Exposure of metal toxicity in Alzheimer’s disease: An extensive review
Open accessAbstract
Metals serve important roles in the human body, including the maintenance of cell structure and the regulation of gene expression, the antioxidant response, and neurotransmission. High metal uptake in the nervous system is harmful because it can cause oxidative stress, disrupt mitochondrial function, and impair the activity of various enzymes. Metal accumulation can cause lifelong deterioration, including severe neurological problems. There is a strong association between accidental metal exposure and various neurodegenerative disorders, including Alzheimer’s disease (AD), the most common form of dementia that causes degeneration in the aged. Chronic exposure to various metals is a well-known environmental risk factor that has become more widespread due to the rapid pace at which human activities are releasing large amounts of metals into the environment. Consequently, humans are exposed to both biometals and heavy metals, affecting metal homeostasis at molecular and biological levels. This review highlights how these metals affect brain physiology and immunity and their roles in creating harmful proteins such as β-amyloid and tau in AD. In addition, we address findings that confirm the disruption of immune-related pathways as a significant toxicity mechanism through which metals may contribute to AD.
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Dementia risk rises with toxic exposure to heavy metals such as lead, mercury, and aluminum.
“Dementia risk has been shown to rise with toxic exposure to heavy metals as lead, mercury, and aluminum [45,46,47,48].”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [47]
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- Authors
- Islam, F., Shohag, S., Akhter, S., Islam, M. R., Sultana, S., Mitra, S., Chandran, D., Khandaker, M. U., Ashraf, G. M., Idris, A. M., Emran, T. B., & Cavalu, S.
- Affiliations
- Daffodil International University (BD)
- Bangladesh Maritime University (BD)
- University of Dhaka (BD)
- Amrita Vishwa Vidyapeetham (IN)
- Sunway University (MY)
- King Abdulaziz University (SA)
- King Khalid University (SA)
- BGC Trust University Bangladesh (BD)
- University of Oradea (RO)
- Corresponding author
- Ashraf, Ghulam Md
- Idris, Abubakr M.
- Emran, Talha Bin
- Cavalu, Simona
- ORCID
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2022-08-29
- Volume
- 13
- Pages
- 903099-903099
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC9465172
- OpenAlex
- W4293537971
- Cited by
- 83
- References
- 243
- Citations by year
- 2026: 26 · 2025: 22 · 2024: 20 · 2023: 14 · 2022: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Funders
- King Khalid University (RGP.2/146/43)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Keywords
- Alzheimer's disease, metal toxicity, heavy metals, biometals, metal homeostasis, oxidative stress, mitochondrial dysfunction, neurodegeneration, amyloid-beta, tau protein, neuroinflammation, immune pathways, environmental exposure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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