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New Insights toward Colorectal Cancer Chemotherapy Using Natural Bioactive Compounds
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“Studies have also noted that increase in stabilized p53 increases the expression of the pro-apoptotic Bax protein,70 which destabilizes the mitochondrial membrane potential and makes it porous in nature, which in turn augments release of the apoptotic inducer cytochrome C proteins in the cytoplasm.71”
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Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Chou, T.-C., & Talalay, P. (1984) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(84)90007-4 · Cited by 7,178
Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935 · cited 1×
“Since the publication in 1997 of the chemopreventive activity of topically applied resveratrol in a mouse model of skin cancer (Jang et al., 1997), this natural compound has been extensively studied for the prevention and also treatment of many diseases, including CRC.”
BackgroundMolecular Pathways Involved in Colorectal Cancer: Implications for Disease Behavior and Prevention
Colussi, D., Brandi, G., Bazzoli, F., & Ricciardiello, L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140816365 · Cited by 429
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Antiproliferative and palliative activity of flavonoids in colorectal cancer
Fernández, J., Silván, B., Entrialgo-Cadierno, R., Villar, C. J., Capasso, R., Uranga, J. A., Lombó, F., & Abalo, R. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112241 · Cited by 258
Self-citationMishra, S., das, K., Chatterjee, S., Sahoo, P., Kundu, S., Pal, M., Bhaumik, A., & Ghosh, C. K. (2023) · ACS Omega · doi:10.1021/acsomega.2c04964 · Cited by 65
Metadata
- Authors
- Redondo-Blanco, S., Fernández, J., Gutiérrez-del-Río, I., Villar, C. J., & Lombó, F.
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2017-03-14
- Volume
- 8
- ISSN
- 1663-9812
- PMC
- PMC5348533
- Cited by
- 113
- References
- 5
- Funders
- Ministerio de Economía y Competitividad (AGL-2010-20622)
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