Cited by 1,971Antioxidant Activity and Oxidative StressPhytochemicals and Antioxidant ActivitiesExercise and Physiological Responses

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Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

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Sharifi-Rad, Mehdi, Anil Kumar, Nanjangud V., Zucca, Paolo, Varoni, Elena Maria, Dini, Luciana, Panzarini, Elisa, Rajkovic, Jovana, Tsouh Fokou, Patrick Valere, Azzini, Elena, Peluso, Ilaria, Prakash Mishra, Abhay, Nigam, Manisha, El Rayess, Youssef, Beyrouthy, Marc El, Polito, Letizia, Iriti, Marcello, Martins, Natália, Martorell, Miquel, Docea, Anca Oana, Setzer, William N., Calina, Daniela, Cho, William C., Sharifi-Rad, Javad·2020·Frontiers in Physiology

DOI 10.3389/fphys.2020.00694PMC PMC7347016

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Abstract

Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term exposure to increased levels of pro-oxidant factors can cause structural defects at a mitochondrial DNA level, as well as functional alteration of several enzymes and cellular structures leading to aberrations in gene expression. The modern lifestyle associated with processed food, exposure to a wide range of chemicals and lack of exercise plays an important role in oxidative stress induction. However, the use of medicinal plants with antioxidant properties has been exploited for their ability to treat or prevent several human pathologies in which oxidative stress seems to be one of the causes. In this review we discuss the diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases. Finally, both the beneficial and detrimental effects of antioxidant molecules that are used to reduce oxidative stress in several human conditions are discussed.

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Authors: Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., Prakash Mishra, A., Nigam, M., El Rayess, Y., Beyrouthy, M. E., Polito, L., Iriti, M., Martins, N., Martorell, M., Docea, A. O., Setzer, W. N., Calina, D., Cho, W. C., & Sharifi-Rad, J.
Affiliations: University of Cagliari (IT)
University of Milan (IT)
University of Salento (IT)
Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria (IT)
Hemwati Nandan Bahuguna Garhwal University (IN)
Holy Spirit University of Kaslik (LB)
Universidade do Porto (PT)
University of Concepción (CL)
University of Medicine and Pharmacy of Craiova (RO)
University of Alabama in Huntsville (US)
Queen Elizabeth Hospital (CN)
Corresponding author: Martorell, Miquel
Cho, William C.
ORCID: Zucca, Paolo
Varoni, Elena Maria
Dini, Luciana
Panzarini, Elisa
Azzini, Elena
Peluso, Ilaria
Nigam, Manisha
Beyrouthy, Marc El
Polito, Letizia
Iriti, Marcello
Martins, Natália
Martorell, Miquel
Docea, Anca Oana
Setzer, William N.
Cho, William C.
Venue: Frontiers in Physiology
Publisher: Frontiers Media SA
Published: 2020-07-02
Volume: 11
Pages: 694-694
ISSN: 1664-042X (ISSN-L)
DOI: 10.3389/fphys.2020.00694
PMC: PMC7347016
OpenAlex: W3039077710
Cited by: 1,971
References: 211
Citations by year: 2026: 181 · 2025: 371 · 2024: 474 · 2023: 467 · 2022: 323 · 2021: 129 · 2020: 25
FWCI: 20.52
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Physiology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion, other-oa)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Research Information System of Ardabil University of Medical Sciences (Ardabil University of Medical Sciences) (submittedVersion)
AIRUS (submittedVersion)
Funders: Fundação para a Ciência e a Tecnologia (01-0145, NORTE-01-0145-FEDER-000012, UID/BIM/04293/2013, UID/BIM/04293, NORTE2020, NORTE-01-0145)
Comisión Nacional de Investigación Científica y Tecnológica (CCTE AFB170007, AFB170007)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: oxidative stress, antioxidants, lifestyle, chronic disease, cardiovascular disease, diabetes mellitus, neurodegenerative diseases, cancer, mitochondrial DNA damage, processed foods, chemical exposure, physical inactivity, medicinal plants, antioxidant defense, disease prevention

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Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

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