Nitric oxide in exercise physiology: past and present perspectives
Open accessAbstract
Nitric oxide (NO) is a ubiquitous signaling molecule known to modulate various physiological processes, with specific implications in skeletal muscle and broader applications in exercise performance. This review focuses on the modulation of skeletal muscle function, mitochondrial adaptation and function, redox state by NO, and the effect of nitrate supplementation on exercise performance. In skeletal muscle function, NO is believed to increase the maximal shortening velocity and peak power output of muscle fibers. However, its effect on submaximal contraction is still undetermined. In mitochondria, NO may stimulate biogenesis and affect respiratory efficiency. NO also plays a role in the redox state within the skeletal muscle, partially through its interaction with respiratory chain enzymes and transcriptional regulators of antioxidant production. Nitrate supplementation leads to an increased bioavailability of NO in skeletal muscle. Thus, nitrate supplementation has been investigated for its ability to impact performance outcomes in endurance and resistance exercise. The effect of nitrate supplementation on endurance exercise is currently indecisive, although evidence indicates that it may extend the time to exhaustion in endurance exercise. Alternatively, the effect of nitrate supplementation on resistance exercise performance has been less studied. Limited research indicates that nitrate supplementation may improve repetitions to failure. Further research is needed to investigate the influence of training status, age, sex, and duration of supplementation to further elucidate the impact of nitrate supplementation on exercise performance.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
NO plays a central role in regulating muscle blood flow, mitochondrial respiration, and contractile function.
“NO plays a central role in regulating muscle blood flow, mitochondrial respiration, and contractile function [184].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [184]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678 · see citing works
Nitric oxide synthases: regulation and function
Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409 · see citing works
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · cited 1× · see citing works
“Although several investigations have provided insight into the impact of the NOS-independent pathway, research has yet to reveal the speci fi c stimuli required to initiate this pathway (Lundberg et al., 2008).”
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
Boveris, A., & Chance, B. (1973) · Biochemical Journal · doi:10.1042/bj1340707 · Cited by 2,626 · see citing works
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807 · see citing works
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide
Nisoli, E., Clementi, E., Paolucci, C., Cozzi, V., Tonello, C., Sciorati, C., Bracale, R., Valerio, A., Francolini, M., Moncada, S., et al. (2003) · Science · doi:10.1126/science.1079368 · Cited by 1,243 · see citing works
Physiology of Nitric Oxide in Skeletal Muscle
Stamler, J. S., & Meissner, G. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.209 · Cited by 1,080 · see citing works
The Role of Nitric Oxide on Endothelial Function
Tousoulis, D., Kampoli, A.-M., Tentolouris Nikolaos Papageorgiou, C., & Stefanadis, C. (2012) · Current Vascular Pharmacology · doi:10.2174/157016112798829760 · Cited by 1,012 · see citing works
Nitric oxide in skeletal muscle
Kobzik, L., Reid, M. B., Bredt, D. S., & Stamler, J. S. (1994) · Nature · doi:10.1038/372546a0 · Cited by 955 · see citing works
Does nitric oxide modulate mitochondrial energy generation and apoptosis?
Moncada, S., & Erusalimsky, J. D. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm762 · Cited by 789 · see citing works
Enzyme-independent formation of nitric oxide in biological tissues
Zweier, J. L., Wang, P., Samouilov, A., & Kuppusamy, P. (1995) · Nature Medicine · doi:10.1038/nm0895-804 · Cited by 788 · see citing works
Bailey, S. J., Winyard, P., Vanhatalo, A., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Tarr, J., Benjamin, N., & Jones, A. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00722.2009 · Cited by 759 · see citing works
Duncan, C., Dougall, H., Johnston, P., Green, S., Brogan, R., Leifert, C., Smith, L., Golden, M., & Benjamin, N. (1995) · Nature Medicine · doi:10.1038/nm0695-546 · Cited by 734 · see citing works
Poderoso, J. J., Carreras, M. C., Lisdero, C., Riobó, N., Schöpfer, F., & Boveris, A. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0146 · Cited by 726 · see citing works
Nitric Oxide and Endothelial Dysfunction
Cyr, A. R., Huckaby, L. V., Shiva, S. S., & Zuckerbraun, B. S. (2020) · Critical Care Clinics · doi:10.1016/j.ccc.2019.12.009 · Cited by 674 · see citing works
Benjamin, N., O'Driscoll, F., Dougall, H., Duncan, C., Smith, L., Golden, M., & McKenzie, H. (1994) · Nature · doi:10.1038/368502a0 · Cited by 665 · see citing works
S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide
Adachi, T. K., Weisbrod, R. M., Pimentel, D. R., Ying, J., Sharov, V. S., Schöneich, C., & Cohen, R. A. (2004) · Nature Medicine · doi:10.1038/nm1119 · Cited by 662 · see citing works
Effects of dietary nitrate on oxygen cost during exercise
Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01713.x · Cited by 637 · see citing works
The role of nitric oxide in cardiovascular diseases
NASEEM, K. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.09.003 · Cited by 557 · see citing works
Lincoln, T., Dey, N. B., & Sellak, H. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.3.1421 · Cited by 520 · see citing works
Beetroot juice and exercise: pharmacodynamic and dose-response relationships
Wylie, L. J., Kelly, J., Bailey, S. J., Blackwell, J. R., Skiba, P. F., Winyard, P. G., Jeukendrup, A. E., Vanhatalo, A., & Jones, A. M. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00372.2013 · Cited by 500 · see citing works
Nitric oxide. A novel signal transduction mechanism for transcellular communication.
Ignarro, L. J. (1990) · Hypertension · doi:10.1161/01.hyp.16.5.477 · Cited by 498 · see citing works
Nitric oxide synthase in cardiac sarcoplasmic reticulum
Xu, K. Y., Huso, D. L., Dawson, T. M., Bredt, D. S., & Becker, L. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.657 · Cited by 480 · see citing works
Dietary Nitrate Supplementation and Exercise Performance
Jones, A. M. (2014) · Sports Medicine · doi:10.1007/s40279-014-0149-y · Cited by 442 · see citing works
Lansley, K. E., Winyard, P. G., Fulford, J., Vanhatalo, A., Bailey, S. J., Blackwell, J. R., DiMenna, F. J., Gilchrist, M., Benjamin, N., & Jones, A. M. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01070.2010 · Cited by 404 · see citing works
Mechanisms of the Antioxidant Effects of Nitric Oxide
Wink, D. A., Miranda, K. M., Espey, M. G., Pluta, R. M., Hewett, S. J., Colton, C. A., Vitek, M. P., Feelisch, M., & Grisham, M. B. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601300185179 · Cited by 400 · see citing works
Acute Dietary Nitrate Supplementation Improves Cycling Time Trial Performance
LANSLEY, K. E., WINYARD, P. G., BAILEY, S. J., VANHATALO, A., WILKERSON, D. P., BLACKWELL, J. R., GILCHRIST, M., BENJAMIN, N., & JONES, A. M. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31821597b4 · Cited by 388 · see citing works
Exercise and the Nitric Oxide Vasodilator System
Maiorana, A., Driscoll, G. O., Taylor, R. R., & GREEN, D. J. (2003) · Sports Medicine · doi:10.2165/00007256-200333140-00001 · Cited by 382 · see citing works
The role of AMP‐activated protein kinase in mitochondrial biogenesis
Reznick, R. M., & Shulman, G. I. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.109512 · Cited by 371 · see citing works
Non-Enzymatic Nitric Oxide Synthesis in Biological Systems
Zweier, J. L., Samouilov, A., & Kuppusamy, P. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00018-3 · Cited by 363 · see citing works
Irrcher, I., Ljubicic, V., & Hood, D. A. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00267.2007 · Cited by 356 · see citing works
Nitrate Supplementation’s Improvement of 10-km Time-Trial Performance in Trained Cyclists
Cermak, N. M., Gibala, M. J., & van Loon, L. J. C. (2012) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.22.1.64 · Cited by 326 · see citing works
Reactive oxygen in skeletal muscle. III. Contractility of unfatigued muscle
Reid, M. B., Khawli, F. A., & Moody, M. R. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.3.1081 · Cited by 297 · see citing works
Nitric Oxide and Peroxynitrite Interactions with Mitochondria
Radí, R., Cassina, A., & Hodara, R. (2002) · Biological Chemistry · doi:10.1515/bc.2002.044 · Cited by 293 · see citing works
Wu, Z., Huang, X., Feng, Y., Handschin, C., Feng, Y., Gullicksen, P. S., Bare, O., Labow, M., Spiegelman, B., & Stevenson, S. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606714103 · Cited by 291 · see citing works
Galdo, N. A. R., Clementi, E., Melani, M., Boveris, A., Cadenas, E., Moncada, S., & Poderoso, J. J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3590139 · Cited by 278 · see citing works
Nitric oxide and mitochondrial biogenesis
Nisoli, E., & Carruba, M. O. (2006) · Journal of Cell Science · doi:10.1242/jcs.03062 · Cited by 278 · see citing works
Nitric oxide activates skeletal and cardiac ryanodine receptors
Stoyanovsky, D. A., Murphy, T. V., Anno, P. R., Kim, Y.-M., & Salama, G. (1997) · Cell Calcium · doi:10.1016/s0143-4160(97)90093-2 · Cited by 267 · see citing works
Role of nitric oxide in skeletal muscle: synthesis, distribution and functional importance
Reid, M. B. (1998) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1998.0303f.x · Cited by 263 · see citing works
Nitrite in nitric oxide biology: Cause or consequence?
Bryan, N. S. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.019 · Cited by 260 · see citing works
Power, precision, and sample size estimation in sport and exercise science research
Abt, G., Boreham, C. A., Davison, G. W., Jackson, R. C., Nevill, A. M., Wallace, E. S., & Williams, M. R. F. (2020) · Journal of Sports Sciences · doi:10.1080/02640414.2020.1776002 · Cited by 260 · see citing works
Role of Superoxide as a Signaling Molecule
Buetler, T. M., Krauskopf, A., & Rüegg, U. T. (2004) · Physiology · doi:10.1152/nips.01514.2003 · Cited by 231 · see citing works
Wilkerson, D. P., Hayward, G. M., Bailey, S. J., Vanhatalo, A., Blackwell, J. R., & Jones, A. M. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2397-6 · Cited by 229 · see citing works
Vascular nitric oxide: formation and function
Loscalzo, J., & Jin (2010) · Journal of Blood Medicine · doi:10.2147/jbm.s7000 · Cited by 227 · see citing works
Reliability of Time-to-Exhaustion versus Time-Trial Running Tests in Runners
Laursen, P. B., FRANCIS, G. T., Abbiss, C. R., Newton, M. J., & Nosaka, K. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31806010f5 · Cited by 221 · see citing works
McMahon, N. F., Leveritt, M. D., & Pavey, T. G. (2017) · Sports Medicine · doi:10.1007/s40279-016-0617-7 · Cited by 221 · see citing works
Nitric Oxide, Cytochrome C Oxidase, and the Cellular Response to Hypoxia
Taylor, C. T., & Moncada, S. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.181628 · Cited by 220 · see citing works
Nitric oxide and mitochondrial respiration in the heart
Brown, G. C., & Borutaite, V. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.03.022 · Cited by 213 · see citing works
Dietary Nitrate and Physical Performance
Jones, A. M., Thompson, C., Wylie, L. J., & Vanhatalo, A. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051622 · Cited by 206 · see citing works
Nitric oxide and AMPK cooperatively regulate PGC-1α in skeletal muscle cells
Lira, V. A., Brown, D. L., Lira, A. K., Kavazis, A. N., Soltow, Q. A., Zeanah, E. H., & Criswell, D. S. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.194035 · Cited by 185 · see citing works
Self-citationThe effect of nitric oxide on mitochondrial respiration
Poderoso, J. J., Helfenberger, K. E., & Poderoso, C. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.04.005 · Cited by 183 · see citing works
Cooper, C. E., & Giulivi, C. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00310.2006 · Cited by 176 · see citing works
NO-synthase independent NO generation in mammals
Lundberg, J. O., & Weitzberg, E. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.136 · Cited by 172 · see citing works
Gilchrist, M., Winyard, P. G., & Benjamin, N. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.10.005 · Cited by 157 · see citing works
Hoon, M. W., Johnson, N. A., Chapman, P., & Burke, L. M. (2013) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.23.5.522 · Cited by 157 · see citing works
Jones, A. M., Vanhatalo, A., Seals, D. R., Rossman, M. J., Piknova, B., & Jonvik, K. L. (2021) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002470 · Cited by 156 · see citing works
Snyder, S. H. (1992) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(92)90123-3 · Cited by 155 · see citing works
Fiber Type-Specific Effects of Dietary Nitrate
Jones, A. M., Ferguson, S. K., Bailey, S. J., Vanhatalo, A., & Poole, D. C. (2016) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000074 · Cited by 149 · see citing works
Regulation of Mitochondrial Respiration by Oxygen and Nitric Oxide
BOVERIS, A., Costa, L. E., Poderoso, J. J., Carreras, M. C., & Cadenas, E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06181.x · Cited by 148 · see citing works
Inhibition of the skeletal muscle ryanodine receptor calcium release channel by nitric oxide
Mészáros, L., Minarovič, I., & Zahradnı́ková, A. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00003-8 · Cited by 148 · see citing works
No Improvement in Endurance Performance after a Single Dose of Beetroot Juice
Cermak, N. M., Res, P., Stinkens, R., Lundberg, J. O., Gibala, M. J., & van Loon, L. J. C. (2012) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.22.6.470 · Cited by 144 · see citing works
Characterization and function of mitochondrial nitric-oxide synthase
Giulivi, C. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01298-4 · Cited by 144 · see citing works
Jones, A. M. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0036 · Cited by 144 · see citing works
Effects of nitric oxide on the contraction of skeletal muscle
Maréchal, G., & Gailly, P. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050359 · Cited by 135 · see citing works
Nitric Oxide Protects the Skeletal Muscle Ca2+Release Channel from Oxidation Induced Activation
Aghdasi, B., Reid, M. B., & Hamilton, S. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25462 · Cited by 128 · see citing works
Bailey, S. J., Varnham, R. L., DiMenna, F. J., Breese, B. C., Wylie, L. J., & JONES, A. M. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01141.2014 · Cited by 128 · see citing works
Nitric oxide and mitochondria in metabolic syndrome
Litvinova, L. S., Atochin, D. N., Fattakhov, N. S., Василенко, М., Затолокин, П. А., & Кириенкова, Е. В. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00020 · Cited by 127 · see citing works
Nitric Oxide in Skeletal Muscle: Role on Mitochondrial Biogenesis and Function
Tengan, C., Rodrigues, G., & Godinho, R. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131217160 · Cited by 123 · see citing works
Differential Modulation of Nitric Oxide Synthases in Aging: Therapeutic Opportunities
Cáu, S. B. D. A., Carneiro, F. S., & Tostes, R. C. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00218 · Cited by 121 · see citing works
Nitric oxide regulation of mitochondrial oxygen consumption I: cellular physiology
Giulivi, C., Kato, K., & Cooper, C. E. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00307.2006 · Cited by 119 · see citing works
Whitfield, J., Ludzki, A., Heigenhauser, G. J. F., Senden, J. M. G., Verdijk, L. B., van Loon, L. J. C., Spriet, L. L., & Holloway, G. P. (2016) · The Journal of Physiology · doi:10.1113/jp270844 · Cited by 115 · see citing works
Poduslo, J. F., Curran, G. L., Kumar, A. R., Frangione, B., & Soto, C. A. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19990605)39:3 · Cited by 114 · see citing works
Modulation of the Mitochondrial Permeability Transition by Nitric Oxide
Balakirev, M. Y., Khramtsov, V. V., & Zimmer, G. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00710.x · Cited by 112 · see citing works
Inorganic nitrate and nitrite and control of blood pressure
Gilchrist, M., Shore, A. C., & Benjamin, N. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq309 · Cited by 110 · see citing works
[43] Antioxidant effects of nitric oxide
Wink, D. A., Yoram Vodovotz, B., Grisham, M. B., DeGraff, W., Cook, J. C., Pacelli, R., Krishna, M. C., & Mitchell, J. B. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)01105-2 · Cited by 109 · see citing works
Muscle redox signalling pathways in exercise. Role of antioxidants
Mason, S. A., Morrison, D., McConell, G. K., & Wadley, G. D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.022 · Cited by 103 · see citing works
An Overview of NO Signaling Pathways in Aging
Pourbagher-Shahri, A. M., Farkhondeh, T., Talebi, M., Kopustinskiene, D. M., Samarghandian, S., & Bernatoniene, J. (2021) · Molecules · doi:10.3390/molecules26154533 · Cited by 101 · see citing works
Gonzalez, A. M., Townsend, J. R., Pinzone, A. G., & Hoffman, J. R. (2023) · Nutrients · doi:10.3390/nu15030660 · Cited by 89 · see citing works
Regulation of mitochondrial function and energetics by reactive nitrogen oxides
Larsen, F. J., Schiffer, T. A., Weitzberg, E., & Lundberg, J. O. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.580 · Cited by 87 · see citing works
Ingestion of a Nitric Oxide Enhancing Supplement Improves Resistance Exercise Performance
Mosher, S. L., Sparks, S. A., Williams, E. L., Bentley, D. J., & Mc Naughton, L. R. (2016) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001437 · Cited by 82 · see citing works
McConell, G. K., Ng, G. P. Y., Phillips, M., Ruan, Z., Macaulay, S. L., & Wadley, G. D. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00377.2009 · Cited by 80 · see citing works
Effect of Acute Beetroot Juice Supplementation on Bench Press Power, Velocity, and Repetition Volume
Williams, T. D., Martin, M. P., Mintz, J. A., Rogers, R. R., & Ballmann, C. G. (2020) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003509 · Cited by 78 · see citing works
Nitrate as a source of nitrite and nitric oxide during exercise hyperemia in rat skeletal muscle
Piknova, B., Park, J. W., Kwan (Jeff) Lam, K., & Schechter, A. N. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.03.005 · Cited by 75 · see citing works
Nitric oxide regulation of cellular metabolism: Adaptive tuning of cellular energy
Pappas, G., Wilkinson, M. L., & Gow, A. J. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.11.006 · Cited by 71 · see citing works
Ji, L. L., Gómez‐Cabrera, M. C., & Viña, J. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-098 · Cited by 71 · see citing works
Biochemistry primer for exercise science
Malone, T. (1996) · Choice Reviews Online · doi:10.5860/choice.33-2746 · Cited by 67 · see citing works
Dietary nitrate-induced increases in human muscle power: High versus low responders
Coggan, A. R., Broadstreet, S. R., Mikhalkova, D., Bole, I., Leibowitz, J. L., Kadkhodayan, A., Park, S., Thomas, D. P., Thies, D., & Peterson, L. R. (2018) · Physiological Reports · doi:10.14814/phy2.13575 · Cited by 66 · see citing works
Silva, K. V. C., Costa, B. D., Gomes, A. C., Saunders, B., & Mota, J. F. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac054 · Cited by 64 · see citing works
Nitric oxide effects on shortening velocity and power production in the rat diaphragm
Morrison, R. J., Miller, C. C., & Reid, M. B. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.3.1065 · Cited by 63 · see citing works
Ranchal-Sanchez, A., Diaz-Bernier, V. M., De La Florida-Villagran, C. A., Llorente-Cantarero, F. J., Campos-Perez, J., & Jurado-Castro, J. M. (2020) · Nutrients · doi:10.3390/nu12071912 · Cited by 63 · see citing works
Effect of dietary nitrate levels on nitrate fluxes in rat skeletal muscle and liver
Gilliard, C. N., Lam, J. K., Cassel, K. S., Park, J. W., Schechter, A. N., & Piknova, B. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.01.010 · Cited by 63 · see citing works
Effects of Dietary Supplements on Adaptations to Endurance Training
Rothschild, J. A., & Bishop, D. J. (2019) · Sports Medicine · doi:10.1007/s40279-019-01185-8 · Cited by 61 · see citing works
Targeting NOS as a therapeutic approach for heart failure
Tang, L., Wang, H., & Ziolo, M. T. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.12.013 · Cited by 60 · see citing works
Stanaway, L., Rutherfurd-Markwick, K., Page, R., & Ali, A. (2017) · Nutrients · doi:10.3390/nu9111171 · Cited by 60 · see citing works
From nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease
Liu, H., Huang, Y., Huang, M., Wang, M., Ming, Y., Chen, W., Chen, Y., Tang, Z., & Jia, B. (2023) · European Journal of Medical Research · doi:10.1186/s40001-023-01413-y · Cited by 58 · see citing works
Van De Walle, G. P., & Vukovich, M. D. (2018) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002046 · Cited by 56 · see citing works
Nitric oxide, aging and aerobic exercise: Sedentary individuals to Master's athletes
Shannon, O. M., Clifford, T., Seals, D. R., Craighead, D. H., & Rossman, M. J. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.06.002 · Cited by 51 · see citing works
Does dietary nitrate say NO to cardiovascular ageing? Current evidence and implications for research
Siervo, M., Scialò, F., Shannon, O. M., Stephan, B. C. M., & Ashor, A. W. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118000058 · Cited by 48 · see citing works
Effect of nitric oxide on the maximal velocity of shortening of a mouse skeletal muscle
Maréchal, G., & Beckersbleukx, G. (1998) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050722 · Cited by 43 · see citing works
Fernandez, A. R., Castillo, D., González, J. R., Domínguez, R., & Bailey, S. J. (2020) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2020.05.018 · Cited by 42 · see citing works
Petrov, K. A., Malomouzh, A. I., Kovyazina, I. V., Krejci, É., Nikitashina, A. D., Proskurina, S. E., Васильевич, З. В., & Nikolsky, E. E. (2012) · European Journal of Neuroscience · doi:10.1111/ejn.12029 · Cited by 39 · see citing works
Cyclic GMP is a Second Messenger by which Nitric Oxide Inhibits Diaphragm Contraction
Abraham, R. Z., Kobzik, L., Moody, M. R., Reid, M. B., & Stamler, J. S. (1998) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(97)00421-2 · Cited by 39 · see citing works
Nitric oxide and skeletal muscle contractile function
Kumar, R. A., Coggan, A. R., & Ferreira, L. F. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.04.001 · Cited by 36 · see citing works
San Juan, A. F., Dominguez, R., Lago-Rodríguez, Á., Montoya, J. J., Tan, R., & Bailey, S. J. (2020) · Nutrients · doi:10.3390/nu12082227 · Cited by 36 · see citing works
The role of nitric oxide in muscle fibers with oxidative phosphorylation defects
Tengan, C. H., Kiyomoto, B. H., Godinho, R. O., Gamba, J., Neves, A. C., Schmidt, B., Oliveira, A. S. B., & Gabbai, A. A. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.184 · Cited by 35 · see citing works
Ntessalen, M., Procter, N. E. K., Schwarz, K., Loudon, B. L., Minnion, M., Fernandez, B. O., Vassiliou, V. S., Vauzour, D., Madhani, M., Constantin‐Teodosiu, D., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz245 · Cited by 28 · see citing works
Rho-kinase as a therapeutic target in vascular diseases: Striking nitric oxide signaling
Kolluru, G. K., Majumder, S., & Chatterjee, S. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.09.002 · Cited by 27 · see citing works
The State of the Nitric Oxide Cycle in Respiratory Tract Diseases
Келдибековна, С. С., Klimanov, I. A., Kubysheva, N. I., Попова, Н. А., & Batyrshin, I. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4859260 · Cited by 24 · see citing works
Early reduction of cytochrome c in hypoxia
Chance, B. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)81451-0 · Cited by 24 · see citing works
Tan, R., Pennell, A., Karl, S. T., Cass, J. K., Go, K., Clifford, T., Bailey, S. J., & Storm, C. P. (2023) · Nutrients · doi:10.3390/nu15112493 · Cited by 23 · see citing works
DOES NITRIC OXIDE MODULATE TRANSMITTER RELEASE AT THE MAMMALIAN NEUROMUSCULAR JUNCTION?
Nickels, T. J., Reed, G. W., Drummond, J. T., Blevins, D. E., Lutz, M. C., & Wilson, D. F. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04562.x · Cited by 21 · see citing works
Tan, R., Pennell, A., Price, K. M., Karl, S. T., Seekamp-Hicks, N. G., Paniagua, K. K., Weiderman, G. D., Powell, J. P., Sharabidze, L. K., Lincoln, I. G., et al. (2022) · Nutrients · doi:10.3390/nu14183703 · Cited by 21 · see citing works
Liu, G., Guo, H., Zhao, W., Yan, H., Zhang, E., & Gao, L. (2023) · Molecules · doi:10.3390/molecules28207122 · Cited by 20 · see citing works
Imaizumi, N., & Aniya, Y. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.10.012 · Cited by 14 · see citing works
Effects of Nitrate Supplementation on Muscle Strength and Mass: A Systematic Review
Anderson, O. K., Martínez‐Ferrán, M., Calvo, J. L., Sáiz, S. L. J., & Pareja-Galeano, H. (2021) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000004101 · Cited by 14 · see citing works
Underpowered studies in muscle metabolism research: Determinants and considerations
Houtvast, D. C. J., Betz, M. W., Hooren, B. V., Vanbelle, S., Verdijk, L. B., van Loon, L. J. C., & Trommelen, J. (2024) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2024.10.152 · Cited by 11 · see citing works
Tan, R., Cass, J. K., Lincoln, I. G., Wideen, L. E., Nicholl, M. J., Molnar, T. J., Gough, L. A., Bailey, S. J., & Pennell, A. (2024) · Nutrients · doi:10.3390/nu16162764 · Cited by 10 · see citing works
Tan, R., Baranauskas, M. N., Karl, S. T., de Zevallos, J. O., Shei, R., Paris, H. L. R., Wiggins, C. C., & Bailey, S. J. (2023) · Nitric Oxide · doi:10.1016/j.niox.2023.05.003 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lecce, E., Amoruso, P., Felici, F., & Bazzucchi, I. (2025) · The Journal of Physiology · doi:10.1113/jp289716 · Cited by 47 · see citing works
The Role of Nitric Oxide in Cancer Treatment: Ally or Foe?
Myśliwiec, A., Bartusik‐Aebisher, D., & Aebisher, D. (2025) · Molecules · doi:10.3390/molecules30132802 · Cited by 24 · see citing works
Salem, A., Ammar, A., Kerkeni, M., Boujelbane, M. A., Uyar, A. M., Köbel, L. M., Selvaraj, S. A., Zare, R., Heinrich, K. M., Jahrami, H., et al. (2025) · Nutrients · doi:10.3390/nu17101720 · Cited by 15 · see citing works
Laird, P.-A. R., Wall, R. M., & Craige, S. M. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156360 · Cited by 11 · see citing works
Sun, Y., Xiong, C., Yuan, J.-Y., & Guo, Z. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.162378 · Cited by 6 · see citing works
Wilkinson, M., Rollin, T., Kuriakose, M., Haggerty-Goede, R. A. L., Miller, D. M., & Dunham‐Snary, K. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110370 · Cited by 6 · see citing works
Meng, Q., & Su, C.-H. (2025) · Antioxidants · doi:10.3390/antiox14070815 · Cited by 6 · see citing works
Eroğlu, M. N., Köse, B., Kolayiş, İ. E., & Haberal, B. (2026) · Scientific Reports · doi:10.1038/s41598-026-37514-x · Cited by 5 · see citing works
Stahl, M. E., Grammer, E. E., WELTMAN, A. L., Burleigh, M. C., Derella, C. C., Abbate, A., Denicolai, M., & Allen, J. D. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00567.2025 · Cited by 4 · see citing works
Kovyazina, I. V., Mukhutdinova, K. A., & Petrov, A. M. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04563-z · Cited by 4 · see citing works
Balogh, L., Szklenár, E., Diós, Á., Arany, A. C., Pucsok, J. M., Bács, Z. M., Rátgéber, L., Csiki, Z., Gyetvai, Á., & Papp, G. (2026) · Life · doi:10.3390/life16010084 · Cited by 4 · see citing works
McIntosh, M. C., Mueller, B. J., Tiede, D., Anglin, D. A., Kontos, G. J., Plotkin, D. L., Mattingly, M. L., Kontos, N. J., Michel, J. M., Agyin-Birikorang, A., et al. (2026) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00195.2025 · Cited by 5 · see citing works
Self-citationKurtz, J. A., Feresin, R. G., Grazer, J. L., Otis, J. S., Wilson, K. E., Doyle, J. A., & Zwetsloot, K. A. (2025) · Nutrients · doi:10.3390/nu17020224 · Cited by 3 · see citing works
Kurhaluk, N., Kołodziejska, R., Buyun, L., Kamiński, P., & Tkaczenko, H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083461 · Cited by 3 · see citing works
“NO plays a central role in regulating muscle blood flow, mitochondrial respiration, and contractile function [184].”
Gunasekaran, S. K., Khan, M. A., Mirza, M. A., Bhupathi, S. S., & Azeeze, M. S. T. A. (2026) · Muscles · doi:10.3390/muscles5010013 · Cited by 2 · see citing works
Anti-Photoaging Activities of Limosilactobacillus reuteri Culture Broth
Song, N. R., Shin, S. Y., Kim, K. M., Choi, S. R., Park, D. S., Kim, S. O., Jung, D. H., & Park, K. M. (2025) · Biocell · doi:10.32604/biocell.2025.065467 · Cited by 2 · see citing works
Ramírez-Munera, M., Arcusa, R., López-Román, F. J., Ávila-Gandía, V., Pérez-Piñero, S., Muñoz-Carrillo, J. C., Luque-Rubia, A. J., & Marhuenda, J. (2025) · Nutrients · doi:10.3390/nu17142381 · Cited by 2 · see citing works
Nie, R., Zhang, G., Kong, J., Wang, X., Xie, Z., Lin, L., Li, T., & Liang, Y. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1699766 · Cited by 1 · see citing works
Bellanova, L., Viappiani, C., Scarano, A., Bruno, S., Morreale, K., Franzen, A., Santiago-Schübel, B., Cupellini, L., Svensson, V., Drepper, T., et al. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.151666 · Cited by 1 · see citing works
Yun, H. R., Singh, M. K., Han, S., Ranbhise, J. S., Seo, H., Kim, S. S., & Kang, I. (2026) · Antioxidants · doi:10.3390/antiox15060678 · Cited by 1 · see citing works
Eroğlu, M. N., Pancar, S., Torres, O. L., & Fernández-Elías, V. E. (2026) · Nutrients · doi:10.3390/nu18152513 · Cited by 1 · see citing works
Roohi, H. (2026) · Journal of Fluorescence · doi:10.1007/s10895-026-04876-4 · Cited by 1 · see citing works
Mangine, G. T., King, W. W., Henley, J. W., Hines, A., McGeehan, K. C., Fanno, J. D., Esmat, T. A., McLester, J. R., & Grazer, J. L. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1741204
Ammar, A., Salem, A., Kerkeni, M., Mera, T. A., Baťalík, L., Toral-Noristz, M., Jahrami, H., Tounsi, S., Żmijewski, P., Ghazzawi, H., et al. (2026) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2026.2625827
Zandonai, T., Peiró, A. M., Nuño, I., & Segura, A. (2026) · European Urology Focus · doi:10.1016/j.euf.2026.05.001
Sex Differences in Exercise-Induced Arteriolar Remodeling of Skeletal Muscle
Hainzl, T., Nádasy, G. L., Márka, E. R., Nagy, K., Tõkés, A., Oláh, A., Radovits, T., Merkely, B. P., Ács, N., Várbı́ró, S., et al. (2026) · Applied Sciences · doi:10.3390/app16105041
Majrshi, M. S., Alzahrani, A. A., George, P. M., Perkins, A., Philip, K. E. J., Alshehri, M., Fenwick, P. S., Alsulayyim, A. S., Price, L., Polkey, M. I., et al. (2026) · Thorax · doi:10.1136/thorax-2026-224919
Cherappurath, N., Navaf, M., YILDIZ, M., Ceylan, H. İ., Thoompenthodi, M. A., Elayaraja, M., Muntean, R. I., Ștefănică, V., Sunooj, K. V., & Pelasseri, M. (2026) · Nutrients · doi:10.3390/nu18152551
Lamatta, A. O., Quezada, R. S., Cuevas, J. P., Rabanal, D. O., & Machuca, L. H. L. (2026) · Archivos de la Sociedad Chilena de Medicina del Deporte · doi:10.59856/arch.soc.chil.med.deporte.v71i1.92
Chimeric Construct with mTagBFP2 and mCherry Is a Ratiometric Fluorescent Sensor for Nitric Oxide
Bellanova, L., Scarano, A., Viappiani, C., Mariangeli, M., Simeone, M., Mussini, A., Bruno, S., Franzen, A., Svensson, V., Drepper, T., et al. (2026) · Chemical & Biomedical Imaging · doi:10.1021/cbmi.6c00130
Frenda, S., Pinto, G., Nakamura, M., Konrad, A., Iovane, A., Bellafiore, M., Bianco, A., & Thomas, E. (2026) · European Journal of Applied Physiology · doi:10.1007/s00421-026-06411-6
Mueller, B. J., McIntosh, M. C., Tiede, D., Anglin, D. A., Kontos, G. J., Lewis, D. T., Goodlett, M. D., Frugé, A. D., Mobley, C. B., Judd, R. L., et al. (2026) · European Journal of Applied Physiology · doi:10.1007/s00421-026-06460-x · Cited by 1 · see citing works
Self-citation
- Authors
- Mueller, B. J., Roberts, M. D., Mobley, C. B., Judd, R. L., & Kavazis, A. N.
- Affiliations
- Auburn University (US)
- Corresponding author
- Kavazis, Andreas N.
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2025-01-09
- Volume
- 15
- Pages
- 1504978-1504978
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC11754211
- OpenAlex
- W4406228809
- Cited by
- 32
- References
- 119
- Citations by year
- 2026: 20 · 2025: 12
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- nitric oxide, nitrate supplementation, skeletal muscle function, mitochondrial biogenesis, mitochondrial function, redox state, exercise performance, endurance exercise, resistance training, time to exhaustion, muscle contraction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review