PreprintCited by 165Adipose Tissue and MetabolismPeroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases

Molecular determinants of brown adipocyte formation and function: Figure 1.

Open access
Farmer, Stephen R.·2008·Genes & Development

Abstract

Humans contain essentially two types of adipose tissue: brown adipose tissue (BAT) and white adipose tissue (WAT). The function of WAT is to store fat while that of BAT is to burn fat for heat production. A potential strategy to combat obesity and its related disorders is to induce the conversion of WAT into BAT. In this issue of Genes & Development, Kajimura and colleagues (pp. 1397–1409) have identified a mechanism by which PRDM16, the principal regulator of brown adipocyte formation and function, can simultaneously induce BAT gene expression, while suppressing WAT gene expression. The studies suggest that PRDM16 and its associated coregulators PPARγ coactivator-1α (PGC-1α) and C-terminal-binding protein 1/2 (CtBP1/2), which control the switch from WAT to BAT, are potential targets for development of obesity-related therapeutics.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1101/gad.1681308

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Brown fat differentiation involves mechanisms common to both brown and white adipocyte differentiation, as well as some specific factors.

    “At the molecular level, brown fat differentiation involves mechanisms common to both brown and white adipocyte differentiation, as well as some specific factors 89,165–167.”

    From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [167]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Farmer, S. R.
Affiliations
Boston University (US)
Corresponding author
Farmer, Stephen R.
Venue
Genes & Development
Published
2008-05-15
Volume
22
Issue
10
Pages
1269-1275
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W2118369587
Cited by
165
References
47
Citations by year
2026: 1 · 2025: 5 · 2024: 3 · 2023: 1 · 2022: 9 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 14 · 2013: 19 · 2012: 11
Type
posted content
Language
en
Open access
Locations
  • Genes & Development (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
brown adipose tissue, brown adipocyte differentiation, white adipose tissue, PRDM16, PGC-1α, obesity, thermogenesis, adipose tissue gene expression, transcriptional coactivator
MeSH terms
Animals, Cell Differentiation, DNA-Binding Proteins, Humans, Models, Biological, Obesity, Phenotype, Repressor Proteins, Transcription Factors, Neovascularization, Physiologic, Thiazolidinediones, PPAR gamma, Adipose Tissue, White, Adipocytes, Brown

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review