An R2R3-MYB Transcription Factor Positively Regulates the Glandular Secretory Trichome Initiation in Artemisia annua L.
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Artemisia annua L. is known for its specific product “artemisinin” which is an active ingredient for curing malaria. Artemisinin is secreted and accumulated in the glandular secretory trichomes (GSTs) on A. annua leaves. Earlier studies have shown that increasing GST density is effective in increasing artemisinin content. However, the mechanism of GST initiation is not fully understood. To this end, we isolated and characterized an R2R3-MYB gene,AaMYB17, which is expressed specifically in the GSTs of shoot tips. Overexpression of AaMYB17 in A. annua increased GST density and enhanced the artemisinin content, whereas RNA interference of AaMYB17 resulted in the reduction of GST density and artemisinin content. Additionally, neither overexpression lines nor RNAi lines showed an abnormal phenotype in plant growth and the morphology of GSTs. Our study demonstrates that AaMYB17 is a positive regulator of GSTs’ initiation, without influencing the trichome morphology.
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AaMYB17 overexpression lines increased glandular trichome density and artemisinin content, whereas RNAi of AaMYB17 resulted in decreased glandular trichome density.
“They reported that AaMYB17 overexpression lines increased glandular trichome density and artemisinin content, whereas RNAi of AaMYB17 resulted in decreased glandular trichome density.”
From Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches (2021) · cites this paper as Qin et al. 2021
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Tamura, K., Peterson, D., Peterson, N., Stecher, G., Nei, M., & Kumar, S. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr121 · Cited by 39,795 · see citing works
GUS fusions: beta‐glucuronidase as a sensitive and versatile gene fusion marker in higher plants.
Jefferson, R., Kavanagh, T. A., & Bevan, M. W. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02730.x · Cited by 9,854 · see citing works
MYB transcription factors in Arabidopsis
Dubos, C., Stracke, R., Erich Grotewold, A., Weißhaar, B., Martin, C. R., & Lepiniec, L. (2010) · Trends in Plant Science · doi:10.1016/j.tplants.2010.06.005 · Cited by 4,885 · see citing works
The R2R3-MYB gene family in Arabidopsis thaliana
Stracke, R., Werber, M., & Weißhaar, B. (2001) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(00)00199-0 · Cited by 2,180 · see citing works
The function of terpene natural products in the natural world
Gershenzon, J., & Dudareva, N. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.5 · Cited by 2,161 · see citing works
Sparkes, I. A., Runions, J., Kearns, A., & Hawes, C. R. (2006) · Nature Protocols · doi:10.1038/nprot.2006.286 · Cited by 1,913 · see citing works
Natural products and plant disease resistance
Dixon, R. A. (2001) · Nature · doi:10.1038/35081178 · Cited by 1,796 · see citing works
Trichome diversity and development
Werker, E. (2000) · Advances in botanical research · doi:10.1016/s0065-2296(00)31005-9 · Cited by 734 · see citing works
Multifunctionality and diversity within the plant MYB-gene family
Jin, H., & Martin, C. R. (1999) · Plant Molecular Biology · doi:10.1023/a:1006319732410 · Cited by 705 · see citing works
MYB transcription factors in plants
Martin, C. R., & Paz‐Ares, J. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(96)10049-4 · Cited by 617 · see citing works
New Approaches for Studying and Exploiting an Old Protuberance, the Plant Trichome
Wagner, G. J. (2003) · Annals of Botany · doi:10.1093/aob/mch011 · Cited by 616 · see citing works
Kranz, H. D., Denekamp, M., Greco, R., Jin, H., Leyva, A., Meissner, R. C., Petroni, K., Urzainqui, A., Bevan, M. W., Martin, C. R., et al. (1998) · The Plant Journal · doi:10.1046/j.1365-313x.1998.00278.x · Cited by 608 · see citing works
Mauricio, R., & Rausher, M. D. (1997) · Evolution · doi:10.1111/j.1558-5646.1997.tb01467.x · Cited by 505 · see citing works
Noda, K., Glover, B. J., Linstead, P., & Martin, C. R. (1994) · Nature · doi:10.1038/369661a0 · Cited by 465 · see citing works
Trichomes: different regulatory networks lead to convergent structures
Serna, L., & Martin, C. R. (2006) · Trends in Plant Science · doi:10.1016/j.tplants.2006.04.008 · Cited by 447 · see citing works
Harnessing plant trichome biochemistry for the production of useful compounds
Schilmiller, A. L., Last, R. L., & Pichersky, E. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03432.x · Cited by 439 · see citing works
A role for Arabidopsis cryptochromes and COP1 in the regulation of stomatal opening
Mao, J., Zhang, Y., Sang, Y., Li, Q., & Yang, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501011102 · Cited by 385 · see citing works
Plant Glandular Trichomes: Natural Cell Factories of High Biotechnological Interest
Huchelmann, A., Boutry, M., & Hachez, C. (2017) · PLANT PHYSIOLOGY · doi:10.1104/pp.17.00727 · Cited by 378 · see citing works
Molecular Evolution of the Myb Family of Transcription Factors: Evidence for Polyphyletic Origin
Rosinski, J., & Atchley, W. R. (1998) · Journal of Molecular Evolution · doi:10.1007/pl00006285 · Cited by 368 · see citing works
Graham, I. A., Besser, K., Blumer, S., Branigan, C. A., Czechowski, T., Elias, L., Guterman, I., Harvey, D., Isaac, P. G., Khan, A. M., et al. (2010) · Science · doi:10.1126/science.1182612 · Cited by 348 · see citing works
Self-citationThe MYB transcription factor GhMYB25 regulates early fibre and trichome development
Machado, A., Wu, Y., Yang, Y., Llewellyn, D. J., & Dennis, E. S. (2009) · The Plant Journal · doi:10.1111/j.1365-313x.2009.03847.x · Cited by 335 · see citing works
Oshima, Y., Shikata, M., Koyama, T., Ohtsubo, N., Mitsuda, N., & Ohme‐Takagi, M. (2013) · The Plant Cell · doi:10.1105/tpc.113.110783 · Cited by 316 · see citing works
More than 80R2R3‐MYB regulatory genes in the genome of Arabidopsis thaliana
Romero, Fuertes, Benito, Malpica, Leyva, A., & Paz‐Ares, J. (1998) · The Plant Journal · doi:10.1046/j.1365-313x.1998.00113.x · Cited by 315 · see citing works
Functional Analysis of Transcription Factors in Arabidopsis
Mitsuda, N., & Ohme‐Takagi, M. (2009) · Plant and Cell Physiology · doi:10.1093/pcp/pcp075 · Cited by 299 · see citing works
Shen, Q., Lu, X., Yan, T., Fu, X., Lv, Z., Zhang, F., Pan, Q., Wang, G., Sun, X., & Tang, K. (2016) · New Phytologist · doi:10.1111/nph.13874 · Cited by 296 · see citing works
Self-citationControl of cell and petal morphogenesis by R2R3 MYB transcription factors
Baumann, K., Perez-Rodriguez, M., Bradley, D. J., Venail, J., Bailey, P. C. E., Jin, H., Koes, R. E., Roberts, K., & Martin, C. R. (2007) · Development · doi:10.1242/dev.02836 · Cited by 294 · see citing works
GhMYB25‐like: a key factor in early cotton fibre development
Walford, S., Wu, Y., Llewellyn, D. J., & Dennis, E. S. (2010) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04464.x · Cited by 283 · see citing works
Jakoby, M. J., Falkenhan, D., Mader, M. T., Brininstool, G., Wischnitzki, E., Platz, N., Hudson, A., Hülskamp, M., Larkin, J. C., & Schnittger, A. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.126979 · Cited by 278 · see citing works
Development and Fine Structure of the Glandular Trichomes of Artemisia annua L.
Duke, S. O., & Paul, R. N. (1993) · International Journal of Plant Sciences · doi:10.1086/297096 · Cited by 276 · see citing works
Glandular trichomes: what comes after expressed sequence tags?
Tissier, A. F. (2012) · The Plant Journal · doi:10.1111/j.1365-313x.2012.04913.x · Cited by 261 · see citing works
Trichomes as models for studying plant cell differentiation
Yang, C., & Ye, Z. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1147-6 · Cited by 256 · see citing works
A regulatory gene induces trichome formation and embryo lethality in tomato
Yang, C., Li, J., Zhang, J., Luo, Z., Gong, P., Zhang, C., Li, J., Wang, T., Zhang, Y., Lu, Y., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100532108 · Cited by 245 · see citing works
Maes, L., Van Nieuwerburgh, F. C. W., Zhang, Y., Reed, D. W., Pollier, J., Vande Casteele, S. R. F., Inzé, D., Covello, P. S., Deforce, D. L. D., & Goossens, A. (2011) · New Phytologist · doi:10.1111/j.1469-8137.2010.03466.x · Cited by 240 · see citing works
Review of Cases With the Emerging Fifth Human Malaria Parasite, Plasmodium knowlesi
Kantele, A., & Jokiranta, T. S. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir180 · Cited by 234 · see citing works
Tattini, M., Gravano, E., Pinelli, P., Mulinacci, N., & Romani, A. (2000) · New Phytologist · doi:10.1046/j.1469-8137.2000.00743.x · Cited by 233 · see citing works
Yan, T., Chen, M., Shen, Q., Li, L., Fu, X., Pan, Q., Tang, Y., Shi, P., Lv, Z., Jiang, W., et al. (2016) · New Phytologist · doi:10.1111/nph.14205 · Cited by 232 · see citing works
Self-citationTrichome-derived O -acyl sugars are a first meal for caterpillars that tags them for predation
Weinhold, A., & Baldwin, I. T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101306108 · Cited by 227 · see citing works
Matías‐Hernández, L., Jiang, W., Yang, K., Tang, K., Brodelius, P. E., & Pelaz, S. (2017) · The Plant Journal · doi:10.1111/tpj.13509 · Cited by 218 · see citing works
Self-citationYan, T., Li, L., Xie, L., Chen, M., Shen, Q., Pan, Q., Fu, X., Shi, P., Tang, Y., Huang, H., et al. (2018) · New Phytologist · doi:10.1111/nph.15005 · Cited by 213 · see citing works
Self-citationGlover, B. J., Perez-Rodriguez, M., & Martin, C. R. (1998) · Development · doi:10.1242/dev.125.17.3497 · Cited by 211 · see citing works
Fridman, E., Wang, J., Iijima, Y., Froehlich, J. E., Gang, D. R., Ohlrogge, J. B., & Pichersky, E. (2005) · The Plant Cell · doi:10.1105/tpc.104.029736 · Cited by 189 · see citing works
Tan, H., Ling Zhi, X. I. A. O., Gao, S., Li, Q., Chen, J., Xiao, Y., Ji, Q., Chen, R., Chen, W., & Zhang, L. (2015) · Molecular Plant · doi:10.1016/j.molp.2015.04.002 · Cited by 178 · see citing works
Shi, P., Fu, X., Shen, Q., Liu, M., Pan, Q., Tang, Y., Jiang, W., Lv, Z., Yan, T., Ma, Y., et al. (2017) · New Phytologist · doi:10.1111/nph.14789 · Cited by 178 · see citing works
Self-citationXie, Z., Kapteyn, J., & Gang, D. R. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03429.x · Cited by 152 · see citing works
Thomas Payne, John Clement, Arnold, D. S., & Lloyd, A. (1999) · Development · doi:10.1242/dev.126.4.671 · Cited by 150 · see citing works
Relative expression of genes of terpene metabolism in different tissues of Artemisia annuaL
Olofsson, L., Engström, A., Lundgren, A., & Brodelius, P. E. (2011) · BMC Plant Biology · doi:10.1186/1471-2229-11-45 · Cited by 144 · see citing works
Differential transcriptome analysis of glandular and filamentous trichomes in Artemisia annua
Soetaert, S. S., Van Neste, C. M., Vandewoestyne, M. L., Head, S. R., Goossens, A., Van Nieuwerburgh, F. C., & Deforce, D. L. (2013) · BMC Plant Biology · doi:10.1186/1471-2229-13-220 · Cited by 109 · see citing works
Artemisia annua glandular secretory trichomes: the biofactory of antimalarial agent artemisinin
Ling Zhi, X. I. A. O., Tan, H., & Zhang, L. (2016) · 中国科学通报:英文版 · doi:10.1007/s11434-015-0980-z · Cited by 94 · see citing works
Plett, J. M., Wilkins, O., Campbell, M. M., Ralph, S. G., & Regan, S. (2010) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04343.x · Cited by 73 · see citing works
Brockington, S. F., Álvarez-Fernández, R., Landis, J. B., Alcorn, K., Walker, R. H., Thomas, M. M., Hileman, L. C., & Glover, B. J. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss260 · Cited by 72 · see citing works
Singh, N. D., Kumar, S., & Daniell, H. (2016) · Plant Biotechnology Journal · doi:10.1111/pbi.12476 · Cited by 67 · see citing works
Cheng, Y. F., Cao, L., Wang, S., Yong-Peng, L., Wang, H., & Zhou, Y. (2014) · BIO-PROTOCOL · doi:10.21769/bioprotoc.1165 · Cited by 32 · see citing works
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Research works printed but not linked: 1
- Serna L. Martin C. (2006). Trichomes: different regulatory networks lead to convergent structures. Trends Plant Sci. 11 274– 280. 16697247
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Shen, N., Wang, T. A., Gan, Q., Liu, S., Wang, L., & Jin, B. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132531 · Cited by 2,161 · see citing works
Chen, S., Wang, X., Cheng, Y., Gao, H., & Chen, X. (2023) · Molecules · doi:10.3390/molecules28134982 · Cited by 512 · see citing works
Zhuang, W., Li, Y.-H., Shu, X., Pu, Y.-T., Wang, X., Wang, T., & Wang, Z. (2023) · Molecules · doi:10.3390/molecules28083599 · Cited by 253 · see citing works
Self-citationWu, X., Meng, X., Su, P., Zhang, Y., Tu, L., Zhao, H., Gao, W., Huang, L., & Hu, Y. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136652 · Cited by 133 · see citing works
Liu, H., Li, L., Fu, X., Li, Y., Chen, T., Qin, W. D., Yan, X., Wu, Z., Xie, L., Kayani, S., et al. (2022) · New Phytologist · doi:10.1111/nph.18702 · Cited by 78 · see citing works
Self-citationFunctions of Representative Terpenoids and Their Biosynthesis Mechanisms in Medicinal Plants
Wang, Q., Zhao, X., Jiang, Y., Jin, B., & Wang, L. (2023) · Biomolecules · doi:10.3390/biom13121725 · Cited by 77 · see citing works
Wani, K. I., Choudhary, S., Zehra, A., Naeem, M., Weathers, P., & Aftab, T. (2021) · Planta · doi:10.1007/s00425-021-03676-3 · Cited by 74 · see citing works
Chen, T., Li, Y., Xie, L., Hao, X., Liu, H., Qin, W. D., Wang, C., Yan, X., Wu-Zhang, K., Yao, X., et al. (2021) · Horticulture Research · doi:10.1038/s41438-021-00652-6 · Cited by 68 · see citing works
Self-citationFrom Plant to Yeast—Advances in Biosynthesis of Artemisinin
Zhao, L., Zhu, Y., Jia, H., Han, Y., Zheng, X., Wang, M., & Feng, W. (2022) · Molecules · doi:10.3390/molecules27206888 · Cited by 64 · see citing works
A concise review on Artemisia annua L.: A major source of diverse medicinal compounds
Soni, R., Shankar, G., Mukhopadhyay, P., & Gupta, V. (2022) · Industrial Crops and Products · doi:10.1016/j.indcrop.2022.115072 · Cited by 62 · see citing works
Saxena, S., Pal, L., Naik, J., Singh, Y., Verma, P. K., Chattopadhyay, D., & Pandey, A. K. (2023) · New Phytologist · doi:10.1111/nph.18758 · Cited by 48 · see citing works
Advanced metabolic engineering strategies for increasing artemisinin yield in Artemisia annua L.
Li, Y., Yang, Y., Li, L., Tang, K., Hao, X., & Kai, G. (2024) · Horticulture Research · doi:10.1093/hr/uhad292 · Cited by 42 · see citing works
Self-citationContemporary understanding of transcription factor regulation of terpenoid biosynthesis in plants
Huang, X., Zhang, W., Liao, Y., Ye, J., & Xu, F. (2023) · Planta · doi:10.1007/s00425-023-04268-z · Cited by 40 · see citing works
Chen, T.-T., Liu, H., Li, Y., Yao, X., Qin, W. D., Yan, X., Wang, X., Peng, B., Zhang, Y., Shao, J., et al. (2023) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiad113 · Cited by 39 · see citing works
Self-citationCao, J., Chen, Z., Wang, L., Yan, N., Lin, J., Hou, L.-P., Zhao, Y., Huang, C., Wen, T., Li, C., et al. (2023) · Plant Communications · doi:10.1016/j.xplc.2023.100742 · Cited by 37 · see citing works
Self-citationBhatt, P. A., Gurav, T. P., Kondhare, K. R., & Giri, A. P. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138588 · Cited by 35 · see citing works
Zhou, P., Chen, H., Dang, J., Shi, Z.-R., Shao, Y., Liu, C., Fan, L., & Wu, Q. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.988594 · Cited by 34 · see citing works
Wang, C., Chen, T., Li, Y., Liu, H., Qin, W. D., Wu, Z., Peng, B., Wang, X., Yan, X., Fu, X., et al. (2023) · Plant Science · doi:10.1016/j.plantsci.2023.111602 · Cited by 29 · see citing works
Self-citationHassani, D., Taheri, A., Fu, X., Qin, W. D., Liu, H., Ma, Y., & Tang, K. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1118082 · Cited by 29 · see citing works
Self-citationStructural and interactions analysis of a transcription factor PnMYB2 in Panax notoginseng
Xia, P., Hu, W., Zheng, Y., Wang, Y., Yan, K., & Liang, Z. (2022) · Journal of Plant Physiology · doi:10.1016/j.jplph.2022.153756 · Cited by 26 · see citing works
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Tong, Y., Xue, J., Li, Q., & Zhang, L. (2024) · Journal of Experimental Botany · doi:10.1093/jxb/erae225 · Cited by 25 · see citing works
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Artemisinin production strategies for industrial scale: Current progress and future directions
Qamar, F., Ashrafi, K., Singh, A., Dash, P. K., & Abdin, M. Z. (2024) · Industrial Crops and Products · doi:10.1016/j.indcrop.2024.118937 · Cited by 24 · see citing works
Ueda, T., Murata, M., & Yokawa, K. (2021) · Plants · doi:10.3390/plants10071420 · Cited by 22 · see citing works
Hu, P., Suriguga, Zhao, M., Chen, S., Wu, X., & Wan, Q. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.972990 · Cited by 22 · see citing works
Zhou, P., Dang, J., Shi, Z.-R., Shao, Y., Sang, M., Dai, S., Yue, W., Liu, C., & Wu, Q. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.936244 · Cited by 21 · see citing works
Qamar, F., Mishra, A., Ashrafi, K., Saifi, M., Dash, P. K., Kumar, S. B., & Abdin, M. Z. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136291 · Cited by 19 · see citing works
Yang, L., Miao, L., Gong, Q., & Guo, J. (2022) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-022-02334-0 · Cited by 17 · see citing works
JA-Regulated AaGSW1–AaYABBY5/AaWRKY9 Complex Regulates Artemisinin Biosynthesis in Artemisia annua
Kayani, S., Yanan, M., Fu, X., Shen, Q., Li, Y., Rahman, S.-U., Peng, B., Huang, L., & Tang, K. (2023) · Plant and Cell Physiology · doi:10.1093/pcp/pcad035 · Cited by 17 · see citing works
Self-citationLiu, H., He, W., Yao, X., Yan, X., Wang, X., Peng, B., Zhang, Y., Shao, J., Hu, X., Miao, Q., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612929 · Cited by 18 · see citing works
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Xing, B., Lin, Q., Wang, Z., Wang, F., Yu, H., Li, W., Li, Y., Abozeid, A., Xia, P., Zhang, L., et al. (2025) · Plant Biotechnology Journal · doi:10.1111/pbi.70241 · Cited by 14 · see citing works
Self-citationMADS-box gene AaSEP4 promotes artemisinin biosynthesis in Artemisia annua
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Self-citationFu, X., Zhang, Y., Yu, M., Zheng, H., Pan, Y., Liu, P., Li, L., Sun, X., Wang, Y., Zhao, J., et al. (2026) · Journal of Integrative Plant Biology · doi:10.1111/jipb.70133 · Cited by 14 · see citing works
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Li, Y., Chen, T., Liu, H., Qin, W. D., Yan, X., Wu-Zhang, K., Peng, B., Zhang, Y., Yao, X., Fu, X., et al. (2022) · Journal of Plant Physiology · doi:10.1016/j.jplph.2022.153712 · Cited by 11 · see citing works
Self-citationSuárez‐Baron, H., Álzate, J. F., Ambrose, B. A., Pelaz, S., González, F., & Pabón‐Mora, N. (2023) · Journal of Experimental Botany · doi:10.1093/jxb/erad345 · Cited by 9 · see citing works
Yang, X., Meng, F., Cheng, Q., Feng, P., Song, X., & Chen, W. (2025) · Horticulture Research · doi:10.1093/hr/uhaf229 · Cited by 9 · see citing works
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A eudicot MIXTA family ancestor likely functioned in both conical cells and trichomes
Zahid, S., Schulfer, A. F., & Stilio, V. S. D. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1288961 · Cited by 5 · see citing works
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Zakariya, A. M., Saiman, M. Z., Simonsen, H. T., & Ikram, N. K. K. (2023) · Phytochemistry Reviews · doi:10.1007/s11101-023-09897-6 · Cited by 5 · see citing works
Yang, Y., Li, Y., Li, J., Li, P., Zhou, Q., Sheng, M., Ma, X., Shoji, T., Hao, X., & Kai, G. (2024) · BMC Genomics · doi:10.1186/s12864-024-10683-7 · Cited by 5 · see citing works
Self-citationTamiru, M., Hurgobin, B., Berkowitz, O., Yin, L., Jost, R., Gvaramiya, S., Welling, M. T., Doblin, M. S., Bacic, A., Whelan, J., et al. (2026) · The Plant Journal · doi:10.1111/tpj.70774 · Cited by 4 · see citing works
Yang, Y., Xiao, C., Cai, Y., Wang, J., Ruan, Q., Sheng, M., Li, L., Tang, K., Kai, G., & Hao, X. (2023) · Industrial Crops and Products · doi:10.1016/j.indcrop.2023.116769 · Cited by 4 · see citing works
Self-citationLi, D., Song, J., Tang, Y., Zhang, Z., Yang, C., Zeng, L., Liu, X., Chen, M., Lan, X., Zhang, F., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062441 · Cited by 3 · see citing works
Sinha, H., Rai, T., Kumar, R. S., Datta, T., Srivastava, S., Singh, A., & Trivedi, P. K. (2026) · Physiological and Molecular Plant Pathology · doi:10.1016/j.pmpp.2026.103131 · Cited by 2 · see citing works
Liu, H., Farmer, R., Payyavula, R. S., Chengalrayan, K., & Timko, M. P. (2026) · Plant Biotechnology Journal · doi:10.1111/pbi.70655 · Cited by 2 · see citing works
Self-citationIn Vitro Production of Flavonoids
Amer, A., & Shahin, A. (2025) · Reference series in phytochemistry · doi:10.1007/978-3-031-51158-5_30 · Cited by 1 · see citing works
Cold atmospheric plasma preserves the antioxidant capacity in postharvest mulberry fruit
Yinxin, L., Peiyao, C., Lixue, W., Cheng, L., Ziwen, C., Chongde, S., & Lingxia, H. (2025) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2025.113933 · Cited by 1 · see citing works
Li, X., Li, Y., Shi, Y., Wei, Y., Yang, Y., & Liu, H. (2026) · Plant Science · doi:10.1016/j.plantsci.2026.113002 · Cited by 1 · see citing works
Self-citationComparative analysis of gene expression and metabolites in female and male Cannabis sativa flowers
Chen, Y., Qi, G., Zhang, J., Dai, Z., Deng, C., Cheng, C., Yang, Z., Chen, J., Zhang, X., Zhu, S., et al. (2026) · iScience · doi:10.1016/j.isci.2026.114941 · Cited by 1 · see citing works
Yuan, M., & Zhou, F. (2026) · Genes · doi:10.3390/genes17080883 · Cited by 1 · see citing works
Li, Y., Tang, H., Zhang, T., Li, X., Zheng, B., Cheng, M., Yang, G., & Pan, G. (2026) · Frontiers in Plant Science · doi:10.3389/fpls.2026.1914974 · Cited by 1 · see citing works
Self-citationMetabolic engineering of microbial and plant chasses to optimize artemisinin production
Behera, J. R., Ekwudo, M. N., Nohoesu, O. R., & Kilaru, A. (2023) · CABI Reviews · doi:10.1079/cabireviews.2023.0044 · Cited by 1 · see citing works
In Vitro Production of Flavonoids
Amer, A., & Shahin, A. (2025) · Reference series in phytochemistry · doi:10.1007/978-3-031-30037-0_30-1 · Cited by 1 · see citing works
Fakhrah, S., Chauhan, A., Mishra, P., Asif, M. H., Jena, S. N., & Mohanty, C. S. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4846944
Genetic engineering as a means to maximize secondary metabolite production
Sharma, A., Qamar, F., Ashrafi, K., & Saifi, M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33959-2.00022-8
CsMYB6 promotes crocins biosynthesis in response to JA signaling in Crocus sativus L
Wang, S., Lin, C., Shi, X., Zhou, A., Chen, T., Zheng, Y., Shao, Q., Zhang, L., Ding, L., & Xing, B. (2026) · Journal of Plant Physiology · doi:10.1016/j.jplph.2026.154801
Self-citationKashyap, D., Sharma, R., Munda, V. S., Garg, V. K., Thakur, S., Sharma, D., Okpala, C. O. R., & Dhiman, V. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-42855-5.00004-2
Biosynthesis and Production of Artemisinin
Mathew, G., Lakshmaiah, V. V., Al-Khayri, J. M., & Nagella, P. (2026) · Springer eBooks · doi:10.1007/978-3-642-36202-6_221-1
Flavonoids and neurodegeneration: Structure-activity relationship and therapeutic insights
Paragas, D. S., Ortinero, C., Feliciano, M. A. M., Lazaro, S. E., Quitos, L. S., Gonzales, R. L., Hsieh, C.-Y., Chen, B.-Y., Hsueh, C., & Tsai, P. (2026) · Studies in natural products chemistry · doi:10.1016/b978-0-443-49142-9.00010-x
From Model Plants to Cannabis: Genetic Regulation of Glandular Trichome Development
Betancourt, J. D. R., Sarmiento, F., & Germain, H. (2026) · Plants · doi:10.3390/plants15182810
- Authors
- Qin, W., Xie, L., Li, Y., Liu, H., Fu, X., Chen, T., Hassani, D., Li, L., Sun, X., & Tang, K.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Tang, Kexuan
- Venue
- Frontiers in Plant Science
- Publisher
- Frontiers Media SA
- Published
- 2021-04-09
- Volume
- 12
- Pages
- 657156-657156
- ISSN
- 1664-462X (ISSN-L)
- PMC
- PMC8063117
- OpenAlex
- W3154901582
- Cited by
- 66
- References
- 53
- Citations by year
- 2026: 13 · 2025: 9 · 2024: 9 · 2023: 18 · 2022: 14 · 2021: 3
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Plant Science (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Bill and Melinda Gates Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Gene Expression Analysis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- R2R3-MYB transcription factor, trichome initiation, Artemisia annua, artemisinin biosynthesis, trichome density, trichome morphology, gene overexpression, RNA interference
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