The brain in (Willed) action: a meta-analytical comparison of imaging studies on motor intentionality and sense of agency
Open accessAbstract
Voluntary actions can be fractionated in different phenomena: from the emergence of intentions and the ensuing motor plans and actions, to the anticipation and monitoring of their outcomes, to the appreciation of their congruency with intentions and to the eventual emergence of a sense of agency. It follows that motor intention and the sense of agency should occur at different stages in the normal generation of willed actions. Both these processes have been associated with a fronto-parietal motor network, but no study has investigated to what extent the two experiences can be dissociated for the brain regions involved. To this end, we assessed the PET/fMRI literature on agency and intentionality using a meta-analytic technique based on a hierarchical clustering algorithm. Beside a shared brain network involving the meso-frontal and prefrontal regions, the middle insula and subcortical structures, we found that motor intention and the sense of agency are functionally underpinned by separable sets of brain regions: an "intentionality network," involving the rostral area of the mesial frontal cortex (middle cingulum and pre-supplementary motor area), the anterior insula and the parietal lobules, and a "self-agency network," which involves the posterior areas of the mesial frontal cortex (the SMA proper), the posterior insula, the occipital lobe and the cerebellum. We were then able to confirm this functional organization by a subsequent seed-based fMRI resting-state functional connectivity analysis, with seeds derived from the intentionality/sense of agency specific clusters of the medial wall of the frontal lobe. Our results suggest the existence of a rostro-caudal gradient within the mesial frontal cortex, with the more anterior regions linked to the concept of motor intentionality and the brain areas located more posteriorly associated with the direct monitoring between the action and its outcome. This suggestion is reinforced by the association between the sense of agency and the activation of the occipital lobes, to suggest a direct comparison between the movement and its external (e.g., visual) consequences. The shared network may be important for the integration of intentionality and agency in a coherent appreciation of self-generated actions.
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The network activated when agency is disrupted consistently involves the temporo-parietal junction or inferior parietal lobule, the dorsomedial prefrontal cortex, the precuneus, the pre-supplementary motor area, the superior and middle temporal gyrus, and the angular gyrus.
“The network that is activated when the agency is disrupted consistently involves the temporo-parietal junction (TPJ) or inferior parietal lobule (IPL), the dorsomedial prefrontal cortex, the precuneus, the pre-supplementary motor area (preSMA), the superior and middle temporal gyrus, the angular gyrus (Sperduti et al., 2011; Seghezzi et al., 2019; Zito et al., 2020).”
From The Forward Model: A Unifying Theory for the Role of the Cerebellum in Motor Control and Sense of Agency (2021) · cites this paper as Seghezzi et al., 2019
The Explorative Meta-Analysis (page unavailable) assigns the inferior parietal lobule and pre-SMA to motor intention, not specifically to self-agency. It identifies SMA proper, posterior insula, calcarine fissure and cerebellum as self-agency-specific clusters. The paper does not describe the claimed list as a network consistently activated when agency is disrupted. (LLM, conf=0.85)
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Experimental — accuracy not yet measuredPositive self-agency has been associated with the insula, the primary somatosensory cortex, the premotor cortex, the SMA, the calcarine sulcus, and the cerebellum.
“By contrast, the “positive” self-agency has been associated with the insula, the primary somatosensory cortex, the premotor cortex, the SMA, the calcarine sulcus, the cerebellum (Sperduti et al., 2011; Seghezzi et al., 2019).”
From The Forward Model: A Unifying Theory for the Role of the Cerebellum in Motor Control and Sense of Agency (2021) · cites this paper as Seghezzi et al., 2019
The Explorative Meta-Analysis results identify the SMA, posterior insula, calcarine fissure, and cerebellum as self-agency-specific clusters. The Discussion also includes premotor areas in a network shared with motor intention, while the Confirmative Analysis reports connectivity between the agency-associated SMA and the postcentral gyrus. The paper does not distinguish “positive” self-agency, and it does not identify the primary somatosensory cortex or premotor cortex as self-agency-specific clusters. The supplied passages have section labels but no page numbers. (LLM, conf=0.87)
Experimental — accuracy not yet measuredDifferent measures of the sense of agency-explicit judgment of agency, non-agency, and intentional binding-have been associated with different brain regions.
“As stressed in the previous paragraph, the different measures of the sense of agency (explicit judgment of the agency, “non-agency” and intentional binding) have been associated with different brain regions, that have been recently reviewed in meta-analyzes (Sperduti et al., 2011; Seghezzi et al., 2019; Zito et al., 2020).”
From The Forward Model: A Unifying Theory for the Role of the Cerebellum in Motor Control and Sense of Agency (2021) · cites this paper as Seghezzi et al., 2019
The Introduction distinguishes explicit judgments of agency from implicit measures such as intentional binding. The Explorative Meta-Analysis reports brain-region clusters for self-agency and external-agency, but the passages do not report a distinct brain-region association for intentional binding. Thus this paper supports only part of the three-measure claim. (LLM, conf=0.87)
Experimental — accuracy not yet measuredThe cerebellum is involved in detecting a mismatch between the expected and actual sensory feedback, leading to a feeling of disrupted agency.
“Second, as shown in the previous section, the cerebellum is involved in detecting a mismatch between the expected and actual sensory feedback, leading to a feeling of disrupted agency (Blakemore et al., 2001; Nahab et al., 2011; Seghezzi et al., 2019).”
From The Forward Model: A Unifying Theory for the Role of the Cerebellum in Motor Control and Sense of Agency (2021) · cites this paper as Seghezzi et al., 2019
The Introduction’s comparator-model section says that a mismatch between predicted and actual outcomes prevents an outcome from being attributed to one’s own action. The Explorative Meta-Analysis links the right cerebellum to self-agency, but our copy does not identify the cerebellum specifically as the detector of that mismatch. Page numbers are not available in the indexed passages. (LLM, conf=0.85)
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- Authors
- Seghezzi, S., Zirone, E., Paulesu, E., & Zapparoli, L.
- Affiliations
- University of Milano-Bicocca (IT)
- IRCCS Ospedale Galeazzi - Sant'Ambrogio (IT)
- Corresponding author
- Zapparoli, Laura
- Venue
- Frontiers in Psychology
- Publisher
- Frontiers Media SA
- Published
- 2019-04-12
- Volume
- 10
- Pages
- 804-804
- ISSN
- 1664-1078 (ISSN-L)
- PMC
- PMC6473038
- OpenAlex
- W2937117144
- Cited by
- 68
- References
- 3
- Citations by year
- 2026: 13 · 2025: 9 · 2024: 6 · 2023: 9 · 2022: 11 · 2021: 8 · 2020: 10 · 2019: 2
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Psychology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministero della Salute (Ricerca Corrente; Project L3025, L3025)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Free Will and Agency
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- motor intentionality, sense of agency, voluntary action, pre-supplementary motor area, supplementary motor area, anterior insula, posterior insula, parietal lobule, cerebellum, occipital lobe, resting-state functional connectivity, rostrocaudal gradient, self-generated action
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