Cited by 113

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

New Insights toward Colorectal Cancer Chemotherapy Using Natural Bioactive Compounds

Redondo-Blanco, Saúl, Fernández, Javier, Gutiérrez-del-Río, Ignacio, Villar, Claudio J., Lombó, Felipe·2017·Frontiers in Pharmacology

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fphar.2017.00109

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 Chemical structures of bioactive stilbenes and flavonoids described in the text. (A) Resveratrol, (B) pterostilbene, (C) isoliquiritigenin, (D) apigenin, (E) chrysin, (F) quercetin, (G) oroxylin, (H) kaempferol, (I) genistein, (J) flavopiridol, (K) silibinin, (L) scutellarin, (M) EGCG.
Figure 1 Chemical structures of bioactive stilbenes and flavonoids described in the text. (A) Resveratrol, (B) pterostilbene, (C) isoliquiritigenin, (D) apigenin, (E) chrysin, (F) quercetin, (G) oroxylin, (H) kaempferol, (I) genistein, (J) flavopiridol, (K) silibinin, (L) scutellarin, (M) EGCG.CC BY · PubMed Central
Figure 2 Chemical structures of bioactive terpenoids and other compounds described in the text. (A) geraniol, (B) irofulven, (C) artesunate, (D) triptolide, (E) ursolic acid, (F) ginsenoside, (G) celastrol, (H) betulinic acid, (I) fucoxanthin, (J) curcumin, (K) gossypol.
Figure 2 Chemical structures of bioactive terpenoids and other compounds described in the text. (A) geraniol, (B) irofulven, (C) artesunate, (D) triptolide, (E) ursolic acid, (F) ginsenoside, (G) celastrol, (H) betulinic acid, (I) fucoxanthin, (J) curcumin, (K) gossypol.CC BY · PubMed Central
Figure 3 Chemotherapy compounds that have been mentioned in this work and their main side effects.
Figure 3 Chemotherapy compounds that have been mentioned in this work and their main side effects.CC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 5 references

Research works printed but not linked: 192

  1. Achenbach, 2000, Bcl-2 independence of flavopiridol-induced apoptosis. Mitochondrial depolarization in the absence of cytochrome c release, J. Biol. Chem., 275, 32089, 10.1074/jbc.M005267200 · DOI
  2. Adachi, 2008, (-)-Epigallocatechin gallate causes internalization of the epidermal growth factor receptor in human colon cancer cells, Carcinogenesis, 29, 1986, 10.1093/carcin/bgn128 · DOI
  3. Adachi, 2009, (-)-Epigallocatechin gallate downregulates EGF receptor via phosphorylation at Ser1046/1047 by p38 MAPK in colon cancer cells, Carcinogenesis, 30, 1544, 10.1093/carcin/bgp166 · DOI
  4. Aggarwal, 2013, Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: identification of novel components of turmeric, Mol. Nutr. Food Res., 57, 1529, 10.1002/mnfr.201200838 · DOI
  5. Ali, 2014, Resveratrol enhances mitomycin C-mediated suppression of human colorectal cancer cell proliferation by up-regulation of p21WAF1/CIP1, Anticancer Res., 34, 5439
  6. Almasan, 2003, Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy, Cytokine Growth Factor Rev., 14, 337, 10.1016/S1359-6101(03)00029-7 · DOI
  7. Ambrosini, 2008, The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner, Cancer Res., 68, 2312, 10.1158/0008-5472.CAN-07-2395 · DOI
  8. Amiri, 2013, Synergistic anti-proliferative effect of resveratrol and etoposide on human hepatocellular and colon cancer cell lines, Eur. J. Pharmacol., 718, 34, 10.1016/j.ejphar.2013.09.020 · DOI
  9. Anitha, 2014, In vitro combinatorial anticancer effects of 5-fluorouracil and curcumin loaded N,O-carboxymethyl chitosan nanoparticles toward colon cancer and in vivo pharmacokinetic studies, Eur. J. Pharm. Biopharm., 88, 238, 10.1016/j.ejpb.2014.04.017 · DOI
  10. Bar-Sela, 2010, Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications, Curr. Med. Chem., 17, 190, 10.2174/092986710790149738 · DOI
  11. Bode, 2013, In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota, Am. J. Clin. Nutr., 97, 295, 10.3945/ajcn.112.049379 · DOI
  12. Braun, 2011, Balancing the efficacy and toxicity of chemotherapy in colorectal cancer, Ther. Adv. Med. Oncol., 3, 43, 10.1177/1758834010388342 · DOI · Paper page
  13. Bray, 2013, Global estimates of cancer prevalence for 27 sites in the adult population in 2008, Int. J. Cancer, 132, 1133, 10.1002/ijc.27711 · DOI
  14. Britten, 1999, Enhanced antitumor activity of 6-hydroxymethylacylfulvene in combination with irinotecan and 5-fluorouracil in the HT29 human colon tumor xenograft model, Cancer Res., 59, 1049
  15. Brown, 2010, Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis, Cancer Res., 70, 9003, 10.1158/0008-5472.CAN-10-2364 · DOI
  16. Buhrmann, 2015, Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, Epithelial-to-mesenchymal transition and apoptosis in colorectal cancer, Biochem. Pharmacol., 98, 51, 10.1016/j.bcp.2015.08.105 · DOI
  17. Burns, 2002, Plant foods and herbal sources of resveratrol, J. Agric. Food Chem., 50, 3337, 10.1021/jf0112973 · DOI
  18. Carnesecchi, 2004, Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts, Cancer Lett., 215, 53, 10.1016/j.canlet.2004.06.019 · DOI
  19. Caro, 2004, Oxidative stress, toxicology, and pharmacology of CYP2E1, Annu. Rev. Pharmacol. Toxicol., 44, 27, 10.1146/annurev.pharmtox.44.101802.121704 · DOI
  20. Carter, 2014, Resveratrol and cancer: focus on in vivo evidence, Endocr. Relat. Cancer, 21, R209, 10.1530/ERC-13-0171 · DOI
  21. Chan, 2009, Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation, Anticancer Res., 29, 3043
  22. Chauhan, 2002, Chemotherapeutic potential of curcumin for colorectal cancer, Curr. Pharm. Des., 8, 1695, 10.2174/1381612023394016 · DOI
  23. Cheah, 2014, Low molecular weight procyanidins from grape seeds enhance the impact of 5-Fluorouracil chemotherapy on Caco-2 human colon cancer cells, PLoS ONE, 9, e98921, 10.1371/journal.pone.0098921 · DOI
  24. Chen, 2004, Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships, Mol. Pharmacol., 66, 683, 10.1124/mol.66.3 · DOI
  25. Chen, 2002, TNF-R1 signaling: a beautiful pathway, Science, 296, 1634, 10.1126/science.1071924 · DOI
  26. Chen, 2000, Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor- kappaB activation, Biochem. Pharmacol., 59, 1445, 10.1016/S0006-2952(00)00255-0 · DOI
  27. Cho, 2013, Kaempferol induces cell cycle arrest in HT-29 human colon cancer cells, J. Cancer Prev., 18, 1, 10.15430/JCP.2013.18.3.257 · DOI
  28. Colombo, 2011, Chemotherapeutic activity of silymarin combined with doxorubicin or paclitaxel in sensitive and multidrug-resistant colon cancer cells, Cancer Chemother. Pharmacol., 67, 369, 10.1007/s00280-010-1335-8 · DOI
  29. Darpolor, 2011, Preclinical study of treatment response in HCT-116 cells and xenografts with 1H-decoupled 31P MRS, NMR Biomed., 24, 1159, 10.1002/nbm.1674 · DOI
  30. Dasari, 2014, Cisplatin in cancer therapy: molecular mechanisms of action, Eur. J. Pharmacol., 740, 364, 10.1016/j.ejphar.2014.07.025 · DOI · Paper page
  31. Del Follo-Martinez, 2013, Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a, Nutr. Cancer, 65, 494, 10.1080/01635581.2012.725194 · DOI
  32. Ding, 2012, Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression, J. Biol. Chem., 287, 641, 10.1074/jbc.M111.286526 · DOI
  33. Du, 2006, Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29, Chemotherapy, 52, 23, 10.1159/000090238 · DOI
  34. Du, 2016, BAY61-3606 potentiates the anti-tumor effects of TRAIL against colon cancer through up-regulating DR4 and down-regulating NF-κB, Cancer Lett., 383, 145, 10.1016/j.canlet.2016.10.002 · DOI
  35. Engelmann, 2002, Apigenin – strong cytostatic and anti-angiogenic action in vitro contrasted by lack of efficacy in vivo, Phytomedicine, 9, 489, 10.1078/09447110260573100 · DOI
  36. Erdogan, 2016, The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-κB signaling, Life Sci., 162, 77, 10.1016/j.lfs.2016.08.019 · DOI
  37. Evangelou, 2002, Vanadium in cancer treatment, Crit. Rev. Oncol. Hematol., 42, 249, 10.1016/S1040-8428(01)00221-9 · DOI
  38. Ferlay, 2015, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012, Int. J. Cancer, 136, E359, 10.1002/ijc.29210 · DOI · Paper page
  39. Fernández, 2016, Colon microbiota fermentation of dietary prebiotics towards short-chain fatty acids and their roles as anti-inflammatory and antitumour agents: a review, J. Funct. Foods, 25, 511, 10.1016/j.jff.2016.06.032 · DOI
  40. Fidler, 2003, PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy, Mol. Cancer Ther., 2, 855
  41. Fornier, 2007, Phase I dose-finding study of weekly docetaxel followed by flavopiridol for patients with advanced solid tumors, Clin. Cancer Res., 13, 5841, 10.1158/1078-0432.CCR-07-1218 · DOI
  42. Fuchs, 2003, Phase III comparison of two irinotecan dosing regimens in second-line therapy of metastatic colorectal cancer, J. Clin. Oncol., 21, 807, 10.1200/JCO.2003.08.058 · DOI
  43. Fulda, 2004, Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol, Oncogene, 23, 6702, 10.1038/sj.onc.1207630 · DOI
  44. Ganai, 2015, Bioactivity of genistein: a review of in vitro and in vivo studies, Biomed. Pharmacother., 76, 30, 10.1016/j.biopha.2015.10.026 · DOI
  45. Gao, 2013, Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways, Oncol. Rep., 30, 292, 10.3892/or.2013.2438 · DOI
  46. Gescher, 2013, Resveratrol in the management of human cancer: how strong is the clinical evidence?, Ann. N.Y. Acad. Sci., 1290, 12, 10.1111/nyas.12205 · DOI
  47. Goel, 2008, Curcumin as “Curecumin”: from kitchen to clinic, Biochem. Pharmacol., 75, 787, 10.1016/j.bcp.2007.08.016 · DOI
  48. Gruca, 2014, Synthetic genistein glycosides inhibiting egfr phosphorylation enhance the effect of radiation in HCT 116 colon cancer cells, Molecules, 19, 18558, 10.3390/molecules191118558 · DOI
  49. Guo, 2008, Biotransformation of the chemopreventive agent 2′,4′,4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases, Drug Metab. Dispos., 36, 2104, 10.1124/dmd.108.021857 · DOI
  50. Guo, 2006, Efficacy of sequential treatment of HCT116 colon cancer monolayers and xenografts with docetaxel, flavopiridol, and 5-fluorouracil, Acta Pharmacol. Sin., 27, 1375, 10.1111/j.1745-7254.2006.00421.x · DOI
  51. Gupta, 2011, Chemosensitization of tumors by resveratrol, Ann. N.Y. Acad. Sci., 1215, 150, 10.1111/j.1749-6632.2010.05852.x · DOI
  52. Gupta, 2013, Therapeutic roles of curcumin: lessons learned from clinical trials, AAPS J., 15, 195, 10.1208/s12248-012-9432-8 · DOI
  53. Gutiérrez-del-Río, 2016, Chapter 3. Therapeutic uses of kaempferol: anticancer and anti-inflammatory activity, 71
  54. Ha, 2012, Oroxylin A improves the sensitivity of HT-29 human colon cancer cells to 5-FU through modulation of the COX-2 signaling pathway, Biochem. Cell Biol., 90, 521, 10.1139/o2012-005 · DOI
  55. Hanif, 1997, Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway, J. Lab. Clin. Med., 130, 576, 10.1016/S0022-2143(97)90107-4 · DOI
  56. Harborne, 2000, Advances in flavonoid research since 1992, Phytochemistry, 55, 481, 10.1016/S0031-9422(00)00235-1 · DOI · Paper page
  57. Hirano, 1989, Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1, Res. Commun. Chem. Pathol. Pharmacol., 64, 69
  58. Ho, 2014, Presentation and management of docetaxel-related adverse effects in patients with breast cancer, Cancer Manag. Res., 6, 253, 10.2147/CMAR.S40601 · DOI
  59. Horinaka, 2006, The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand, Mol. Cancer Ther., 5, 945, 10.1158/1535-7163.MCT-05-0431 · DOI
  60. Hosokawa, 2004, Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells, Biochim. Biophys. Acta, 1675, 113, 10.1016/j.bbagen.2004.08.012 · DOI
  61. Housman, 2014, Drug resistance in cancer: an overview, Cancers (Basel)., 6, 1769, 10.3390/cancers6031769 · DOI · Paper page
  62. Hu, 2014, Genistein modulates the anti-tumor activity of cisplatin in MCF-7 breast and HT-29 colon cancer cells, Arch. Toxicol., 88, 625, 10.1007/s00204-013-1184-4 · DOI
  63. Huang, 1994, Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice, Cancer Res., 54, 5841
  64. Huang, 1992, Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene, Carcinogenesis, 13, 2183, 10.1093/carcin/13.11.2183 · DOI
  65. Hwang, 2005, Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways, Biochem. Biophys. Res. Commun., 332, 433, 10.1016/j.bbrc.2005.04.143 · DOI
  66. Hwang, 2007b, Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway, Cancer Lett., 247, 115, 10.1016/j.canlet.2006.03.030 · DOI
  67. Hwang, 2007a, Resveratrol induces apoptosis in chemoresistant cancer cells via modulation of AMPK signaling pathway, Ann. N.Y. Acad. Sci., 1095, 441, 10.1196/annals.1397.047 · DOI
  68. Jagetia, 2007, Recent advances in indian herbal drug research guest editor: thomas paul asir devasagayam radioprotective potential of plants and herbs against the effects of ionizing radiation, J. Clin. Biochem. Nutr., 40, 74, 10.3164/jcbn.40.74 · DOI
  69. James, 2015, Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy, Cancer Lett., 364, 135, 10.1016/j.canlet.2015.05.005 · DOI
  70. Jiang, 2001, Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells, Oncogene, 20, 8009, 10.1038/sj.onc.1204981 · DOI
  71. Jin, 2013, Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling, Onco Targets Ther., 6, 145, 10.2147/OTT.S40914 · DOI
  72. Jin, 2003, Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells, Carcinogenesis, 24, 1767, 10.1093/carcin/bgg097 · DOI
  73. Jung, 2007, Effect of betulinic acid on anticancer drug-resistant colon cancer cells, Basic Clin. Pharmacol. Toxicol., 101, 277, 10.1111/j.1742-7843.2007.00115.x · DOI
  74. Kaminski, 2014, Resveratrol-induced potentiation of the antitumor effects of oxaliplatin is accompanied by an altered cytokine profile of human monocyte-derived macrophages, Apoptosis, 19, 1136, 10.1007/s10495-014-0988-x · DOI
  75. Kantara, 2014, Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA, Cancer Res., 74, 2487, 10.1158/0008-5472.CAN-13-3536 · DOI
  76. Karin, 2004, The IKK NF-kappa B system: a treasure trove for drug development, Nat. Rev. Drug Discov., 3, 17, 10.1038/nrd1279 · DOI · Paper page
  77. Kasala, 2015, Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives, Toxicol. Lett., 233, 214, 10.1016/j.toxlet.2015.01.008 · DOI
  78. Katayama, 2007, Flavonoids inhibit breast cancer resistance protein-mediated drug resistance: transporter specificity and structure-activity relationship, Cancer Chemother. Pharmacol., 60, 789, 10.1007/s00280-007-0426-7 · DOI
  79. Kawamori, 1999, Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer, Cancer Res., 59, 597
  80. Kelland, 2000, Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status, Expert Opin. Investig. Drugs, 9, 2903, 10.1517/13543784.9.12.2903 · DOI
  81. Khan, 2012, Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53, Toxicol. Appl. Pharmacol., 258, 315, 10.1016/j.taap.2011.11.013 · DOI
  82. Kim, 1998, Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation, Carcinogenesis, 19, 81, 10.1093/carcin/19.1.81 · DOI
  83. Kim, 2009, Inhibition of NF-kB by ginsenoside Rg3 enhances the susceptibility of colon cancer cells to docetaxel, Arch. Pharm. Res., 32, 755, 10.1007/s12272-009-1515-4 · DOI
  84. Klein-Marcuschamer, 2007, Engineering microbial cell factories for biosynthesis of isoprenoid molecules: beyond lycopene, Trends Biotechnol., 25, 417, 10.1016/j.tibtech.2007.07.006 · DOI
  85. Koh, 2012, Sensitization of ionizing radiation-induced apoptosis by ursolic acid, Free Radic. Res., 46, 339, 10.3109/10715762.2012.656101 · DOI
  86. Kumar, 2007, Chemistry and biological activities of flavonoids: an overview, Sci. World J., 73, 637, 10.1155/2013/162750 · DOI
  87. Kumar, 2013, Chemistry and biological activities of flavonoids: an overview, Sci. World J., 2013, 162750, 10.1155/2013/162750 · DOI
  88. Kumazaki, 2013, Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells, J. Nutr. Biochem., 24, 1849, 10.1016/j.jnutbio.2013.04.006 · DOI
  89. Kunnumakkara, 2009, Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model, Int. J. Cancer, 125, 2187, 10.1002/ijc.24593 · DOI
  90. Lan, 2015, Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1, Mol. Oncol., 9, 1406, 10.1016/j.molonc.2015.03.014 · DOI
  91. Lee, 2008, Isoliquiritigenin inhibits tumor growth and protects the kidney and liver against chemotherapy-induced toxicity in a mouse xenograft model of colon carcinoma, J. Pharmacol. Sci., 106, 444, 10.1254/jphs.FP0071498 · DOI
  92. Lee, 2014a, Kaempferol Downregulates Insulin-like growth factor-I receptor and ErbB3 signaling in HT-29 human colon cancer cells, J. Cancer Prev., 19, 161, 10.15430/JCP.2014.19.3.161 · DOI
  93. Lee, 2014b, Mechanisms underlying apoptosis-inducing effects of kaempferol in HT-29 human colon cancer cells, Int. J. Mol. Sci., 15, 2722, 10.3390/ijms15022722 · DOI
  94. Lee, 2006, Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry, J. Chromatogr. A, 1116, 57, 10.1016/j.chroma.2006.03.053 · DOI
  95. Lee, 2014, Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells, Int. J. Oncol., 44, 1599, 10.3892/ijo.2014.2339 · DOI
  96. Lefort, 2011, The dietary flavonoid apigenin enhances the activities of the anti-metastatic protein CD26 on human colon carcinoma cells, Clin. Exp. Metastasis, 28, 337, 10.1007/s10585-010-9364-6 · DOI
  97. León, 2015, Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model, J. Biol. Inorg. Chem., 20, 1175, 10.1007/s00775-015-1298-7 · DOI
  98. Li, 2007, Liposomal curcumin with and without oxaliplatin: effects on cell growth, apoptosis, and angiogenesis in colorectal cancer, Mol. Cancer Ther., 6, 1276, 10.1158/1535-7163.MCT-06-0556 · DOI
  99. Li, 2009, Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia mutated-p53 pathway with the involvement of p53 upregulated modulator of apoptosis, Chem. Biol. Interact., 177, 121, 10.1016/j.cbi.2008.10.048 · DOI
  100. Li, 2010, Chrysin sensitizes tumor necrosis factor-α-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB, Cancer Lett., 293, 109, 10.1016/j.canlet.2010.01.002 · DOI
  101. Li, 2009, Panaxadiol, a purified ginseng component, enhances the anti-cancer effects of 5-fluorouracil in human colorectal cancer cells, Cancer Chemother. Pharmacol., 64, 1097, 10.1007/s00280-009-0966-0 · DOI
  102. Liu, 2011, The antimalarial agent artesunate possesses anticancer properties that can be enhanced by combination strategies, Int. J. Cancer, 128, 1471, 10.1002/ijc.25707 · DOI
  103. Liu, 2014, Triptolide synergistically enhances antitumor activity of oxaliplatin in colon carcinoma in vitro and in vivo, DNA Cell Biol., 33, 418, 10.1089/dna.2014.2356 · DOI
  104. Luo, 2014, Apoptotic effect of genistein on human colon cancer cells via inhibiting the nuclear factor-kappa B (NF-B) pathway, Tumour Biol., 35, 11483, 10.1007/s13277-014-2487-7 · DOI
  105. Majumdar, 2009, Curcumin synergizes with resveratrol to inhibit colon cancer, Nutr. Cancer, 61, 544, 10.1080/01635580902752262 · DOI
  106. Marín, 2015, Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties, Biomed Res. Int., 2015, 905215, 10.1155/2015/905215 · DOI
  107. Merrill, 2011, Risk-adjusted colon and rectal cancer incidence rates in the United States, Dis. Colon Rectum, 54, 1301, 10.1097/DCR.0b013e3182242bd3 · DOI
  108. Mertens-Talcott, 2005, Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells, Cancer Lett., 218, 141, 10.1016/j.canlet.2004.06.007 · DOI
  109. Meshnick, 2002, Artemisinin: mechanisms of action, resistance and toxicity, Int. J. Parasitol., 32, 1655, 10.1016/S0020-7519(02)00194-7 · DOI
  110. Misawa, 2011, Pathway engineering for functional isoprenoids, Curr. Opin. Biotechnol., 22, 627, 10.1016/j.copbio.2011.01.002 · DOI
  111. Miyamoto, 2006, Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats, Oncol. Rep., 15, 1169, 10.3892/or.15.5.1169 · DOI
  112. Miyamoto, 2010, Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice, Chem. Biol. Interact., 183, 276, 10.1016/j.cbi.2009.11.002 · DOI
  113. Mizushina, 2013, Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase II activity and cancer cell proliferation, Int. J. Oncol., 43, 1117, 10.3892/ijo.2013.2032 · DOI
  114. Mohapatra, 2011, 5-fluorouracil increases the chemopreventive potentials of resveratrol through DNA damage and MAPK signaling pathway in human colorectal cancer cells, Oncol. Res., 19, 311, 10.3727/096504011X13079697132844 · DOI
  115. Morin, 1997, Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC, Science, 275, 1787, 10.1126/science.275.5307.1787 · DOI
  116. Morris, 2016, Reduction in promotor methylation utilizing EGCG (Epigallocatechin-3-gallate) restores RXRalpha expression in human colon cancer cells, Oncotarget, 7, 11, 10.18632/oncotarget.9204 · DOI
  117. Moseley, 2013, Green tea polyphenol epigallocatechin 3-gallate, contributes to the degradation of DNMT3A and HDAC3 in HCT 116 human colon cancer cells, Anticancer Res., 33, 5325
  118. Motwani, 2001, Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts, Clin. Cancer Res., 7, 4209
  119. Murakami, 2013, Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis, Biofactors, 39, 221, 10.1002/biof.1054 · DOI
  120. Nautiyal, 2011, Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells, J. Mol. Signal., 6, 7, 10.1186/1750-2187-6-7 · DOI
  121. Newcomb, 2004, Flavopiridol: pleiotropic biological effects enhance its anti-cancer activity, Anticancer Drugs, 15, 411, 10.1097/01.cad.0000127332.06439.47 · DOI
  122. Ohishi, 2002, Synergistic effects of (-)-epigallocatechin gallate with sulindac against colon carcinogenesis of rats treated with azoxymethane, Cancer Lett., 177, 118, 10.1016/S0304-3835(01)00767-4 · DOI
  123. Osman, 2015, Luteolin supplementation adjacent to aspirin treatment reduced dimethylhydrazine-induced experimental colon carcinogenesis in rats, Tumour Biol., 36, 1179, 10.1007/s13277-014-2678-2 · DOI
  124. Pampaloni, 2014, In vitro effects of polyphenols on colorectal cancer cells, World J. Gastrointest. Oncol., 6, 289, 10.4251/wjgo.v6.i8.289 · DOI
  125. Pan, 2011, Molecular mechanisms for chemoprevention of colorectal cancer by natural dietary compounds, Mol. Nutr. Food Res., 55, 32, 10.1002/mnfr.201000412 · DOI
  126. Park, 2001, Synergistic effects of dexamethasone and genistein on the expression of Cdk inhibitor p21WAF1/CIP1 in human hepatocellular and colorectal carcinoma cells, Int. J. Oncol., 18, 997, 10.3892/ijo.18.5.997 · DOI
  127. Park, 1999, Glucocorticoid receptor-induced down-regulation of MMP-9 by ginseng components, PD and PT contributes to inhibition of the invasive capacity of HT1080 human fibrosarcoma cells, Mol. Cells, 9, 476, 10.1016/S1016-8478(23)13573-4 · DOI
  128. Patel, 2008, Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R, Int. J. Cancer, 122, 267, 10.1002/ijc.23097 · DOI
  129. Patel, 2010, Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients, Cancer Res., 70, 7392, 10.1158/0008-5472.CAN-10-2027 · DOI
  130. Pavlidis, 2013, Role of bevacizumab in colorectal cancer growth and its adverse effects: a review, World J. Gastroenterol., 19, 5051, 10.3748/wjg.v19.i31.5051 · DOI
  131. Perkins, 2002, Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis, Cancer Epidemiol. Biomarkers Prev., 11, 535
  132. Poindessous, 2003, Enhanced antitumor activity of irofulven in combination with 5-fluorouracil and cisplatin in human colon and ovarian carcinoma cells, Int. J. Oncol., 23, 1347, 10.3892/ijo.23.5.1347 · DOI
  133. Prasad, 2014, Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice, Cancer Res. Treat., 46, 2, 10.4143/crt.2014.46.1.2 · DOI
  134. Prasad, 2012, Ursolic acid inhibits growth and metastasis of human, colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine, Clin. Cancer Res., 18, 4942, 10.1158/1078-0432.CCR-11-2805 · DOI
  135. Psahoulia, 2007, Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts, Mol. Cancer Ther., 6, 2591, 10.1158/1535-7163.MCT-07-0001 · DOI
  136. Ranelletti, 2000, Quercetin inhibits p21-RAS expression in human colon cancer cell lines and in primary colorectal tumors, Int. J. Cancer, 85, 438, 10.1002/(SICI)1097-0215(20000201)85:3438::AID-IJC223.0.CO;2-F · DOI
  137. Rao, 1993, Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon, Carcinogenesis, 14, 2219, 10.1093/carcin/14.11.2219 · DOI
  138. Ravindran, 2009, Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?, AAPS J., 11, 495, 10.1208/s12248-009-9128-x · DOI
  139. Reddivari, 2016, Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis, BMC Complement. Altern. Med., 16, 278, 10.1186/s12906-016-1254-2 · DOI
  140. Renuka, 2016, Chrysin, a flavonoid attenuates histological changes of hyperammonemic rats: a dose dependent study, Biomed. Pharmacother., 82, 345, 10.1016/j.biopha.2016.05.013 · DOI
  141. Romier, 2008, Modulation of signalling nuclear factor-kappaB activation pathway by polyphenols in human intestinal Caco-2 cells, Br. J. Nutr., 100, 542, 10.1017/S0007114508966666 · DOI
  142. Ronnekleiv-Kelly, 2012, Chrysin activates the aryl hydrocarbon receptor and reduces colon cancer cell viability, J. Surg. Res., 172, 305, 10.1016/j.jss.2011.11.536 · DOI
  143. Rossi, 2006, Flavonoids and colorectal cancer in Italy, Cancer Epidemiol. Biomarkers Prev., 15, 1555, 10.1158/1055-9965.EPI-06-0017 · DOI
  144. Rotches-Ribalta, 2012, Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets, Pharmacol. Res., 66, 375, 10.1016/j.phrs.2012.08.001 · DOI
  145. Saldanha, 2014, Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate, Exp. Cell Res., 324, 40, 10.1016/j.yexcr.2014.01.024 · DOI
  146. Santandreu, 2011, Resveratrol potentiates the cytotoxic oxidative stress induced by chemotherapy in human colon cancer cells, Cell. Physiol. Biochem., 28, 219, 10.1159/000331733 · DOI
  147. Serova, 2006, Characterizations of irofulven cytotoxicity in combination with cisplatin and oxaliplatin in human colon, breast, and ovarian cancer cells, Cancer Chemother. Pharmacol., 57, 491, 10.1007/s00280-005-0063-y · DOI
  148. Shao, 2013, Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263, Mol. Cancer Ther., 12, 2640, 10.1158/1535-7163.MCT-13-0066 · DOI
  149. Shi, 2015, Apigenin, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis, Cancer Cell Int., 15, 33, 10.1186/s12935-015-0186-0 · DOI
  150. Shimizu, 2005, (-)-Epigallocatechin gallate and polyphenon e inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells, Clin. Cancer Res., 11, 2735, 10.1158/1078-0432.ccr-04-2014 · DOI
  151. Singh, 2011, Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications, Biochem. Pharmacol., 82, 1807, 10.1016/j.bcp.2011.07.093 · DOI
  152. Singh, 2013, Resveratrol-based combinatorial strategies for cancer management, Ann. N.Y. Acad. Sci., 1290, 113, 10.1111/nyas.12160 · DOI
  153. Singh, 2016, Review on EGFR inhibitors: critical updates, Mini Rev. Med. Chem., 16, 1134, 10.2174/1389557516666160321114917 · DOI
  154. Son, 2013, Protective effect of genistein on radiation-induced intestinal injury in tumor bearing mice, BMC Complement. Altern. Med., 13, 103, 10.1186/1472-6882-13-103 · DOI
  155. Sparks, 1998, Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer, Cancer Res., 58, 1130
  156. Spector, 2003, Soy consumption and colorectal cancer, Nutr. Cancer, 47, 1, 10.1207/s15327914nc4701_1 · DOI
  157. Srimuangwong, 2012a, Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells, World J. Gastroenterol., 18, 2383, 10.3748/wjg.v18.i19.2383 · DOI
  158. Srimuangwong, 2012b, Effects of hexahydrocurcumin in combination with 5-fuorouracil on dimethylhydrazine-induced colon cancer in rats, World J. Gastroenterol., 18, 6951, 10.3748/wjg.v18.i47.6951 · DOI
  159. Suganuma, 1999, Synergistic effects of (–)-epigallocatechin gallate with (–)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9, Cancer Res., 59, 44
  160. Takada, 2004, Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalphakinase and p65 phosphorylation. Abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9, J. Biol. Chem., 279, 4750, 10.1074/jbc.M304546200 · DOI
  161. Tallarida, 2002, The interaction index: a measure of drug synergism, Pain, 98, 163, 10.1016/S0304-3959(02)00041-6 · DOI
  162. Tang, 2007, Synergistic effect of triptolide combined with 5-fluorouracil on colon carcinoma, Postgrad. Med. J., 83, 338, 10.1136/pgmj.2006.055426 · DOI
  163. Thorn, 2011, Doxorubicin pathways: pharmacodynamics and adverse effects, Pharmacogenet. Genomics, 21, 440, 10.1097/FPC.0b013e32833ffb56 · DOI
  164. Tolba, 2015, Pterostilbine, an active component of blueberries, sensitizes colon cancer cells to 5-fluorouracil cytotoxicity, Sci. Rep., 5, 15239, 10.1038/srep15239 · DOI
  165. Tolcher, 2015, Safety, efficacy, and pharmacokinetics of navitoclax (ABT-263) in combination with irinotecan: results of an open-label, phase 1 study, Cancer Chemother. Pharmacol., 76, 1041, 10.1007/s00280-015-2882-9 · DOI
  166. Tsai, 2015, Increase in apoptosis by combination of metformin with silibinin in human colorectal cancer cells, World J. Gastroenterol., 21, 4169, 10.3748/wjg.v21.i14.4169 · DOI
  167. Tsai, 2011, Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration, Int. J. Pharm., 416, 331, 10.1016/j.ijpharm.2011.06.030 · DOI
  168. van der Stok, 2016, Surveillance after curative treatment for colorectal cancer, Nat. Rev. Clin. Oncol., 10.1038/nrclinonc.2016.199 · DOI
  169. Vieira, 2011, Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis, Brazilian J. Med. Biol. Res., 44, 538, 10.1590/S0100-879X2011000600007 · DOI
  170. Walle, 2004, High absorption but very low bioavailability of oral resveratrol in humans, Drug Metab. Dispos., 32, 1377, 10.1124/dmd.104.000885 · DOI
  171. Wang, 2007a, Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells, Cancer Chemother. Pharmacol., 60, 69, 10.1007/s00280-006-0350-2 · DOI
  172. Wang, 2007b, Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells, Int. J. Oncol., 31, 1149
  173. Wang, 2015, Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer, Nutrients, 7, 799, 10.3390/nu7020799 · DOI
  174. Wang, 2004, Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines, Nutr. Cancer, 48, 106, 10.1207/s15327914nc4801_14 · DOI
  175. Wubetu, 2015, Epigallocatechin gallate hinders human hepatoma and colon cancer sphere formation, J. Gastroenterol. Hepatol., 31, 256, 10.1111/jgh.13069 · DOI
  176. Xavier, 2011, Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation, Cancer Chemother. Pharmacol., 68, 1449, 10.1007/s00280-011-1641-9 · DOI
  177. Xiao, 2015, Genistein suppresses FLT4 and inhibits human colorectal cancer metastasis, Oncotarget, 6, 3225, 10.18632/oncotarget.3064 · DOI
  178. Xing, 2011, Metabolic and pharmacokinetic studies of scutellarin in rat plasma, urine, and feces, Acta Pharmacol. Sin., 32, 655, 10.1038/aps.2011.11 · DOI
  179. Yallapu, 2012, Curcumin nanoformulations: a future nanomedicine for cancer, Drug Discov. Today, 17, 71, 10.1016/j.drudis.2011.09.009 · DOI
  180. Yang, 2015, Gossypol sensitizes the antitumor activity of 5-FU through down-regulation of thymidylate synthase in human colon carcinoma cells, Cancer Chemother. Pharmacol., 76, 575, 10.1007/s00280-015-2749-0 · DOI
  181. Yang, 2015, Enhanced action of apigenin and naringenin combination on estrogen receptor activation in non-malignant colonocytes: implications on sorghum-derived phytoestrogens, Food Funct., 6, 749, 10.1039/C4FO00300D · DOI
  182. Yang, 2014, Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents, Life Sci., 100, 75, 10.1016/j.lfs.2014.01.075 · DOI
  183. Yang, 2015, Resveratrol elicits anti-colorectal cancer effect by activating miR-34c-KITLG in vitro and in vivo, BMC Cancer, 15, 969, 10.1186/s12885-015-1958-6 · DOI
  184. Yoshida, 2008, Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis, Biochem. Biophys. Res. Commun., 375, 129, 10.1016/j.bbrc.2008.07.131 · DOI
  185. Yu, 2004, Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells, Cancer Lett., 215, 159, 10.1016/j.canlet.2004.06.010 · DOI
  186. Yue, 2016b, Turmeric ethanolic extract possesses stronger inhibitory activities on colon tumour growth than curcumin - the importance of turmerones, J. Funct. Foods, 22, 565, 10.1016/j.jff.2016.02.011 · DOI
  187. Yue, 2016a, Combined therapy using bevacizumab and turmeric ethanolic extract (with absorbable curcumin) exhibited beneficial efficacy in colon cancer mice, Pharmacol. Res., 111, 43, 10.1016/j.phrs.2016.05.025 · DOI
  188. Zhang, 2003, Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells, Biochem. Pharmacol., 66, 93, 10.1016/S0006-2952(03)00248-X · DOI
  189. Zhang, 2013, Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/β-catenin signalling and reduces colon pre-neoplasia in rats. Br. J, Nutr, 109, 33, 10.1017/S0007114512000876 · DOI
  190. Zhong, 2010, Molecular targets of apigenin in colorectal cancer cells: involvement of p21, NAG-1 and p53, Eur. J. Cancer, 46, 3365, 10.1016/j.ejca.2010.07.007 · DOI
  191. Zhou, 2012, Epigallocatechin-3-gallate inhibits proliferation and migration of human colon cancer SW620 cells in vitro, Acta Pharmacol. Sin., 33, 120, 10.1038/aps.2011.139 · DOI
  192. Zhu, 2010, Synergistic anti-cancer activity by the combination of TRAIL/APO-2L and celastrol, Cancer Invest., 28, 23, 10.3109/07357900903095664 · DOI

Cited by

Sorted by citations

See all 113

Metadata

Authors
Redondo-Blanco, S., Fernández, J., Gutiérrez-del-Río, I., Villar, C. J., & Lombó, F.
Venue
Frontiers in Pharmacology
Published
2017-03-14
Volume
8
ISSN
1663-9812
Cited by
113
References
5
Funders
Ministerio de Economía y Competitividad (AGL-2010-20622)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: New Insights toward Colorectal Cancer Chemotherapy Using Natural Bioactive Compounds. https://app.cochat.ai/papers/10.3389/fphar.2017.00109
The paper
Redondo-Blanco, S., Fernández, J., Gutiérrez-del-Río, I., Villar, C. J., & Lombó, F. (2017). New Insights toward Colorectal Cancer Chemotherapy Using Natural Bioactive Compounds. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2017.00109