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Exercise, telomeres, and cancer: ‘the exercise‐telomere hypothesis
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Tier 1 interventions such as exercise, fasting mimetics like metformin or rapamycin, fasting, and an epigenetic diet remain insufficient to slow down the damaging effects of aging.
“Tier 1 interventions such as staying fit, 1 , 2 taking pills such as fasting mimetics like metformin or rapamycin, 3 , 4 , 5 fasting, 3 , 6 , 7 and an epigenetic diet 8 remain insufficient to slow down the damaging effects of aging.”
From Three Tiers to biological escape velocity: The quest to outwit aging (2022) · cites this paper as [1]
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Blackburn, E. H., Epel, E. S., & Lin, J. (2015) · Science · doi:10.1126/science.aab3389 · Cited by 1,596 · cited 5×
“, 2015), and the literature has been slashing to point that the main reason modulating a possible acceleration or attenuation in this process is the lifestyle (Blackburn et al., 2015; Denham et al., 2016).”
BackgroundInfluentialLiving on a break: cellular senescence as a DNA-damage response
d'Adda di Fagagna, F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2440 · Cited by 1,170
Telomere Shortening Is Associated with Cell Division in Vitro and in Vivo
Allsopp, R. C., Chang, E., Kashefi-Aazam, M., Rogaev, E. I., Piatyszek, M. A., Shay, J. W., & Harley, C. B. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1306 · Cited by 533
Shortened Telomere Length Is Associated with Increased Risk of Cancer: A Meta-Analysis
Ma, H., Zhou, Z., Wei, S., Liu, Z., Pooley, K. A., Dunning, A. M., Svenson, U., Roos, G., Hosgood, H. D., Shen, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020466 · Cited by 376 · cited 1×
“Furthermore, Ma et al. (2011) performed a meta-analysis and reported that, although shortened TL are associated with increase risk of bladder and lung cancer, this association was not found for breast cancer.”
MethodThe power of exercise: buffering the effect of chronic stress on telomere length
Puterman, E., Lin, J., Blackburn, E., O'Donovan, A., Adler, N., & Epel, E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010837 · Cited by 339
Muscle stem cell aging: regulation and rejuvenation
Sousa-Victor, P., García-Prat, L., Serrano, A. L., Perdiguero, E., & Muñoz-Cánoves, P. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.03.006 · Cited by 163
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Cited by
Sorted by citations
Three Tiers to biological escape velocity: The quest to outwit aging
Palmer, R. D. (2022) · AGING MEDICINE · doi:10.1002/agm2.12231 · Cited by 2
Metadata
- Authors
- Nomikos, N. N., Nikolaidis, P. T., Sousa, C. V., Papalois, A. E., Rosemann, T., & Knechtle, B.
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2018-12-18
- Volume
- 9
- ISSN
- 1664-042X
- PMC
- PMC6305363
- Cited by
- 29
- References
- 6
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