Cited by 66Plant biochemistry and biosynthesisPlant Gene Expression AnalysisPlant Molecular Biology Research

An R2R3-MYB Transcription Factor Positively Regulates the Glandular Secretory Trichome Initiation in Artemisia annua L.

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Qin, Wei, Xie, Lihui, Li, Yongpeng, Liu, Hang, Fu, Xueqing, Chen, Tiantian, Hassani, Danial, Li, Ling +2 more·2021·Frontiers in Plant Science

Abstract

Artemisia annua L. is known for its specific product “artemisinin” which is an active ingredient for curing malaria. Artemisinin is secreted and accumulated in the glandular secretory trichomes (GSTs) on A. annua leaves. Earlier studies have shown that increasing GST density is effective in increasing artemisinin content. However, the mechanism of GST initiation is not fully understood. To this end, we isolated and characterized an R2R3-MYB gene,AaMYB17, which is expressed specifically in the GSTs of shoot tips. Overexpression of AaMYB17 in A. annua increased GST density and enhanced the artemisinin content, whereas RNA interference of AaMYB17 resulted in the reduction of GST density and artemisinin content. Additionally, neither overexpression lines nor RNAi lines showed an abnormal phenotype in plant growth and the morphology of GSTs. Our study demonstrates that AaMYB17 is a positive regulator of GSTs’ initiation, without influencing the trichome morphology.

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Crossref · 10.3389/fpls.2021.657156

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  1. Serna L. Martin C. (2006). Trichomes: different regulatory networks lead to convergent structures. Trends Plant Sci. 11 274– 280. 16697247

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Authors
Qin, W., Xie, L., Li, Y., Liu, H., Fu, X., Chen, T., Hassani, D., Li, L., Sun, X., & Tang, K.
Affiliations
Shanghai Jiao Tong University (CN)
Corresponding author
Tang, Kexuan
Venue
Frontiers in Plant Science
Published
2021-04-09
Volume
12
Pages
657156-657156
ISSN
1664-462X (ISSN-L)
OpenAlex
W3154901582
Cited by
66
References
53
Citations by year
2026: 13 · 2025: 9 · 2024: 9 · 2023: 18 · 2022: 14 · 2021: 3
FWCI
3.45
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Plant Science (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Bill and Melinda Gates Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Gene Expression Analysis
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords
R2R3-MYB transcription factor, trichome initiation, Artemisia annua, artemisinin biosynthesis, trichome density, trichome morphology, gene overexpression, RNA interference

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