Induction of miR-155 after Brain Injury Promotes Type 1 Interferon and has a Neuroprotective Effect
Open accessAbstract
Traumatic brain injury produces profound and lasting neuroinflammation that has both beneficial and detrimental effects. Recent evidence has implicated microRNAs (miRNAs) in the regulation of inflammation both in the periphery and the CNS. We examined the expression of inflammation associated miRNAs in the context of traumatic brain injury using a mouse controlled cortical impact (CCI) model and found increased levels of miR-21, miR-223, and miR-155 in the hippocampus after CCI. The expression of miR-155 was elevated 9-fold after CCI, an increase confirmed by in situ hybridization. Interestingly, expression of miR-155 was largely found in neuronal nuclei as evidenced by co-localization with DAPI in MAP2 positive neurons. In miR-155 knock out mice expression of type I interferons IFNα and IFNβ, as well as interferon regulatory factor 1 and interferon-induced chemokine CXCL10 was decreased after TBI relative to WT mice. Unexpectedly, miR-155 KO mice had increased levels of microglial marker Iba1 and increased neuronal degeneration as measured by fluorojade C staining, suggesting a neuroprotective role for miR-155 in the context of TBI. This work demonstrates a role for miR-155 in regulation of the IFN response and neurodegeneration in the aftermath of TBI. While the presence of neuronal nuclear miRNAs has been described previously, their importance in disease states is relatively unknown. Here, we show evidence of dynamic regulation and pathological function of a nuclear miRNA in TBI.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Since many disorders share the same proteins or micro RNAs as markers, it is impossible to have selective detection of diseases.
“Also, since many disorders share the same proteins or micro RNAs as markers, it is impossible to have selective detection of diseases [313–317].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [316]
The Discussion (page not available) describes miR-155 as having roles in several neurological disease models, supporting the narrower point that one microRNA is associated with multiple disorders. It does not establish that these microRNAs or proteins are shared diagnostic markers, or that selective disease detection is impossible. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
NIH Image to ImageJ: 25 years of image analysis
Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638 · see citing works
Non-coding RNAs in human disease
Esteller, M. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3074 · Cited by 4,825 · see citing works
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
MicroRNA-155 is induced during the macrophage inflammatory response
O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G., & Baltimore, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610731104 · Cited by 1,866 · see citing works
Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.
Valencia-Sanchez, M. A., Liu, J., Hannon, G. J., & Parker, R. (2006) · Genes & Development · doi:10.1101/gad.1399806 · Cited by 1,751 · see citing works
Honda, K., & Taniguchi, T. (2006) · Nature reviews. Immunology · doi:10.1038/nri1900 · Cited by 1,676 · see citing works
Inflammation and white matter degeneration persist for years after a single traumatic brain injury
Johnson, V. E., Stewart, J. E., Begbie, F. D., Trojanowski, J. Q., Smith, D. H., & Stewart, W. (2013) · Brain · doi:10.1093/brain/aws322 · Cited by 1,045 · see citing works
microRNA Regulation of Inflammatory Responses
O’Connell, R. M., Rao, D. S., & Baltimore, D. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075013 · Cited by 957 · see citing works
Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis
Stańczyk, J., Pedrioli, D. M. L., Brentano, F., Sánchez‐Pernaute, O., Kolling, C., Gay, R. E., Detmar, M. J., Gay, S., & Kyburz, D. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23386 · Cited by 905 · see citing works
Inositol phosphatase SHIP1 is a primary target of miR-155
O'Connell, R. M., Chaudhuri, A. A., Rao, D. S., & Baltimore, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902636106 · Cited by 826 · see citing works
Kosik, K. S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2037 · Cited by 823 · see citing works
Ceppi, M., Pereira, P. M., Dunand-Sauthier, I., Barras, E., Reith, W., Santos, M. A. S., & Pierre, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811073106 · Cited by 713 · see citing works
SOCS-1 Participates in Negative Regulation of LPS Responses
Nakagawa, R., Naka, T., Tsutsui, H., Fujimoto, M., Kimura, A., Abe, T., Seki, E., Sato, S., Takeuchi, O., Takeda, K., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00449-1 · Cited by 638 · see citing works
Löffler, D., Brocke-Heidrich, K., Pfeifer, G., Stocsits, C., Hackermüller, J., Kretzschmar, A. K., Burger, R., Gramatzki, M., Blumert, C., Bauer, K., et al. (2007) · Blood · doi:10.1182/blood-2007-03-081133 · Cited by 637 · see citing works
Zaloshnja, E., Miller, T. R., Langlois, J. A., & Selassie, A. W. (2008) · Journal of Head Trauma Rehabilitation · doi:10.1097/01.htr.0000341435.52004.ac · Cited by 609 · see citing works
Fitch, M. T., Doller, C. M., Combs, C. K., Landreth, G. E., & Silver, J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08182.1999 · Cited by 600 · see citing works
SMITH, D. H., SOARES, H. D., PIERCE, J. S., PERLMAN, K. G., SAATMAN, K. E., MEANEY, D. F., DIXON, C. E., & McINTOSH, T. K. (1995) · Journal of Neurotrauma · doi:10.1089/neu.1995.12.169 · Cited by 451 · see citing works
MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases
Dai, R., & Ahmed, S. A. (2011) · Translational research · doi:10.1016/j.trsl.2011.01.007 · Cited by 443 · see citing works
Wang, P., Hou, J., Lin, L., Wang, C., Liu, X., Li, D., Ma, F., Wang, Z., & Cao, X. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000491 · Cited by 431 · see citing works
Trends in Traumatic Brain Injury in the U.S. and the public health response: 1995–2009
Coronado, V. G., McGuire, L., Sarmiento, K., Bell, J. M., Lionbarger, M. R., Jones, C. D., Geller, A. I., Khoury, N. M., & Xu, L. (2012) · Journal of Safety Research · doi:10.1016/j.jsr.2012.08.011 · Cited by 420 · see citing works
Butovsky, O., Jedrychowski, M. P., Cialic, R., Krasemann, S., Murugaiyan, G., Fanek, Z., Greco, D. J., Wu, P. M., Doykan, C. E., Kiner, O., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24304 · Cited by 358 · see citing works
Cardoso, A. L., Guedes, J. R., Pereira de Almeida, L., & Pedroso de Lima, M. C. (2012) · Immunology · doi:10.1111/j.1365-2567.2011.03514.x · Cited by 336 · see citing works
The role of miRNA in inflammation and autoimmunity
Singh, R. P., Massachi, I., Manickavel, S., Singh, S., Rao, N. P., Hasan, S., Curdy, D. K. M., Sharma, S. P., Wong, D. T., Hahn, B. H., et al. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.07.003 · Cited by 334 · see citing works
Transcriptome-wide miR-155 Binding Map Reveals Widespread Noncanonical MicroRNA Targeting
Loeb, G. B., Khan, A. A., Canner, D., Hiatt, J. B., Shendure, J., Darnell, R. B., Leslie, C. S., & Rudensky, A. Y. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.10.002 · Cited by 311 · see citing works
Mattson, M. P., & Scheff, S. W. (1994) · Journal of Neurotrauma · doi:10.1089/neu.1994.11.3 · Cited by 308 · see citing works
The Mechanism of Action of Interferon-β in Relapsing Multiple Sclerosis
Kieseier, B. C. (2011) · CNS Drugs · doi:10.2165/11591110-000000000-00000 · Cited by 308 · see citing works
Neurons produce type I interferon during viral encephalitis
Delhaye, S., Paul, S., Blakqori, G., Minet, M., Weber, F., Staeheli, P., & Michiels, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602460103 · Cited by 266 · see citing works
MicroRNA-223 is neuroprotective by targeting glutamate receptors
Harraz, M. M., Eacker, S. M., Wang, X., Dawson, T. M., & Dawson, V. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121288109 · Cited by 258 · see citing works
Zhou, H., Huang, X., Cui, H., Luo, X., Tang, Y., Chen, S., Wu, L., & Shen, N. (2010) · Blood · doi:10.1182/blood-2010-04-280156 · Cited by 249 · see citing works
microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease
Thome, A. D., Harms, A. S., Volpicelli‐Daley, L. A., & Standaert, D. G. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3900-15.2016 · Cited by 249 · see citing works
MicroRNA‐21 protects neurons from ischemic death
Buller, B., Liu, X., Wang, X., Zhang, R. L., Zhang, L., Hozeska‐Solgot, A., Chopp, M., & Zhang, Z. G. (2010) · The FEBS Journal · doi:10.1111/j.1742-4658.2010.07818.x · Cited by 242 · cited 1× · see citing works
“Increasing evidence points to important functions for inflammation-associated miRNAs in neurological disease (Buller et al., 2010; Yelamanchili et al., 2010; Harraz et al., 2012; Zhang L. et al., 2012; Ge et al., 2014).”
Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice
Koval, E. D., Shaner, C., Zhang, P., du Maine, X., Fischer, K., Tay, J., Chau, B. N., Wu, G. F., & Miller, T. M. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt261 · Cited by 236 · see citing works
Redell, J. B., Liu, Y., & Dash, P. K. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21945 · Cited by 214 · see citing works
Microarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury
Lei, P., Li, Y., Chen, X., Yang, S., & Zhang, J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.05.074 · Cited by 193 · see citing works
The MicroRNA Biology of the Mammalian Nucleus
Roberts, T. C. (2014) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2014.40 · Cited by 191 · see citing works
Effects of central and peripheral inflammation on hippocampal synaptic plasticity.
Filippo, M. D., Chiasserini, D., Gardoni, F., Viviani, B., Tozzi, A., Giampà, C., Costa, C., Tantucci, M., Zianni, E., Boraso, M., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.12.009 · Cited by 187 · see citing works
Giulian, D., Li, J., Leara, B., & Keenen, C. (1994) · Neurochemistry International · doi:10.1016/0197-0186(94)90066-3 · Cited by 181 · see citing works
MicroRNA-21 Modulates the Levels of Reactive Oxygen Species by Targeting SOD3 and TNF α
Zhang, X., Ng, W. L., Wang, P., Tian, L., Werner, E., Wang, H., Doetsch, P. W., & Wang, Y. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0639 · Cited by 181 · see citing works
Clinical evidence of inflammation driving secondary brain injury
Hinson, H. E., Rowell, S., & Schreiber, M. A. (2015) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000000468 · Cited by 179 · see citing works
Differential Behavioral and Histopathological Responses to Graded Cortical Impact Injury in Mice
Saatman, K. E., Feeko, K. J., Pape, R. L., & Raghupathi, R. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.1241 · Cited by 173 · see citing works
miR-21 improves the neurological outcome after traumatic brain injury in rats
Ge, X.-T., Lei, P., Wang, H.-C., Zhang, A.-L., Han, Z.-L., Chen, X., Li, S.-H., Jiang, R.-C., Kang, C.-S., & Zhang, J.-N. (2014) · Scientific Reports · doi:10.1038/srep06718 · Cited by 167 · see citing works
Parisi, C., Arisi, I., D’Ambrosi, N., Storti, A. E., Brandi, R., D’Onofrio, M., & Volonté, C. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.491 · Cited by 153 · see citing works
Harrison, E. B., Hochfelder, C. G., Lamberty, B. G., Meays, B. M., Morsey, B. M., Kelso, M. L., Fox, H. S., & Yelamanchili, S. V. (2016) · FEBS Open Bio · doi:10.1002/2211-5463.12092 · Cited by 151 · see citing works
Self-citationGuedes, J. R., Custódia, C. M., Silva, R. J., de Almeida, L. P., Pedroso de Lima, M. C., & Cardoso, A. L. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu348 · Cited by 150 · see citing works
Neural bases of recovery after brain injury
Nudo, R. J. (2011) · Journal of Communication Disorders · doi:10.1016/j.jcomdis.2011.04.004 · Cited by 144 · see citing works
Hauss‐Wegrzyniak, B., Lynch, M. A., Vraniak, P., & Wenk, G. L. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7966 · Cited by 143 · see citing works
Lippai, D., Bala, S., Csák, T., Kurt‐Jones, E. A., & Szabó, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070945 · Cited by 141 · see citing works
Neuroinflammation: beneficial and detrimental effects after traumatic brain injury
Finnie, J. (2013) · InflammoPharmacology · doi:10.1007/s10787-012-0164-2 · Cited by 136 · see citing works
Han, Z., Chen, F., Ge, X., Tan, J., Lei, P., & Zhang, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.07.045 · Cited by 128 · see citing works
Toll-Like Receptors and Ischemic Brain Injury
Gesuete, R., Kohama, S. G., & Stenzel‐Poore, M. P. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000068 · Cited by 117 · see citing works
miR-21 alleviates secondary blood–brain barrier damage after traumatic brain injury in rats
Ge, X., Han, Z., Chen, F., Wang, H., Zhang, B., Jiang, R., Lei, P., & Zhang, J. (2015) · Brain Research · doi:10.1016/j.brainres.2015.01.009 · Cited by 110 · see citing works
Yelamanchili, S. V., Chaudhuri, A. D., Chen, L.-N., Xiong, H., & Fox, H. S. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.56 · Cited by 108 · see citing works
Self-citationZhang, L., Dong, L., Li, Y., Hong, Z., & Wei, W. (2012) · Glia · doi:10.1002/glia.22404 · Cited by 103 · see citing works
Traumatic Brain Injury Dysregulates MicroRNAs to Modulate Cell Signaling in Rat Hippocampus
Liu, L., Sun, T., Liu, Z., Chen, X., Zhao, L., Qu, G., & Li, Q. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103948 · Cited by 98 · see citing works
Serafini, G., Pompili, M., Hansen, K. F., Obrietan, K. H., Dwivedi, Y., Shomron, N., & Girardi, P. (2013) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-9997-5 · Cited by 93 · see citing works
Maussion, G., Yang, J., Yerko, V., Barker, P., Mechawar, N., Ernst, C., & Turecki, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039301 · Cited by 91 · see citing works
Rosato, P. C., & Leib, D. A. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005028 · Cited by 84 · see citing works
A comprehensive characterization of the nuclear microRNA repertoire of post-mitotic neurons
Khudayberdiev, S., Zampa, F., Rajman, M., & Schratt, G. M. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00043 · Cited by 82 · see citing works
Gabhann, J. N., Higgs, R., Brennan, K., Thomas, W., Damen, J. E., Ben Larbi, N., Krystal, G., & Jefferies, C. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902589 · Cited by 81 · see citing works
Hu, Z., Yu, D., Almeida-Suhett, C. P., Tu, K., Marini, A. M., Eiden, L. E., Braga, M. F. M., Zhu, J., & Li, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039357 · Cited by 78 · see citing works
miR-155 regulates HGAL expression and increases lymphoma cell motility
Dagan, L. N., Jiang, X., Bhatt, S., Cubedo, E., Rajewsky, K., & Lossos, I. S. (2011) · Blood · doi:10.1182/blood-2011-08-370536 · Cited by 72 · see citing works
Critical Role of MicroRNA-155 in Herpes Simplex Encephalitis
Bhela, S., Mulik, S., Reddy, P. B. J., Richardson, R. L., Giménez, F., Rajasagi, N. K., Veiga‐Parga, T., Osmand, A. P., & Rouse, B. T. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302326 · Cited by 72 · see citing works
Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions
Cardoso, A. L., Guedes, J. R., & de Lima, M. C. P. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.09.001 · Cited by 70 · see citing works
Temporal Profile of MicroRNA Expression in Contused Cortex after Traumatic Brain Injury in Mice
Meissner, L., Gallozzi, M., Balbi, M., Schwarzmaier, S., Tiedt, S., Terpolilli, N. A., & Plesnila, N. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2015.4077 · Cited by 68 · see citing works
MicroRNAs in the Brain: It's Regulatory Role in Neuroinflammation
Thounaojam, M. C., Kaushik, D. K., & Basu, A. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8400-3 · Cited by 66 · see citing works
Karve, I. P., Zhang, M., Habgood, M. D., Frugier, T., Brody, K. M., Sashindranath, M., Ek, C. J., Chappaz, S., Kile, B. T., Wright, D. K., et al. (2016) · eNeuro · doi:10.1523/eneuro.0128-15.2016 · Cited by 64 · see citing works
Eisenhardt, S. U., Weiss, J., Smolka, C., Maxeiner, J. M., Pankratz, F., Bemtgen, X., Kustermann, M., Thiele, J. R., Schmidt, Y., Stark, G. B., et al. (2015) · Basic Research in Cardiology · doi:10.1007/s00395-015-0490-9 · Cited by 62 · see citing works
Nuclear microRNAs in normal hemopoiesis and cancer
Rasko, J. E. J., & Wong, J. J. L. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-016-0375-x · Cited by 51 · see citing works
MicroRNAs as Novel Regulators of Neuroinflammation
Ksiazek-Winiarek, D. J., Kacperska, M. J., & Glabinski, A. R. (2013) · Mediators of Inflammation · doi:10.1155/2013/172351 · Cited by 50 · see citing works
Chaudhuri, A. D., Yelamanchili, S. V., & Fox, H. S. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00160 · Cited by 44 · see citing works
Self-citationExpression profiling of MicroRNAs in hippocampus of rats following traumatic brain injury
Sun, T., Chen, X., Liu, Z.-L., Zhao, L., Jiang, Y., Qu, G., Wang, R., Huang, S., & Liu, L. (2014) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-014-1313-1 · Cited by 35 · see citing works
Butovsky, O., Jedrychowski, M. P., Cialic, R., Murugaiyan, G., Wu, P. M., Doykan, C. E., Fanek, Z., Greco, D. J., Kiner, O., Lawson, R. J., et al. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.04.023 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
MiR-155: An Important Regulator of Neuroinflammation
Zingale, V. D., Gugliandolo, A., & Mazzon, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010090 · Cited by 163 · see citing works
Maarouf, M., Chen, B., Chen, Y., Wang, X., Rai, K. R., Zhao, Z., Liu, S., Li, Y., Xiao, M., & Chen, J. (2019) · Cellular Microbiology · doi:10.1111/cmi.13036 · Cited by 86 · see citing works
Henry, R. J., Doran, S. J., Barrett, J. P., Meadows, V. E., Sabirzhanov, B. E., Stoica, B. A., Loane, D. J., & Faden, A. I. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0665-9 · Cited by 82 · see citing works
Epigenetic mechanisms of neurodegenerative diseases and acute brain injury
Bertogliat, M. J., Morris-Blanco, K. C., & Vemuganti, R. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104642 · Cited by 77 · see citing works
LaRocca, D., Barns, S., Hicks, S. D., Brindle, A., Williams, J. R., Uhlig, R., Johnson, P. R., Neville, C., & Middleton, F. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0207785 · Cited by 67 · see citing works
Kumar, A., Henry, R. J., Stoica, B. A., Loane, D. J., Abulwerdi, G. A., Bhat, S. A., & Faden, A. I. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.253955 · Cited by 63 · see citing works
Roselli, F., Chandrasekar, A., & Morganti-Kossmann, M. C. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00458 · Cited by 60 · see citing works
Cooke, P., Janowitz, H. N., & Dougherty, S. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.872501 · Cited by 57 · see citing works
Qu, H., Liu, R., Chen, J., Zheng, L., & Chen, R. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17082676 · Cited by 53 · see citing works
Huang, L.-G., Zou, J., & Lu, Q.-C. (2018) · Brain Research · doi:10.1016/j.brainres.2017.11.019 · Cited by 65 · see citing works
Taraschenko, O. D., Fox, H. S., Ζεκερίδου, Α., Pittock, S. J., Eldridge, E., Farukhuddin, F., Al‐Saleem, F. H., Kattala, C. D., Dessain, S. K., Casale, G. P., et al. (2021) · Epilepsia · doi:10.1111/epi.16838 · Cited by 46 · see citing works
Self-citationSchjenken, J. E., Moldenhauer, L. M., Zhang, B., Care, A. S., Groome, H. M., Chan, H. Y., Hope, C. M., Barry, S. C., & Robertson, S. A. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0255-0 · Cited by 46 · see citing works
Korotkov, A., Puhakka, N., Gupta, S. D., Vuokila, N., Broekaart, D. W. M., Anink, J. J., Heiskanen, M., Karttunen, J., van Scheppingen, J., Huitinga, I., et al. (2020) · Brain Pathology · doi:10.1111/bpa.12865 · Cited by 46 · see citing works
Ciccacci, C., Latini, A., Colantuono, A., Politi, C., D’Amato, C., Greco, C., Rinaldi, M. E., Lauro, D., Novelli, G., Spallone, V., et al. (2020) · Epigenomics · doi:10.2217/epi-2019-0242 · Cited by 39 · see citing works
Zhang, Z., Liang, K., Zou, G., Chen, X., Shi, S., Wang, G., Zhang, K., Li, K., & Zhai, S. (2018) · Bioscience Reports · doi:10.1042/bsr20171432 · Cited by 36 · see citing works
MiR-206-3p alleviates chronic constriction injury-induced neuropathic pain through targeting HDAC4
Wen, J., He, T., Qi, F., & Chen, H. (2018) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.18-0091 · Cited by 36 · see citing works
Gomes, C., Sequeira, C., Barbosa, M., Cunha, C., Vaz, A. R., & Brites, D. M. T. O. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112209 · Cited by 36 · see citing works
Wang, T., Li, B., Wang, Z., Yuan, X., Chen, C., Zhang, Y., Xia, Z., Wang, X., Yu, M., Tao, W., et al. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.31904 · Cited by 33 · see citing works
Wang, W., Prajapati, P., Vekaria, H. J., Spry, M. L., Cloud, A. L., Sullivan, P. G., & Springer, J. E. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.293149 · Cited by 29 · see citing works
Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions
Choi, H. K., Chen, M., Goldston, L. L., & Lee, K.-B. (2024) · Nano Convergence · doi:10.1186/s40580-024-00426-5 · Cited by 26 · see citing works
Aggio‐Bruce, R., Chu‐Tan, J. A., Wooff, Y., Cioanca, A. V., Schümann, U., & Natoli, R. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02158-z · Cited by 25 · see citing works
Pathogenesis of miR-155 on nonmodifiable and modifiable risk factors in Alzheimer’s disease
Liu, J.-J., Long, Y.-F., Xu, P., Guo, H.-D., & Cui, G.-H. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01264-z · Cited by 25 · see citing works
Pittenger, S. T., Schaal, V. L., Moore, D. Y., Guda, R. S., Koul, S., Yelamanchili, S. V., Bevins, R. A., & Pendyala, G. (2018) · Scientific Reports · doi:10.1038/s41598-018-35747-z · Cited by 22 · see citing works
Self-citationLong non-coding RNA LNC_000641 regulates pseudorabies virus replication
Fang, L., Gao, Y., Liu, X., Bai, J., Jiang, P., & Wang, X. (2021) · Veterinary Research · doi:10.1186/s13567-021-00922-0 · Cited by 21 · see citing works
What Is in the Field for Genetics and Epigenetics of Diabetic Neuropathy: The Role of MicroRNAs
Spallone, V., Ciccacci, C., Latini, A., & Borgiani, P. (2021) · Journal of Diabetes Research · doi:10.1155/2021/5593608 · Cited by 22 · see citing works
Increased ISGylation in Cases of TBI-Exposed ALS Veterans
Schwartzenburg, J., Juncker, M. A., Reed, R. E., & Desai, S. D. (2018) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nly129 · Cited by 20 · see citing works
Herrold, A. A., Kletzel, S., Foecking, E. M., Saban, K. L., Przybycien–Szymanska, M. M., Zilliox, M. J., Bhaumik, D. K., Lange, D., Radke, J. R., Salinas, I. G., et al. (2020) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000632 · Cited by 18 · see citing works
A miRNA Signature for Cognitive Deficits and Alcohol Use Disorder in Persons Living with HIV/AIDS
Wyczechowska, D. D., Lin, H., LaPlante, A., Jeansonne, D. P., Lassak, A., Parsons, C. H., Molina, P. E., & Peruzzi, F. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00385 · Cited by 18 · see citing works
Takahashi, K., Sato, Y., Sekizuka, T., Kuroda, M., Suzuki, T., Hasegawa, H., & Katano, H. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008523 · Cited by 18 · see citing works
Inflammation-associated miR-155 activates differentiation of muscular satellite cells
Onodera, Y., Teramura, T., Takehara, T., Itokazu, M., Mori, T., & Fukuda, K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204860 · Cited by 11 · see citing works
El-Gazar, A. A., El‐Emam, S. Z., El-Sayyad, S. M., El-Mancy, S. S., Fayez, S. M., Sheta, N. M., Al‐Mokaddem, A. K., & Ragab, G. M. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112118 · Cited by 11 · see citing works
Yousefi, M. J., Rezvanimehr, A., Saleki, K., Mehrani, A., Barootchi, E., Ramezankhah, M., Mazloomi, A., Nateri, A. S., Barootchi, S., & Rezaei, N. (2025) · Reviews in the Neurosciences · doi:10.1515/revneuro-2025-0041 · Cited by 9 · see citing works
Lasarzik, I., Nagel, N., Sebastiani, A., Griemert, E., & Thal, S. C. (2019) · BMC Neuroscience · doi:10.1186/s12868-019-0531-7 · Cited by 9 · see citing works
Interaction Between Non-Coding RNAs and Interferons: With an Especial Focus on Type I Interferons
Ghafouri‐Fard, S., Poornajaf, Y., Dashti, F., Hussen, B. M., Taheri, M. N., & Jamali, E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.877243 · Cited by 9 · see citing works
Pazzaglia, S., Tanno, B., Antonelli, F., Giardullo, P., Babini, G., Subedi, P., Azimzadeh, O., Khan, Z. N., Oleksenko, K., Metzger, F., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084290 · Cited by 8 · see citing works
Schmidt, A. T., Hicks, S. D., Bergquist, B. K., Maloney, K. A., Dennis, V. E., & Bammel, A. C. (2024) · Genes · doi:10.3390/genes15111433 · Cited by 8 · see citing works
Applications of cerebrospinal miRNA in the detection and treatment of acute CNS injury
Yang, Q. E., Shi, Q., & Fu, J. (2018) · Frontiers in Laboratory Medicine · doi:10.1016/j.flm.2018.08.001 · Cited by 5 · see citing works
Kelani, H., Nuovo, G. J., Bratasz, A., Rajan, J., Efanov, A. A., Michaille, J., Awad, H., & Tili, E. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.788301 · Cited by 1 · see citing works
Diagnosis and Assessment of Microbial Infections with Host and Microbial MicroRNA Profiles
Cui, L., Markou, A. N., Stratton, C. W., & Lianidou, E. S. (2018) · Springer eBooks · doi:10.1007/978-3-319-95111-9_23 · Cited by 1 · see citing works
Zhu, X., Haure‐Mirande, J., Bicak, M., Dong, P., Kruglikov, I., Al-subaie, A., Fossati, V., Noggle, S., Gandy, S., & Ehrlich, M. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.28.679053 · Cited by 1 · see citing works
Sequence-Specific Extracellular MicroRNAs Activate TLR7
Wu, N. (2018) · DigitalCommons@UNMC
Li, W., Zhu, H., Liang, Y., Tong, F., & Zhou, Y. (2020) · doi:10.21203/rs.3.rs-40711/v1
The potential role of microRNA-155 in Neurodegenerative diseases with a focus on Alzheimer's diseasePreprint
Rasmi, Y., Shokati, A., Rahimi, A., Aziz, S. G., Farnamian, Y., Hassan, A., & Alipour, S. (2022) · Research Square · doi:10.21203/rs.3.rs-2314903/v1
Sarkar, S., Pandey, A. K., Khan, B., & Pant, A. B. (2025) · BMC Genomics · doi:10.1186/s12864-025-11970-7
Zhang, X., Chen, B., Yi, X., Duan, M., Wang, C., Li, S., & Wei, W. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1816232
Demoz, A., Shynykul, Z., Zhang, A., Lyu, W., Wang, X., & Shin, H. (2026) · Clinical and Translational Neuroscience · doi:10.3390/ctn10020017
Zhu, X., Haure‐Mirande, J., Bicak, M., Dong, P., Kruglikov, I., Li, A., Al‐subaie, A., Fossati, V., Noggle, S., Gandy, S., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71684 · Cited by 1 · see citing works
Xu, J., Zuo, Y., Zhang, T., He, Y., Long, T., Jiao, M., Lu, R., Xiong, K., & Chen, Y. (2025) · Advanced technology in neuroscience . · doi:10.4103/atn.atn-d-25-00022
- Authors
- Harrison, E. B., Emanuel, K., Lamberty, B. G., Morsey, B. M., Li, M., Kelso, M. L., Yelamanchili, S. V., & Fox, H. S.
- Affiliations
- Nebraska Medical Center (US)
- Corresponding author
- Fox, Howard S.
- Venue
- Frontiers in Molecular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2017-07-28
- Volume
- 10
- Pages
- 228-228
- ISSN
- 1662-5099 (ISSN-L)
- PMC
- PMC5532436
- OpenAlex
- W2734372389
- Cited by
- 48
- References
- 72
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 10 · 2019: 5 · 2018: 11 · 2017: 2
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Molecular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- DigitalCommons@UNMC (submittedVersion, cc-by)
- Creighton Digital Repository (CDR) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UNC Libraries
- Funders
- University of Nebraska Medical Center
- National Cancer Institute (T32CA196589)
- Topics
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- miR-155, traumatic brain injury, type I interferon, neuroinflammation, neuroprotection, controlled cortical impact, hippocampus, microglia, neurodegeneration, IRF1, CXCL10, miR-21, miR-223
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
