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Effects of low-carbohydrate diets versus low-fat diets on metabolic risk factors in overweight and obese adults: A meta-analysis of randomized controlled trials

Lei, Lifu, Huang, Juan, Zhang, Longlong, Hong, Yuqin, Hui, Suocheng, Yang, Jian·2022·Frontiers in Nutrition
DOI 10.3389/fnut.2022.935234PMC PMC9397119
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Abstract

Background and aims: Low-carbohydrate diets (LCD) and low-fat diets (LFD) have shown beneficial effects on the management of obesity. Epidemiological studies were conducted to compare the effects of the two diets. However, the results were not always consistent. This study aimed to conduct a meta-analysis to compare the long-term effects of LCD and LFD on metabolic risk factors and weight loss in overweight and obese adults. Methods: We performed a systematic literature search up to 30 March, 2022 in PubMed, EMBASE, and Cochrane Library. The meta-analysis compared the effects of LCD (carbohydrate intake ≤ 40%) with LFD (fat intake < 30%) on metabolic risk factors and weight loss for ≥6 months. Subgroup analyses were performed based on participant characteristics, dietary energy intake, and the proportions of carbohydrates. Results: 33 studies involving a total of 3,939 participants were included. Compared with participants on LFD, participants on LCD had a greater reduction in triglycerides (–0.14 mmol/L; 95% CI, –0.18 to –0.10 mmol/L), diastolic blood pressure (–0.87 mmHg; 95% CI, –1.41 to –0.32 mmHg), weight loss (–1.33 kg; 95% CI, –1.79 to –0.87 kg), and a greater increase in high-density lipoprotein cholesterol (0.07 mmol/L; 95% CI, 0.06 to 0.09 mmol/L) in 6–23 months. However, the decrease of total cholesterol (0.14 mmol/L; 95% CI, 0.07 to 0.20 mmol/L) and low-density lipoprotein cholesterol (0.10 mmol/L; 95% CI, 0.06 to 0.14 mmol/L) was more conducive to LFD in 6–23 months. There was no difference in benefits between the two diets after 24 months. Subgroup analyses showed no significant difference in the reduction of total cholesterol, low-density lipoprotein cholesterol, and blood pressure between the two diets in participants with diabetes, hypertension, or hyperlipidemia. Conclusion: The results suggest that LCD and LFD may have specific effects on metabolic risk factors and weight loss in overweight and obese adults over 6 months. At 24 months, the effects on weight loss and improvement of metabolic risk factors were at least the same. These indicated that we might choose different diets to manage the overweight and obese subjects. However, the long-term clinical efficacy and effects of various sources of carbohydrates or fat in the two diets need to be studied in the future.

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Research works printed but not linked: 60

  1. 2022, Obesity and Overweight.
  2. Tremmel, 2017, Economic burden of obesity: a systematic literature review., Int J Environ Res Public Health., 14, 10.3390/ijerph14040435 · DOI
  3. Hayes, 2014, Economic evaluation of “healthy beginnings” an early childhood inter-vention to prevent obesity., Obesity (Silver Spring)., 22, 1709, 10.1002/oby.20747 · DOI
  4. Hollingworth, 2012, Economic evaluation of lifestyle interventions to treat overweight or obesity in children., Int J Obes (Lond)., 36, 559, 10.1038/ijo.2011.272 · DOI
  5. O’Neill, 2020, Effect of low-carbohydrate diets on cardiometabolic risk, insulin resistance, and metabolic syndrome., Curr Opin Endocrinol Diabetes Obes., 27, 301, 10.1097/MED.0000000000000569 · DOI
  6. Hall, 2018, Low-carbohydrate diets for the treatment of obesity and type 2 diabetes., Curr Opin Clin Nutr Metab Care., 21, 308, 10.1097/MCO.0000000000000470 · DOI
  7. Brehm, 2003, A randomized trial comparing a very low carbohydrate diet and a calo-rie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women., J Clin Endocrinol Metab., 88, 1617, 10.1210/jc.2002-021480 · DOI · Paper page
  8. Tay, 2008, Metabolic effects of weight loss on a very-low-carbohydrate diet com-pared with an isocaloric high-carbohydrate diet in abdominally obese subjects., J Am Coll Cardiol., 51, 59, 10.1016/j.jacc.2007.08.050 · DOI · Paper page
  9. De Luis, 2015, Effects of a high-protein/low carbohydrate versus a standard hypocaloric diet on adipocytokine levels and insulin resistance in obese patients along 9 months., J Diabetes Complicat., 29, 950, 10.1016/j.jdiacomp.2015.06.002 · DOI
  10. Jonasson, 2014, Advice to follow a low-carbohydrate diet has a favourable impact on low-grade inflammation in type 2 diabetes compared with advice to follow a low-fat diet., Ann Med., 46, 182, 10.3109/07853890.2014.894286 · DOI
  11. Bazzano, 2014, Effects of low-carbohydrate and low-fat diets: a randomized trial., Ann Intern Med., 161, 309, 10.7326/M14-0180 · DOI · Paper page
  12. Perk, 2012, European guidelines on cardiovascular disease pre-vention in clinical practice (version 2012). The fifth joint task force of the european society of cardiology and other societies on cardiovascular disease rrevention in clinical practice (constituted by representatives of nine societies and by invited experts)., Eur Heart J., 33, 1635, 10.1093/eurheartj/ehs092 · DOI · Paper page
  13. 2010, Summary of revisions for the 2010 clinical practice recommendations., Diabetes Care., 33, 10.2337/dc10-S003 · DOI
  14. Haufe, 2012, Left ventricular mass and function with reduced-fat or re-duced-carbohydrate hypocaloric diets in overweight and obese subjects., Hypertension., 59, 70, 10.1161/HYPERTENSIONAHA.111.178616 · DOI · Paper page
  15. Jenkins, 2014, Effect of a 6-month vegan low-carbohydrate (’Eco-Atkins’) diet on cardiovascular risk factors and body weight in hyperlipidaemic adults: a randomised controlled trial., BMJ Open., 4, 10.1136/bmjopen-2013-003505 · DOI · Paper page
  16. Gardner, 2018, Effect of low-fat vs low-carbohydrate diet on 12-month weight loss in overweight adults and the association with genotype pattern or insulin secretion: the DIETFITS randomized clinical trial., JAMA., 319, 667, 10.1001/jama.2018.0245 · DOI · Paper page
  17. Hooper, 2020, Effects of total fat intake on body fatness in adults., Cochrane Database Syst Rev., 6, 10.1002/14651858.CD013636 · DOI
  18. Higgins, 2011, The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials., BMJ., 343, 10.1136/bmj.d5928 · DOI · Paper page
  19. Balshem, 2011, GRADE guidelines: 3.rating the quality of evidence., J Clin Epidemiol., 64, 401, 10.1016/j.jclinepi.2010.07.015 · DOI · Paper page
  20. Meader, 2014, A checklist designed to aid consistency and reproducibility of GRADE assessments: development and pilot validation., Syst Rev., 24, 10.1186/2046-4053-3-82 · DOI
  21. Egger, 1997, Bias in meta-analysis detected by a simple, graphical test., BMJ., 315, 629, 10.1136/bmj.315.7109.629 · DOI · Paper page
  22. Thomson, 2010, Changes in body weight and metabolic indexes in overweight breast cancer survivors enrolled in a randomized trial of low-fat vs. reduced carbohydrate diets., Nutr Cancer., 62, 1142, 10.1080/01635581.2010.513803 · DOI · Paper page
  23. Yancy, 2004, low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial., Ann Intern Med., 140, 769, 10.7326/0003-4819-140-10-200405180-00006 · DOI · Paper page
  24. Dansinger, 2005, Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial., JAMA., 293, 43, 10.1001/jama.293.1.43 · DOI · Paper page
  25. Ebbeling, 2007, Effects of a low-glycemic load vs low-fat diet in obese young adults: a randomized trial., JAMA., 297, 2092, 10.1001/jama.297.19.2092 · DOI · Paper page
  26. Elhayany, 2010, A low carbohydrate Mediterranean diet improves cardiovascular risk factors and diabetes control among overweight patients with type 2 diabetes mellitus: a 1-year prospective randomized intervention study., Diabetes Obes Metab., 12, 204, 10.1111/j.1463-1326.2009.01151.x · DOI · Paper page
  27. Frisch, 2009, A randomized controlled trial on the efficacy of carbohydrate-reduced or fat-reduced diets in patients attending a telemedically guided weight loss program., Cardiovasc Diabetol., 8, 10.1186/1475-2840-8-36 · DOI · Paper page
  28. Hockaday, 1978, Prospective comparison of modified fat-high-carbohydrate with standard low-carbohydrate dietary advice in the treatment of diabetes: one year follow-up study., Br J Nutr., 39, 357, 10.1079/bjn19780045 · DOI
  29. Klemsdal, 2010, Effects of a low glycemic load diet versus a low-fat diet in subjects with and without the metabolic syndrome., Nutr Metab Cardiovasc Dis., 20, 195, 10.1016/j.numecd.2009.03.010 · DOI
  30. Lim, 2010, Long-term effects of a low carbohydrate, low fat or high unsaturated fat diet compared to a no-intervention control., Nutr Metab Cardiovasc Dis., 20, 599, 10.1016/j.numecd.2009.05.003 · DOI · Paper page
  31. McAuley, 2006, Long-term effects of popular dietary approaches on weight loss and features of insulin resistance., Int J Obes (Lond)., 30, 342, 10.1038/sj.ijo.0803075 · DOI
  32. Wolever, 2008, The canadian trial of carbohydrates in diabetes (CCD), a 1-y controlled trial of low-glycemic-index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C-reactive protein., Am J Clin Nutr., 87, 114, 10.1093/ajcn/87.1.114 · DOI · Paper page
  33. Wycherley, 2010, Long-term effects of weight loss with a very low carbohydrate and low fat diet on vascular function in overweight and obese patients., J Intern Med., 267, 452, 10.1111/j.1365-2796.2009.02174.x · DOI
  34. Guldbrand, 2012, In type 2 diabetes, randomisation to advice to follow a low-carbohydrate diet transiently improves glycaemic control compared with advice to follow a low-fat diet producing a similar weight loss., Diabetologia., 55, 2118, 10.1007/s00125-012-2567-4 · DOI · Paper page
  35. Mazidi, 2018, Dietary inflammatory index and cardiometabolic risk in US adults., Atherosclerosis., 276, 23, 10.1016/j.atherosclerosis.2018.02.020 · DOI
  36. Mela, 1996, Eating behaviour, food preferences and dietary intake in relation to obesity and body-weight status., Proc Nutr Soc., 55, 803, 10.1079/pns19960080 · DOI
  37. Bueno, 2013, Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials., Br J Nutr, 110, 1178, 10.1017/S0007114513000548 · DOI · Paper page
  38. Hatahet, 2003, Dietary fats differentially modulate the expression of lecithin:cholesterol acyltransferase, apoprotein-A1 and scavenger receptor b1 in rats., J Nutr., 133, 689, 10.1093/jn/133.3.689 · DOI
  39. Lu, 2018, Effects of low-fat compared with high-fat diet on cardiometabolic indicators in people with overweight and obesity without overt metabolic disturbance: a systematic review and meta-analysis of randomised controlled trials., Br J Nutr., 119, 96, 10.1017/S0007114517002902 · DOI · Paper page
  40. Harvey, 2019, Low-carbohydrate diets differing in carbohydrate restriction improve cardiometabolic and anthropometric markers in healthy adults: a randomised clinical trial., PeerJ., 5, 10.7717/peerj.6273 · DOI
  41. Sasanfar, 2019, Adherence to the low carbohydrate diet and the risk of breast Cancer in Iran., Nutr J., 18, 10.1186/s12937-019-0511-x · DOI
  42. Rajaie, 2014, Moderate replacement of carbohydrates by dietary fats affects features of metabolic syndrome: a randomized crossover clinical trial., Nutrition., 30, 61, 10.1016/j.nut.2013.06.011 · DOI
  43. Smith, 2020, systematic review and meta-analysis comparing heterogeneity in body mass responses between low-carbohydrate and low-fat diets., Obesity (Silver Spring)., 28, 1833, 10.1002/oby.22968 · DOI
  44. Abbasnezhad, 2020, Effect of different dietary approaches in comparison with high/low-carbohydrate diets on systolic and diastolic blood pressure in type 2 diabetic patients: a systematic review and meta-analysis., Prev Nutr Food Sci., 25, 233, 10.3746/pnf.2020.25.3.233 · DOI
  45. Macedo, 2020, Low-carbohydrate diets: effects on metabolism and exercise - a comprehensive literature review., Clin Nutr ESPEN., 40, 17, 10.1016/j.clnesp.2020.07.022 · DOI
  46. Essah, 2007, Effect of macronutrient composition on postprandial peptide YY levels., J Clin Endocrinol Metab., 92, 4052, 10.1210/jc.2006-2273 · DOI
  47. Huntriss, 2018, The interpretation and effect of a low-carbohydrate diet in the management of type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials., Eur J Clin Nutr., 72, 311, 10.1038/s41430-017-0019-4 · DOI · Paper page
  48. Churuangsuk, 2018, Low-carbohydrate diets for overweight and obesity: a systematic review of the systematic reviews., Obes Rev., 19, 1700, 10.1111/obr.12744 · DOI · Paper page
  49. Noto, 2013, Low-carbohydrate diets and all-cause mortality: a systematic review and meta-analysis of observational studies., PLoS One., 8, 10.1371/journal.pone.0055030 · DOI
  50. D’Anci, 2009, Low-carbohydrate weight-loss diets. effects on cognition and mood., Appetite., 52, 96, 10.1016/j.appet.2008.08.009 · DOI
  51. Halyburton, 2007, Low- and high-carbohydrate weight-loss diets have similar effects on mood but not cognitive performance., Am J Clin Nutr., 86, 580, 10.1093/ajcn/86.3.580 · DOI
  52. Wing, 1995, Cognitive effects of ketogenic weight-reducing diets., Int J Obes Relat Metab Disord., 19, 811
  53. Daneshzad, 2020, Association between a low-carbohydrate diet and sleep status, depression, anxiety, and stress score., J Sci Food Agric., 100, 2946, 10.1002/jsfa.10322 · DOI
  54. Ren, 2020, An almond-based low carbohydrate diet improves depression and glycometabolism in patients with type 2 diabetes through modulating gut microbiota and GLP-1: a randomized controlled trial., Nutrients., 12, 10.3390/nu12103036 · DOI
  55. Hofman, 2004, The effect of different nutritional feeds on the postprandial glucose response in healthy volunteers and patients with type II diabetes., Eur J Clin Nutr., 58, 1553, 10.1038/sj.ejcn.1602007 · DOI
  56. Silverii, 2020, Low-carbohydrate diets and type 2 diabetes treatment: a meta-analysis of randomized controlled trials., Acta Diabetol., 57, 1375, 10.1007/s00592-020-01568-8 · DOI
  57. Esposito, 2003, Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial., JAMA., 289, 1799, 10.1001/jama.289.14.1799 · DOI · Paper page
  58. Qureshi, 2002, Effects of stabilized rice bran, its soluble and fiber fractions on blood glucose levels and serum lipid parameters in humans with diabetes mellitus types I and II., J Nutr Biochem., 13, 175, 10.1016/s0955-2863(01)00211-x · DOI
  59. Ravaut, 2020, Monounsaturated fatty acids in obesity-related inflammation., Int J Mol Sci., 22, 10.3390/ijms22010330 · DOI
  60. Silva Figueiredo, 2017, Fatty acids consumption: the role metabolic aspects involved in obesity and its associated disorders., Nutrients., 9, 10.3390/nu9101158 · DOI

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Metadata

Authors
Lei, L., Huang, J., Zhang, L., Hong, Y., Hui, S., & Yang, J.
Venue
Frontiers in Nutrition
Publisher
Frontiers Media SA
Published
2022-08-09
Volume
9
ISSN
2296-861X
DOI
10.3389/fnut.2022.935234
PMC
PMC9397119
Cited by
35
References
24
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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