Shortened Telomere Length Is Associated with Increased Risk of Cancer: A Meta-Analysis
Open accessAbstract
BACKGROUND: Telomeres play a key role in the maintenance of chromosome integrity and stability, and telomere shortening is involved in initiation and progression of malignancies. A series of epidemiological studies have examined the association between shortened telomeres and risk of cancers, but the findings remain conflicting. METHODS: A dataset composed of 11,255 cases and 13,101 controls from 21 publications was included in a meta-analysis to evaluate the association between overall cancer risk or cancer-specific risk and the relative telomere length. Heterogeneity among studies and their publication bias were further assessed by the χ(2)-based Q statistic test and Egger's test, respectively. RESULTS: The results showed that shorter telomeres were significantly associated with cancer risk (OR = 1.35, 95% CI = 1.14-1.60), compared with longer telomeres. In the stratified analysis by tumor type, the association remained significant in subgroups of bladder cancer (OR = 1.84, 95% CI = 1.38-2.44), lung cancer (OR = 2.39, 95% CI = 1.18-4.88), smoking-related cancers (OR = 2.25, 95% CI = 1.83-2.78), cancers in the digestive system (OR = 1.69, 95% CI = 1.53-1.87) and the urogenital system (OR = 1.73, 95% CI = 1.12-2.67). Furthermore, the results also indicated that the association between the relative telomere length and overall cancer risk was statistically significant in studies of Caucasian subjects, Asian subjects, retrospective designs, hospital-based controls and smaller sample sizes. Funnel plot and Egger's test suggested that there was no publication bias in the current meta-analysis (P = 0.532). CONCLUSIONS: The results of this meta-analysis suggest that the presence of shortened telomeres may be a marker for susceptibility to human cancer, but single larger, well-design prospective studies are warranted to confirm these findings.
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Inter-individual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases.
“Inter-individual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases.”
From Identification of seven loci affecting mean telomere length and their association with disease (2013) · cites this paper as [4]
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“Several studies have documented correlations between shortened telomeres and multiple human diseases associated with age, such as Alzheimer’s disease [6], myocardial infarction [7], vascular dementia [8], liver cirrhosis [9], atherosclerosis [10], ulcerative colitis [11] and premature aging syndromes [12].”
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“Human telomeres are approximately 10–15 kb in somatic cells and progressively shortened by ,30 to 200 bp after each cycle of mitotic division, due to incomplete replication of linear DNA molecules and the absence of a mechanism for elongation of telomeres [3].”
Leukocyte telomere length in a population-based case–control study of ovarian cancer: a pilot study
Mirabello, L. J., García‐Closas, M., Cawthon, R., Lissowska, J., Brinton, L. A., Pepłońska, B., Sherman, M. E., & Savage, S. A. (2009) · Cancer Causes & Control · doi:10.1007/s10552-009-9436-6 · Cited by 66 · cited 2× · see citing works
“Our meta-analysis included nine breast cancer studies [21,29,31,35,36,38], four bladder studies [19,20,23], three lung cancer studies [19,24,34], two renal cancer studies [19,22], two gastric cancers [27,30], two colorectal cancers [38] and seven studies of other cancers [19,26,28,32,33,37] (Table 1).”
Zee, R. Y. L., Castonguay, A. J., Barton, N. S., & Buring, J. E. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0360 · Cited by 61 · cited 1× · see citing works
“Among those 26 publications, five were excluded either because they did not provide available data to extract the ORs and 95% CI [40,41,43,44] or the subjects were of cancer-prone predisposition [42].”
Telomere length in blood cells and breast cancer risk: investigations in two case–control studies
Zheng, Y., Ambrosone, C. B., Byrne, C., Davis, W., Nesline, M., & McCann, S. E. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0440-z · Cited by 59 · cited 10× · see citing works
“Our meta-analysis included nine breast cancer studies [21,29,31,35,36,38], four bladder studies [19,20,23], three lung cancer studies [19,24,34], two renal cancer studies [19,22], two gastric cancers [27,30], two colorectal cancers [38] and seven studies of other cancers [19,26,28,32,33,37] (Table 1).”
InfluentialTelomerase activity and telomere length in benign and malignant human thyroid tissues
Kammori, M. (2000) · Cancer Letters · doi:10.1016/s0304-3835(00)00547-4 · Cited by 57 · cited 1× · see citing works
“For example, short telomeres cause an increased risk of developing epithelial cancers by the formation of complex non-reciprocal translocations [15,16], and telomeres in tumor cells and their precursor lesions are significantly shorter than that in surrounding non-tumor cells [17,18].”
Unryn, B. M., Hao, D., Glück, S., & Riabowol, K. T. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0486 · Cited by 55 · cited 1× · see citing works
“Further, there is some evidence that treatment status (chemotherapy or radiation) can alter telomere length [67,68], and we cannot rule out the possibility of such an effect because of unavailable information about the disease treatment status from the studies used in the analysis.”
The human telomere and its relationship to human disease, therapy, and tissue engineering
Ian, K. M. (2007) · Frontiers in bioscience · doi:10.2741/2412 · Cited by 54 · see citing works
Telomere Length in Subpopulations of Human Hematopoietic Cells
Ziffle, J. V., Baerlocher, G. M., & Lansdorp, P. M. (2003) · Stem Cells · doi:10.1634/stemcells.21-6-654 · Cited by 52 · see citing works
Joshua, A. M., Vukovic, B., Braudey, I., Hussein, S., Zieleńska, M., Srigleyb, J., Evans, A. J., & Squire, J. A. (2007) · Neoplasia · doi:10.1593/neo.06745 · Cited by 47 · cited 1× · see citing works
“For example, short telomeres cause an increased risk of developing epithelial cancers by the formation of complex non-reciprocal translocations [15,16], and telomeres in tumor cells and their precursor lesions are significantly shorter than that in surrounding non-tumor cells [17,18].”
Liu, X., Bao, G., Huo, T., Wang, Z., He, X., & Dong, G. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01169.x · Cited by 45 · cited 3× · see citing works
“In fact, we did try to calculate the summary ORs using adjusted ORs available from only nine original papers [21,24,26,27,28, 29,31,36,39], and we found that there were no substantial changes in the pooled, adjusted ORs (OR = 1.”
Alterations of p16-pRb Pathway and Chromosome Locus 9p21–22 in Sporadic Invasive Breast Carcinomas
Gorgoulis, V. G., Koutroumbi, E., Kotsinas, A., Zacharatos, P., Markopoulos, C. J., Giannikos, L., Kyriakou, V., Voulgaris, Z., Gogas, I., & Kittas, C. N. (1998) · Molecular Medicine · doi:10.1007/bf03401773 · Cited by 40 · see citing works
Barwell, J., Pangon, L., Georgiou, A., Docherty, Z., Kesterton, I., Ball, J., Camplejohn, R. S., Berg, J., Aviv, A., Gardner, J. P., et al. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6604085 · Cited by 40 · cited 1× · see citing works
“Among those 26 publications, five were excluded either because they did not provide available data to extract the ORs and 95% CI [40,41,43,44] or the subjects were of cancer-prone predisposition [42].”
An, H., Niederacher, D., Picard, F., van Roeyen, C. R. C., Bender, H., & Beckmann, M. W. (1996) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199609)17:1 · Cited by 39 · see citing works
Lee, I.-M. M., Lin, J., Castonguay, A. J., Barton, N. S., Buring, J. E., & Zee, R. Y. L. (2009) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2010.049 · Cited by 38 · cited 1× · see citing works
“Among those 26 publications, five were excluded either because they did not provide available data to extract the ORs and 95% CI [40,41,43,44] or the subjects were of cancer-prone predisposition [42].”
Fern, L. A., Pallis, M., Carter, G. I., Seedhouse, C., Russell, N. H., & Byrne, J. (2004) · British Journal of Haematology · doi:10.1111/j.1365-2141.2004.05006.x · Cited by 37 · cited 1× · see citing works
“Further, there is some evidence that treatment status (chemotherapy or radiation) can alter telomere length [67,68], and we cannot rule out the possibility of such an effect because of unavailable information about the disease treatment status from the studies used in the analysis.”
Telomere Length Changes in Colorectal Cancers and Polyps
Kim, H. R., Kim, Y. J., Kim, H. J., Kim, S. K., & Lee, J. H. (2002) · Journal of Korean Medical Science · doi:10.3346/jkms.2002.17.3.360 · Cited by 32 · cited 1× · see citing works
“Both of animal studies and clinical observations have shown that shorter telomeres were associated with increased risk of cancers, such as epithelial cancers [52,53,54].”
Idei, T., Sakamoto, H., & Yamamoto, T. (2002) · Journal of International Medical Research · doi:10.1177/147323000203000304 · Cited by 13 · cited 1× · see citing works
“Among those 26 publications, five were excluded either because they did not provide available data to extract the ORs and 95% CI [40,41,43,44] or the subjects were of cancer-prone predisposition [42].”
Flagged first, then by citations
1 of the 73 references couldn’t be matched to a known paper.
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Blackburn, E. H., Epel, E. S., & Lin, J. (2015) · Science · doi:10.1126/science.aab3389 · Cited by 1,596 · see citing works
Identification of seven loci affecting mean telomere length and their association with disease
CARDIoGRAM consortium, Codd, V., Nelson, C. P., Albrecht, E., Mangino, M., Deelen, J., Buxton, J. L., Hottenga, J. J., Fischer, K., Esko, T., et al. (2013) · Nature Genetics · doi:10.1038/ng.2528 · Cited by 933 · see citing works
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis
Haycock, P. C., Heydon, E. E., Kaptoge, S., Butterworth, A. S., Thompson, A., & Willeit, P. (2014) · BMJ · doi:10.1136/bmj.g4227 · Cited by 856 · see citing works
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases
Haycock, P., Burgess, S., Nounu, A., Zheng, J., Okoli, G. N., Bowden, J., Wade, K. H., Timpson, N. J., Evans, D. M., Willeit, P., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2016.5945 · Cited by 510 · see citing works
“Mechanisms of Association Our cancer findings are compatible with known biology.(127) By limiting the proliferative potential of cells, telomere shorteningmay serve as a tumor suppressor, and individualswith longer telomeres may be more likely to acquire somatic mutationsowing to increasedproliferativepotential.”
BackgroundResultInfluentialSelf-citationA systematic review of leukocyte telomere length and age in adults
Müezzinler, A., Zaineddin, A. K., & Brenner, H. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.003 · Cited by 474 · see citing works
“…been linked to mortality, several diseases and ageing related pathologies, including some cancers, cardiovascular diseases, obesity, Alzheimer’s disease, diabetes mellitus and osteoporosis in recent years (Jeyapalan and Sedivy, 2008; Aviv, 2002; Blasco, 2005; Ma et al., 2011; Valdes et al., 2007).”
BackgroundAgeing and the telomere connection: An intimate relationship with inflammation
Zhang, J., Rane, G., Dai, X., Shanmugam, M. K., Arfuso, F., Samy, R. P., Lai, M. K. P., Kappei, D., Kumar, A. P., & Sethi, G. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.11.006 · Cited by 386 · see citing works
“…shorter LTL to disease risk for metabolic disorders such as cardiovascular disease (Huzen et al., 2010), obesity (Valdes et al., 2005), type 2 diabetes (Adaikalakoteswari et al., 2005), dementia (Eitan et al., 2014; Moverare-Skrtic et al., 2012) and cancer (Ma et al., 2011; Zhang et al., 2015a).”
BackgroundTelomere Biology and Human Phenotype
Turner, K. J., Vasu, V., & Griffin, D. K. (2019) · Cells · doi:10.3390/cells8010073 · Cited by 391 · see citing works
“While some studies report that longer telomeres are associated with an increased risk of developing cancer [165–167], others argue that shortened telomeres increase cancer risk [160,168,169].”
BackgroundThe Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks
Aunan, J. R., Cho, W. C. S., & Søreide, K. (2017) · Aging and Disease · doi:10.14336/ad.2017.0103 · Cited by 374 · see citing works
“Some studies showed that telomere attrition and short telomeres is a risk factor for cancer development [40-42].”
BackgroundThe role of childhood trauma in bipolar disorders
Aas, M., Henry, C., Andreassen, O. A., Bellivier, F., Melle, I. S., & Étain, B. (2016) · International Journal of Bipolar Disorders · doi:10.1186/s40345-015-0042-0 · Cited by 345 · see citing works
“2013), as well as being associated with diabetes mellitus type II, coronary heart disease and cancer in the general population (Haycock et al. 2014; Ma et al. 2011; Wentzensen et al. 2011; Willeit et al. 2014).”
BackgroundTelomeres and early-life stress: an overview
Price, L. H., Kao, H.-T., Burgers, D. E., Carpenter, L. L., & Tyrka, A. R. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.025 · Cited by 339 · see citing works
Entringer, S., Buss, C., & Wadhwa, P. D. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.08.019 · Cited by 324 · see citing works
Bone marrow failure and the telomeropathies
Townsley, D. M., Dumitriu, B., & Young, N. S. (2014) · Blood · doi:10.1182/blood-2014-05-526285 · Cited by 290 · see citing works
Marioni, R. E., Harris, S. E., Shah, S. H., McRae, A. F., von Zglinicki, T., Martin-Ruiz, C. M., Wray, N. R., Visscher, P. M., & Deary, I. J. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw041 · Cited by 285 · see citing works
Hillary, R. F., Stevenson, A. J., McCartney, D. L., Campbell, A. I., Walker, R. M., Howard, D. M., Ritchie, C. W., Horvath, S., Hayward, C., McIntosh, A. M., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00905-6 · Cited by 241 · see citing works
Short Telomere Length, Cancer Survival, and Cancer Risk in 47102 Individuals
Weischer, M., Nordestgaard, B. G., Cawthon, R., Freiberg, J., Tybjærg‐Hansen, A., & Bojesen, S. E. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt016 · Cited by 228 · see citing works
Starkweather, A. R., Alhaeeri, A. A., Montpetit, A. J., Brumelle, J., Filler, K., Montpetit, M., Mohanraj, L., Lyon, D., & Jackson‐Cook, C. K. (2013) · Nursing Research · doi:10.1097/nnr.0000000000000009 · Cited by 217 · see citing works
“…from studies in which TLs have been positively associated with longevity (longer telomeres in centenarians; Atzmon et al., 2010; Garagnani et al., 2013) and negatively associated increased risk of cancer (patients with these conditions have shortened telomeres; Codd et al., 2013; Ma et al., 2011).”
BackgroundWilleit, P., Raschenberger, J., Heydon, E. E., Tsimikas, S., Haun, M., Mayr, A., Weger, S., Witztum, J. L., Butterworth, A. S., Willeit, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112483 · Cited by 211 · see citing works
Eisenberg, D. T. A., Hayes, M. G., & Kuzawa, C. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202092109 · Cited by 193 · see citing works
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk
Walsh, K. M., Codd, V., Smirnov, I. V., Rice, T., Decker, P. A., Hansen, H. M., Kollmeyer, T. M., Kosel, M., Molinaro, A. M., Mccoy, L. S., et al. (2014) · Nature Genetics · doi:10.1038/ng.3004 · Cited by 189 · see citing works
Physical activity, sedentary behavior, and leukocyte telomere length in women.
Du, M., Prescott, J., Kraft, P., Han, J.-L., Giovannucci, E., Hankinson, S., & de Vivo, I. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kwr330 · Cited by 180 · see citing works
Weischer, M., Bojesen, S. E., & Nordestgaard, B. G. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004191 · Cited by 167 · see citing works
“Several cross-sectional and prospective studies have associated short telomere length with increased risk of any early death [2,4,5], cardiovascular disease [2,6], cancer [7,8], and early death after a cancer diagnosis [9].”
BackgroundPuterman, E., Gemmill, A., Karasek, D., Weir, D., Adler, N. E., Prather, A. A., & Epel, E. S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525602113 · Cited by 165 · see citing works
“Other recent meta-analyses support the concurrent associations between short telomeres and diabetes (8) and several cancers (9, 10).”
ResultThe Role of Telomere Biology in Cancer
Xu, L., Li, S., & Stohr, B. A. (2013) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-164030 · Cited by 160 · see citing works
Heim, C. M., Entringer, S., & Buss, C. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.12.011 · Cited by 158 · see citing works
“…including cardiovascular disease, diabetes, obesity, psychiatric diseases like depression, dementia, and schizophrenia (Armanios and Blackburn, 2012; Haycock et al., 2014; Ma et al., 2011; Zhao et al., 2013) and earlier mortality (Cawthon et al., 2003; Kimura et al., 2008; Rode et al., 2015).”
BackgroundThe association between telomere length and cancer risk in population studies
Zhu, X., Han, W., Xue, W., Zou, Y., Xie, C., Du, J., & Jin, G. (2016) · Scientific Reports · doi:10.1038/srep22243 · Cited by 146 · see citing works
Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study
Zhang, C., Doherty, J. A., Burgess, S., Hung, R. J., Lindström, S., Kraft, P. L., Gong, J., Amos, C. I., Sellers, T. A., Monteiro, Á. N. A., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv252 · Cited by 143 · see citing works
“Indeed, short relative TLmeasured in surrogate tissues, such as peripheral blood cells, has been associatedwith increased risk for lung (6,7), ovarian (8), colorectal (9) and breast cancers (10,11) in epidemiological studies (with the interpretation that blood TL predicts cancer risk because it is a proxy for TL in ca…”
BackgroundBojesen, S. E. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12083 · Cited by 141 · see citing works
Ness, K. K., Kirkland, J. L., Gramatges, M. M., Wang, Z., Kundu, M., McCastlain, K., Li-Harms, X., Zhang, J., Tchkonia, T., Pluijm, S. M. F., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.7467 · Cited by 140 · see citing works
“leukocyte TL (mLTL) shortening is associated with aging-related diseases(56) including type 2 diabetes,(57) cardiovascular disease,(58) dementia,(59) and increased cancer risk in the general population.(60,61) In addition, shorter mLTL is observed in individuals with impaired grip strength, reduced lean muscle mass, a…”
BackgroundHastings, W. J., Shalev, I., & Belsky, D. W. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.012 · Cited by 142 · see citing works
Seow, W. J., Cawthon, R., Purdue, M. P., Hu, W., Gao, Y.-T., Huang, W., Weinstein, S. J., Ji, B., Virtamo, J. R. K., Hosgood, H. D., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0459 · Cited by 132 · see citing works
Self-citationWong, J. Y. Y., Vivo, I. D., Lin, X., Fang, S. C., & Christiani, D. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087348 · Cited by 132 · see citing works
“For instance, previous studies have reported that shorter telomeres were significantly associated with increased overall cancer risk, in addition to decreased survival rate amongst diagnosed cases [2–4].”
ResultBeginning at the ends: telomeres and human disease
Savage, S. A. (2018) · F1000Research · doi:10.12688/f1000research.14068.1 · Cited by 124 · see citing works
Long telomeres and cancer risk among 95 568 individuals from the general population
Rode, L., Nordestgaard, B. G., & Bojesen, S. E. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw179 · Cited by 120 · see citing works
Surrogate tissue telomere length and cancer risk: Shorter or Longer?
Hou, L., Zhang, X., Gawron, A. J., & Liu, J. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.01.028 · Cited by 118 · see citing works
Use of acetochlor and cancer incidence in the A gricultural H ealth S tudy
Lerro, C. C., Koutros, S., Andreotti, G., Hines, C. J., Blair, A. E., Lubin, J. H., Ma, X., Zhang, Y., & Freeman, L. E. B. (2015) · International Journal of Cancer · doi:10.1002/ijc.29416 · Cited by 118 · see citing works
“Telomere length has been implicated in cancer etiology.(35) Another proposed mechanism of carcinogenicity for chloracetanilide herbicides involves bioactivation through several steps to DNA-reactive metabolites (2-methyl-6-ethylbenzoquinone imine for acetochlor and metolachlor and 2,6-diethylbenzoquinone imine for ala…”
BackgroundSystematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes
Lin, J., Cheon, J., Brown, R. R., Coccia, M., Puterman, E. M., Aschbacher, K., Sinclair, E., Epel, E. S., & Blackburn, E. H. (2016) · Journal of Immunology Research · doi:10.1155/2016/5371050 · Cited by 118 · see citing works
“The cellular signals and pathways that determine telomere length changes are largely unknown, but several have been proposed.”
The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length
Iles, M. M., Bishop, D. T., Taylor, J., Hayward, N. K., Brossard, M., Cust, A. E., Dunning, A. M., Lee, J. E., Moses, E. K., Akslen, L. A., et al. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju267 · Cited by 117 · see citing works
“Telomere length has been associated with risk of various age-related diseases, including cancers (3,4).”
BackgroundSelf-citationEffects of physical activity in telomere length: Systematic review and meta-analysis
Mundstock, E., Zatti, H., Louzada, F. M., Oliveira, S. G., Guma, F. T. C. R., Paris, M. M., Rueda, A. M. B., Machado, D. G., Stein, R. T., Jones, M. H., et al. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.02.004 · Cited by 115 · see citing works
Mons, U., Müezzinler, A., Schöttker, B., Dieffenbach, A. K., Butterbach, K., Schick, M., Peasey, A., Vivo, I. D., Trichopoulou, A., Boffetta, P., et al. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kww210 · Cited by 113 · see citing works
Telomere length varies by DNA extraction method: implications for epidemiologic research
Cunningham, J. M., Johnson, R. A., Litzelman, K., Skinner, H. G., Seo, S., Engelman, C. D., Vanderboom, R. J., Kimmel, G. W., Gangnon, R. E., Riegert-Johnson, D. L., et al. (2013) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-0409 · Cited by 111 · see citing works
“9 PubMed (US Library of Medicine, Bethesda MD) using the terms “cancer and telomeres” and “cancer and telomere length”, and we cross-referenced these articles with those reported in two published meta-analyses of telomere length and cancer risk (25,31).”
MethodLatifovic, L., Peacock, S. D., Massey, T. E., & King, W. D. (2015) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-14-1364 · Cited by 109 · see citing works
“Evidence from two recent meta-analyses supports an inverse association between telomere length and overall risk of cancer, stratified analysis by subtype support an association with lung, bladder, esophageal, gastric, and renal cancers, while results for breast and colorectal cancer were inconsistent (3, 4).”
ResultEisenberg, D. T. A., & Kuzawa, C. W. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0442 · Cited by 108 · see citing works
Pellatt, A. J., Wolff, R. K., Torres-Mejı́a, G., John, E. M., Herrick, J. S., Lundgreen, A., Baumgartner, K. B., Giuliano, A. R., Hines, L. M., Fejerman, L., et al. (2013) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22056 · Cited by 102 · see citing works
“Meta-analyses of TL data and cancer further support the inconsistency of data on associations between TL and cancer, although they have summarized that shortened TL in most often associated with increased cancer risk (Ma et al., 2011; Wentzensen et al., 2011).”
ResultSánchez‐Espiridión, B., Chen, M., Chang, J. Y., Lu, C. S., Chang, D. W., Roth, J. A., Wu, X., & Gu, J. H. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2968 · Cited by 97 · see citing works
“Authors have reported association of short telomeres with increased risk of bladder, esophageal, gastric, head and neck, ovarian, renal cancer, oral premalignant lesions, and oral squamous cell carcinoma (16, 25, 34, 35).”
BackgroundWalsh, K. M., Codd, V., Rice, T., Nelson, C. P., Smirnov, I. V., Mccoy, L. S., Hansen, H. M., Elhauge, E., Ojha, J., Francis, S. S., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6468 · Cited by 100 · see citing works
“Observational data support a connection between both longer and shorter telomere length and increased cancer risk [15-17].”
BackgroundShorter Telomeres Associate with a Reduced Risk of Melanoma Development
Nan, H., Du, M., Vivo, I. D., Manson, J. E., Liu, S., McTiernan, A., Curb, J. D., Lessin, L. S., Bonner, M. R., Guo, Q., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1988 · Cited by 98 · see citing works
Race, Ethnicity, Psychosocial Factors, and Telomere Length in a Multicenter Setting
Lynch, S. M., Peek, M. K., Mitra, N., Ravichandran, K., Branas, C. C., Spangler, E., Zhou, W., Paskett, E. D., Gehlert, S. J., DeGraffinreid, C. R., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146723 · Cited by 97 · see citing works
“We also found that male cancer cases had longer telomeres compared to non-cancer cases, and this has been observed in literature[57, 58], although inconsistently[59].”
ResultThe Association between Telomere Length and Cancer Prognosis: Evidence from a Meta-Analysis
Zhang, C., Chen, X., Li, L., Zhou, Y. Y., Wang, C., & Hou, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133174 · Cited by 95 · see citing works
Machiela, M. J., Hsiung, C. A., Shu, X., Seow, W. J., Wang, Z., Matsuo, K., Hong, Y., Seow, A., Wu, C., Hosgood, H. D., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29393 · Cited by 90 · see citing works
Self-citationTelomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training
Denham, J., O’Brien, B. J., & Charchar, F. J. (2016) · Sports Medicine · doi:10.1007/s40279-016-0482-4 · Cited by 91 · see citing works
“Shorter average leukocyte telomere length is typically associated with age-related chronic diseases, such as cardiovascular disease [5–7], type 2 diabetes mellitus (T2DM) [8, 9], some cancers [10], and psychological stress [11, 12].”
BackgroundYe, Q., Apsley, A. T., Etzel, L. C., Hastings, W. J., Kozlosky, J. T., Walker, C., Wolf, S. E., & Shalev, I. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102031 · Cited by 89 · see citing works
“Moreover, shorter TL has been linked with increased risk of cardiovascular diseases (CVDs) (Weischer et al., 2012), certain cancers (Ma et al., 2011; Wentzensen et al., 2011), and more recently, severe COVID-19 (Anderson et al., 2022; Aviv, 2021).”
Mitochondrial DNA Copy Number and Exposure to Polycyclic Aromatic Hydrocarbons
Pavanello, S., Dioni, L., Hoxha, M., Fedeli, U., Mielżyńska‐Švach, D., & Baccarelli, A. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-0118 · Cited by 89 · see citing works
“results have provided both positive (26) and negative correlations (27, 28).”
Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy
Gramatges, M. M., & Bertuch, A. A. (2013) · Translational research · doi:10.1016/j.trsl.2013.05.003 · Cited by 89 · see citing works
“Although results from individual studies are somewhat conflicting, when taken together, 2 metaanalyses including data from 27 publications have demonstrated an overall increased risk for cancer with shortened telomere length.(108,109) In addition, the risk for developing de novo cancers has been estimated in healthy i…”
ResultGenetic susceptibility to lung cancer--light at the end of the tunnel?
Marshall, A. L., & Christiani, D. C. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt016 · Cited by 85 · see citing works
Shortened telomere length in patients with depression: A meta-analytic study.
Lin, P., Huang, Y.-C., & Hung, C.-F. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.01.015 · Cited by 82 · see citing works
“…age-related physical illnesses, such as cardiovascular disease (CVD) (Fitzpatrick et al., 2007; Haycock et al., 2014), cancer (Campisi, 2005; Ma et al., 2011), Alzheimer disease (Hochstrasser et al., 2012), cancer mortality or all-cause mortality (Cawthon et al., 2003; Rode et al., 2015;…”
The association of female and male infertility with telomere length (Review)
Vasilopoulos, E., Fragkiadaki, P., Kalliora, C., Fragou, D., Docea, A. O., Vakonaki, E., Tsoukalas, D., Călina, D. C., Bugă, A. M., Georgiadis, G., et al. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4225 · Cited by 84 · see citing works
“It is known that shorter telomeres are associated with a range of chronic diseases, such as cardiovascular disease (CAD), stroke, cancer, arthritis, osteoporosis, diabetes type 2, hypertension, mental diseases, chronic obstructive pulmonary disease and dementia (27-31).”
BackgroundTelomere length and common disease: study design and analytical challenges
Barrett, J. H., Iles, M. M., Dunning, A. M., & Pooley, K. A. (2015) · Human Genetics · doi:10.1007/s00439-015-1563-4 · Cited by 84 · see citing works
“Wentzensen et al. (2011) and Ma et al. (2011) conducted similar meta-analyses of 25–29 epidemiological studies of TL and cancer risk published prior to 2010, including 13 different cancers and overall incident cancer.”
MethodResultInfluentialSelf-citationRobust measurement of telomere length in single cells
Wang, F., Pan, X., Kalmbach, K., Seth-Smith, M. L., Ye, X., Antumes, D. M. F., Yin, Y., Liu, L., Keefe, D. L., & Weissman, S. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306639110 · Cited by 83 · see citing works
“This process will facilitate the identification and functional studies of cancer stem cells and pluripotent stem cells, and distinguish them from other cells in mixed populations (24), and advance our understanding of the molecular mechanisms underlying variation of individual cells in development, disease, senescence…”
BackgroundTelomere maintenance and the etiology of adult glioma
Walsh, K. M., Wiencke, J. K., Lachance, D. H., Wiemels, J. L., Molinaro, A. M., Eckel‐Passow, J. E., Jenkins, R. B., & Wrensch, M. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov082 · Cited by 81 · see citing works
Parity associated with telomere length among US reproductive age women
Pollack, A. Z., Rivers, K., & Ahrens, K. A. (2018) · Human Reproduction · doi:10.1093/humrep/dey024 · Cited by 78 · see citing works
Hou, L., Andreotti, G., Baccarelli, A., Savage, S. A., Hoppin, J. A., Sandler, D. P., Barker, J., Zhu, Z., Hoxha, M., Dioni, L., et al. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1206432 · Cited by 75 · see citing works
“While most studies have reported that shorter telomeres in surrogate tissue are positively associated with cancer [as reviewed by Ma et al. (2011) and Wentzensen et al. (2011)], longer telo meres have been associated with cancer in some studies and reviews (Gramatges et al. 2010; Han et al. 2009;…”
BackgroundMartínez, P., & Blasco, M. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.312202 · Cited by 71 · see citing works
Qu, S., Wen, W., Shu, X., Chow, W., Xiang, Y., Wu, J., Ji, B.-T., Rothman, N., Yang, G., Cai, Q., et al. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kws291 · Cited by 70 · see citing works
“Epidemiologic studies have linked short telomeres in peripheral blood leukocytes to elevated risks of several human cancers, including cancers of the bladder, esophagus, stomach, head and neck, ovary, and kidneys (11, 12, 25).”
BackgroundChange in Peripheral Blood Leukocyte Telomere Length and Mortality in Breast Cancer Survivors
Duggan, C. R., Risques, R. A., Alfano, C. M., Prunkard, D. E., Imayama, I., Holte, S., Baumgartner, K. B., Baumgartner, R., Bernstein, L., Ballard-Barbash, R. R., et al. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju035 · Cited by 70 · see citing works
“4- to threefold increased risk of cancer in those with shortest vs longest telomeres (14,15).”
BackgroundLynch, S. M., Major, J. M., Cawthon, R., Weinstein, S. J., Virtamo, J. R. K., Qing Lan, B., Rothman, N., Albanes, D., & Stolzenberg‐Solomon, R. Z. (2013) · International Journal of Cancer · doi:10.1002/ijc.28272 · Cited by 69 · see citing works
“87) were also associated with shorter telomeres as compared to longer telomeres, and an association between relative telomere length and overall cancer risk was reported in studies using retrospective designs, hospital-based controls and smaller sample sizes.(25) Most of the studies included in the meta-analysis measu…”
ResultBlood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort
Hou, L., Joyce, B. T., Gao, T., Liu, L., Zheng, Y., Penedo, F. J., Liu, S., Zhang, W., Bergan, R. C., Dai, Q., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.04.008 · Cited by 69 · see citing works
“Telomeres are tandem repeats of TTAGGG nucleotides at the ends of eukaryotic chromosomes that, along with telomere binding proteins, help maintain genomic stability (Ma et al., 2011).”
BackgroundTelomere tracking from birth to adulthood and residential traffic exposure
Bijnens, E. M., Zeegers, M. P., Derom, C. A., Martens, D. S., Gielen, M., Hageman, G. J., Plusquin, M., Thiery, E. W., VLIETINCK, R. F., & Nawrot, T. S. (2017) · BMC Medicine · doi:10.1186/s12916-017-0964-8 · Cited by 69 · see citing works
“Short telomeres have been implicated in the pathology of several age-related diseases, including cardiovascular disease [4], diabetes mellitus [5], and cancer [6, 7].”
Chen, S., Yeh, F., Lin, J., Matsuguchi, T., Blackburn, E. H., Lee, E. T., Howard, B. V., & Zhao, J. (2014) · Aging · doi:10.18632/aging.100664 · Cited by 67 · see citing works
“Shorter leukocyte telomere length (LTL) has been associated with a variety of age-related disorders, such as hypertension [2], diabetes [3], cardiovascular diseases (CVD) [4, 5] and certain types of cancers [6, 7].”
BackgroundBrody, G. H., Yu, T., & Shalev, I. (2017) · Health Psychology · doi:10.1037/hea0000443 · Cited by 65 · see citing works
Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?
Shalev, I., & Belsky, J. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.03.002 · Cited by 64 · see citing works
“And this is because telomere regulation appears receptive and malleable in response to environmental inputs [22], requires energy for its maintenance [23], and is predictive of health [24,25] and early mortality [26].”
BackgroundTelomere Length and Pancreatic Cancer: A Case–Control Study
Skinner, H. G., Gangnon, R. E., Litzelman, K., Johnson, R., Chari, S. T., Petersen, G. M., & Boardman, L. A. (2012) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0671 · Cited by 63 · see citing works
Cumulative PM2.5Exposure and Telomere Length in Workers Exposed to Welding Fumes
Wong, J. Y. Y., Vivo, I. D., Lin, X., & Christiani, D. C. (2014) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2013.875497 · Cited by 60 · see citing works
“Indeed, telomere length has been established as a biomarker of numerous chronic diseases such as cancer and cardiovascular disease (Ma et al., 2011).”
Cui, Y., Cai, Q., Qu, S., Chow, W., Wen, W., Xiang, Y.-B., Wu, J., Rothman, N., Yang, G., Shu, X., et al. (2012) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0657 · Cited by 59 · see citing works
“Recently, several epidemiologic studies have evaluated telomere length as a potential predictor for cancer risk and prognosis, measured using DNA fromperipheral blood cells or buccal cells (6, 15, 16).”
BackgroundObesity, weight loss, and influence on telomere length: New insights for personalized nutrition
Welendorf, C. R., Nicoletti, C. F., Pinhel, M. A. D. S., Noronha, N. Y., de Paula, B. M. F., & Nonino, C. B. (2019) · Nutrition · doi:10.1016/j.nut.2019.05.002 · Cited by 59 · see citing works
Caini, S., Raimondi, S., Johansson, H. A., GIORGI, V. D., Zanna, I., Palli, D., & Gandini, S. (2015) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2015.08.003 · Cited by 57 · see citing works
Pesticide Use and Relative Leukocyte Telomere Length in the Agricultural Health Study
Andreotti, G., Hoppin, J. A., Hou, L., Koutros, S., Gadalla, S. M., Savage, S. A., Lubin, J. H., Blair, A. E., Hoxha, M., Baccarelli, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133382 · Cited by 57 · see citing works
“Both shorter and TL have linked to various diseases; most studies to date have reported associations between shorter TL and higher cancer risk [27,28], although longer TL has also been implicated [29].”
BackgroundAmeer, S. S., Xu, Y., Engström, K. S., Li, H., Tallving, P., Nermell, B., Boemo, A., Parada, L. A., Peñaloza, L. G., Concha, G., et al. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00087 · Cited by 57 · see citing works
“The mitochondrion is the key organelle for energy metabolism, but it also has important functions in the regulation of apoptosis (Lee and Wei, 2000) and cell proliferation (Martinez-Outschoorn et al., 2011).”
BackgroundImpact of prenatal heavy metal exposure on newborn leucocyte telomere length: A birth-cohort study
Wai, K. M., Umezaki, M., Kosaka, S., Mar, O., Umemura, M., Fillman, T. J., & Watanabe, C. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.09.090 · Cited by 56 · see citing works
Li, H., Hedmer, M., Wojdacz, T. K., Hossain, M. B., Lindh, C. H., Tinnerberg, H., Albin, M. C., & Bröberg, K. (2015) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21958 · Cited by 56 · see citing works
“The finding of shorter telomeres in welders suggests that this exposure might be carcinogenic, as short telomeres in peripheral blood have been associated with various types of cancer, including lung cancer [Ma et al., 2011; Willeit et al., 2011].”
BackgroundInfluentialA meta-analysis of the relationship between anxiety and telomere length
Malouff, J. M., & Schutte, N. S. (2016) · Anxiety Stress & Coping · doi:10.1080/10615806.2016.1261286 · Cited by 56 · see citing works
“Shorter telomeres are associated with poor health (Epel, 2012), including increased risk of stroke, myocardial infarction, diabetes (D’Mello et al., 2015), and cancer (Ma et al., 2011).”
BackgroundMendelian Randomization Studies of Cancer Risk: a Literature Review
Pierce, B. L., Kraft, P., & Zhang, C. (2018) · Current Epidemiology Reports · doi:10.1007/s40471-018-0144-1 · Cited by 55 · see citing works
Brody, G. H., Yu, T., Beach, S. R. H., & Philibert, R. A. (2014) · Prevention Science · doi:10.1007/s11121-014-0474-2 · Cited by 55 · see citing works
Effects of maternal exposure to ambient air pollution on newborn telomere length
Song, L., Zhang, B., Liu, B., Wu, M., Zhang, L., Wang, L., Xu, S., Cao, Z., & Wang, Y. (2019) · Environment International · doi:10.1016/j.envint.2019.04.064 · Cited by 53 · see citing works
Müezzinler, A., Mons, U., Dieffenbach, A. K., Butterbach, K., Saum, K.-U., Schick, M., Stammer, H., Boukamp, P., Holleczek, B., Stegmaier, C., et al. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.07.002 · Cited by 53 · see citing works
“Numerous studies reported links between TL and ageing-related outcomes such as cardiovascular diseases, some cancers, diabetes mellitus, dementia and osteoporosis (Salpea and Humphries, 2010; Aviv, 2002; Blasco, 2005; Grodstein et al., 2008; Jeyapalan and Sedivy, 2008; Ma et al., 2011).”
BackgroundLeucocyte telomere length, genetic variants at the TERT gene region and risk of pancreatic cancer
Bao, Y., Prescott, J., Yuan, C., Zhang, M., Kraft, P., Babić, A., Morales‐Oyarvide, V., Qian, Z. R., Buring, J. E., Cochrane, B. B., et al. (2016) · Gut · doi:10.1136/gutjnl-2016-312510 · Cited by 52 · see citing works
Sharpe, K. H., McMahon, A. D., RAAB, G. M., Brewster, D., & Conway, D. I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089513 · Cited by 51 · see citing works
Telomere Homeostasis: Interplay with Magnesium
Maguire, D., Neytchev, O., Talwar, D., McMillan, D., & Shiels, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010157 · Cited by 50 · see citing works
Biegler, K. A., Anderson, A. K. L., Wenzel, L. B., Osann, K., & Nelson, E. L. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0008 · Cited by 48 · see citing works
Litzelman, K., Witt, W. P., Gangnon, R. E., Nieto, F. J., Engelman, C. D., Seltzer, M. M., & Skinner, H. G. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu066 · Cited by 51 · see citing works
Telomere length, telomerase expression, and oxidative stress in lead smelters
Pawlas, N., Płachetka, A., Kozłowska, A., Mikołajczyk, A., Kasperczyk, A., Dobrakowski, M., & Kasperczyk, S. (2015) · Toxicology and Industrial Health · doi:10.1177/0748233715601758 · Cited by 50 · see citing works
“Shorter telomere lengths are the known predictors of dementia and morbidity (Honig et al., 2012), diabetes type 2 (Willeit et al., 2014; Zhao et al., 2013), cancer (Ma et al., 2011; Willeit et al., 2010a), and cardiovascular diseases (Muller and Rabelink, 2014; Willeit et al., 2010b).”
BackgroundAttachment security moderates the link between adverse childhood experiences and cellular aging
Dagan, O., Asok, A., Steele, H., Steele, M., & Bernard, K. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001705 · Cited by 50 · see citing works
“, 2009), cancer (Ma et al., 2011; Willeit et al., 2010; Zhang et al., 2015), dementia (Honig, Kang, Schupf, Lee, & Mayeux, 2012; von Zglinicki et al.”
BackgroundAlcohol consumption and leukocyte telomere length
Dixit, S., Whooley, M. A., Vittinghoff, E., Roberts, J. D., Heckbert, S. R., Fitzpatrick, A. L., Lin, J., Leung, C. W., Mukamal, K. J., & Marcus, G. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-38904-0 · Cited by 49 · see citing works
Telomere length in children environmentally exposed to low-to-moderate levels of lead
Pawlas, N., Płachetka, A., Kozłowska, A., Bröberg, K., & Kasperczyk, S. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.05.005 · Cited by 49 · see citing works
Telomeres, Early-Life Stress and Mental Illness
Ridout, S. J., Ridout, K. K., Kao, H., Carpenter, L. L., Philip, N. S., Tyrka, A. R., & Price, L. H. (2015) · Advances in psychosomatic medicine · doi:10.1159/000369088 · Cited by 47 · see citing works
Shoeb, M., Kodali, V., Farris, B. Y., Bishop, L. M., Meighan, T. G., Salmen, R., Eye, T., Friend, S. A., Schwegler‐Berry, D., Roberts, J. R., et al. (2017) · NanoImpact · doi:10.1016/j.impact.2017.01.001 · Cited by 46 · see citing works
“Both shorter (Ma et al., 2011; Jang et al., 2008) and longer (Seow et al.”
BackgroundXie, H., Wu, X., Wang, S., Chang, D. W., Pollock, R. E., Lev, D. C., & Gu, J. H. (2013) · Cancer · doi:10.1002/cncr.27984 · Cited by 45 · see citing works
Mason, A. E., Adler, J. M., Puterman, E. M., Lakmazaheri, A., Brucker, M., Aschbacher, K., & Epel, E. S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.12.010 · Cited by 43 · see citing works
“Although much evidence associates short LTL with cancer (Ma et al., 2011; Wentzensen, Mirabello, Pfeiffer, & Savage, 2011; Willeit et al., 2010), there is also some evidence that longer LTL may increase risk for certain cancers (Codd et al.”
BackgroundLi, D., de Glas, N. A., & Hurria, A. (2015) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2015.08.003 · Cited by 44 · see citing works
“with the shortest versus longest telomeres have been shown to have an increased risk of cancer development.(37,38) Furthermore, telomerase, the enzyme that promotes telomere repair, has been reported to be activated in up to 80% of tumors.”
BackgroundTERT polymorphisms modify the risk of acute lymphoblastic leukemia in Chinese children
Sheng, X., Tong, N., Tao, G., Luo, D., Wang, M., Fang, Y., Li, J., Xu, M. J., Zhang, Z., & Wu, D. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs325 · Cited by 44 · see citing works
“Recent metaanalyses have reported an association between short telomeres and the increased risk of several types of human cancers, including breast cancer, bladder cancer, lung cancer, esophageal cancer, gastric cancer, ovarian cancer, renal cell cancer, non-Hodgkin lymphoma and head and neck cancer (12,13).”
BackgroundLeung, C. W., Fung, T. T., McEvoy, C. T., Lin, J., & Epel, E. S. (2018) · American Journal of Epidemiology · doi:10.1093/aje/kwy124 · Cited by 43 · see citing works
“American Journal of Epidemiology, 187(10), 2192-2201.”
Background
- Authors
- Ma, H., Zhou, Z., Wei, S., Liu, Z., Pooley, K. A., Dunning, A. M., Svenson, U., Roos, G., Hosgood, H. D., Shen, M., & Wei, Q.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- University of Cambridge (GB)
- Umeå University (SE)
- National Institutes of Health (US)
- Corresponding author
- Wei, Qingyi
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-06-10
- Volume
- 6
- Issue
- 6
- Pages
- e20466
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3112149
- OpenAlex
- W2136996519
- Cited by
- 376
- References
- 73
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 21 · 2023: 16 · 2022: 19 · 2021: 24 · 2020: 25 · 2019: 32 · 2018: 34 · 2017: 27 · 2016: 33 · 2015: 34 · 2014: 35 · 2013: 36 · 2012: 18
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DiVA at Umeå University (Umeå University) (submittedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Cancer Institute (R01CA131274, P30CA016672)
- National Institute of Environmental Health Sciences (R01ES011740)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- telomere length, telomere shortening, cancer risk, cancer susceptibility, bladder cancer, lung cancer, tobacco-related cancer, gastrointestinal cancer, urogenital cancer, biomarkers
- MeSH terms
- Humans, Neoplasms, Risk Factors, Confidence Intervals, Odds Ratio, Telomere, Publication Bias, Genetic Predisposition to Disease
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