Lin, L., Martin, R. J., Schaffhauser, A. O., & York, D. A. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.2.r504 · Cited by 93
Sucrose‐predictive cues evoke greater phasic dopamine release than saccharin‐predictive cues
McCutcheon, J. E., Beeler, J. A., & Roitman, M. F. (2011) · Synapse · doi:10.1002/syn.21519 · Cited by 92
Self-citation
Three weeks of early-onset exercise prolongs obesity resistance in DIO rats after exercise cessation
Patterson, C. M., Dunn-Meynell, A. A., & Levin, B. E. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00661.2007 · Cited by 92
The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signaling
Morton, G. J., Blevins, J. E., Kim, F., Matsen, M. E., & Figlewicz, D. P. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90865.2008 · Cited by 92
Voluntary Exercise Improves High-Fat Diet-Induced Leptin Resistance Independent of Adiposity
Carhuatanta, K. A. K., Demuro, G., Tschöp, M. H., Pfluger, P. T., Benoit, S. C., & Obici, S. (2011) · Endocrinology · doi:10.1210/en.2010-1340 · Cited by 89
Metabolic Adaptations of Three Inbred Strains of Mice (C57BL/6, DBA/2, and 129T2) in Response to a High-Fat Diet
Funkat, A., Massa, C. M., Jovanovska, V., Proietto, J., & Andrikopoulos, S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.12.3264 · Cited by 88
Voluntary Wheel Running Decreases Adipose Tissue Mass and Expression of Leptin mRNA in Osborne-Mendel Rats
Zachwieja, J. J., Hendry, S. L., Smith, S. R., & Harris, R. B. S. (1997) · Diabetes · doi:10.2337/diab.46.7.1159 · Cited by 86
High-fat diet decreases tyrosine hydroxylase mRNA expression irrespective of obesity susceptibility in mice
Li, Y., South, T., Han, M., Chen, J., Wang, R., & Huang, X. (2009) · Brain Research · doi:10.1016/j.brainres.2009.02.075 · Cited by 83
Lifetime Leisure Exercise and Osteoporosis
Lane, M. J. (1995) · Clinical Journal of Sport Medicine · doi:10.1097/00042752-199510000-00014 · Cited by 83
The hyperactive syndrome: Metanalysis of genetic alterations, pharmacological treatments and brain lesions which increase locomotor activity
Viggiano, D. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.06.033 · Cited by 82
Contrasting Effects of Leptin on Food Anticipatory and Total Locomotor Activity
Ribeiro, A. C. D. M., Ceccarini, G., Dupré, C., Friedman, J. M., Pfaff, D. W., & Mark, A. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023364 · Cited by 81
Exercise for prevention and treatment of cardiovascular disease, type 2 diabetes, and metabolic syndrome
Gaesser, G. A. (2007) · Current Diabetes Reports · doi:10.1007/s11892-007-0004-8 · Cited by 81
Neural mechanisms underlying obesity and drug addiction
Trinko, R., Sears, R. M., Guarnieri, D. J., & Dileone, R. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.01.001 · Cited by 79
Temporal-Difference Reinforcement Learning with Distributed Representations
Kurth-Nelson, Z. L., & Redish, A. D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007362 · Cited by 79
Food motivated behavior in genetically obese and hypothalamic-hyperphagic rats and mice
Greenwood, M. R. C., Quartermain, D., Johnson, P. R., Cruce, J. A. F., & Hirsch, J. (1974) · Physiology & Behavior · doi:10.1016/0031-9384(74)90241-8 · Cited by 77
Dopamine D1 receptor modulation in nucleus accumbens lowers voluntary wheel running in rats bred to run high distances
Roberts, M. D., Gilpin, L., Parker, K. E., Childs, T. E., Will, M. J., & Booth, F. W. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.09.024 · Cited by 77
Dissociable effects of disconnecting amygdala central nucleus from the ventral tegmental area or substantia nigra on learned orienting and incentive motivation
El‐Amamy, H., & Holland, P. C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05402.x · Cited by 75
GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior
Young, J. W., Goey, A. K. L., Minassian, A., Perry, W., Paulus, M. P., & Geyer, M. A. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1744-8 · Cited by 75
Taste uncoupled from nutrition fails to sustain the reinforcing properties of food
Beeler, J. A., McCutcheon, J. E., Cao, Z. F. H., Murakami, M., Alexander, E. R., Roitman, M. F., & Zhuang, X. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08167.x · Cited by 73
Self-citation
Functions of mesolimbic dopamine: changing concepts and shifting paradigms
Salamone, J. D. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0623-9 · Cited by 73
The role of motor activity in diet-induced obesity in C57BL/6J mice
Brownlow, B. S., Petro, A. E., Feinglos, M. N., & Surwit, R. S. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02210-4 · Cited by 72
Unilateral 6-hydroxydopamine lesions of nigrostriatal or mesolimbic dopamine-containing terminals and the drug-induced rotation of rats
Kelly, P. H. (1975) · Brain Research · doi:10.1016/0006-8993(75)90253-x · Cited by 72
Treadmill running induces striatal Fos expression via NMDA glutamate and dopamine receptors
Liste, I., Guerra, M. J., Caruncho, H. J., & Labandeira-García, J. L. (1997) · Experimental Brain Research · doi:10.1007/pl00005715 · Cited by 72
Hyperphagia and obesity of OLETF rats lacking CCK1 receptors: Developmental aspects
Moran, T. H., & Bi, S. (2006) · Developmental Psychobiology · doi:10.1002/dev.20149 · Cited by 68
Western diet increases wheel running in mice selectively bred for high voluntary wheel running
Meek, T. H., Eisenmann, J. C., & Garland, T. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.25 · Cited by 66
Genetic architecture of voluntary exercise in an advanced intercross line of mice
Kelly, S. A., Nehrenberg, D. L., Peirce, J. L., Hua, K., Steffy, B. M., Wiltshire, T., de Villena, F. P., Garland, T., & Pomp, D. (2010) · Physiological Genomics · doi:10.1152/physiolgenomics.00028.2010 · Cited by 63
Food scarcity, neuroadaptations, and the pathogenic potential of dieting in an unnatural ecology: Binge eating and drug abuse
Carr, K. D. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.023 · Cited by 59
Low amplitude entrainment of mice and the impact of circadian phase on behavior tests
Beeler, J. A., Prendergast, B. J., & Zhuang, X. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.01.037 · Cited by 59
Self-citation
Developmental gene×environment interactions affecting systems regulating energy homeostasis and obesity
Levin, B. E. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.02.005 · Cited by 59
Decreased Vesicular Somatodendritic Dopamine Stores in Leptin-Deficient Mice
Roseberry, A. G., Painter, T., Mark, G. P., & Williams, J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1235-07.2007 · Cited by 58
Effect of exercise and calorie restriction on biomarkers of aging in mice
Huffman, D. M., Moellering, D. R., Grizzle, W. E., Stockard, C. R., Johnson, M. S., & Nagy, T. R. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00890.2007 · Cited by 58
Waging war on modern chronic diseases: primary prevention through exercise biology
Booth, F. W., Gordon, S. E., Carlson, C. J., & Hamilton, M. T. (2000) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1034/j.1600-0838.2000.010005308.x · Cited by 58
Extracellular dopamine in the nucleus accumbens of the rat during treadmill running
Wilson, W. M., & Marsden, C. A. (1995) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1995.tb09997.x · Cited by 56
Suppression of exploratory locomotor activity and increase in dopamine turnover following the local application of cis-flupenthixol into limbic projection areas of the rat striatum
Ahlénius, S., Hillegaart, V., Thorell, G., Magnusson, O., & Fowler, C. J. (1987) · Brain Research · doi:10.1016/0006-8993(87)91055-9 · Cited by 54
Quantitative descriptions of generalized arousal, an elementary function of the vertebrate brain
Quinkert, A. W., Vimal, V., Weil, Z. M., Reeke, G. N., Schiff, N. D., Banavar, J. R., & Pfaff, D. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101894108 · Cited by 52
Physical activity and stroke risk
Alevizos, A., Lentzas, J., Kokkoris, S., Mariolis, A. D., & Korantzopoulos, P. G. (2005) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2005.00536.x · Cited by 52
Morphine-induced motor stimulation, motor incoordination, and hypothermia in adolescent and adult mice
Koek, W., France, C. P., & Javors, M. A. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2432-z · Cited by 51
Homologies and Differences in the Action of Drugs of Abuse and a Conventional Reinforcer (Food) on Dopamine Transmission: An Interpretative Framework of the Mechanism of Drug Dependence
Chiara, G. D., Tanda, G., Cadoni, C., Acquas, E., Bassareo, V., & Caronboni, E. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60911-4 · Cited by 50
Neurological and stress related effects of shifting obese rats from a palatable diet to chow and lean rats from chow to a palatable diet
South, T., Westbrook, R. F., & Morris, M. J. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.11.019 · Cited by 50
An Epistatic Genetic Basis for Physical Activity Traits in Mice
Leamy, L. J., Pomp, D., & Lightfoot, J. T. (2008) · Journal of Heredity · doi:10.1093/jhered/esn045 · Cited by 50
Hypoinsulinemia may mediate the lowering of self-stimulation thresholds by food restriction and streptozotocin-induced diabetes
Carr, K. D., Kim, G.-Y., & de Vaca, S. C. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02143-0 · Cited by 49
Catecholamine Reuptake Inhibition Causes Weight Loss by Increasing Locomotor Activity and Thermogenesis
Billes, S. K., & Cowley, M. A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301526 · Cited by 48
The effects of feeding conditions on drug-reinforced behavior: Maintenance at reduced body weight versus availability of food
Carroll, M. E., & Meisch, R. A. (1980) · Psychopharmacology · doi:10.1007/bf00432128 · Cited by 47
Metabolic Sensing in Brain Dopamine Systems
de Araújo, I. E., Ren, X., & Ferreira, J. G. P. (2010) · Results and problems in cell differentiation · doi:10.1007/978-3-642-14426-4_7 · Cited by 47
In vivo dialysis measurements of dopamine and DOPAC in rats trained to turn on a circular treadmill
Sabol, K. E., Richards, J. B., & Freed, C. R. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90119-3 · Cited by 46
Loss of Cocaine Locomotor Response in Pitx3-Deficient Mice Lacking a Nigrostriatal Pathway
Beeler, J. A., Cao, Z. F. H., Kheirbek, M. A., & Zhuang, X. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.117 · Cited by 45
Self-citation
Minireview: Exercise and Longevity: Studies on Rats
Holloszy, J. O. (1988) · Journal of Gerontology · doi:10.1093/geronj/43.6.b149 · Cited by 44
Waging war on modern chronic diseases: primary prevention through exercise biology
Booth, F. W., Gordon, S., Carlson, C. J., & Hamilton, M. T. (2000) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2000.100509.x · Cited by 43
Insulin and raclopride combine to decrease short-term intake of sucrose solutions
Sipols, A. J., Stuber, G. D., Klein, S. N., Higgins, M. S., & Figlewicz, D. P. (2000) · Peptides · doi:10.1016/s0196-9781(00)00279-5 · Cited by 38
TESTS OF BEHAVIORAL‐ECONOMIC ASSESSMENTS OF RELATIVE REINFORCER EFFICACY: ECONOMIC SUBSTITUTES
Madden, G. J., Smethells, J. R., Ewan, E. E., & Hursh, S. R. (2007) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.2007.80-06 · Cited by 38
On the neuronal circuitries and neurotransmitters involved in the control of locomotor activity.
Carlsson, A. (1993) · PubMed · Cited by 36
Effects of blocking the dopamine biosynthesis and of neurotoxic dopamine depletion with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on voluntary wheel running in mice
Leng, A., Mura, A., Hengerer, B., Feldon, J., & Ferger, B. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.03.004 · Cited by 35
The emergence of saliency and novelty responses from Reinforcement Learning principles
Laurent, P. A. (2008) · Neural Networks · doi:10.1016/j.neunet.2008.09.004 · Cited by 35
Commentary: WILL THE LAST PERSON WHO USES THE TERM ‘REWARD’ PLEASE TURN OUT THE LIGHTS? COMMENTS ON PROCESSES RELATED TO REINFORCEMENT, LEARNING, MOTIVATION AND EFFORT
Salamone, J. D. (2006) · Addiction Biology · doi:10.1111/j.1369-1600.2006.00011.x · Cited by 35
A cAMP Pathway Underlying Reward Prediction in Associative Learning
Kheirbek, M. A., Beeler, J. A., Ishikawa, Y., & Zhuang, X. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4115-08.2008 · Cited by 33
Self-citation
Dopamine, effort, and decision making: Theoretical comment on Bardgett et al. (2009).
Salamone, J. D. (2009) · Behavioral Neuroscience · doi:10.1037/a0015381 · Cited by 31
Gene–Physical Activity Interactions in the Etiology of Obesity: Behavioral Considerations
Dishman, R. K. (2008) · Obesity · doi:10.1038/oby.2008.520 · Cited by 30
Voluntary wheel running decreases adipose tissue mass and expression of leptin mRNA in Osborne-Mendel rats
Zachwieja, J. J., Hendry, S. L., Smith, S. R., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.7.1159 · Cited by 30
Importance of D1 and D2 receptors in the dorsal caudate-putamen for the locomotor activity and stereotyped behaviors of preweanling rats
Charntikov, S., Der-Ghazarian, T. S., Herbert, M. S., Horn, L. R., Widarma, C. B., Gutierrez, A., Varela, F. A., & McDougall, S. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.037 · Cited by 29
TESTS OF BEHAVIORAL‐ECONOMIC ASSESSMENTS OF RELATIVE REINFORCER EFFICACY II: ECONOMIC COMPLEMENTS
Madden, G. J., Smethells, J. R., Ewan, E. E., & Hursh, S. R. (2007) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.2007.88-355 · Cited by 29
Preservation of function in Parkinson's disease: What's learning got to do with it?
Beeler, J. A. (2011) · Brain Research · doi:10.1016/j.brainres.2011.09.040 · Cited by 29
Self-citation
Altered basal and stimulated accumbens dopamine release in obese OLETF rats as a function of age and diabetic status
Anderzhanova, E. A., Covașă, M., & Hajnal, A. S. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00301.2007 · Cited by 29
Demand for sucrose in the genetically obese Zucker (fa/fa) rat
Rasmussen, E. B., Reilly, W., & Hillman, C. N. (2010) · Behavioural Processes · doi:10.1016/j.beproc.2010.07.008 · Cited by 26
Presynaptic stimulation and development of locomotor sensitization to the dopamine agonist quinpirole
Lomanowska, A. M., Gormley, S., & Szechtman, H. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.12.018 · Cited by 26
Dopaminergic enhancement of local food‐seeking is under global homeostatic control
Beeler, J. A., Frazier, C. R. M., & Zhuang, X. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07916.x · Cited by 25
Self-citation
Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet- induced obesity
Hesse, D., Dunn, M. T., Heldmaier, G., Klingenspor, M., & Rozman, J. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.12.001 · Cited by 24
Behavioral Modulation of Gustatory Cortical Activity
Fontanini, A., & Katz, D. B. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.03922.x · Cited by 20
Developing brain as an endocrine organ: Secretion of dopamine
Ugrumov, M. V., Saifetyarova, J. Y., Lavrentieva, A. V., & Sapronova, A. Y. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.07.038 · Cited by 19
Treadmill running combined with microdialysis can evaluate motor deficit and improvement following dopaminergic grafts in 6-OHDA lesioned rats
Hattori, S., Li, Q., Matsui, N., & Nishino, H. (1993) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-1993-6107 · Cited by 18
A single administration of methamphetamine to mice early in the light period decreases running wheel activity observed during the dark period
Kitanaka, N., Kitanaka, J., Hall, F. S., Uhl, G. R., Watabe, K., Kubo, H., Takahashi, H., Tatsuta, T., Morita, Y., & Takemura, M. (2011) · Brain Research · doi:10.1016/j.brainres.2011.10.037 · Cited by 15
High‐resolution mapping of a novel genetic locus regulating voluntary physical activity in mice
Yang, H. S., Shimomura, K., Vitaterna, M. H., & Turek, F. W. (2011) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2011.00737.x · Cited by 15
Hyperactivity and impaired response habituation in hyperdopaminergic mice
Zhuang, X., Oosting, R. S., Jones, S. R., Gainetdinov, R. R., Miller, G. W., Caron, M. G., & Hen, R. (2001) · Routledge eBooks · doi:10.4324/9781315054315-17 · Cited by 15
Self-citation
Food demand functions in mice
Chaney, M. A., & Rowland, N. E. (2008) · Appetite · doi:10.1016/j.appet.2008.06.002 · Cited by 14
Basal ganglia disorders
Melnick, M. E. (2013) · Elsevier eBooks · doi:10.1016/b978-0-323-07586-2.00029-7 · Cited by 13
The Effects of Exercise on Food Intake and Body Fatness: A Summary of Published Studies
Elder, S. J., & Roberts, S. B. (2007) · Nutrition Reviews · doi:10.1301/nr.2007.jan.1-19 · Cited by 10
A role for accumbens neurons in exertion of effort and evaluating effort-related costs of instrumental actions (Commentary on Day et al.)
Salamone, J. D. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07566.x · Cited by 4
An Epistatic Genetic Basis for Physical Activity Traits in Mice
Pomp, D., Leamy, L. J., & Lightfoot, J. T. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/pvj4-gs09 · Cited by 4
Metabolic sensing in brain dopamine systems
de Araújo, I. E. (2011) · Appetite · doi:10.1016/j.appet.2011.05.153 · Cited by 3
Western diet increases wheel running in mice selectively bred for high voluntary wheel running
Garland, T., Meek, T. H., & Eisenmann, J. C. (2010) · The FASEB Journal · doi:10.1096/fasebj.24.1_supplement.805.2 · Cited by 1

Flagged first, then by citations

Sorted by citations

The mysterious motivational functions of mesolimbic dopamine
Salamone, J. D., & Correa, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.021 · Cited by 1,418
What does dopamine mean?
Berke, J. D. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0152-y · Cited by 904
Mesolimbic dopamine signals the value of work
Hamid, A., Pettibone, J. R., Mabrouk, O. S., Hetrick, V. L., Schmidt, R., Weele, C. M. V., Kennedy, R. T., Aragona, B. J., & Berke, J. D. (2015) · Nature Neuroscience · doi:10.1038/nn.4173 · Cited by 848
Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease
Petzinger, G. M., Fisher, B. E., McEwen, S., Beeler, J. A., Walsh, J. P., & Jakowec, M. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70123-6 · Cited by 798
Self-citation
Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology
Salamone, J. D., Yohn, S. E., López-Cruz, L., San Miguel, N., & Correa, M. (2016) · Brain · doi:10.1093/brain/aww050 · Cited by 350

See all 143

Authors: Beeler, J. A., Frazier, C. R. M., & Zhuang, X.
Affiliations: University of Chicago (US)
Corresponding author: Beeler, Jeff A.
ORCID: Beeler, Jeff A.
Zhuang, Xiaoxi
Venue: Frontiers in Integrative Neuroscience
Publisher: Frontiers Media SA
Published: 2012
Volume: 6
Pages: 49-49
ISSN: 1662-5145 (ISSN-L)
DOI: 10.3389/fnint.2012.00049
PMC: PMC3400936
OpenAlex: W2149878007
Cited by: 136
References: 301
Citations by year: 2026: 7 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 33 · 2021: 10 · 2020: 11 · 2019: 9 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 4 · 2013: 7 · 2012: 5
FWCI: 3.43
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Integrative Neuroscience (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute on Drug Abuse (F31DA026802, R01DA25875, R01DA025875)
National Institute of General Medical Sciences (R01GM100768)
National Institute of Diabetes and Digestive and Kidney Diseases (R56DK088515)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords: dopamine, energy expenditure, energy balance, reward, obesity, energy conservation, food seeking, sedentary lifestyle, metabolic signals, homeostasis, psychostimulants

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks