The effect of theta-burst TMS on cognitive control networks measured with resting state fMRI
Open accessAbstract
IT HAS BEEN PROPOSED THAT TWO RELATIVELY INDEPENDENT COGNITIVE CONTROL NETWORKS EXIST IN THE BRAIN: the cingulo-opercular network (CO) and the fronto-parietal network (FP). Past work has shown that chronic brain lesions affect these networks independently. It remains unclear, however, how these two networks are affected by acute brain disruptions. To examine this, we conducted a within-subject theta-burst transcranial magnetic stimulation (TBS) experiment in healthy individuals that targeted left anterior insula/frontal operculum (L aI/fO, a region in the CO network), left dorsolateral prefrontal cortex (L dlPFC, a region in the FP network), or left primary somatosensory cortex (L S1, an experimental control region). Functional connectivity (FC) was measured in resting state fMRI scans collected before and after continuous TBS on each day. We found that TBS was accompanied by generalized increases in network connectivity, especially FP network connectivity, after TBS to either region involved in cognitive control. Whole-brain analyses demonstrated that the L dlPFC and L aI/fO showed increased connectivity with regions in frontal, parietal, and cingulate cortex after TBS to either L dlPFC or L aI/fO, but not to L S1. These results suggest that acute disruption by TBS to cognitive control regions causes widespread changes in network connectivity not limited to the targeted networks.
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Secondary activations are not necessarily confined to the networks associated with the primary site, but can be widespread.
“Furthermore, these activations are not necessarily confined to the networks associated with the primary site, but can be widespread (Gratton et al., 2013).”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Gratton et al., 2013
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Cites
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190 · see citing works
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913 · see citing works
<i>The Brain's Default Network</i>: <i>Anatomy, Function, and Relevance to Disease</i>
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761 · see citing works
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553 · see citing works
Ashburner, J., & Friston, K. J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.018 · Cited by 7,507 · see citing works
Saliency, switching, attention and control: a network model of insula function
Menon, V., & Uddin, L. Q. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0262-0 · Cited by 5,592 · see citing works
Large-scale brain networks and psychopathology: a unifying triple network model
Menon, V. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.08.003 · Cited by 4,168 · see citing works
Theta Burst Stimulation of the Human Motor Cortex
Huang, Y.-Z., Edwards, M. J., Rounis, E., Bhatia, K. P., & Rothwell, J. C. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.033 · Cited by 4,158 · see citing works
Tracking whole-brain connectivity dynamics in the resting state
Allen, E. A., Damaraju, E., Plis, S. M., Erhardt, E. B., Eichele, T., & Calhoun, V. D. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs352 · Cited by 2,992 · see citing works
Sridharan, D., Levitin, D. J., & Menon, V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800005105 · Cited by 2,892 · see citing works
Distinct brain networks for adaptive and stable task control in humans
Dosenbach, N. U. F., Fair, D. A., Miezin, F. M., Cohen, A. L., Wenger, K. K., Dosenbach, R. A. T., Fox, M. D., Snyder, A. Z., Vincent, J. L., Raichle, M. E., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704320104 · Cited by 2,632 · see citing works
Morris, S. B., & DeShon, R. P. (2002) · Psychological Methods · doi:10.1037/1082-989x.7.1.105 · Cited by 2,502 · see citing works
Common regions of the human frontal lobe recruited by diverse cognitive demands
Duncan, J., & Owen, A. M. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01633-7 · Cited by 2,498 · see citing works
A dual-networks architecture of top-down control
Dosenbach, N. U. F., Fair, D. A., Cohen, A. L., Schlaggar, B. L., & Petersen, S. E. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.01.001 · Cited by 1,931 · see citing works
The Architecture of Cognitive Control in the Human Prefrontal Cortex
Koechlin, E., Ody, C., & Kouneiher, F. (2003) · Science · doi:10.1126/science.1088545 · Cited by 1,922 · see citing works
A Core System for the Implementation of Task Sets
Dosenbach, N. U. F., Visscher, K. M., Palmer, E. D., Miezin, F. M., Wenger, K. K., Kang, H. C., Burgund, E. D., Grimes, A. L., Schlaggar, B. L., & Petersen, S. E. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.031 · Cited by 1,772 · see citing works
Spreng, R. N., Stevens, W. D., Chamberlain, J. P., Gilmore, A. W., & Schacter, D. L. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.016 · Cited by 1,256 · see citing works
He, B. J., Snyder, A. Z., Vincent, J. L., Epstein, A. A., Shulman, G. L., & Corbetta, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.013 · Cited by 916 · see citing works
Saad, Z. S., Gotts, S. J., Murphy, K., Chen, G., Jo, H. J., Martin, A., & Cox, R. W. (2012) · Brain Connectivity · doi:10.1089/brain.2012.0080 · Cited by 859 · see citing works
Ridding, M. C., & Ziemann, U. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.190314 · Cited by 787 · see citing works
Carter, A. R., Astafiev, S. V., Lang, C. E., Connor, L. T., Rengachary, J., Strube, M., Pope, D. L. W., Shulman, G. L., & Corbetta, M. (2009) · Annals of Neurology · doi:10.1002/ana.21905 · Cited by 763 · see citing works
Physiology of repetitive transcranial magnetic stimulation of the human brain
Hoogendam, J. M., Ramakers, G. M. J., & Di Lazzaro, V. (2010) · Brain Stimulation · doi:10.1016/j.brs.2009.10.005 · Cited by 669 · see citing works
Dynamic functional reorganization of the motor execution network after stroke
Wang, L. Y., Yu, C., Chen, H., Qin, W., Yong He, A., Fan, F., Zhang, Y., Wang, M., Li, K., Zang, Y., et al. (2010) · Brain · doi:10.1093/brain/awq043 · Cited by 630 · see citing works
Badre, D., & D'Esposito, M. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.12.2082 · Cited by 615 · see citing works
Self-citationSalience network integrity predicts default mode network function after traumatic brain injury
Bonnelle, V., Ham, T. E., Leech, R., Kinnunen, K. M., Mehta, M. A., Greenwood, R. J., & Sharp, D. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113455109 · Cited by 606 · see citing works
Cortical connectivity after subcortical stroke assessed with functional magnetic resonance imaging
Grefkes, C., Nowak, D. A., Eickhoff, S. B., Dafotakis, M., Küst, J., Karbe, H., & Fink, G. R. (2007) · Annals of Neurology · doi:10.1002/ana.21228 · Cited by 575 · see citing works
Longitudinal Changes of Resting-State Functional Connectivity During Motor Recovery After Stroke
Park, C.-H., Chang, W. H., Ohn, S. H., Kim, S. T., Bang, O. Y., Pascual‐Leone, Á., & Kim, Y. (2011) · Stroke · doi:10.1161/strokeaha.110.596155 · Cited by 499 · see citing works
Fox, M. D., Halko, M. A., Eldaief, M. C., & Pascual-Leone, A. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.035 · Cited by 395 · see citing works
Thut, G., & Pascual-Leone, A. (2010) · Brain Topography · doi:10.1007/s10548-009-0115-4 · Cited by 388 · see citing works
Fox, M., Liu, H., & Pascual‐Leone, Á. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.10.082 · Cited by 380 · see citing works
Fukunaga, M., Horovitz, S. G., van Gelderen, P., de Zwart, J. A., Jansma, J. M., Ikonomidou, V. N., Chu, R., Deckers, R., Leopold, D. A., & Duyn, J. H. (2006) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2006.04.018 · Cited by 365 · see citing works
Manoliu, A., Riedl, V., Zherdin, A., Mühlau, M., Schwerthöffer, D., Scherr, M., Peters, H., Zimmer, C., Förstl, H., Bäuml, J., et al. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt037 · Cited by 354 · see citing works
Gentner, R., Wankerl, K., Reinsberger, C., Zeller, D., & Claßen, J. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm239 · Cited by 350 · see citing works
Gratton, C., Nomura, E. M., Pérez, F., & D’Esposito, M. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00222 · Cited by 336 · see citing works
Self-citationvan Meer, M. P. A., van der Marel, K., Wang, K., Otte, W. M., el Bouazati, S., Roeling, T. A. P., Viergever, M. A., van der Sprenkel, J. W. B., & Dijkhuizen, R. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5709-09.2010 · Cited by 336 · see citing works
Effect of Physiological Activity on an NMDA-Dependent Form of Cortical Plasticity in Human
Huang, Y., Rothwell, J. C., Edwards, M. J., & Chen, R. S. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm087 · Cited by 320 · see citing works
The theoretical model of theta burst form of repetitive transcranial magnetic stimulation
Huang, Y., Rothwell, J. C., Chen, R., Lu, C., & Chuang, W. (2010) · Clinical Neurophysiology · doi:10.1016/j.clinph.2010.08.016 · Cited by 300 · see citing works
Thielscher, A., & Kammer, T. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.02.019 · Cited by 295 · see citing works
Eldaief, M. C., Halko, M. A., Buckner, R. L., & Pascual‐Leone, Á. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113103109 · Cited by 288 · see citing works
Sharma, N., Baron, J., & Rowe, J. (2009) · Annals of Neurology · doi:10.1002/ana.21810 · Cited by 273 · see citing works
Vercammen, A., Knegtering, H., den Boer, J. A., Liemburg, E. J., & Aleman, A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.017 · Cited by 261 · see citing works
The salience network causally influences default mode network activity during moral reasoning
Chiong, W., Wilson, S. M., D’Esposito, M., Kayser, A. S., Grossman, S. N., Poorzand, P., Seeley, W. W., Miller, B. L., & Rankin, K. P. (2013) · Brain · doi:10.1093/brain/awt066 · Cited by 227 · see citing works
Self-citationDefault Network Modulation and Large-Scale Network Interactivity in Healthy Young and Old Adults
Spreng, R. N., & Schacter, D. L. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr339 · Cited by 214 · see citing works
Anterior temporal lobe connectivity correlates with functional outcome after aphasic stroke
Warren, J. E., Crinion, J., Ralph, M. A. L., & Wise, R. J. S. (2009) · Brain · doi:10.1093/brain/awp270 · Cited by 188 · see citing works
Double dissociation of two cognitive control networks in patients with focal brain lesions
Nomura, E. M., Gratton, C., Visser, R. M., Kayser, A. S., Pérez, F., & D’Esposito, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002431107 · Cited by 167 · see citing works
Self-citationDistributed and causal influence of frontal operculum in task control
Higo, T., Mars, R. B., Boorman, E. D., Buch, E. R., & Rushworth, M. F. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013361108 · Cited by 164 · see citing works
The Dynamic Nature of Top-Down Signals Originating from Prefrontal Cortex: A Combined fMRI–TMS Study
Lee, T. G., & D’Esposito, M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0627-12.2012 · Cited by 161 · see citing works
Self-citationConnectivity Gradients Between the Default Mode and Attention Control Networks
Anderson, J. S., Ferguson, M. A., Lopez-Larson, M. P., & Yurgelun-Todd, D. A. (2011) · Brain Connectivity · doi:10.1089/brain.2011.0007 · Cited by 150 · see citing works
Watanabe, T., Hanajima, R., Shirota, Y., Ohminami, S., Tsutsumi, R., Terao, Y., Ugawa, Y., Hirose, S., Miyashita, Y., Konishi, S., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22300 · Cited by 99 · see citing works
Bilek, E., Schäfer, A., Ochs, E., Esslinger, C., Zangl, M., Plichta, M. M., Braun, U., Kirsch, P., Schulze, T. G., Rietschel, M., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3081-12.2013 · Cited by 89 · see citing works
Modulating spontaneous brain activity using repetitive transcranial magnetic stimulation
van der Werf, Y. D., Sanz‐Arigita, E., Menning, S., & van den Heuvel, O. A. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-145 · Cited by 84 · see citing works
Longitudinal Effects of Lesions on Functional Networks after Stroke
Ovadia‐Caro, S., Villringer, K., Fiebach, J. B., Jungehulsing, G. J., van der Meer, E. E., Margulies, D. S., & Villringer, A. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.80 · Cited by 79 · see citing works
Hubl, D., Nyffeler, T., Wurtz, P., Chaves, S., Pflugshaupt, T., Lüthi, M., von Wartburg, R., Wiest, R., Dierks, T., Strik, W. K., et al. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.049 · Cited by 78 · see citing works
Sommer, M., Wu, T., Tergau, F., et al. (2002) · Clinical Neurophysiology · doi:10.1016/s1388-2457(01)00726-x · Cited by 76 · see citing works
Focality Assessment in Transcranial Magnetic Stimulation With Double and Cone Coils
Lontis, R., Voigt, M., & Struijk, J. J. (2006) · Journal of Clinical Neurophysiology · doi:10.1097/01.wnp.0000229944.63011.a1 · Cited by 75 · see citing works
Cárdenas‐Morales, L., Grön, G., & Kammer, T. (2010) · Human Brain Mapping · doi:10.1002/hbm.21160 · Cited by 63 · see citing works
Connectivity alterations assessed by combining fMRI and MR-compatible hand robots in chronic stroke
Mintzopoulos, D., Astrakas, L. G., Khanicheh, A., Konstas, A. A., Singhal, A. B., Moskowitz, M. A., Rosen, B. R., & Tzika, A. A. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.03.007 · Cited by 63 · see citing works
Striatal Dopamine Influences the Default Mode Network to Affect Shifting between Object Features
Dang, L. C., Donde, A., Madison, C. M., O’Neil, J. P., & Jagust, W. J. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00252 · Cited by 61 · see citing works
The effects of lateral prefrontal transcranial magnetic stimulation on item memory encoding
Blumenfeld, R. S., Lee, T. G., & D’Esposito, M. (2013) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2013.11.021 · Cited by 47 · see citing works
Self-citationLee, T. G., Blumenfeld, R. S., & D’Esposito, M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5652-12.2013 · Cited by 44 · see citing works
Self-citationApplications of transcranial magnetic stimulation in studies on motor learning.
Pascual‐Leone, Á., Tarazona, F., & Catalá, M. D. (1999) · PubMed · Cited by 40 · see citing works
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Gu, S., Pasqualetti, F., Cieslak, M., Telesford, Q. K., Yu, A. B., Kahn, A. E., Medaglia, J. D., Vettel, J. M., Miller, M. B., Grafton, S. T., et al. (2015) · Nature Communications · doi:10.1038/ncomms9414 · Cited by 912 · see citing works
The role of PFC networks in cognitive control and executive function
Menon, V., & D’Esposito, M. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01152-w · Cited by 654 · see citing works
Self-citationHanlon, C. A., Dowdle, L. T., Austelle, C. W., DeVries, W., Mithoefer, O., Badran, B. W., & George, M. S. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.053 · Cited by 166 · see citing works
The neural crossroads of psychiatric illness: an emerging target for brain stimulation
Downar, J., Blumberger, D. M., & Daskalakis, Z. J. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.10.007 · Cited by 166 · see citing works
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To, W. T., De Ridder, D., Hart Jr., J., & Vanneste, S. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00128 · Cited by 135 · see citing works
“For example, studies targeting the left DLPFC in healthy subjects using TBS have demonstrated influence on regional and more remote functions using resting-state fMRI (e.g., Gratton et al., 2013; Iwabuchi et al., 2017).”
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- Authors
- Gratton, C., Lee, T. G., Nomura, E. M., & D'Esposito, M.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Gratton, Caterina
- Venue
- Frontiers in Systems Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 124-124
- ISSN
- 1662-5137 (ISSN-L)
- PMC
- PMC3874542
- OpenAlex
- W2010661140
- Cited by
- 138
- References
- 61
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 10 · 2023: 10 · 2022: 8 · 2021: 14 · 2020: 11 · 2019: 17 · 2018: 13 · 2017: 17 · 2016: 7 · 2015: 10 · 2014: 6
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Systems Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- U.S. Department of Defense
- National Institutes of Health
- National Defense Science and Engineering Graduate
- National Institute of Mental Health (R01MH063901)
- National Institute of Neurological Disorders and Stroke (R01NS079698)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- theta-burst transcranial magnetic stimulation, cognitive control, cingulo-opercular network, frontoparietal network, dorsolateral prefrontal cortex, primary somatosensory cortex, resting-state functional connectivity
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