CoChat
Sign Up
Cited by 58Sports Performance and TrainingMuscle metabolism and nutritionCardiovascular and exercise physiology

Influence of Oral Contraceptive Use on Adaptations to Resistance Training

Open access
Dalgaard, Line B., Dalgas, Ulrik, Andersen, Jesper L., Rossen, Nicklas B., Møller, Andreas Buch, Stødkilde-Jørgensen, Hans, Jørgensen, Jens Otto, Kovanen, Vuokko +4 more·2019·Frontiers in Physiology
DOI 10.3389/fphys.2019.00824PMC PMC6614284
Open this paper in CoChat — free accountOpen PDF

Abstract

Introduction: The majority of young women use oral contraceptives (OCs). Use of OCs has been associated with lower myofibrillar protein and tendon collagen synthesis rates, but it is unknown whether OCs will limit the adaptive response of myotendinous tissue to resistance training. Design and Methods: Fourteen healthy untrained young regular OC users (24±1 yrs, fat% 32±1, 35±2 mlO2·min-1·kg-1) and 14 NOC users (non-OC, controls) (24±1 yrs, fat% 32±2, 34±2 mlO2·min-1·kg-1) performed a 10-week supervised progressive resistance lower extremity training program. Before and after the intervention biopsies from the vastus lateralis muscle and the patellar tendon were obtained. Muscle (quadriceps) and tendon cross-sectional area (CSA) was determined by MRI scans, and muscle fiber CSA was determined by histochemistry. Maximal isometric muscle strength was assessed by dynamometry while 1 repetition of maximum (RM) was determined during knee extension. Results: Training enhanced CSA in both muscle (p<0.001) and tendon (p<0.01). A trend towards a greater increase in muscle CSA was observed for OC (11%) compared to NOC (8%)(interaction p=0.06). Analysis of mean muscle fiber type CSA showed a trend towards an increase in type II muscle fiber area in both groups (p=0.11, interaction p=0.98), whereas type I muscle fiber CSA increased in the OC group (n=9, 3821±197 to 4490±313 mm2, p<0.05), but not in NOC (n=7, 4020±348 to 3777±354 mm2, p=0.40)(interaction p<0.05). Post hoc analyses indicated that the effect of OCs on muscle mass increase was induced by the OC-users (n=7), who used OCs containing 30 µg ethinyl estradiol (EE), whereas the response in users taking OCs with 20 µg ethinyl estradiolEE (n=7) did not differ from NOC. Both the OC and NOC group experienced an increase in maximal isometric strength (p<0.001) and 1RM leg extension (p<0.001) after the training period with no difference between groups. Conclusion: Use of OCs during a 10-week supervised progressive resistance training program was associated with a tendency towards a greater increase in muscle mass and a significantly greater increase in type I muscle fiber area compared to controls. Yet, use of OCs did not influence the overall increase in muscle strength related to training.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fphys.2019.00824

Cites

81 of 81 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Low androgenic activity progestins impair myofibrillar protein fractional synthesis rate at rest and 24 h post-endurance exercise compared to rates observed during the follicular phase of eumenorrheic women, but have no effect on myofibrillar protein breakdown.

    “recent data have shown that low androgenic activity progestins impairs myofibrillar protein FSR at rest and 24 h post-endurance exercise as compared to rates observed during the follicular phase of eumenorrheic women, but they have no effect on myofibrillar protein breakdown [226].”

    From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [226]

    Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 82 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Dalgaard, L. B., Dalgas, U., Andersen, J. L., Rossen, N. B., Møller, A. B., Stødkilde-Jørgensen, H., Jørgensen, J. O., Kovanen, V., Couppé, C., Langberg, H., Kjær, M., & Hansen, M.
Affiliations
  • Aarhus University (DK)
  • University of Copenhagen (DK)
  • Aarhus University Hospital (DK)
  • University of Jyväskylä (FI)
Corresponding author
Hansen, Mette
ORCID
Venue
Frontiers in Physiology
Publisher
Frontiers Media SA
Published
2019-07-02
Volume
10
Pages
824-824
ISSN
1664-042X (ISSN-L)
DOI
10.3389/fphys.2019.00824
PMC
PMC6614284
OpenAlex
W2954407053
Cited by
58
References
82
Citations by year
2026: 5 · 2025: 7 · 2024: 8 · 2023: 16 · 2022: 9 · 2021: 7 · 2020: 5 · 2019: 1
FWCI
5.84
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Physiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
  • Jyväskylä University Digital Archive (University of Jyväskylä) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Fonden til Lægevidenskabens Fremme
  • Steno Diabetes Center Aarhus
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
oral contraceptives, resistance training, muscle hypertrophy, patellar tendon, tendon cross-sectional area, muscle fiber type, maximal isometric strength, young women, quadriceps, knee extension, training effects, sex hormones

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review