A Non-calorie-restricted Low-carbohydrate Diet is Effective as an Alternative Therapy for Patients with Type 2 Diabetes
Open accessAbstract
OBJECTIVE: Although caloric restriction is a widely used intervention to reduce body weight and insulin resistance, many patients are unable to comply with such dietary therapy for long periods. The clinical effectiveness of low-carbohydrate diets was recently described in a position statement of Diabetes UK and a scientific review conducted by the American Diabetes Association. However, randomised trials of dietary interventions in Japanese patients with type 2 diabetes are scarce. Therefore, the aim of this study was to examine the effects of a non-calorie-restricted, low-carbohydrate diet in Japanese patients unable to adhere to a calorie-restricted diet. METHODS: The enrolled patients were randomly allocated to receive a conventional calorie-restricted diet or low-carbohydrate diet. The patients received consultations every two months from a registered dietician for six months. We compared the effects of the two dietary interventions on glycaemic control and metabolic profiles. RESULTS: The HbA1c levels decreased significantly from baseline to six months in the low-carbohydrate diet group (baseline 7.6±0.4%, six months 7.0±0.7%, p=0.03) but not in the calorie-restricted group (baseline 7.7±0.6%, six months 7.5±1.0%, n.s.), (between-group comparison, p=0.03). The patients in the former group also experienced improvements in their triglyceride levels, without experiencing any major adverse effects or a decline in the quality of life. CONCLUSION: Our findings suggest that a low-carbohydrate diet is effective in lowering the HbA1c and triglyceride levels in patients with type 2 diabetes who are unable to adhere to a calorie-restricted diet.
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Low-carbohydrate diets have consistently elicited improvements in T2D, metabolic disease, and obesity up to one year.
“Low-carbohydrate diets have consistently elicited improvements in T2D, metabolic disease, and obesity up to one year (21, 22), however, longer-term studies and studies including patients prescribed insulin are limited.”
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- Authors
- Yamada, Y., Uchida, J., Izumi, H., Tsukamoto, Y., Inoue, G., Watanabe, Y., Irie, J., & Yamada, S.
- Affiliations
- Kitasato Institute Hospital (JP)
- Venue
- Internal Medicine
- Published
- 2014
- Volume
- 53
- Issue
- 1
- Pages
- 13-19
- ISSN
- 0918-2918 (ISSN-L)
- 1349-7235
- OpenAlex
- W2080204420
- Cited by
- 133
- References
- 27
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 20 · 2021: 12 · 2020: 17 · 2019: 16 · 2018: 16 · 2017: 9 · 2016: 7 · 2015: 3 · 2014: 1
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 2 diabetes, low-carbohydrate diet, calorie-restricted diet, dietary adherence, glycemic control, HbA1c, triglycerides, Japanese patients
- MeSH terms
- Aged, Complementary Therapies, Blood Glucose, Energy Intake, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Weight Loss, Treatment Outcome, Diet, Carbohydrate-Restricted
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